PE20081370A1 - Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas - Google Patents
Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismasInfo
- Publication number
- PE20081370A1 PE20081370A1 PE2007001210A PE2007001210A PE20081370A1 PE 20081370 A1 PE20081370 A1 PE 20081370A1 PE 2007001210 A PE2007001210 A PE 2007001210A PE 2007001210 A PE2007001210 A PE 2007001210A PE 20081370 A1 PE20081370 A1 PE 20081370A1
- Authority
- PE
- Peru
- Prior art keywords
- optionally substituted
- methyl
- alkylene
- substituted
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DE AMIDA SUSTITUIDAS DE FORMULA (I), EN DONDE R ES ARILO O HETEROARILO TAL COMO 4,5,6,7-TETRAHIDROBENZO[b]TIOFEN-2-ILO OPCIONALMENTE SUSTITUIDO; R4 ES H, ALQUILO O ALCOXI INFERIOR, OPCIONALMENTE SUSTITUIDO, HALO Y HIDROXI; R21 Y R22 SON INDEPENDIENTEMENTE H Y ALQUILO INFERIOR; R16 ES H, CIANO, CICLOALQUILO Y ALQUILO INFERIOR, OPCIONALMENTE SUSTITUIDOS; A ES HETEROARILO DE 5 MIEMBROS, PIRIDAZINILO, PIRIMIDINILO, Y PIRAZINILO, OPCIONALMENTE SUSTITUIDOS; L ES ALQUILENO(C0-C4), O- ALQUILENO(C0-C4), OPCIONALMENTE SUSTITUIDOS, ALQUILENO(C0-C4)(SO)-, ENTRE OTROS; G ES H, HALO, HIDROXI, ALCOXI, NITRO, ALQUILO, AMINO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS. SON SELECCIONADOS 4-TER-BUTIL-N-{2-METIL-3-[1-METIL-6-OXO-5-(TIAZOL-2-ILAMINO)-1,6-DIHIDRO-PIRIDIN-3-IL]FENIL}-BENZAMIDA, N-(2-METIL-3-(1-METIL-5-(6-MORFOLINOPIRIDAZIN-3-ILAMINO)-6-OXO-1,6-DIHIDROPIRIDIN-3-IL)FENIL)-4,5,6,7-TETRAHIDROBENZO[b]TIOFEN-2-CARBOXAMIDA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE Btk (PROTEINA QUINASA DE BRUTON) Y DE LA ACTIVIDAD DE LA CELULA B, SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, TRASTORNOS ALERGICOS Y/O INFLAMATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84383306P | 2006-09-11 | 2006-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081370A1 true PE20081370A1 (es) | 2008-11-28 |
Family
ID=39184519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001210A PE20081370A1 (es) | 2006-09-11 | 2007-09-10 | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP2079726B1 (es) |
| JP (1) | JP5563301B2 (es) |
| KR (1) | KR101444481B1 (es) |
| CN (1) | CN101605778A (es) |
| AR (1) | AR063707A1 (es) |
| AT (1) | ATE496909T1 (es) |
| AU (1) | AU2007296563B2 (es) |
| BR (1) | BRPI0716914A2 (es) |
| CA (1) | CA2661951C (es) |
| CL (1) | CL2007002642A1 (es) |
| CO (1) | CO6180464A2 (es) |
| CR (1) | CR10709A (es) |
| DE (1) | DE602007012281D1 (es) |
| EC (1) | ECSP099238A (es) |
| ES (1) | ES2363269T3 (es) |
| IL (1) | IL197264A0 (es) |
| MA (1) | MA31276B1 (es) |
| MX (1) | MX2009002651A (es) |
| NO (1) | NO20091426L (es) |
| PE (1) | PE20081370A1 (es) |
| RU (1) | RU2009113692A (es) |
| TW (1) | TWI398439B (es) |
| WO (1) | WO2008033857A2 (es) |
| ZA (1) | ZA200901634B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080839A1 (es) * | 2006-09-11 | 2008-08-23 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas |
| EP2205564B1 (en) * | 2007-10-23 | 2014-07-30 | F. Hoffmann-La Roche AG | Novel kinase inhibitors |
| US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| US8426424B2 (en) | 2008-05-06 | 2013-04-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
| PE20100851A1 (es) | 2008-06-24 | 2011-01-31 | Hoffmann La Roche | PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk |
| PE20110164A1 (es) | 2008-07-02 | 2011-03-28 | Hoffmann La Roche | Nuevas fenilpirazinonas como inhibidores de quinasa |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| AU2013293087B2 (en) | 2012-07-24 | 2017-08-31 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK) |
| DK2989106T3 (en) | 2013-04-25 | 2017-03-20 | Beigene Ltd | CONDENSED HETEROCYCLIC COMPOUNDS AS PROTEINKINASE INHIBITORS |
| CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
| HUE060420T2 (hu) | 2013-09-13 | 2023-02-28 | Beigene Switzerland Gmbh | Anti-PD1 antitestek, valamint terapeutikumként és diagnosztikumként történõ alkalmazásuk |
| KR101813830B1 (ko) * | 2013-12-05 | 2017-12-29 | 에프. 호프만-라 로슈 아게 | 친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물 |
| EP3160505A4 (en) | 2014-07-03 | 2018-01-24 | BeiGene, Ltd. | Anti-pd-l1 antibodies and their use as therapeutics and diagnostics |
| WO2016079669A1 (en) * | 2014-11-19 | 2016-05-26 | Novartis Ag | Labeled amino pyrimidine derivatives |
| MA52119A (fr) | 2015-10-19 | 2018-08-29 | Ncyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| JP7148401B2 (ja) | 2015-11-19 | 2022-10-05 | インサイト・コーポレイション | 免疫調節剤としての複素環化合物 |
| TW201726623A (zh) * | 2015-12-17 | 2017-08-01 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
| SI3394033T1 (sl) | 2015-12-22 | 2021-03-31 | Incyte Corporation | Heterociklične spojine kot imunomodulatorji |
| US20170320875A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3464279B1 (en) | 2016-05-26 | 2021-11-24 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| KR20210019607A (ko) | 2016-06-07 | 2021-02-22 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| MX2018016273A (es) | 2016-06-20 | 2019-07-04 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores. |
| JP6993056B2 (ja) | 2016-07-05 | 2022-02-15 | ベイジーン リミテッド | 癌治療のためのｐｄ－１アンタゴニスト及びｒａｆ阻害剤の組合せ |
| WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CN116478166A (zh) | 2016-08-16 | 2023-07-25 | 百济神州(苏州)生物科技有限公司 | 一种化合物的晶型、其制备和用途 |
| AU2017313085A1 (en) | 2016-08-19 | 2019-03-14 | Beigene Switzerland Gmbh | Use of a combination comprising a Btk inhibitor for treating cancers |
| EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MA46285A (fr) | 2016-09-19 | 2019-07-31 | Mei Pharma Inc | Polythérapie |
| BR112019012993A2 (pt) | 2016-12-22 | 2019-12-03 | Incyte Corp | derivados de benzo-oxazol como imunomoduladores |
| US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| HUE060233T2 (hu) | 2016-12-22 | 2023-02-28 | Incyte Corp | Tetrahidro imidazo[4,5-c]piridin-származékok mint a PD-L1 internalizációját indukáló szerek |
| EP3573989A4 (en) | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF |
| CA3057582C (en) | 2017-03-23 | 2024-01-09 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| US11597768B2 (en) | 2017-06-26 | 2023-03-07 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
| US11377449B2 (en) | 2017-08-12 | 2022-07-05 | Beigene, Ltd. | BTK inhibitors with improved dual selectivity |
| CN111801334B (zh) | 2017-11-29 | 2023-06-09 | 百济神州瑞士有限责任公司 | 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤 |
| SI3774791T1 (sl) | 2018-03-30 | 2023-04-28 | Incyte Corporation | Heterociklične spojine kot imunomodulatorji |
| HUE061503T2 (hu) | 2018-05-11 | 2023-07-28 | Incyte Corp | Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok |
| JP2022544189A (ja) | 2019-08-09 | 2022-10-17 | インサイト・コーポレイション | Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩 |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式 |
| AR124001A1 (es) | 2020-11-06 | 2023-02-01 | Incyte Corp | Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1144390A2 (en) * | 1999-01-22 | 2001-10-17 | Amgen Inc., | Kinase inhibitors |
| JP2005255675A (ja) * | 2004-02-09 | 2005-09-22 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2008524233A (ja) * | 2004-12-16 | 2008-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 炎症性疾患、増殖性疾患および免疫介在性疾患の治療のためのｔｅｃファミリータンパク質キナーゼのインヒビターとして有用なピリド−２−オン |
-
2007
- 2007-09-10 AR ARP070103989A patent/AR063707A1/es unknown
- 2007-09-10 PE PE2007001210A patent/PE20081370A1/es not_active Application Discontinuation
- 2007-09-11 TW TW096133935A patent/TWI398439B/zh not_active IP Right Cessation
- 2007-09-11 BR BRPI0716914-0A patent/BRPI0716914A2/pt not_active Application Discontinuation
- 2007-09-11 KR KR1020097007473A patent/KR101444481B1/ko active IP Right Grant
- 2007-09-11 EP EP07842267A patent/EP2079726B1/en active Active
- 2007-09-11 ES ES07842267T patent/ES2363269T3/es active Active
- 2007-09-11 DE DE602007012281T patent/DE602007012281D1/de active Active
- 2007-09-11 MX MX2009002651A patent/MX2009002651A/es not_active Application Discontinuation
- 2007-09-11 CA CA2661951A patent/CA2661951C/en not_active Expired - Fee Related
- 2007-09-11 CN CNA200780041899XA patent/CN101605778A/zh active Pending
- 2007-09-11 AU AU2007296563A patent/AU2007296563B2/en not_active Ceased
- 2007-09-11 AT AT07842267T patent/ATE496909T1/de not_active IP Right Cessation
- 2007-09-11 RU RU2009113692/04A patent/RU2009113692A/ru not_active Application Discontinuation
- 2007-09-11 WO PCT/US2007/078185 patent/WO2008033857A2/en active Application Filing
- 2007-09-11 CL CL200702642A patent/CL2007002642A1/es unknown
- 2007-09-11 JP JP2009527626A patent/JP5563301B2/ja active Active
-
2009
- 2009-02-26 IL IL197264A patent/IL197264A0/en unknown
- 2009-03-06 ZA ZA200901634A patent/ZA200901634B/xx unknown
- 2009-04-01 CO CO09033749A patent/CO6180464A2/es not_active Application Discontinuation
- 2009-04-03 CR CR10709A patent/CR10709A/es unknown
- 2009-04-06 MA MA31767A patent/MA31276B1/fr unknown
- 2009-04-07 NO NO20091426A patent/NO20091426L/no not_active Application Discontinuation
- 2009-04-07 EC EC2009009238A patent/ECSP099238A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2661951C (en) | 2014-11-18 |
| ZA200901634B (en) | 2009-12-30 |
| AU2007296563A1 (en) | 2008-03-20 |
| WO2008033857A2 (en) | 2008-03-20 |
| EP2079726A2 (en) | 2009-07-22 |
| JP5563301B2 (ja) | 2014-07-30 |
| BRPI0716914A2 (pt) | 2013-11-05 |
| DE602007012281D1 (de) | 2011-03-10 |
| ECSP099238A (es) | 2009-07-31 |
| KR20090074192A (ko) | 2009-07-06 |
| CN101605778A (zh) | 2009-12-16 |
| TW200829567A (en) | 2008-07-16 |
| AR063707A1 (es) | 2009-02-11 |
| CA2661951A1 (en) | 2008-03-20 |
| AU2007296563B2 (en) | 2013-01-10 |
| KR101444481B1 (ko) | 2014-09-24 |
| MA31276B1 (fr) | 2010-04-01 |
| CR10709A (es) | 2009-07-14 |
| EP2079726B1 (en) | 2011-01-26 |
| ES2363269T3 (es) | 2011-07-28 |
| IL197264A0 (en) | 2009-12-24 |
| NO20091426L (no) | 2009-06-10 |
| ATE496909T1 (de) | 2011-02-15 |
| CL2007002642A1 (es) | 2008-07-18 |
| JP2010502750A (ja) | 2010-01-28 |
| WO2008033857A3 (en) | 2008-06-05 |
| TWI398439B (zh) | 2013-06-11 |
| RU2009113692A (ru) | 2010-10-20 |
| CO6180464A2 (es) | 2010-07-19 |
| MX2009002651A (es) | 2009-03-26 |
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