EA200300788A1 - Производные замещенных алкиламинов и их применение - Google Patents

Производные замещенных алкиламинов и их применение

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Publication number
EA200300788A1
EA200300788A1 EA200300788A EA200300788A EA200300788A1 EA 200300788 A1 EA200300788 A1 EA 200300788A1 EA 200300788 A EA200300788 A EA 200300788A EA 200300788 A EA200300788 A EA 200300788A EA 200300788 A1 EA200300788 A1 EA 200300788A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
derivatives
application
alkylamins
substituted
Prior art date
Application number
EA200300788A
Other languages
English (en)
Other versions
EA006973B1 (ru
Inventor
Гуокинг Чен
Джеффри Л. Адамс
Джин Бемис
Шон Букер
Гуолин Каи
Майкл Крогэн
Люсиан Дипьетро
Селиа Домингэз
Дэниел Елбаум
Джули Гермэйн
Стефани Гюнс-Мейер
Майкл Хэндли
Ки Хуанг
Джозеф Л. Ким
Тае-Сеонг КИМ
Александр Киселев
Ксиаоху Оуянг
Винод Ф. Пэтел
Леон М. Смит
Маркиан Стек
Эндрю Тэскер
Нинг Кси
Шимин Ксу
Честер Ченгуанг Юан
Original Assignee
Амген Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA200300788A1 publication Critical patent/EA200300788A1/ru
Publication of EA006973B1 publication Critical patent/EA006973B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Выбранные гетероциклические соединения эффективны для профилактики и лечения заболеваний, например, связанных с ангиогенезом. Данное изобретение включает новые соединения, аналоги, предшественники и их фармацевтически приемлемые производные, фармацевтические композиции и методы профилактики и лечения болезней или других заболеваний, в том числе онкологических и родственных им. Данное изобретение охватывает процессы получения указанных соединений и промежуточных соединений, используемых в этих процессах.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300788A 2001-01-12 2002-01-11 Производные замещенных алкиламинов и их применение EA006973B1 (ru)

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