US6207646B1
(en)
*
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US20030026782A1
(en)
*
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
UA67760C2
(ru)
*
|
1997-12-11 |
2004-07-15 |
Міннесота Майнінг Енд Мануфакчурінг Компані |
Имидазонафтиридины и их применение для индуцирования биосинтеза цитокинов
|
WO2000061151A2
(en)
|
1999-04-12 |
2000-10-19 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
US6331539B1
(en)
*
|
1999-06-10 |
2001-12-18 |
3M Innovative Properties Company |
Sulfonamide and sulfamide substituted imidazoquinolines
|
US20030129251A1
(en)
*
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
US6660735B2
(en)
*
|
2000-12-08 |
2003-12-09 |
3M Innovative Properties Company |
Urea substituted imidazoquinoline ethers
|
US6667312B2
(en)
*
|
2000-12-08 |
2003-12-23 |
3M Innovative Properties Company |
Thioether substituted imidazoquinolines
|
JP2008531580A
(ja)
*
|
2000-12-08 |
2008-08-14 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答修飾因子の標的化送達のための組成物および方法
|
US6677347B2
(en)
*
|
2000-12-08 |
2004-01-13 |
3M Innovative Properties Company |
Sulfonamido ether substituted imidazoquinolines
|
UA74852C2
(en)
|
2000-12-08 |
2006-02-15 |
3M Innovative Properties Co |
Urea-substituted imidazoquinoline ethers
|
US6664265B2
(en)
|
2000-12-08 |
2003-12-16 |
3M Innovative Properties Company |
Amido ether substituted imidazoquinolines
|
US6664264B2
(en)
*
|
2000-12-08 |
2003-12-16 |
3M Innovative Properties Company |
Thioether substituted imidazoquinolines
|
US6545016B1
(en)
|
2000-12-08 |
2003-04-08 |
3M Innovative Properties Company |
Amide substituted imidazopyridines
|
ES2421532T3
(es)
*
|
2001-06-21 |
2013-09-03 |
Dynavax Tech Corp |
Compuestos inmunomoduladores quiméricos y métodos de uso de los mismos
|
US7321033B2
(en)
*
|
2001-11-27 |
2008-01-22 |
Anadys Pharmaceuticals, Inc. |
3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
|
US6797718B2
(en)
|
2002-06-07 |
2004-09-28 |
3M Innovative Properties Company |
Ether substituted imidazopyridines
|
JP4768263B2
(ja)
|
2002-09-27 |
2011-09-07 |
大日本住友製薬株式会社 |
新規アデニン化合物及びその用途
|
KR20050089799A
(ko)
*
|
2002-10-29 |
2005-09-08 |
콜리 파마슈티칼 그룹, 리미티드 |
C형 간염 바이러스 감염의 치료에 있어 CpG올리고뉴클레오티드의 용도
|
MXPA05006740A
(es)
|
2002-12-20 |
2005-10-05 |
3M Innovative Properties Co |
Imidazoquinolinas arilo-sustituidas.
|
US20040265351A1
(en)
|
2003-04-10 |
2004-12-30 |
Miller Richard L. |
Methods and compositions for enhancing immune response
|
US20040214851A1
(en)
*
|
2003-04-28 |
2004-10-28 |
3M Innovative Properties Company |
Compositions and methods for induction of opioid receptors
|
AR045260A1
(es)
*
|
2003-08-12 |
2005-10-19 |
3M Innovative Properties Co |
Compuestos que contienen imidazo-oxima sustituidos
|
AU2004266657B2
(en)
*
|
2003-08-14 |
2009-07-02 |
3M Innovative Properties Company |
Lipid-modified immune response modifiers
|
CA2536249A1
(en)
*
|
2003-08-25 |
2005-03-10 |
3M Innovative Properties Company |
Delivery of immune response modifier compounds
|
BRPI0413998A
(pt)
*
|
2003-08-27 |
2006-11-07 |
3M Innovative Properties Co |
imidazoquinolinas arilóxi e arilalquilenóxi substituìdas
|
AU2004270201A1
(en)
*
|
2003-09-05 |
2005-03-17 |
3M Innovative Properties Company |
Treatment for CD5+ B cell lymphoma
|
AU2004275876B2
(en)
*
|
2003-09-25 |
2011-03-31 |
Coley Pharmaceutical Gmbh |
Nucleic acid-lipophilic conjugates
|
US7544697B2
(en)
*
|
2003-10-03 |
2009-06-09 |
Coley Pharmaceutical Group, Inc. |
Pyrazolopyridines and analogs thereof
|
US20090075980A1
(en)
*
|
2003-10-03 |
2009-03-19 |
Coley Pharmaceutical Group, Inc. |
Pyrazolopyridines and Analogs Thereof
|
WO2005079195A2
(en)
|
2003-10-03 |
2005-09-01 |
3M Innovative Properties Company |
Pyrazolopyridines and analogs thereof
|
US8871782B2
(en)
|
2003-10-03 |
2014-10-28 |
3M Innovative Properties Company |
Alkoxy substituted imidazoquinolines
|
AU2004291101A1
(en)
*
|
2003-11-14 |
2005-06-02 |
3M Innovative Properties Company |
Oxime substituted imidazo ring compounds
|
JP2007511535A
(ja)
|
2003-11-14 |
2007-05-10 |
スリーエム イノベイティブ プロパティズ カンパニー |
ヒドロキシルアミン置換イミダゾ環化合物
|
MXPA06005910A
(es)
|
2003-11-25 |
2006-08-23 |
3M Innovative Properties Co |
Sistemas de anillo imidazo sustituido y metodos.
|
CA2547085A1
(en)
*
|
2003-11-25 |
2005-06-09 |
3M Innovative Properties Company |
Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
|
US20050226878A1
(en)
*
|
2003-12-02 |
2005-10-13 |
3M Innovative Properties Company |
Therapeutic combinations and methods including IRM compounds
|
TW200533352A
(en)
*
|
2003-12-04 |
2005-10-16 |
3M Innovative Properties Co |
Sulfone substituted imidazo ring ethers
|
WO2005066172A1
(en)
*
|
2003-12-29 |
2005-07-21 |
3M Innovative Properties Company |
Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds
|
EP1701955A1
(en)
*
|
2003-12-29 |
2006-09-20 |
3M Innovative Properties Company |
Arylalkenyl and arylalkynyl substituted imidazoquinolines
|
CA2551399A1
(en)
*
|
2003-12-30 |
2005-07-21 |
3M Innovative Properties Company |
Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
|
AU2005228150A1
(en)
*
|
2004-03-24 |
2005-10-13 |
3M Innovative Properties Company |
Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
|
CN1938307B
(zh)
*
|
2004-03-26 |
2010-06-16 |
大日本住友制药株式会社 |
9-取代的8-氧代腺嘌呤
|
US20060051374A1
(en)
*
|
2004-04-28 |
2006-03-09 |
3M Innovative Properties Company |
Compositions and methods for mucosal vaccination
|
US20050267145A1
(en)
*
|
2004-05-28 |
2005-12-01 |
Merrill Bryon A |
Treatment for lung cancer
|
WO2005123079A2
(en)
*
|
2004-06-14 |
2005-12-29 |
3M Innovative Properties Company |
Urea substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
|
WO2005123080A2
(en)
*
|
2004-06-15 |
2005-12-29 |
3M Innovative Properties Company |
Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
|
WO2006065280A2
(en)
*
|
2004-06-18 |
2006-06-22 |
3M Innovative Properties Company |
Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
|
CA2571360C
(en)
*
|
2004-06-18 |
2014-11-25 |
3M Innovative Properties Company |
Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines useful in inducing cytokine biosynthesis in animals
|
US8541438B2
(en)
|
2004-06-18 |
2013-09-24 |
3M Innovative Properties Company |
Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
|
US8026366B2
(en)
*
|
2004-06-18 |
2011-09-27 |
3M Innovative Properties Company |
Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
|
US7897609B2
(en)
*
|
2004-06-18 |
2011-03-01 |
3M Innovative Properties Company |
Aryl substituted imidazonaphthyridines
|
EP1786450A4
(en)
*
|
2004-08-27 |
2009-11-11 |
3M Innovative Properties Co |
HIV IMMUNOSTIMATORY COMPOSITIONS
|
EP1784180A4
(en)
|
2004-09-02 |
2009-07-22 |
3M Innovative Properties Co |
2-AMINO-1H-IMIDAZO RING SYSTEMS AND METHOD
|
PL1789042T3
(pl)
*
|
2004-09-02 |
2012-09-28 |
3M Innovative Properties Co |
Układy pierścieni 1-alkoksy 1H-imidazo i sposoby
|
US20090270443A1
(en)
*
|
2004-09-02 |
2009-10-29 |
Doris Stoermer |
1-amino imidazo-containing compounds and methods
|
WO2006042254A2
(en)
*
|
2004-10-08 |
2006-04-20 |
3M Innovative Properties Company |
Adjuvant for dna vaccines
|
US20110070575A1
(en)
*
|
2004-12-08 |
2011-03-24 |
Coley Pharmaceutical Group, Inc. |
Immunomodulatory Compositions, Combinations and Methods
|
CA2592904C
(en)
|
2004-12-30 |
2015-04-07 |
3M Innovative Properties Company |
Chiral fused [1,2]imidazo[4,5-c] ring compounds
|
AU2005326708C1
(en)
|
2004-12-30 |
2012-08-30 |
3M Innovative Properties Company |
Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
|
PL1830876T3
(pl)
*
|
2004-12-30 |
2015-09-30 |
Meda Ab |
Zastosowanie imikwimodu do leczenia przerzutów do skóry wywodzących się od guza stanowiącego raka piersi
|
US8436176B2
(en)
*
|
2004-12-30 |
2013-05-07 |
Medicis Pharmaceutical Corporation |
Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine
|
US20080188513A1
(en)
*
|
2004-12-30 |
2008-08-07 |
Taked Pharmaceutical Company Limited |
1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Ethanesulfonate and 1-(2-Methylpropyl)-1H-Imidazo[4,5-C](1,5]Naphthyridin-4-Amine Methanesulfonate
|
CA2597092A1
(en)
*
|
2005-02-04 |
2006-08-10 |
Coley Pharmaceutical Group, Inc. |
Aqueous gel formulations containing immune reponse modifiers
|
WO2007120121A2
(en)
|
2005-02-09 |
2007-10-25 |
Coley Pharmaceutical Group, Inc. |
Oxime and hydroxylamine substituted thiazolo[4,5-c] ring compounds and methods
|
JP5122980B2
(ja)
|
2005-02-09 |
2013-01-16 |
スリーエム イノベイティブ プロパティズ カンパニー |
アルキルオキシ置換チアゾロキノリン類およびアルキルオキシ置換チアゾロナフチリデン類
|
WO2006086634A2
(en)
|
2005-02-11 |
2006-08-17 |
Coley Pharmaceutical Group, Inc. |
Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
|
EP1845988A2
(en)
|
2005-02-11 |
2007-10-24 |
3M Innovative Properties Company |
Substituted imidazoquinolines and imidazonaphthyridines
|
US8178677B2
(en)
|
2005-02-23 |
2012-05-15 |
3M Innovative Properties Company |
Hydroxyalkyl substituted imidazoquinolines
|
JP2008538203A
(ja)
|
2005-02-23 |
2008-10-16 |
コーリー ファーマシューティカル グループ,インコーポレイテッド |
インターフェロンの生合成を優先的に誘導する方法
|
AU2006216798A1
(en)
|
2005-02-23 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Hydroxyalkyl substituted imidazoquinoline compounds and methods
|
WO2006091568A2
(en)
|
2005-02-23 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Hydroxyalkyl substituted imidazonaphthyridines
|
CA2602098A1
(en)
|
2005-03-14 |
2006-09-21 |
Graceway Pharmaceuticals, Llc |
Method of treating actinic keratosis
|
WO2006107851A1
(en)
|
2005-04-01 |
2006-10-12 |
Coley Pharmaceutical Group, Inc. |
1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
|
US7943610B2
(en)
|
2005-04-01 |
2011-05-17 |
3M Innovative Properties Company |
Pyrazolopyridine-1,4-diamines and analogs thereof
|
EP1874345B1
(en)
*
|
2005-04-25 |
2012-08-15 |
3M Innovative Properties Company |
Immunostimulatory compositions
|
CA2607780A1
(en)
*
|
2005-05-04 |
2006-11-09 |
Pfizer Limited |
Purine derivatives
|
WO2007011777A2
(en)
*
|
2005-07-18 |
2007-01-25 |
Novartis Ag |
Small animal model for hcv replication
|
US20090324551A1
(en)
*
|
2005-08-22 |
2009-12-31 |
The Regents Of The University Of California Office Of Technology Transfer |
Tlr agonists
|
CA2621831A1
(en)
|
2005-09-09 |
2007-03-15 |
Coley Pharmaceutical Group, Inc. |
Amide and carbamate derivatives of n-{2-[4-amino-2- (ethoxymethyl)-1h-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods
|
ZA200803029B
(en)
*
|
2005-09-09 |
2009-02-25 |
Coley Pharm Group Inc |
Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
|
AU2006294528A1
(en)
*
|
2005-09-27 |
2007-04-05 |
Coley Pharmaceutical Gmbh |
Modulation of TLR-mediated immune responses using adaptor oligonucleotides
|
AU2006311871B2
(en)
|
2005-11-04 |
2011-03-03 |
3M Innovative Properties Company |
Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods
|
AU2006311462A1
(en)
*
|
2005-11-09 |
2007-05-18 |
Cheng Si Yuan (China-International) Hepatitis Research Foundation |
Diagnostic and therapeutic methods and agents
|
EA200801404A1
(ru)
|
2005-11-21 |
2008-10-30 |
Анадис Фармасьютикалз, Инк. |
Новый способ получения 5-амино-3н-тиазоло[4,5-d]пиримидин-2-она
|
BRPI0707945A2
(pt)
*
|
2006-02-17 |
2011-05-17 |
Pfizer Ltd |
derivados de 3-deazapurina como modulares de tlr7
|
US8951528B2
(en)
|
2006-02-22 |
2015-02-10 |
3M Innovative Properties Company |
Immune response modifier conjugates
|
US8329721B2
(en)
|
2006-03-15 |
2012-12-11 |
3M Innovative Properties Company |
Hydroxy and alkoxy substituted 1H-imidazonaphthyridines and methods
|
US7825152B2
(en)
|
2006-04-11 |
2010-11-02 |
Novartis Ag |
Organic compounds and their uses
|
CN101426514A
(zh)
*
|
2006-04-25 |
2009-05-06 |
英特塞尔股份公司 |
Hcv疫苗
|
CA2652349A1
(en)
*
|
2006-05-15 |
2007-11-22 |
University Of Kentucky Research Foundation |
Toll-like receptor (tlr) stimulation for ocular angiogenesis and macular degeneration
|
CL2007001427A1
(es)
*
|
2006-05-22 |
2008-05-16 |
Novartis Ag |
Sal de maleato de 5-amino-3-(2',3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d]pirimidin-2-ona; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una infeccion po
|
EP2700638A1
(en)
*
|
2006-05-31 |
2014-02-26 |
The Regents Of the University of California |
Purine analogs
|
BRPI0713680A2
(pt)
*
|
2006-06-22 |
2012-10-23 |
Anadys Pharmaceuticals Inc |
composto, composição farmacêutica e métodos de modulação das atividades imuno da citocina, de tratamento de infecção de vìrus da hepatite c em paciente e de tratamento de desordem de proliferação relacionada em mamìfero carecido do mesmo
|
WO2008004948A1
(en)
|
2006-07-05 |
2008-01-10 |
Astrazeneca Ab |
8-oxoadenine derivatives acting as modulators of tlr7
|
US7906506B2
(en)
*
|
2006-07-12 |
2011-03-15 |
3M Innovative Properties Company |
Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
|
DE602007012881D1
(en)
|
2006-07-18 |
2011-04-14 |
Anadys Pharmaceuticals Inc |
Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
|
US8178539B2
(en)
|
2006-09-06 |
2012-05-15 |
3M Innovative Properties Company |
Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods
|
BRPI0717741A2
(pt)
*
|
2006-10-17 |
2014-04-08 |
Anadys Pharmaceuticals Inc |
Compostos e respectivos método de preparação, método de redução de composto de sulfonil substituído, composição farmacêutica método de tratamento ou prevenção de doença
|
TW200831105A
(en)
*
|
2006-12-14 |
2008-08-01 |
Astrazeneca Ab |
Novel compounds
|
US20080149123A1
(en)
*
|
2006-12-22 |
2008-06-26 |
Mckay William D |
Particulate material dispensing hairbrush with combination bristles
|
EP2115140B8
(en)
*
|
2007-01-31 |
2017-01-25 |
Chongxi Yu |
Positively charged water-soluble prodrugs of 1H-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates
|
AU2008227128B2
(en)
|
2007-02-07 |
2012-12-06 |
The Regents Of The University Of California |
Conjugates of synthetic TLR agonists and uses therefor
|
DK2125792T3
(da)
*
|
2007-02-19 |
2011-03-07 |
Glaxosmithkline Llc |
Purinderivater som immunomodulatorer
|
ATE530549T1
(de)
*
|
2007-03-19 |
2011-11-15 |
Astrazeneca Ab |
9-substituierte 8-oxoadeninverbindungen als modulatoren des toll-like-receptor (tlr7)
|
EP2132209B8
(en)
*
|
2007-03-19 |
2014-04-16 |
AstraZeneca AB |
9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators
|
AR065784A1
(es)
*
|
2007-03-20 |
2009-07-01 |
Dainippon Sumitomo Pharma Co |
Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
|
JPWO2008114819A1
(ja)
*
|
2007-03-20 |
2010-07-08 |
大日本住友製薬株式会社 |
新規アデニン化合物
|
CA2686163A1
(en)
*
|
2007-05-08 |
2008-11-13 |
Astrazenca Ab |
Imidazoquinolines with immuno-modulating properties
|
US20110166092A1
(en)
*
|
2007-08-20 |
2011-07-07 |
Anadys Pharmaceuticals, Inc. |
Dosing methods for treating disease
|
PE20091236A1
(es)
*
|
2007-11-22 |
2009-09-16 |
Astrazeneca Ab |
Derivados de pirimidina como immunomoduladores de tlr7
|
PE20091156A1
(es)
*
|
2007-12-17 |
2009-09-03 |
Astrazeneca Ab |
Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
|
WO2009099650A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Carson Dennis A |
Treatment of bladder diseases with a tlr7 activator
|
KR101616396B1
(ko)
|
2008-08-11 |
2016-04-28 |
글락소스미스클라인 엘엘씨 |
신규의 아데닌 유도체
|
US8575181B2
(en)
|
2008-08-11 |
2013-11-05 |
Glaxosmithkline Llc |
Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
|
US8802684B2
(en)
|
2008-08-11 |
2014-08-12 |
Glaxosmithkline Llc |
Adenine derivatives
|
UA103195C2
(ru)
|
2008-08-11 |
2013-09-25 |
Глаксосмитклайн Ллк |
Производные пурина для применения в лечении аллергий, воспалительных и инфекционных заболеваний
|
CA2738970A1
(en)
*
|
2008-10-31 |
2010-05-06 |
Moberg Derma Ab |
Topical composition comprising a combination of at least two penetration enhancing agents
|
GB0820698D0
(en)
*
|
2008-11-12 |
2008-12-17 |
Ludwig Inst Cancer Res |
Uses of immunomodulators
|
US8552165B2
(en)
*
|
2008-12-09 |
2013-10-08 |
Heather Davis |
Immunostimulatory oligonucleotides
|
AU2009325926B2
(en)
|
2008-12-09 |
2013-05-16 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory oligonucleotides
|
JP5600116B2
(ja)
|
2008-12-09 |
2014-10-01 |
ギリアード サイエンシーズ, インコーポレイテッド |
Toll様受容体のモジュレーター
|
WO2010091265A1
(en)
*
|
2009-02-05 |
2010-08-12 |
Yale University |
Compounds and methods for treating viral encephalitis
|
WO2010088924A1
(en)
|
2009-02-06 |
2010-08-12 |
Telormedix Sa |
Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
|
KR20110117705A
(ko)
|
2009-02-11 |
2011-10-27 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
톨-유사 수용체 조정제 및 질병의 치료
|
US8512690B2
(en)
|
2009-04-10 |
2013-08-20 |
Novartis Ag |
Derivatised proline containing peptide compounds as protease inhibitors
|
US20110182850A1
(en)
|
2009-04-10 |
2011-07-28 |
Trixi Brandl |
Organic compounds and their uses
|
JP5913093B2
(ja)
|
2009-05-21 |
2016-04-27 |
アストラゼネカ アクチボラグ |
新規ピリミジン誘導体と、癌とさらなる疾患の治療におけるそれらの使用
|
GB0908772D0
(en)
*
|
2009-05-21 |
2009-07-01 |
Astrazeneca Ab |
New salts 756
|
WO2011068233A1
(en)
*
|
2009-12-03 |
2011-06-09 |
Dainippon Sumitomo Pharma Co., Ltd. |
Imidazoquinolines which act via toll - like receptors (tlr)
|
JP2013519644A
(ja)
|
2010-02-10 |
2013-05-30 |
グラクソスミスクライン エルエルシー |
プリン誘導体およびそれらの薬学的使用
|
WO2011101332A1
(en)
|
2010-02-16 |
2011-08-25 |
Proyecto De Biomedicina Cima, S.L. |
Compositions based on the fibronectin extracellular domain a for the treatment of melanoma
|
CN103221067B
(zh)
|
2010-04-30 |
2016-01-06 |
泰勒麦迪克斯公司 |
磷脂药物类似物
|
US9050319B2
(en)
|
2010-04-30 |
2015-06-09 |
Telormedix, Sa |
Phospholipid drug analogs
|
JP2013534248A
(ja)
|
2010-08-17 |
2013-09-02 |
スリーエム イノベイティブ プロパティズ カンパニー |
脂質付加された免疫反応調節化合物の組成物、製剤及び方法
|
CA2811799A1
(en)
|
2010-10-08 |
2012-04-12 |
Novartis Ag |
Vitamin e formulations of sulfamide ns3 inhibitors
|
JP5978225B2
(ja)
|
2010-12-16 |
2016-08-24 |
大日本住友製薬株式会社 |
治療に有用なイミダゾ[4,5−c]キノリン−1−イル誘導体
|
EP2651943B1
(en)
|
2010-12-17 |
2017-03-22 |
Sumitomo Dainippon Pharma Co., Ltd. |
Purine derivatives
|
ES2887303T3
(es)
|
2011-04-08 |
2021-12-22 |
Janssen Sciences Ireland Unlimited Co |
Derivados de pirimidina para el tratamiento de infecciones víricas
|
BR112013031039B1
(pt)
|
2011-06-03 |
2020-04-28 |
3M Innovative Properties Co |
compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado
|
MX347240B
(es)
|
2011-06-03 |
2017-04-20 |
3M Innovative Properties Co |
Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos.
|
DK2734186T3
(en)
|
2011-07-22 |
2019-01-07 |
Glaxosmithkline Llc |
COMPOSITION
|
ES2572328B1
(es)
|
2011-10-21 |
2017-08-24 |
Abbvie Inc. |
Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para su uso en el tratamiento del vhc
|
DE202012012954U1
(de)
|
2011-10-21 |
2014-08-12 |
Abbvie Inc. |
Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV
|
US8492386B2
(en)
|
2011-10-21 |
2013-07-23 |
Abbvie Inc. |
Methods for treating HCV
|
US8466159B2
(en)
|
2011-10-21 |
2013-06-18 |
Abbvie Inc. |
Methods for treating HCV
|
WO2013068438A1
(en)
|
2011-11-09 |
2013-05-16 |
Janssen R&D Ireland |
Purine derivatives for the treatment of viral infections
|
AR090699A1
(es)
*
|
2012-04-18 |
2014-12-03 |
Biocryst Pharm Inc |
Compuestos inhibidores de la actividad de la arn polimerasa viral
|
MX2014014031A
(es)
|
2012-05-18 |
2015-02-12 |
Sumitomo Dainippon Pharma Co Ltd |
Compuestos de acido carboxilico.
|
US20150047463A1
(en)
*
|
2012-06-26 |
2015-02-19 |
California Institute Of Technology |
Systems and methods for implementing bulk metallic glass-based macroscale gears
|
MX360718B
(es)
|
2012-07-13 |
2018-11-13 |
Janssen Sciences Ireland Uc |
Purinas macrocíclicas para el tratamiento de infecciones víricas.
|
CN112587658A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
UA114109C2
(xx)
|
2012-08-24 |
2017-04-25 |
|
Піразолопіримідинові сполуки
|
LT2906563T
(lt)
|
2012-10-10 |
2018-06-11 |
Janssen Sciences Ireland Uc |
Pirolo[3,2-d]pirimidino dariniai virusinių infekcijų ir kitų ligų gydymui
|
MX361585B
(es)
|
2012-11-16 |
2018-12-11 |
Janssen Sciences Ireland Uc |
Derivados 2-aminoquinazolínicos sustituidos heterocíclicos para el tratamiento de infecciones víricas.
|
RU2640200C2
(ru)
|
2012-11-20 |
2017-12-27 |
ГЛАКСОСМИТКЛАЙН ЭлЭлСи |
Новые соединения
|
LT2922549T
(lt)
|
2012-11-20 |
2017-09-11 |
Glaxosmithkline Llc |
Naujieji junginiai
|
US9550785B2
(en)
|
2012-11-20 |
2017-01-24 |
Glaxosmithkline Llc |
Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
|
CN105189468B
(zh)
|
2013-02-21 |
2018-10-30 |
爱尔兰詹森科学公司 |
用于治疗病毒性感染的2-氨基嘧啶衍生物
|
ES2625456T3
(es)
|
2013-03-29 |
2017-07-19 |
Janssen Sciences Ireland Uc |
Desazapurinonas macrocíclicas para el tratamiento de infecciones víricas
|
MX365848B
(es)
|
2013-05-24 |
2019-06-17 |
Janssen Sciences Ireland Uc |
Derivados de piridona para el tratamiento de infecciones virales y enfermedades adicionales.
|
WO2014205199A2
(en)
*
|
2013-06-22 |
2014-12-24 |
Nitor Therapeutics |
Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
|
EP3030563B1
(en)
|
2013-06-27 |
2017-08-09 |
Janssen Sciences Ireland UC |
Pyrrolo [3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases
|
DK3027624T3
(en)
|
2013-07-30 |
2019-01-07 |
Janssen Sciences Ireland Uc |
THIENO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS
|
AU2015205756A1
(en)
|
2014-01-10 |
2016-07-21 |
Birdie Biopharmaceuticals Inc. |
Compounds and compositions for treating EGFR expressing tumors
|
CA2938280C
(en)
*
|
2014-04-22 |
2022-07-12 |
F. Hoffmann-La Roche Ag |
4-amino-imidazoquinoline compounds
|
AP2016009653A0
(en)
*
|
2014-06-24 |
2016-12-31 |
Alios Biopharma Inc |
Substituted nucleosides, nucleotides and analogs thereof
|
CN105440135A
(zh)
|
2014-09-01 |
2016-03-30 |
博笛生物科技有限公司 |
用于***的抗-pd-l1结合物
|
CN112546231A
(zh)
|
2014-07-09 |
2021-03-26 |
博笛生物科技有限公司 |
用于治疗癌症的联合治疗组合物和联合治疗方法
|
WO2016004876A1
(en)
|
2014-07-09 |
2016-01-14 |
Shanghai Birdie Biotech, Inc. |
Anti-pd-l1 combinations for treating tumors
|
CN113577081A
(zh)
|
2014-07-11 |
2021-11-02 |
吉利德科学公司 |
用于治疗hiv的toll样受体调节剂
|
ES2835717T3
(es)
|
2014-09-16 |
2021-06-23 |
Gilead Sciences Inc |
Formas sólidas de un modulador de receptor de tipo Toll
|
KR20230113824A
(ko)
|
2014-12-08 |
2023-08-01 |
에프. 호프만-라 로슈 아게 |
바이러스 감염의 치료 또는 예방을 위한 3-치환된 5-아미노-6H-티아졸로[4,5-d]피리미딘-2,7-다이온화합물
|
EP3695837A1
(en)
|
2015-03-16 |
2020-08-19 |
F. Hoffmann-La Roche AG |
Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
|
CN107743491B
(zh)
|
2015-05-08 |
2020-08-21 |
豪夫迈·罗氏有限公司 |
用于治疗和预防病毒感染的新的氧硫杂环戊烷甲酸及其衍生物
|
EP4001283A1
(en)
|
2015-05-12 |
2022-05-25 |
F. Hoffmann-La Roche AG |
Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection
|
KR101729236B1
(ko)
|
2015-06-01 |
2017-04-21 |
(주)노터스생명과학 |
Tlr7 항진제를 포함하는 비만 또는 간질환 예방 및 치료용 약학 조성물
|
JP6839104B2
(ja)
|
2015-06-30 |
2021-03-03 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ウイルス感染の治療及び予防のための新規な置換アミノチアゾロピリミジンジオン
|
CN106943598A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技(北京)有限公司 |
用于***的抗-her2组合
|
CN106943597A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技(北京)有限公司 |
用于***的抗-egfr组合
|
CN115554406A
(zh)
|
2016-01-07 |
2023-01-03 |
博笛生物科技有限公司 |
用于***的抗-cd20组合
|
BR112018071347A2
(pt)
|
2016-04-19 |
2019-02-05 |
Innate Tumor Immunity Inc |
moduladores de nlrp3
|
WO2017184735A1
(en)
|
2016-04-19 |
2017-10-26 |
Ifm Therapeutics, Inc |
Nlrp3 modulators
|
US10703755B2
(en)
|
2016-04-26 |
2020-07-07 |
Sumitomo Dainippon Pharma Co., Ltd. |
Substituted purine derivative
|
CN109689063A
(zh)
|
2016-04-28 |
2019-04-26 |
埃默里大学 |
含有炔烃的核苷酸和核苷治疗组合物及其相关用途
|
US11697851B2
(en)
|
2016-05-24 |
2023-07-11 |
The Regents Of The University Of California |
Early ovarian cancer detection diagnostic test based on mRNA isoforms
|
AU2017289418B2
(en)
|
2016-07-01 |
2021-06-03 |
Janssen Sciences Ireland Unlimited Company |
Dihydropyranopyrimidines for the treatment of viral infections
|
KR20160141683A
(ko)
|
2016-09-21 |
2016-12-09 |
(주)노터스생명과학 |
Tlr7 항진제를 포함하는 비만 또는 간질환 예방 및 치료용 약학 조성물
|
US10968184B2
(en)
|
2016-09-29 |
2021-04-06 |
Janssen Sciences Ireland Unlimited Company |
Pyrimidine prodrugs for the treatment of viral infections and further diseases
|
PT3546457T
(pt)
|
2016-11-28 |
2021-08-06 |
Jiangsu Hengrui Medicine Co |
Derivado de pirazolo-heteroarílico, método de preparação e a utilização médica do mesmo
|
AU2018205994B2
(en)
|
2017-01-06 |
2021-09-09 |
F. Hoffmann-La Roche Ag |
Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
|
KR20170010887A
(ko)
|
2017-01-20 |
2017-02-01 |
(주)노터스생명과학 |
Tlr7 항진제를 포함하는 비만 또는 간질환 예방 및 치료용 약학 조성물
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
WO2018162450A1
(en)
|
2017-03-06 |
2018-09-13 |
Fundación Para La Investigación Médica Aplicada |
New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells
|
CN108794467A
(zh)
|
2017-04-27 |
2018-11-13 |
博笛生物科技有限公司 |
2-氨基-喹啉衍生物
|
TW201900647A
(zh)
*
|
2017-05-18 |
2019-01-01 |
大陸商江蘇恒瑞醫藥股份有限公司 |
雜芳基并吡唑類衍生物、其製備方法及其在醫藥上的應用
|
BR112019027025A2
(pt)
|
2017-06-23 |
2020-06-30 |
Birdie Biopharmaceuticals, Inc. |
composições farmacêuticas
|
WO2019123178A1
(en)
|
2017-12-20 |
2019-06-27 |
3M Innovative Properties Company |
Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
|
CN108558864B
(zh)
*
|
2018-01-30 |
2020-07-03 |
中国医学科学院药用植物研究所 |
一种瑞喹莫德的酰化衍生物及制备方法与应用
|
TW201945003A
(zh)
|
2018-03-01 |
2019-12-01 |
愛爾蘭商健生科學愛爾蘭無限公司 |
2,4-二胺基喹唑啉衍生物及其醫學用途
|
SG11202011667WA
(en)
*
|
2018-05-25 |
2020-12-30 |
Primmune Therapeutics Inc |
Tlr7 agonists
|
KR20210013624A
(ko)
|
2018-05-25 |
2021-02-04 |
지앙수 헨그루이 메디슨 컴퍼니 리미티드 |
피라졸로헤테로아릴 유도체의 하이드로클로라이드의 결정 형태 및 제조 방법
|
WO2020040327A1
(ko)
*
|
2018-08-23 |
2020-02-27 |
광주과학기술원 |
시클로피록스의 hbv 코어조립 저해 용도
|
JP2022501327A
(ja)
*
|
2018-09-07 |
2022-01-06 |
バーディー バイオファーマシューティカルズ インコーポレイテッド |
イミダゾキノリン化合物およびその使用
|
BR112022000965A2
(pt)
*
|
2019-07-27 |
2022-06-14 |
Brii Biosciences Inc |
Derivado de adenosina e composição farmacêutica que compreende o mesmo
|
IL293293A
(en)
|
2019-11-26 |
2022-07-01 |
Primmune Therapeutics Inc |
tlr7 agonists
|
CN114901275A
(zh)
|
2019-12-20 |
2022-08-12 |
纳米医疗有限公司 |
可用于治疗癌症的含有Toll样受体(“TLR”)激动剂前药的配制和/或共同配制的脂质体组合物及其方法
|
US11530218B2
(en)
|
2020-01-20 |
2022-12-20 |
Incyte Corporation |
Spiro compounds as inhibitors of KRAS
|
WO2021231526A1
(en)
|
2020-05-13 |
2021-11-18 |
Incyte Corporation |
Fused pyrimidine compounds as kras inhibitors
|
US11767320B2
(en)
|
2020-10-02 |
2023-09-26 |
Incyte Corporation |
Bicyclic dione compounds as inhibitors of KRAS
|
TW202237146A
(zh)
|
2021-01-25 |
2022-10-01 |
美商布里生物科學股份有限公司 |
使用腺苷衍生物及衣殼抑制劑之hiv組合療法
|
WO2023064857A1
(en)
|
2021-10-14 |
2023-04-20 |
Incyte Corporation |
Quinoline compounds as inhibitors of kras
|