MX2017003645A - Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva. - Google Patents

Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva.

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Publication number
MX2017003645A
MX2017003645A MX2017003645A MX2017003645A MX2017003645A MX 2017003645 A MX2017003645 A MX 2017003645A MX 2017003645 A MX2017003645 A MX 2017003645A MX 2017003645 A MX2017003645 A MX 2017003645A MX 2017003645 A MX2017003645 A MX 2017003645A
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MX
Mexico
Prior art keywords
receptor
car
adoptive immunotherapy
chimeric receptors
cytotoxic cells
Prior art date
Application number
MX2017003645A
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English (en)
Inventor
Loew Andreas
Beatty Gregory
ENGELS Boris
Song Huijuan
C Milone Michael
IDAMAKANTI Neeraja
Wang Enxiu
Wu Quilong
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2017003645A publication Critical patent/MX2017003645A/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2319/00—Fusion polypeptide
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    • C12N2510/00—Genetically modified cells

Abstract

La presente invención proporciona composiciones y métodos para regular la especificidad y actividad de las células inmunoefectoras para utilizarse en inmunoterapia. En una modalidad, la invención proporciona un tipo de receptor de antígeno quimérico (CAR), en donde el CAR se denomina como un "NKR-CAR", el cual es un diseño de CAR que comprende un componente de un receptor que se encuentra naturalmente sobre las células aniquiladoras naturales (NK). En una modalidad, el receptor de NK incluye, pero no se limita a, un receptor activador e inhibidor de las células NK que se presenta naturalmente, el cual se conoce como un receptor de tipo inmunoglobulina de células aniquiladoras (KIR).
MX2017003645A 2014-09-17 2015-09-17 Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva. MX2017003645A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014086694 2014-09-17
CN2014090578 2014-11-07
PCT/US2015/050715 WO2016044605A1 (en) 2014-09-17 2015-09-17 Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy

Publications (1)

Publication Number Publication Date
MX2017003645A true MX2017003645A (es) 2017-05-30

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MX2017003645A MX2017003645A (es) 2014-09-17 2015-09-17 Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva.
MX2022012082A MX2022012082A (es) 2014-09-17 2017-03-17 Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva.

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MX2022012082A MX2022012082A (es) 2014-09-17 2017-03-17 Direccion de celulas citotoxicas con receptores quimericos para inmunoterapia adoptiva.

Country Status (14)

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US (1) US10577417B2 (es)
EP (2) EP3967709A1 (es)
JP (3) JP6839074B2 (es)
KR (3) KR20230149327A (es)
CN (2) CN114621969A (es)
AU (2) AU2015317608B2 (es)
BR (1) BR112017005390A2 (es)
CA (1) CA2961636A1 (es)
DK (1) DK3194443T3 (es)
EA (1) EA201790624A1 (es)
ES (1) ES2891332T3 (es)
MX (2) MX2017003645A (es)
PL (1) PL3194443T3 (es)
WO (1) WO2016044605A1 (es)

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