DK3558990T3 - Tetrahydroimidazo[4,5-c]pyridinderivater som pd-l1 internaliseringsinducere - Google Patents

Tetrahydroimidazo[4,5-c]pyridinderivater som pd-l1 internaliseringsinducere Download PDF

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Publication number
DK3558990T3
DK3558990T3 DK17835760.4T DK17835760T DK3558990T3 DK 3558990 T3 DK3558990 T3 DK 3558990T3 DK 17835760 T DK17835760 T DK 17835760T DK 3558990 T3 DK3558990 T3 DK 3558990T3
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tetrahydroimidazo
internalization
inducer
pyridine derivatives
pyridine
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DK17835760.4T
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Inventor
Phillip C Liu
Alla Volgina
Richard Wynn
Nina Zolotarjova
Liangxing Wu
Kaijiong Xiao
Song Mei
Liang Lu
Wenyu Zhu
Yingda Ye
Haisheng Wang
Ding-Quan Qian
Wenqing Yao
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Incyte Corp
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/42—Oxazoles
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    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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DK17835760.4T 2016-12-22 2017-12-21 Tetrahydroimidazo[4,5-c]pyridinderivater som pd-l1 internaliseringsinducere DK3558990T3 (da)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201662438020P 2016-12-22 2016-12-22
US201662438038P 2016-12-22 2016-12-22
US201662438001P 2016-12-22 2016-12-22
US201662437998P 2016-12-22 2016-12-22
US201662438009P 2016-12-22 2016-12-22
US201762487457P 2017-04-19 2017-04-19
US201762487341P 2017-04-19 2017-04-19
US201762487362P 2017-04-19 2017-04-19
US201762487365P 2017-04-19 2017-04-19
US201762487336P 2017-04-19 2017-04-19
US201762487356P 2017-04-19 2017-04-19
US201762551033P 2017-08-28 2017-08-28
US201762551011P 2017-08-28 2017-08-28
US201762569936P 2017-10-09 2017-10-09
PCT/US2017/067886 WO2018119224A1 (en) 2016-12-22 2017-12-21 Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers

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DK3558990T3 true DK3558990T3 (da) 2022-09-12

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US (2) US10806785B2 (da)
EP (2) EP3558990B1 (da)
JP (1) JP7149276B2 (da)
KR (1) KR102641030B1 (da)
CN (2) CN110267953B (da)
AU (1) AU2017382258B2 (da)
BR (1) BR112019012957A2 (da)
CA (1) CA3047980A1 (da)
CL (1) CL2019001743A1 (da)
CO (1) CO2019007852A2 (da)
CR (1) CR20190317A (da)
DK (1) DK3558990T3 (da)
EC (1) ECSP19052315A (da)
ES (1) ES2929193T3 (da)
HR (1) HRP20221216T1 (da)
HU (1) HUE060233T2 (da)
IL (1) IL267458A (da)
LT (1) LT3558990T (da)
MD (1) MD3558990T2 (da)
MX (2) MX2019007651A (da)
MY (1) MY197501A (da)
PE (1) PE20200005A1 (da)
PH (1) PH12019501448A1 (da)
PL (1) PL3558990T3 (da)
PT (1) PT3558990T (da)
RS (1) RS63710B1 (da)
SG (1) SG10202106743QA (da)
TW (1) TWI798192B (da)
UA (1) UA127785C2 (da)
WO (1) WO2018119224A1 (da)

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US20180016260A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
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AU2017382870B2 (en) 2016-12-22 2022-03-24 Incyte Corporation Benzooxazole derivatives as immunomodulators
ES2929193T3 (es) 2016-12-22 2022-11-25 Incyte Corp Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de la internalización de PD-L1
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
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