DK3303307T3 - Nye gadoliniumchelatforbindelser til anvendelse til magnetisk resonans-billeddannelse - Google Patents

Nye gadoliniumchelatforbindelser til anvendelse til magnetisk resonans-billeddannelse Download PDF

Info

Publication number
DK3303307T3
DK3303307T3 DK16726531T DK16726531T DK3303307T3 DK 3303307 T3 DK3303307 T3 DK 3303307T3 DK 16726531 T DK16726531 T DK 16726531T DK 16726531 T DK16726531 T DK 16726531T DK 3303307 T3 DK3303307 T3 DK 3303307T3
Authority
DK
Denmark
Prior art keywords
magnetic resonance
resonance imaging
chelate compounds
gadolinium chelate
new gadolinium
Prior art date
Application number
DK16726531T
Other languages
English (en)
Inventor
Markus Berger
Jessica Lohrke
Christoph-Stephan Hilger
Gregor Jost
Thomas Frenzel
Detlev Sülzle
Johannes Platzek
Olaf Panknin
Hubertus Pietsch
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53396265&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3303307(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Application granted granted Critical
Publication of DK3303307T3 publication Critical patent/DK3303307T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK16726531T 2015-06-04 2016-05-30 Nye gadoliniumchelatforbindelser til anvendelse til magnetisk resonans-billeddannelse DK3303307T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15170658.7A EP3101012A1 (en) 2015-06-04 2015-06-04 New gadolinium chelate compounds for use in magnetic resonance imaging
PCT/EP2016/062105 WO2016193190A1 (en) 2015-06-04 2016-05-30 New gadolinium chelate compounds for use in magnetic resonance imaging

Publications (1)

Publication Number Publication Date
DK3303307T3 true DK3303307T3 (da) 2019-11-25

Family

ID=53396265

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16726531T DK3303307T3 (da) 2015-06-04 2016-05-30 Nye gadoliniumchelatforbindelser til anvendelse til magnetisk resonans-billeddannelse
DK19194723.3T DK3611169T3 (da) 2015-06-04 2016-05-30 Nye gadoliniumchelatforbindelser til anvendelse ved magnetisk resonans-billeddannelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19194723.3T DK3611169T3 (da) 2015-06-04 2016-05-30 Nye gadoliniumchelatforbindelser til anvendelse ved magnetisk resonans-billeddannelse

Country Status (42)

Country Link
US (4) US10137209B2 (da)
EP (3) EP3101012A1 (da)
JP (1) JP6703012B2 (da)
KR (1) KR102162742B1 (da)
CN (1) CN107667096B (da)
AR (1) AR104897A1 (da)
AU (1) AU2016272602B2 (da)
CA (1) CA2987993C (da)
CL (1) CL2017003083A1 (da)
CO (1) CO2017012490A2 (da)
CU (1) CU24467B1 (da)
CY (2) CY1122323T1 (da)
DK (2) DK3303307T3 (da)
DO (1) DOP2017000282A (da)
EA (1) EA033612B1 (da)
EC (1) ECSP17080394A (da)
ES (2) ES2893244T3 (da)
GE (1) GEP20207146B (da)
HK (1) HK1246281A1 (da)
HR (2) HRP20211467T1 (da)
HU (2) HUE045967T2 (da)
IL (1) IL255945B (da)
JO (1) JO3702B1 (da)
LT (2) LT3303307T (da)
MA (2) MA43146B1 (da)
MX (1) MX2017015669A (da)
NI (1) NI201700149A (da)
NZ (1) NZ737707A (da)
PE (1) PE20180261A1 (da)
PH (1) PH12017502205A1 (da)
PL (2) PL3303307T3 (da)
PT (2) PT3303307T (da)
RS (2) RS62353B1 (da)
SA (1) SA517390476B1 (da)
SI (2) SI3303307T1 (da)
SV (1) SV2017005578A (da)
TN (1) TN2017000505A1 (da)
TW (1) TWI699358B (da)
UA (1) UA123313C2 (da)
UY (1) UY36711A (da)
WO (1) WO2016193190A1 (da)
ZA (1) ZA201800024B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (ko) * 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
BR112021007707A2 (pt) * 2018-11-23 2021-07-27 Bayer Aktiengesellschaft formulação de meios de contraste e processo de preparação da mesma
CN110396122B (zh) * 2019-08-13 2020-10-27 牡丹江医学院 一种核磁共振造影剂、制备方法及其用于肿瘤诊断中的用途
KR102386595B1 (ko) * 2019-10-29 2022-04-14 경북대학교 산학협력단 신규한 가돌리늄계 화합물, 이의 제조 방법, 및 이를 함유하는 mri 조영제
CN111393544A (zh) * 2020-03-02 2020-07-10 合肥工业大学 一种具有靶向核磁共振造影和荧光成像功能的聚合物、制备方法及应用
CN114181233B (zh) * 2021-11-24 2023-10-31 复旦大学 一种钆基T1磁共振造影剂FD-Gd-123及其制备方法和应用
CN114276309B (zh) * 2021-12-24 2023-08-11 南京科技职业学院 一类含乙氧基芳环的钆磁共振造影剂及其制备方法与应用
WO2024046833A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046831A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024046832A1 (de) 2022-08-30 2024-03-07 Bayer Aktiengesellschaft Erzeugen von synthetischen radiologischen aufnahmen
WO2024052156A1 (de) 2022-09-05 2024-03-14 Bayer Aktiengesellschaft Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen
EP4335461A1 (en) 2022-09-09 2024-03-13 Bayer AG Combinations of contrast agents
WO2024063529A1 (ko) * 2022-09-20 2024-03-28 주식회사 테라노큐어 신규 화합물 및 이를 포함하는 염증성 질환과 암에 대한 진단 및 치료에 사용되는 mri 조영제
WO2024083466A1 (de) 2022-10-17 2024-04-25 Bayer Aktiengesellschaft Automatisches analysieren von radiologischen aufnahmen
EP4360660A1 (en) 2022-10-24 2024-05-01 Bayer AG Process for the preparation of a gadolinium contrast agent
EP4369353A1 (de) 2022-11-12 2024-05-15 Bayer Aktiengesellschaft Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen
EP4369285A1 (de) 2022-11-12 2024-05-15 Bayer AG Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US5560903A (en) 1981-07-24 1996-10-01 Schering Aktiengesellschaft Method of enhancing paramagnetism in chelates for MRI
US4485237A (en) 1983-03-08 1984-11-27 The United States Of America As Represented By The Secretary Of The Navy Insensitive polynitramine compound
DE3625417C2 (de) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5039512A (en) 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
DE3728525A1 (de) 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5138923A (en) 1988-11-18 1992-08-18 Atlas Die, Inc. Rotary die cutter
US5011925A (en) 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
ATE173336T1 (de) 1989-08-28 1998-11-15 Gen Hospital Corp Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
GB8923843D0 (en) 1989-10-23 1989-12-13 Salutar Inc Compounds
GB9320277D0 (en) 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
DE69032374T2 (de) 1989-10-23 1998-12-17 Nycomed Salutar Inc Mehrzähnige metall-chelatierende verbindungen
US5650133A (en) 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5679810A (en) 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
US5141740A (en) 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
US5167942A (en) 1990-11-21 1992-12-01 Board Of Regents, The University Of Texas System Methods for the preparation of molecular sieves, including zeolites, using metal chelate complexes
EP0660925A1 (en) 1990-11-21 1995-07-05 Mallinckrodt Medical, Inc. Alkoxyamide derivatized chelates for mri
CA2106874A1 (en) 1991-04-22 1992-10-29 Theofilus J. Visser Method for detecting and localizing tissues having neurokinine 1 receptors
CA2102605A1 (en) 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
EP0643706A1 (en) 1991-11-27 1995-03-22 Zynaxis Inc. Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
US5324503A (en) 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
DE4232925A1 (de) 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
EP0703790B1 (en) 1993-06-02 2000-08-16 BRACCO S.p.A. Iodinated paramagnetic chelates, and their use as contrast agents
IT1264690B1 (it) 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi
WO1995020353A1 (en) 1994-01-28 1995-08-03 Mallinckrodt Medical, Inc. Functionalized aza-bimacrocyclic ligands for imaging applications
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
DE4425857A1 (de) 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
NZ280272A (en) 1994-10-21 1996-11-26 Nihon Mediphysics Co Ltd Diagnostic imaging agent comprising a metal ion and bifunctional ligand bonded to an amino- or dialdehyde- oligosaccharide
US5672335A (en) 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
US5707605A (en) 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
DE19525924A1 (de) 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
DE19549286A1 (de) 1995-12-22 1997-06-26 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19603033A1 (de) 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19608278A1 (de) 1996-02-23 1997-08-28 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5866562A (en) 1996-10-25 1999-02-02 Bayer Aktiengesellschaft Ring-bridged bis-quinolines
US6045776A (en) 1996-12-04 2000-04-04 Schering Aktiengesellschaft Process for the production of metal-complex carboxylic acid amides
DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
DE19652387A1 (de) 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
US5919433A (en) 1996-12-04 1999-07-06 Schering Aktiengesellschaft Macrocyclic metal complex carboxylic acids, their use as well as process for their production
DE19729013A1 (de) 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
DE19744003B4 (de) 1997-09-26 2004-07-08 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
DE69811931T2 (de) 1997-10-27 2003-12-18 Res Corp Technologies Inc Mri-mittel für die verabreichung von therapeutischen mitteln
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
DE19831217A1 (de) 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
EP0998946A1 (en) 1998-08-14 2000-05-10 K.U. Leuven Research & Development Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
US6056939A (en) 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
US6232265B1 (en) 1999-06-11 2001-05-15 Ibc Advanced Technologies, Inc. Particulate solid supports functionalized with polyhydroxypyridinone ligands
US6221476B1 (en) 1999-06-11 2001-04-24 Ibc Advanced Technologies, Inc. Polymeric membranes functionalized with polyhydroxypyridinone ligands
DE19930177B4 (de) 1999-06-30 2007-02-08 Nikolai Vladimirovich Bovin Intermolekular assoziierende Verbindungen und deren Verwendung
DE19948651B4 (de) 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
EP1088559A3 (de) 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE10002939C1 (de) 2000-01-13 2001-09-20 Schering Ag Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln
JP2003520255A (ja) 2000-01-22 2003-07-02 エピックス メディカル， インコーポレイテッド 酵素的な切断によって生理活性化される造影剤プロドラッグを使用した磁気共鳴画像法
US20020052354A1 (en) * 2000-01-27 2002-05-02 Schering Ag Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
IT1317862B1 (it) 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
WO2001097848A2 (en) 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
JP2005538030A (ja) 2000-06-21 2005-12-15 デュポン ファーマシューティカルズ カンパニー 組み合わせ療法での使用のための血管新生障害の画像診断用医薬
DE10066210B4 (de) 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040381C1 (de) 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040858C2 (de) 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
IL145723A0 (en) 2000-10-11 2002-07-25 Nihon Mediphysics Co Ltd Process for producing an amide compound
US20030050452A1 (en) 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030004236A1 (en) 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
DE10135355C1 (de) 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
ITMI20011708A1 (it) 2001-08-03 2003-02-03 Bracco Imaging Spa Coniugati di peptidi, loro derivati con complessi metallici e utilizzo per i'indagine diagnostica tramite imaging per risonanza magnetica(m
FR2836916B1 (fr) 2002-03-05 2004-06-11 Guerbet Sa Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese
US20030198597A1 (en) 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
DE10231799B4 (de) 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10307759B3 (de) 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
CA2526760A1 (en) 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
AR047692A1 (es) 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US7211237B2 (en) 2003-11-26 2007-05-01 3M Innovative Properties Company Solid state synthesis of lithium ion battery cathode material
DE102004023093B3 (de) 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
ATE430146T1 (de) 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
US8153784B2 (en) 2004-07-07 2012-04-10 The General Hospital Corporation Imaging of enzyme activity
US20060057071A1 (en) 2004-09-14 2006-03-16 Wing-Tak Wong Paramagnetic complexes with pendant crown compounds showing improved targeting-specificity as MRI contrast agents
US7205385B2 (en) 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
WO2006080022A2 (en) 2005-01-31 2006-08-03 Yeda Research And Development Co. Ltd. Mri contrast agents for diagnosis and prognosis of tumors
GB0512751D0 (en) 2005-06-22 2005-07-27 Glaxo Group Ltd New adjuvant
FR2891830B1 (fr) 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
ATE534407T1 (de) 2005-12-01 2011-12-15 Ge Healthcare As Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions
BRPI0619198A2 (pt) 2005-12-02 2011-09-20 Ge Healthcare As composto, composição, uso da composição, e, métodos para formação de imagem por rm e/ou de espectroscopia por rm, e para a preparação de compostos
EP1962912B1 (en) 2005-12-16 2012-09-26 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
WO2007084264A2 (en) 2005-12-29 2007-07-26 Epix Pharmaceuticals, Inc. Methods for myocardial imaging
US20070202047A1 (en) * 2006-01-05 2007-08-30 Markus Wolf Polyamine-substituted ligands for use as contrast agents
EP1815870A1 (en) 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
EP1988925A2 (en) 2006-02-24 2008-11-12 Mallinckrodt, Inc. Bifunctional resorcinol, thioresorcinol, and dithioresorcinol derivative metal chelating conjugates
WO2007112100A2 (en) 2006-03-24 2007-10-04 The University Of Utah Research Foundation Highly fluorinated oils and surfactants and methods of making and using same
EP1998813A2 (en) 2006-03-29 2008-12-10 GE Healthcare AS Method to produce hyperpolarised carboxylates and sulphonates in the presence of inorganic cations
WO2007111514A1 (en) 2006-03-29 2007-10-04 Ge Healthcare As Contrast agents for magnetic resonance imaging and spectroscopy consisting of a cyclic oligoamid core of 3 to 4 identical monomer units with 3 to 4 paramagnetic chelate side chains
WO2007128873A1 (en) 2006-05-05 2007-11-15 Wallac Oy A method for the preparation of maleimido derivatives of biomolecule labeling reactants and conjugates derived thereof
DE102006021495A1 (de) 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
JP2008012596A (ja) 2006-07-03 2008-01-24 Aji Kk 把持装置
WO2008017122A1 (en) * 2006-08-11 2008-02-14 Starpharma Pty Ltd Polylysine dendrimer contrast agent
EP2053968A4 (en) 2006-08-17 2015-10-21 Epix Pharm Inc METHOD FOR ILLUMINATING THE LYMPH SYSTEM
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP1980251A1 (en) 2007-04-13 2008-10-15 Glaxo Group Limited Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis
JP2010534498A (ja) 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
WO2009018332A1 (en) 2007-08-01 2009-02-05 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a metal-chelating ligand
JP5693224B2 (ja) 2007-08-27 2015-04-01 ジーイー・ヘルスケア・リミテッド 方法及び該方法で使用するためのイメージング媒体
WO2009030735A1 (en) 2007-09-07 2009-03-12 Ge Healthcare Limited Method of determination of pdh activity and imaging media for use in said method
FR2921929B1 (fr) 2007-10-08 2013-01-11 Commissariat Energie Atomique Procede de preparation de materiaux polymeriques dopes par des elements metalliques et materiaux obtenus par ce procede
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009080739A1 (en) 2007-12-21 2009-07-02 Ge Healthcare Limited Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
GB0801199D0 (en) 2008-01-23 2008-02-27 Acal Energy Ltd Fuel cells
US8545813B2 (en) 2008-01-25 2013-10-01 Northwestern University Pre-templated macromolecular architectures with multiple Gd(III) complexes and methods of use as MRI contrast agents
CN101932340A (zh) 2008-02-04 2010-12-29 通用电气健康护理有限公司 生产超极化的氨基酸和氨基磺酸的方法
WO2009098192A1 (en) 2008-02-04 2009-08-13 Ge Healthcare Limited Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used
EP2279190A1 (en) 2008-04-18 2011-02-02 Ge Healthcare As Compounds comprising paramagnetic chelates arranged around a central core and their use in magneto resonance imaging and spectroscopy
CN102076214A (zh) 2008-05-19 2011-05-25 伯拉考成像股份公司 释放胃泌素的肽化合物
EP2149567A1 (en) 2008-07-18 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Cyclic polyamines for binding phosphatidylserine
JP6013735B2 (ja) 2008-09-30 2016-10-25 マリンクロット ニュークリア メディシン エルエルシー 画像目的のためのヘキソースおよび金属配位結合化合物の結合体
US20110217241A1 (en) 2008-11-14 2011-09-08 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
FR2939318B1 (fr) 2008-12-10 2012-07-13 Guerbet Sa Systeme d'encapsulation pour imagerie cest avec quelate q superieur ou egal a 2
CA3035532C (en) 2009-03-19 2021-10-26 The Johns Hopkins University Psma-targeting compounds and uses thereof
WO2010147666A1 (en) 2009-06-19 2010-12-23 Memorial Sloan-Kettering Cancer Center Compounds useful as carbonic anhydrase modulators and uses thereof
WO2011031740A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US20110081428A1 (en) 2009-09-16 2011-04-07 The Buck Institute For Age Research Use of thioflavin-like compounds to increase life span and/or health span
NO331773B1 (no) 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
EP2555803B1 (en) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Process for preparing hyperpolarized substrates and method for mri
EP2397466B1 (en) 2010-06-15 2012-11-28 Centre National De La Recherche Scientifique CNRS X-ray and gamma-photon activatable organic compounds, their preparation and their uses
KR101236142B1 (ko) * 2010-09-30 2013-02-21 경북대학교 산학협력단 가돌리늄 착물을 함유하는 ｍｒｉ조영제
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
US9011816B2 (en) 2011-03-25 2015-04-21 Case Western Reserve University Fibronectin targeting contrast agent
JP2014515750A (ja) 2011-04-20 2014-07-03 アールエフ セラピューティクス インコーポレイテッド 標的型造影剤及びその使用
EP2739316B1 (en) 2011-08-05 2019-04-10 Molecular Insight Pharmaceuticals, Inc. Radiolabeled prostate specific membrane antigen inhibitors
CN102973955B (zh) 2011-09-06 2016-03-23 中国科学院福建物质结构研究所 一种含三价铝的磁共振成像造影剂
CN102442996B (zh) 2011-09-16 2014-09-24 中山大学附属第一医院 多胺类小分子显像剂、其生产方法及其应用
ES2414291B2 (es) 2011-12-16 2014-02-13 Universitat De Valencia Compuestos macrocíclicos de tipo escorpiando y su uso como antiparasitarios.
KR101336071B1 (ko) 2012-01-04 2013-12-05 한국원자력의학원 암 진단용 ｍｒｉ／ｃｔ 이중 조영제 및 그 제조방법
CN102614531B (zh) 2012-04-06 2013-06-05 中国科学院长春应用化学研究所 以二乙酰基苯或三乙酰基苯为连接体的多核非离子型磁共振成像造影剂
US9585975B2 (en) 2012-04-27 2017-03-07 Northwestern University MRI contrast agents
KR101456234B1 (ko) 2012-08-09 2014-11-04 한국원자력의학원 아미노시클로헥산카르복실산-함유 시클로 ｒｇｄ 유도체, 그 제조방법 및 그것을 포함하는 ｍｒｉ 조영제
KR101456233B1 (ko) 2012-08-09 2014-11-04 한국원자력의학원 아미노시클로펜탄카르복실산-함유 시클로 ｒｇｄ 유도체, 그 제조방법 및 그것을 포함하는 ｍｒｉ 조영제
PL2900279T3 (pl) 2012-09-25 2020-05-18 Advanced Accelerator Applications Usa, Inc. Antagonisty grpr do wykrywania, diagnostyki i leczenia raka grpr-pozytywnego
WO2014075079A1 (en) 2012-11-12 2014-05-15 The General Hospital Corporation Peptidic structures incorporating an amino acid metal complex and applications in magnetic resonance imaging
HUE044552T2 (hu) 2013-01-14 2019-11-28 Molecular Insight Pharm Inc Triazinalapú radiogyógyszerek és radiológiai képalkotó ágensek
US20160008490A1 (en) 2013-02-12 2016-01-14 Bayer Pharma Aktiengesellschaft Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia
WO2014197763A1 (en) 2013-06-07 2014-12-11 The Board Of Regents Of The University Of Teas System Molecular design toward dual-modality probes for radioisotope-based imaging (pet or spect) and mri
CN103554185A (zh) 2013-07-04 2014-02-05 上海工程技术大学 一类大环多胺类多齿配体及其合成方法
EP2873680A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Oligopeptide and methods for producing conjugates thereof
EP2873679A1 (en) 2013-11-13 2015-05-20 F.Hoffmann-La Roche Ag Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof
CN103611171B (zh) 2013-11-25 2015-03-25 中国科学院长春应用化学研究所 以四苯酰基甲烷为连接体的非离子型多核磁共振成像造影剂及其制备方法
EP3140282B1 (en) 2014-05-06 2019-07-10 The Johns Hopkins University Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy
WO2016050210A1 (zh) 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 一种多官能化聚乙二醇衍生物及其制备方法
WO2016149363A1 (en) 2015-03-16 2016-09-22 Northwestern University Contrast-agent-labeled peptide amphiphile nanofibers
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US20160375155A1 (en) 2015-06-29 2016-12-29 Collagen Medical, LLC Collagen Imaging Compositions
US10927108B2 (en) 2015-08-17 2021-02-23 Southwestern Oklahoma State University Compositions comprising macrocycle derivatives incorporating bridged macrocycles and methods of producing and using same
CN108289970B (zh) 2015-11-30 2022-04-08 通用电气医疗集团股份有限公司 包含mri造影剂的组合的制剂
US10781188B2 (en) 2015-12-10 2020-09-22 Bracco Imaging S.P.A. Contrast agents
BR112018010815B1 (pt) 2015-12-10 2022-05-17 Bracco Imaging Spa Compostos diméricos, complexo quelante e composição farmacêutica compreendendo o refrido complexo quelante
US10656229B2 (en) 2016-04-06 2020-05-19 Northwestern University Magnetic barcode imaging
JP6909234B2 (ja) 2016-04-13 2021-07-28 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤
KR102464647B1 (ko) * 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
HUE056114T2 (hu) 2016-12-12 2022-01-28 Bracco Imaging Spa Dimer kontrasztanyagok

Also Published As

Publication number Publication date
AU2016272602B2 (en) 2020-04-30
HRP20211467T1 (hr) 2021-12-24
HK1246281A1 (zh) 2018-09-07
CY1124544T1 (el) 2022-07-22
JP6703012B2 (ja) 2020-06-03
CU24467B1 (es) 2020-01-03
KR20180011264A (ko) 2018-01-31
PT3611169T (pt) 2021-10-06
DOP2017000282A (es) 2017-12-31
SI3611169T1 (sl) 2021-11-30
EP3611169B1 (en) 2021-07-21
GEP20207146B (en) 2020-09-10
SV2017005578A (es) 2018-05-29
AU2016272602A1 (en) 2017-12-14
DK3611169T3 (da) 2021-10-11
TW201708198A (zh) 2017-03-01
CA2987993A1 (en) 2016-12-08
CL2017003083A1 (es) 2018-05-25
ES2893244T3 (es) 2022-02-08
SA517390476B1 (ar) 2020-05-11
MA43146B1 (fr) 2020-01-31
RS59565B1 (sr) 2019-12-31
EP3303307B1 (en) 2019-09-04
PH12017502205A1 (en) 2018-06-11
RS62353B1 (sr) 2021-10-29
SI3303307T1 (sl) 2019-11-29
ECSP17080394A (es) 2018-01-31
EP3303307A1 (en) 2018-04-11
LT3303307T (lt) 2019-11-11
HUE045967T2 (hu) 2020-01-28
AU2016272602A2 (en) 2018-04-19
EA201792675A1 (ru) 2018-05-31
IL255945A (en) 2018-01-31
CA2987993C (en) 2021-08-31
MA50918B1 (fr) 2021-12-31
US10137209B2 (en) 2018-11-27
HRP20191631T1 (hr) 2019-12-13
PL3303307T3 (pl) 2020-04-30
TN2017000505A1 (en) 2019-04-12
PE20180261A1 (es) 2018-02-05
US20180169274A1 (en) 2018-06-21
JP2018521017A (ja) 2018-08-02
US11491245B2 (en) 2022-11-08
KR102162742B1 (ko) 2020-10-07
ES2756703T3 (es) 2020-04-27
CO2017012490A2 (es) 2018-03-09
LT3611169T (lt) 2021-10-11
IL255945B (en) 2020-02-27
BR112017026135A2 (pt) 2018-08-28
EP3611169A1 (en) 2020-02-19
CY1122323T1 (el) 2021-01-27
AR104897A1 (es) 2017-08-23
MX2017015669A (es) 2018-04-18
US20230113481A1 (en) 2023-04-13
WO2016193190A1 (en) 2016-12-08
UA123313C2 (uk) 2021-03-17
MA50918A (fr) 2021-03-17
PT3303307T (pt) 2019-11-25
US20190083659A1 (en) 2019-03-21
NZ737707A (en) 2022-11-25
CU20170155A7 (es) 2018-04-03
PL3611169T3 (pl) 2021-12-27
HUE056328T2 (hu) 2022-02-28
JO3702B1 (ar) 2021-01-31
US20200353104A1 (en) 2020-11-12
EA033612B1 (ru) 2019-11-08
TWI699358B (zh) 2020-07-21
NI201700149A (es) 2018-04-11
ZA201800024B (en) 2022-05-25
UY36711A (es) 2016-12-30
CN107667096A (zh) 2018-02-06
US10722601B2 (en) 2020-07-28
CN107667096B (zh) 2021-02-02
EP3101012A1 (en) 2016-12-07

Similar Documents

Publication Publication Date Title
DK3303307T3 (da) Nye gadoliniumchelatforbindelser til anvendelse til magnetisk resonans-billeddannelse
HK1243307A1 (zh) 用於低場磁共振的脈衝序列
IL250933B (en) Ferromagnetic magnification for magnetic resonance imaging
DK3143161T3 (da) Nukleinsyresynteseteknikker
DK2970951T3 (da) Fremgangsmåder til nukleinsyresekventering
HK1221285A1 (zh) 用於磁共振成像的線圈組件
DK3063119T3 (da) Fremgangsmåde til fremstilling af hyperpolariserede carboxylatforbindelser
ES2972570T3 (es) Imán para obtención de imágenes de cabeza y extremidades
DK2941434T3 (da) Mangan-baseret mr-kontraststof (magnetisk resonans)
ITUB20169987A1 (it) Connettore per bobina magnetica
IL247146A0 (en) A coil for magnetic induction tomography imaging
HK1222112A1 (zh) 用於磁共振成像研究的足部定位系統
DK3369724T3 (da) Fremgangsmåde til fremstilling af iopamidol
DE112014004044A5 (de) Rektalspule für Magnet-Resonanz-Tomographie
DK3454942T3 (da) Apparat til kernemagnetisk resonansterapi
DK3212733T3 (da) Nye kromofore strukturer til makrocykliske lanthanidchelater
GB2553465B (en) Shimming coils for magnetic resonance imaging
GB201311351D0 (en) Nuclear magnetic resonance probes
GB2546673B (en) Nuclear magnetic resonance tool with projections for improved measurements
GB201613149D0 (en) Nuclear magnetic resonance detector
GB201513194D0 (en) Nuclear magnetic resonance detector
GB201411487D0 (en) Nuclear magnetic resonance detector
UA32687S (uk) Котушка для металодетектора
UA32686S (uk) Котушка для металодетектора
TH1601001335A (th) เครื่องกรองแม่เหล็ก