DK2125792T3 - Purinderivater som immunomodulatorer - Google Patents
Purinderivater som immunomodulatorerInfo
- Publication number
- DK2125792T3 DK2125792T3 DK08716859.7T DK08716859T DK2125792T3 DK 2125792 T3 DK2125792 T3 DK 2125792T3 DK 08716859 T DK08716859 T DK 08716859T DK 2125792 T3 DK2125792 T3 DK 2125792T3
- Authority
- DK
- Denmark
- Prior art keywords
- immunomodulators
- purine derivatives
- purine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89052307P | 2007-02-19 | 2007-02-19 | |
US97231307P | 2007-09-14 | 2007-09-14 | |
US2192108P | 2008-01-18 | 2008-01-18 | |
PCT/EP2008/051832 WO2008101867A1 (en) | 2007-02-19 | 2008-02-15 | Purine derivatives as immunomodulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2125792T3 true DK2125792T3 (da) | 2011-03-07 |
Family
ID=39473324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08716859.7T DK2125792T3 (da) | 2007-02-19 | 2008-02-15 | Purinderivater som immunomodulatorer |
Country Status (15)
Country | Link |
---|---|
US (4) | US7977344B2 (da) |
EP (1) | EP2125792B1 (da) |
JP (1) | JP2010519186A (da) |
AR (1) | AR065372A1 (da) |
AT (1) | ATE490249T1 (da) |
CL (1) | CL2008000496A1 (da) |
CY (1) | CY1111281T1 (da) |
DE (1) | DE602008003764D1 (da) |
DK (1) | DK2125792T3 (da) |
HR (1) | HRP20110115T1 (da) |
PL (1) | PL2125792T3 (da) |
PT (1) | PT2125792E (da) |
SI (1) | SI2125792T1 (da) |
TW (1) | TW200843779A (da) |
WO (1) | WO2008101867A1 (da) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4472693B2 (ja) | 2004-03-26 | 2010-06-02 | 大日本住友製薬株式会社 | 9置換−8−オキソアデニン化合物 |
US20090118263A1 (en) * | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
US7989459B2 (en) * | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
US20090281075A1 (en) * | 2006-02-17 | 2009-11-12 | Pharmacopeia, Inc. | Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
WO2008004948A1 (en) * | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
WO2008101867A1 (en) * | 2007-02-19 | 2008-08-28 | Smithkline Beecham Corporation | Purine derivatives as immunomodulators |
ES2457316T3 (es) * | 2007-03-19 | 2014-04-25 | Astrazeneca Ab | Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7) |
ES2373616T3 (es) * | 2007-03-19 | 2012-02-07 | Astrazeneca Ab | Compuestos de 8-oxo-adenina 9 sustituidos como moduladores del receptor de tipo toll (tlr7). |
PE20081887A1 (es) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
JPWO2008114819A1 (ja) * | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
DK2155743T3 (da) * | 2007-05-08 | 2012-11-05 | Astrazeneca Ab | Imidazoquinoliner med immunmodulerende egenskaber |
MX2009013832A (es) | 2007-06-29 | 2010-03-10 | Gilead Sciences Inc | Derivados de purina y su uso como moduladores del receptor 7 similar a un puente. |
PE20091156A1 (es) | 2007-12-17 | 2009-09-03 | Astrazeneca Ab | Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo |
US20110054168A1 (en) * | 2008-01-17 | 2011-03-03 | Ayumu Kurimoto | Method for preparing adenine compound |
US8865896B2 (en) * | 2008-01-17 | 2014-10-21 | Astrazeneca Aktiebolag | Method for preparing adenine compound |
JP5519670B2 (ja) * | 2008-08-11 | 2014-06-11 | グラクソスミスクライン エルエルシー | アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体 |
WO2010018132A1 (en) * | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Compounds |
WO2010018131A1 (en) * | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
US8802684B2 (en) | 2008-08-11 | 2014-08-12 | Glaxosmithkline Llc | Adenine derivatives |
KR101649881B1 (ko) | 2008-08-11 | 2016-08-30 | 글락소스미스클라인 엘엘씨 | 신규의 아데닌 유도체 |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
EP2364314B1 (en) | 2008-12-09 | 2014-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
KR20120034592A (ko) | 2009-04-09 | 2012-04-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Hiv 복제의 저해제 |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
NO2477987T3 (da) | 2009-09-14 | 2018-06-09 | ||
JP5694345B2 (ja) * | 2009-10-22 | 2015-04-01 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体の調節因子 |
JP2013512859A (ja) * | 2009-12-03 | 2013-04-18 | 大日本住友製薬株式会社 | トール様受容体(tlr)を介して作用するイミダゾキノリン |
WO2011079016A1 (en) * | 2009-12-22 | 2011-06-30 | Gilead Sciences, Inc. | Methods of treating hbv and hcv infection |
WO2011098451A1 (en) | 2010-02-10 | 2011-08-18 | Glaxosmithkline Llc | Purine derivatives and their pharmaceutical uses |
ES2525826T3 (es) | 2010-02-10 | 2014-12-30 | Glaxosmithkline Llc | Maleato de 6-amino-2-{[(1s)-1-metilbutil]-oxi}-9-[5-(1-piperidinil)pentil]-7,9-dihidro-8H-purin-8-ona |
US9050319B2 (en) | 2010-04-30 | 2015-06-09 | Telormedix, Sa | Phospholipid drug analogs |
AU2011247358B2 (en) | 2010-04-30 | 2014-10-30 | Urogen Pharma Ltd. | Phospholipid drug analogs |
GB201012410D0 (en) | 2010-07-23 | 2010-09-08 | Medical Res Council | Intracellular immunity |
ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
JP5978225B2 (ja) | 2010-12-16 | 2016-08-24 | 大日本住友製薬株式会社 | 治療に有用なイミダゾ[4,5−c]キノリン−1−イル誘導体 |
DK2651943T3 (da) | 2010-12-17 | 2017-06-06 | Sumitomo Dainippon Pharma Co Ltd | Purinderivater |
RU2013144207A (ru) | 2011-03-02 | 2015-04-10 | Новартис Аг | Комбинированные вакцины с пониженными дозами антигена и/или адъюванта |
US20140113824A1 (en) | 2011-05-10 | 2014-04-24 | Bayer Intellectual Property Gmbh | Bicyclic (thio)carbonylamidines |
PL2734186T3 (pl) | 2011-07-22 | 2019-01-31 | Glaxosmithkline Llc | Kompozycja |
WO2013030378A1 (en) | 2011-09-01 | 2013-03-07 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
CA2866426A1 (en) | 2012-03-07 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of rabies virus immunogens |
EP2822586A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of streptococcus pneumoniae antigens |
CA2866406A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
SG11201500787YA (en) | 2012-08-24 | 2015-03-30 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
US9526776B2 (en) | 2012-09-06 | 2016-12-27 | Glaxosmithkline Biologicals Sa | Combination vaccines with serogroup B meningococcus and D/T/P |
US9550785B2 (en) | 2012-11-20 | 2017-01-24 | Glaxosmithkline Llc | Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
JP6228223B2 (ja) | 2012-11-20 | 2017-11-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 新規化合物 |
ES2625023T3 (es) | 2012-11-20 | 2017-07-18 | Glaxosmithkline Llc | Compuestos novedosos |
WO2014159940A1 (en) | 2013-03-14 | 2014-10-02 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor |
NZ728072A (en) | 2014-07-11 | 2018-06-29 | Gilead Sciences Inc | Modulators of toll-like receptors for the treatment of hiv |
JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体モジュレーターの固体形態 |
CN107074860B (zh) | 2014-09-16 | 2022-07-15 | 吉利德科学公司 | 制备toll样受体调节剂的方法 |
EP3201227A4 (en) | 2014-09-29 | 2018-04-18 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
JP2017533925A (ja) * | 2014-11-13 | 2017-11-16 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | アレルギー性疾患又は他の炎症状態の治療に有用なアデニン誘導体 |
WO2017219931A1 (zh) * | 2016-06-22 | 2017-12-28 | 四川科伦博泰生物医药股份有限公司 | 二氢蝶啶酮类衍生物、其制备方法及其用途 |
AR110963A1 (es) | 2017-02-07 | 2019-05-22 | Dae Woong Pharma | Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende |
WO2018181420A1 (ja) | 2017-03-29 | 2018-10-04 | 大日本住友製薬株式会社 | ワクチンアジュバント製剤 |
CA3085424A1 (en) | 2017-12-21 | 2019-06-27 | Sumitomo Dainippon Pharma Co., Ltd. | Combination drug including tlr7 agonist |
WO2020022272A1 (ja) | 2018-07-23 | 2020-01-30 | 公益財団法人ヒューマンサイエンス振興財団 | インフルエンザワクチンを含む組成物 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
US7067664B1 (en) * | 1995-06-06 | 2006-06-27 | Pfizer Inc. | Corticotropin releasing factor antagonists |
TW572758B (en) * | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
US20030187261A1 (en) * | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
US7754728B2 (en) * | 2002-09-27 | 2010-07-13 | Dainippon Sumitomo Pharma Co., Ltd. | Adenine compound and use thereof |
US20060148805A1 (en) * | 2003-07-01 | 2006-07-06 | Meng Hsin Chen | Opthalmic compositions for treating ocular hypertension |
EA200600540A1 (ru) * | 2003-09-05 | 2006-08-25 | Анадис Фармасьютикалз, Инк. | Введение лигандов tlr7 и их пролекарств для лечения инфекции вируса гепатита с |
JP4472693B2 (ja) * | 2004-03-26 | 2010-06-02 | 大日本住友製薬株式会社 | 9置換−8−オキソアデニン化合物 |
US20060029642A1 (en) * | 2004-08-03 | 2006-02-09 | Dusan Miljkovic | Methods and compositions for improved chromium complexes |
EP1888587A1 (en) * | 2005-05-04 | 2008-02-20 | Pfizer Limited | 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c |
CN101304748A (zh) * | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
US20100152230A1 (en) | 2005-09-02 | 2010-06-17 | Pfizer Inc. | Hydroxy substituted 1h-imidazopyridines and methods |
TW200801003A (en) * | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
WO2007034916A1 (ja) * | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
WO2007034881A1 (ja) * | 2005-09-22 | 2007-03-29 | Dainippon Sumitomo Pharma Co., Ltd. | 新規アデニン化合物 |
JPWO2007034917A1 (ja) * | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規なアデニン化合物 |
US20090118263A1 (en) * | 2005-09-22 | 2009-05-07 | Dainippon Sumitomo Pharma Co., Ltd. | Novel Adenine Compound |
TW200745114A (en) * | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
EP1939199A4 (en) * | 2005-09-22 | 2010-10-20 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
CN1947717B (zh) | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
ES2374455T3 (es) * | 2006-02-17 | 2012-02-16 | Pfizer Limited | Derivados de 3-deazapurinza como moduladores de tlr7. |
WO2008004948A1 (en) * | 2006-07-05 | 2008-01-10 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of tlr7 |
DK2038290T3 (da) * | 2006-07-07 | 2013-12-02 | Gilead Sciences Inc | Modulatorer af toll-lignende receptor 7 |
TW200831105A (en) * | 2006-12-14 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
WO2008101867A1 (en) * | 2007-02-19 | 2008-08-28 | Smithkline Beecham Corporation | Purine derivatives as immunomodulators |
ES2373616T3 (es) * | 2007-03-19 | 2012-02-07 | Astrazeneca Ab | Compuestos de 8-oxo-adenina 9 sustituidos como moduladores del receptor de tipo toll (tlr7). |
ES2457316T3 (es) * | 2007-03-19 | 2014-04-25 | Astrazeneca Ab | Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7) |
PE20081887A1 (es) * | 2007-03-20 | 2009-01-16 | Dainippon Sumitomo Pharma Co | Nuevo compuesto de adenina |
JPWO2008114819A1 (ja) * | 2007-03-20 | 2010-07-08 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
MX2009013832A (es) * | 2007-06-29 | 2010-03-10 | Gilead Sciences Inc | Derivados de purina y su uso como moduladores del receptor 7 similar a un puente. |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
WO2010018131A1 (en) * | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
WO2010018132A1 (en) * | 2008-08-11 | 2010-02-18 | Smithkline Beecham Corporation | Compounds |
UA103195C2 (uk) * | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
JP5519670B2 (ja) * | 2008-08-11 | 2014-06-11 | グラクソスミスクライン エルエルシー | アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体 |
KR101649881B1 (ko) * | 2008-08-11 | 2016-08-30 | 글락소스미스클라인 엘엘씨 | 신규의 아데닌 유도체 |
-
2008
- 2008-02-15 WO PCT/EP2008/051832 patent/WO2008101867A1/en active Application Filing
- 2008-02-15 JP JP2009549421A patent/JP2010519186A/ja active Pending
- 2008-02-15 AR ARP080100658A patent/AR065372A1/es not_active Application Discontinuation
- 2008-02-15 PT PT08716859T patent/PT2125792E/pt unknown
- 2008-02-15 US US12/031,764 patent/US7977344B2/en active Active
- 2008-02-15 EP EP08716859A patent/EP2125792B1/en active Active
- 2008-02-15 DK DK08716859.7T patent/DK2125792T3/da active
- 2008-02-15 AT AT08716859T patent/ATE490249T1/de active
- 2008-02-15 SI SI200830160T patent/SI2125792T1/sl unknown
- 2008-02-15 PL PL08716859T patent/PL2125792T3/pl unknown
- 2008-02-15 US US12/527,820 patent/US20100120799A1/en not_active Abandoned
- 2008-02-15 CL CL200800496A patent/CL2008000496A1/es unknown
- 2008-02-15 DE DE602008003764T patent/DE602008003764D1/de active Active
- 2008-02-15 TW TW097105460A patent/TW200843779A/zh unknown
-
2011
- 2011-02-16 HR HR20110115T patent/HRP20110115T1/hr unknown
- 2011-02-22 CY CY20111100214T patent/CY1111281T1/el unknown
- 2011-06-07 US US13/154,818 patent/US20110269781A1/en not_active Abandoned
-
2012
- 2012-07-18 US US13/551,946 patent/US20120283438A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE602008003764D1 (de) | 2011-01-13 |
EP2125792B1 (en) | 2010-12-01 |
TW200843779A (en) | 2008-11-16 |
US20110269781A1 (en) | 2011-11-03 |
AR065372A1 (es) | 2009-06-03 |
ATE490249T1 (de) | 2010-12-15 |
US20120283438A1 (en) | 2012-11-08 |
CY1111281T1 (el) | 2015-08-05 |
PL2125792T3 (pl) | 2011-05-31 |
PT2125792E (pt) | 2011-03-01 |
SI2125792T1 (sl) | 2011-03-31 |
US7977344B2 (en) | 2011-07-12 |
HRP20110115T1 (hr) | 2011-03-31 |
CL2008000496A1 (es) | 2008-09-22 |
WO2008101867A1 (en) | 2008-08-28 |
EP2125792A1 (en) | 2009-12-02 |
JP2010519186A (ja) | 2010-06-03 |
US20090131458A1 (en) | 2009-05-21 |
US20100120799A1 (en) | 2010-05-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2125792T3 (da) | Purinderivater som immunomodulatorer | |
DK2300465T3 (da) | Imidazopyridinderivater som hæmmere af receptortyrosinkinaser | |
DK2164844T3 (da) | Pyrimidinyl-pyridazinonderivater | |
DK2209786T3 (da) | Pyrimidinsubstituerede purinderivater | |
DK2220070T3 (da) | 2-benzylpyridazinonderivater som Met-kinaseinhibitorer | |
DK2139892T3 (da) | Substituerede pyrimidodiazepiner nyttige som PLK1-inhibitorer | |
BRPI0820112A2 (pt) | Derivados de isoxazol-piridina | |
DK2414362T3 (da) | Pyrimidinsubstituerede purinforbindelser som kinaseinhibitorer | |
BRPI0809992A2 (pt) | Derivados de pirrolopirimidina | |
BRPI0820113A2 (pt) | Derivados de isoxazolo-piridazina | |
BRPI0813836A2 (pt) | Derivados pirazólicos | |
DK2421825T3 (da) | Azetidinyldiamider som monoacylglycerollipase-inhibitorer | |
DK2086939T3 (da) | Pyridiacarboxamid som II-beta-HSDI-inhibitorer | |
DK2308877T3 (da) | Imidazopyridin-2-on-derivater | |
BRPI0817935A2 (pt) | Derivados de biarila | |
BRPI0812155A2 (pt) | derivados de espiroindolinona | |
ATE518837T1 (de) | Indazolamidderivate | |
BRPI0814236A2 (pt) | Derivados de quinazolinamida | |
BRPI0820649A2 (pt) | Derivados de isoxazalo-pirazina | |
DK2152370T3 (da) | Aryletherpyridazinonderivater | |
DK2078001T3 (da) | Diazepan-acetamidderivater som selektive 11-HSD1-inhibitorer | |
DK2275414T3 (da) | Cyclopentylacrylamidderivat | |
DK2007396T3 (da) | Enfumafungin-derivat som antimykotika | |
ATE519760T1 (de) | Isoxazolimidazolderivate | |
DE112007003225A5 (de) | Fräsvorrichtung |