|
EP0739984A1
(en)
*
|
1995-04-26 |
1996-10-30 |
San Tumorforschungs-Gmbh |
Bivalent polypeptides containing at least two domains
|
|
US7973137B1
(en)
*
|
1996-03-28 |
2011-07-05 |
Johns Hopkins University |
Cell compositions comprising molecular complexes that modify immune responses
|
|
DK0894135T3
(en)
*
|
1996-04-04 |
2004-12-06 |
Unilever Nv |
Multivalent and multispecific antigen binding protein
|
|
DK1049787T3
(en)
*
|
1998-01-23 |
2005-04-04 |
Vlaams Interuniv Inst Biotech |
Antibody derivatives with multiple uses
|
|
DE10021678A1
(en)
*
|
2000-05-05 |
2002-04-18 |
Stefan Duebel |
Recombinant polyspecific antibody constructs, useful for diagnosis and treatment of cancer, comprises three antibody fragments,where at least one comprises a disulfide bridge
|
|
CA2417185A1
(en)
*
|
2000-07-25 |
2002-01-31 |
Shui-On Leung |
Multivalent target binding protein
|
|
EP1900753B1
(en)
|
2002-11-08 |
2017-08-09 |
Ablynx N.V. |
Method of administering therapeutic polypeptides, and polypeptides therefor
|
|
EP1867661A1
(en)
*
|
2006-06-12 |
2007-12-19 |
Diatos |
Compositions and methods for delivering anti-activated ras antibodies into cells
|
|
EP2069401A4
(en)
*
|
2007-07-31 |
2011-02-23 |
Medimmune Llc |
Multispecific epitope binding proteins and uses thereof
|
|
ES2667729T3
(en)
|
2007-09-26 |
2018-05-14 |
Ucb Biopharma Sprl |
Fusions of antibodies with double specificity
|
|
CA2706419A1
(en)
*
|
2007-11-30 |
2009-06-04 |
Glaxo Group Limited |
Antigen-binding constructs binding il-13
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
CA2713055C
(en)
|
2008-01-25 |
2018-03-13 |
Aarhus Universitet |
Selective exosite inhibition of papp-a activity against igfbp-4
|
|
US8460657B2
(en)
|
2008-06-25 |
2013-06-11 |
H. Lundbeck A/S |
Modulation of the TrpV: Vps10p receptor system for the treatment of pain
|
|
EP2334705B1
(en)
|
2008-09-26 |
2016-12-14 |
UCB Biopharma SPRL |
Biological products
|
|
CN105641694B
(en)
|
2008-12-19 |
2020-08-14 |
H.隆德贝克有限公司 |
Modulation of the Vps10 p-domain receptor family for the treatment of mental and behavioural disorders
|
|
WO2010112034A2
(en)
|
2009-04-02 |
2010-10-07 |
Aarhus Universitet |
Compositions and methods for treatment and diagnosis of synucleinopathies
|
|
EP2414391B1
(en)
|
2009-04-02 |
2018-11-28 |
Roche Glycart AG |
Multispecific antibodies comprising full length antibodies and single chain fab fragments
|
|
WO2010115589A1
(en)
*
|
2009-04-07 |
2010-10-14 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
|
AU2010252284A1
(en)
*
|
2009-05-27 |
2011-11-17 |
F. Hoffmann-La Roche Ag |
Tri- or tetraspecific antibodies
|
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
RU2573915C2
(en)
|
2009-09-16 |
2016-01-27 |
Дженентек, Инк. |
Protein complexes containing superhelix and/or banding, and their use
|
|
GB201005063D0
(en)
*
|
2010-03-25 |
2010-05-12 |
Ucb Pharma Sa |
Biological products
|
|
WO2011054359A2
(en)
|
2009-11-06 |
2011-05-12 |
University Of Copenhagen |
Method for early detection of cancer
|
|
AR080793A1
(en)
|
2010-03-26 |
2012-05-09 |
Roche Glycart Ag |
BISPECIFIC ANTIBODIES
|
|
CN103154025B
(en)
*
|
2010-08-02 |
2015-07-01 |
宏观基因有限公司 |
Covalent diabodies and uses thereof
|
|
WO2012025530A1
(en)
|
2010-08-24 |
2012-03-01 |
F. Hoffmann-La Roche Ag |
Bispecific antibodies comprising a disulfide stabilized - fv fragment
|
|
WO2012085111A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
JP5768147B2
(en)
|
2011-02-28 |
2015-08-26 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Monovalent antigen binding protein
|
|
KR101638224B1
(en)
|
2011-02-28 |
2016-07-08 |
에프. 호프만-라 로슈 아게 |
Antigen binding proteins
|
|
CN103842383B
(en)
*
|
2011-05-16 |
2017-11-03 |
健能隆医药技术（上海）有限公司 |
Polyspecific FAB fusion proteins and its application method
|
|
CN103781801B
(en)
*
|
2011-08-23 |
2018-02-09 |
罗切格利卡特公司 |
Include the antibody and application method without Fc of two Fab fragments
|
|
EP2747781B1
(en)
|
2011-08-23 |
2017-11-15 |
Roche Glycart AG |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
|
KR102100817B1
(en)
|
2012-01-13 |
2020-04-17 |
율리우스-막시밀리안스 우니버지태트 뷔르츠부르크 |
Dual Antigen-Induced Bipartite Functional Complementation
|
|
BR112014019579A2
(en)
|
2012-02-10 |
2019-10-15 |
Genentech, Inc |
SINGLE CHAIN ANTIBODY, POLYNUCLEOTIDE, VECTOR, HOST CELL, METHOD OF PRODUCTION OF A SINGLE CHAIN ANTIBODY, HETEROMULTYMER AND METHOD OF PRODUCTION
|
|
CA2871882A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
|
|
BR112014032193A2
(en)
|
2012-06-27 |
2017-06-27 |
Hoffmann La Roche |
bispecific antibody production and combination determination methods, bispecific antibody, formulation and use of bispecific antibody
|
|
JP2016536326A
(en)
|
2013-08-29 |
2016-11-24 |
ユニバーシティ オブ コペンハーゲン |
Anti-ADAM12 antibody for cancer treatment
|
|
MX2016003593A
(en)
|
2013-10-11 |
2016-06-02 |
Hoffmann La Roche |
Multispecific domain exchanged common variable light chain antibodies.
|
|
JOP20200094A1
(en)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
Antibody molecules to pd-1 and uses thereof
|
|
JOP20200096A1
(en)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
Antibody molecules to tim-3 and uses thereof
|
|
KR102442436B1
(en)
|
2014-03-14 |
2022-09-15 |
노파르티스 아게 |
Antibody molecules to lag-3 and uses thereof
|
|
ES2939760T3
(en)
|
2014-03-15 |
2023-04-26 |
Novartis Ag |
Cancer treatment using a chimeric receptor for antigens
|
|
GB201411320D0
(en)
|
2014-06-25 |
2014-08-06 |
Ucb Biopharma Sprl |
Antibody construct
|
|
CA2955386A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
|
JP2017528433A
(en)
|
2014-07-21 |
2017-09-28 |
ノバルティス アーゲー |
Low immunoenhancing dose of mTOR inhibitor and CAR combination
|
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
TWI719942B
(en)
|
2014-07-21 |
2021-03-01 |
瑞士商諾華公司 |
Treatment of cancer using a cd33 chimeric antigen receptor
|
|
EP3660042B1
(en)
|
2014-07-31 |
2023-01-11 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
EP2985294A1
(en)
*
|
2014-08-14 |
2016-02-17 |
Deutsches Krebsforschungszentrum |
Recombinant antibody molecule and its use for target cell restricted T cell activation
|
|
WO2016025880A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
|
CN112410363A
(en)
|
2014-08-19 |
2021-02-26 |
诺华股份有限公司 |
anti-CD 123 Chimeric Antigen Receptor (CAR) for cancer therapy
|
|
ES2891332T3
(en)
|
2014-09-17 |
2022-01-27 |
Novartis Ag |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
AU2015333687B2
(en)
|
2014-10-14 |
2021-03-18 |
Dana-Farber Cancer Institute, Inc. |
Antibody molecules to PD-L1 and uses thereof
|
|
WO2016090034A2
(en)
|
2014-12-03 |
2016-06-09 |
Novartis Ag |
Methods for b cell preconditioning in car therapy
|
|
WO2016087416A1
(en)
|
2014-12-03 |
2016-06-09 |
F. Hoffmann-La Roche Ag |
Multispecific antibodies
|
|
WO2016146134A1
(en)
|
2015-03-16 |
2016-09-22 |
Aarhus Universitet |
Antibodies towards an extracellular region of nbcn1
|
|
BR112017020091A2
(en)
|
2015-03-20 |
2018-11-06 |
Aarhus Universitet |
pcsk9 inhibitors for treatment of lipoprotein metabolism disorders
|
|
HUE059218T2
(en)
|
2015-04-08 |
2022-11-28 |
Novartis Ag |
Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell
|
|
US20180298068A1
(en)
|
2015-04-23 |
2018-10-18 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
PT3317301T
(en)
|
2015-07-29 |
2021-07-09 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
CN108495651A
(en)
|
2015-12-17 |
2018-09-04 |
诺华股份有限公司 |
The antibody molecule and application thereof of anti-PD-1
|
|
JP2019502695A
(en)
|
2015-12-17 |
2019-01-31 |
ノバルティス アーゲー |
Combination of antibody molecule against PD-1 and C-Met inhibitor and use thereof
|
|
EP3851457A1
(en)
|
2016-01-21 |
2021-07-21 |
Novartis AG |
Multispecific molecules targeting cll-1
|
|
SG11201807489PA
(en)
|
2016-03-04 |
2018-09-27 |
Novartis Ag |
Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
|
|
CN109476756B
(en)
|
2016-03-15 |
2022-05-31 |
埃泰美德(香港)有限公司 |
Multi-specificity Fab fusion protein and application thereof
|
|
EP3432924A1
(en)
|
2016-03-23 |
2019-01-30 |
Novartis AG |
Cell secreted minibodies and uses thereof
|
|
WO2017181119A2
(en)
|
2016-04-15 |
2017-10-19 |
Novartis Ag |
Compositions and methods for selective protein expression
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
CA3030837A1
(en)
|
2016-07-15 |
2018-01-18 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
|
SG11201900677SA
(en)
|
2016-07-28 |
2019-02-27 |
Novartis Ag |
Combination therapies of chimeric antigen receptors adn pd-1 inhibitors
|
|
US20190161542A1
(en)
|
2016-08-01 |
2019-05-30 |
Novartis Ag |
Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
|
|
EP3515455B1
(en)
|
2016-09-20 |
2021-04-14 |
Aarhus Universitet |
Compounds for treatment of lipoprotein metabolism disorders
|
|
EP3523331A1
(en)
|
2016-10-07 |
2019-08-14 |
Novartis AG |
Chimeric antigen receptors for the treatment of cancer
|
|
ES2912408T3
(en)
|
2017-01-26 |
2022-05-25 |
Novartis Ag |
CD28 compositions and methods for therapy with chimeric receptors for antigens
|
|
EP3589647A1
(en)
|
2017-02-28 |
2020-01-08 |
Novartis AG |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
CN110662547A
(en)
|
2017-04-26 |
2020-01-07 |
优瑞科生物技术公司 |
Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
|
|
US20200055948A1
(en)
|
2017-04-28 |
2020-02-20 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
WO2018237157A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
WO2019006007A1
(en)
|
2017-06-27 |
2019-01-03 |
Novartis Ag |
Dosage regimens for anti-tim-3 antibodies and uses thereof
|
|
EP3652209A2
(en)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonist antibodies that bind human cd137 and uses thereof
|
|
CA3070095A1
(en)
|
2017-07-20 |
2019-01-24 |
Novartis Ag |
Dosage regimens of anti-lag-3 antibodies and uses thereof
|
|
WO2019089753A2
(en)
|
2017-10-31 |
2019-05-09 |
Compass Therapeutics Llc |
Cd137 antibodies and pd-1 antagonists and uses thereof
|
|
WO2019089798A1
(en)
|
2017-10-31 |
2019-05-09 |
Novartis Ag |
Anti-car compositions and methods
|
|
AU2018368731A1
(en)
|
2017-11-16 |
2020-05-14 |
Novartis Ag |
Combination therapies
|
|
US11851497B2
(en)
|
2017-11-20 |
2023-12-26 |
Compass Therapeutics Llc |
CD137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
|
AU2019215031A1
(en)
|
2018-01-31 |
2020-08-20 |
Novartis Ag |
Combination therapy using a chimeric antigen receptor
|
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
|
WO2019210153A1
(en)
|
2018-04-27 |
2019-10-31 |
Novartis Ag |
Car t cell therapies with enhanced efficacy
|
|
CN112384534A
(en)
|
2018-05-21 |
2021-02-19 |
指南针制药有限责任公司 |
Compositions and methods for enhancing killing of target cells by NK cells
|
|
WO2019226658A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Multispecific antigen-binding compositions and methods of use
|
|
EP3801769A1
(en)
|
2018-05-25 |
2021-04-14 |
Novartis AG |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
CA3100724A1
(en)
|
2018-06-13 |
2019-12-19 |
Novartis Ag |
B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof
|
|
WO2019246293A2
(en)
|
2018-06-19 |
2019-12-26 |
Atarga, Llc |
Antibody molecules to complement component 5 and uses thereof
|
|
AR116109A1
(en)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
|
|
WO2020021465A1
(en)
|
2018-07-25 |
2020-01-30 |
Advanced Accelerator Applications (Italy) S.R.L. |
Method of treatment of neuroendocrine tumors
|
|
CN113166269A
(en)
|
2018-11-13 |
2021-07-23 |
指南针制药有限责任公司 |
Multispecific binding constructs against checkpoint molecules and uses thereof
|
|
EP3898686A1
(en)
|
2018-12-20 |
2021-10-27 |
Novartis AG |
Pharmaceutical combinations
|
|
BR112021011874A2
(en)
|
2018-12-20 |
2021-09-08 |
Novartis Ag |
DOSAGE SCHEME AND PHARMACEUTICAL COMBINATION INCLUDING DERIVATIVES OF 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE
|
|
US10871640B2
(en)
|
2019-02-15 |
2020-12-22 |
Perkinelmer Cellular Technologies Germany Gmbh |
Methods and systems for automated imaging of three-dimensional objects
|
|
MX2021009763A
(en)
|
2019-02-15 |
2021-09-08 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof.
|
|
KR20210129672A
(en)
|
2019-02-15 |
2021-10-28 |
노파르티스 아게 |
Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
US20220088075A1
(en)
|
2019-02-22 |
2022-03-24 |
The Trustees Of The University Of Pennsylvania |
Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
|
|
MX2021011830A
(en)
|
2019-03-29 |
2022-01-24 |
Atarga Llc |
Anti fgf23 antibody.
|
|
TW202128166A
(en)
|
2019-10-21 |
2021-08-01 |
瑞士商諾華公司 |
Combination therapies
|
|
EP4048285A1
(en)
|
2019-10-21 |
2022-08-31 |
Novartis AG |
Tim-3 inhibitors and uses thereof
|
|
AU2020393912A1
(en)
|
2019-11-26 |
2022-06-09 |
Novartis Ag |
Chimeric antigen receptors binding BCMA and CD19 and uses thereof
|
|
CA3165399A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases
|
|
BR112022012310A2
(en)
|
2020-01-17 |
2022-09-06 |
Novartis Ag |
A COMBINATION COMPRISING A TIM-3 INHIBITOR AND A HYPOMETYLING AGENT FOR USE IN THE TREATMENT OF MYELODYSPLASTIC SYNDROME OR CHRONIC MYELOMONOCYTIC LEUKEMIA
|
|
US20210222244A1
(en)
|
2020-01-17 |
2021-07-22 |
Becton, Dickinson And Company |
Methods and compositions for single cell secretomics
|
|
JP2023515211A
(en)
|
2020-02-27 |
2023-04-12 |
ノバルティス アーゲー |
Method for producing chimeric antigen receptor-expressing cells
|
|
BR112022026202A2
(en)
|
2020-06-23 |
2023-01-17 |
Novartis Ag |
DOSAGE REGIMEN COMPRISING 3-(1-OXOISOINDOLIN-2-IL)PIPERIDINE-2,6-DIONE DERIVATIVES
|
|
TW202216761A
(en)
|
2020-07-16 |
2022-05-01 |
瑞士商諾華公司 |
Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
|
|
WO2022026592A2
(en)
|
2020-07-28 |
2022-02-03 |
Celltas Bio, Inc. |
Antibody molecules to coronavirus and uses thereof
|
|
CN116134027A
(en)
|
2020-08-03 |
2023-05-16 |
诺华股份有限公司 |
Heteroaryl-substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof
|
|
US20230338587A1
(en)
|
2020-08-31 |
2023-10-26 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
US20230321285A1
(en)
|
2020-08-31 |
2023-10-12 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
CN116472288A
(en)
|
2020-11-06 |
2023-07-21 |
诺华股份有限公司 |
Antibody Fc variants
|
|
MX2023005609A
(en)
|
2020-11-13 |
2023-05-29 |
Novartis Ag |
Combination therapies with chimeric antigen receptor (car)-expressing cells.
|
|
EP4284510A1
(en)
|
2021-01-29 |
2023-12-06 |
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