ATE173336T1 - Hydroxy-aryl metallchelate für bildformung zur nmr diagnose - Google Patents
Hydroxy-aryl metallchelate für bildformung zur nmr diagnoseInfo
- Publication number
- ATE173336T1 ATE173336T1 AT90914613T AT90914613T ATE173336T1 AT E173336 T1 ATE173336 T1 AT E173336T1 AT 90914613 T AT90914613 T AT 90914613T AT 90914613 T AT90914613 T AT 90914613T AT E173336 T1 ATE173336 T1 AT E173336T1
- Authority
- AT
- Austria
- Prior art keywords
- iii
- nitrogens
- ligand
- hydroxy
- nmr
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- Epidemiology (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39973789A | 1989-08-28 | 1989-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE173336T1 true ATE173336T1 (de) | 1998-11-15 |
Family
ID=23580762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90914613T ATE173336T1 (de) | 1989-08-28 | 1990-08-28 | Hydroxy-aryl metallchelate für bildformung zur nmr diagnose |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0489869B1 (de) |
JP (1) | JPH05503072A (de) |
AT (1) | ATE173336T1 (de) |
CA (1) | CA2065290C (de) |
DE (1) | DE69032761T2 (de) |
HK (1) | HK1012707A1 (de) |
WO (1) | WO1991003200A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250285A (en) * | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
DE4136489A1 (de) * | 1991-11-06 | 1993-05-13 | Bayer Ag | Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken |
US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
TW319763B (de) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
PT907379E (pt) * | 1996-04-01 | 2004-09-30 | Epix Medical Inc | Agentes de contraste bioactivados para imagiologia de diagnostico |
EP1390079A2 (de) | 2000-11-20 | 2004-02-25 | Board of Regents University of Texas System | Paramagnetischen metallion-basierte makrozyklische kontrastmitteln |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
ES2506142T3 (es) | 2002-03-01 | 2014-10-13 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
EP1603935A4 (de) | 2003-03-03 | 2007-03-21 | Dyax Corp | SPEZIFISCH AN HGF-REZEPTOR (cMet) BINDENDE PEPTIDE UND DEREN VERWENDUNG |
US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
AR075900A1 (es) | 2009-03-19 | 2011-05-04 | Wyeth Llc | Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores. |
WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
US20110077396A1 (en) * | 2009-09-30 | 2011-03-31 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
US8378134B2 (en) | 2009-09-30 | 2013-02-19 | General Electric Company | Hydroxylated contrast enhancement agents |
US8722020B2 (en) * | 2010-03-31 | 2014-05-13 | General Electric Company | Hydroxylated contrast enhancement agents |
JP6297440B2 (ja) * | 2013-07-31 | 2018-03-20 | キヤノンメディカルシステムズ株式会社 | 造影剤 |
WO2015038968A1 (en) | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
US10471162B2 (en) | 2014-06-20 | 2019-11-12 | The General Hospital Corporation | Collagen targeted imaging probes |
EP3270951B1 (de) | 2015-03-16 | 2020-09-09 | California Institute of Technology | Botulinum-neurotoxin-spezifische abscheidungsmittel, zusammensetzungen und verfahren zur verwendung und herstellung |
CN104910030B (zh) * | 2015-05-14 | 2018-03-23 | 石家庄杰克化工有限公司 | 一种高纯度乙醇胺类氨羧螯合剂的合成工艺 |
EP3101012A1 (de) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung |
CN108290927B (zh) | 2015-07-15 | 2022-06-24 | 加州理工学院 | Il-17f-特异性捕获剂、组合物以及使用和制造的方法 |
US9829474B2 (en) * | 2015-10-16 | 2017-11-28 | General Electric Company | Acetate complexes and methods for acetate quantification |
CN115109120A (zh) | 2016-04-04 | 2022-09-27 | 英蒂分子公司 | Cd8-特异性捕获剂、组合物及使用和制备方法 |
US11884707B2 (en) | 2016-09-29 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same |
US11358982B2 (en) | 2016-11-01 | 2022-06-14 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
KR102464647B1 (ko) | 2016-11-28 | 2022-11-08 | 바이엘 파마 악티엔게젤샤프트 | 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물 |
WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
WO2020093055A2 (en) | 2018-11-02 | 2020-05-07 | Indi Molecular, Inc. | Peptide libraries with non-canonical amino acids |
WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
BR112021007707A2 (pt) | 2018-11-23 | 2021-07-27 | Bayer Aktiengesellschaft | formulação de meios de contraste e processo de preparação da mesma |
US20200291391A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
KR20230017207A (ko) | 2020-04-30 | 2023-02-03 | 사이로파 비.브이. | 항-cd103 항체 |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3632637A (en) * | 1968-02-13 | 1972-01-04 | Arthur E Martell | Hydroxyaryl-containing aminocarboxylic chelating agents |
FR2354993A1 (fr) * | 1976-06-16 | 1978-01-13 | Dabeer | Procede pour la preparation de derives phenoliques d'acides hydroxyalcoyl-alcoylene-diaminoacetiques et de leurs sels |
US4687658A (en) * | 1984-10-04 | 1987-08-18 | Salutar, Inc. | Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
US4746507A (en) * | 1985-04-02 | 1988-05-24 | Salutar, Inc. | EDHPA based contrast agents for MR imaging, apparatus and methods |
US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
US4899755A (en) * | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
DE3772785D1 (de) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga. |
GB2205128A (en) * | 1987-05-22 | 1988-11-30 | Daniel Stefanini | Pumps |
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
DE3728600A1 (de) * | 1987-08-27 | 1989-03-09 | Hoechst Ag | Verfahren zur markierung von substanzen mit technetium oder rhenium |
NZ229700A (en) * | 1988-06-24 | 1993-01-27 | Dow Chemical Co | Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments |
WO1990007342A1 (en) * | 1988-12-23 | 1990-07-12 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
FR2643370B1 (fr) * | 1989-02-22 | 1991-08-23 | Air Liquide | Derives polyazotes et leurs complexes metalliques utilisables pour la fixation de l'oxygene |
-
1990
- 1990-08-28 AT AT90914613T patent/ATE173336T1/de not_active IP Right Cessation
- 1990-08-28 CA CA002065290A patent/CA2065290C/en not_active Expired - Fee Related
- 1990-08-28 EP EP90914613A patent/EP0489869B1/de not_active Expired - Lifetime
- 1990-08-28 DE DE69032761T patent/DE69032761T2/de not_active Expired - Fee Related
- 1990-08-28 WO PCT/US1990/004887 patent/WO1991003200A1/en active IP Right Grant
- 1990-08-28 JP JP2513710A patent/JPH05503072A/ja active Pending
-
1998
- 1998-12-16 HK HK98113763A patent/HK1012707A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2065290C (en) | 2000-12-12 |
DE69032761D1 (de) | 1998-12-17 |
HK1012707A1 (en) | 1999-08-06 |
EP0489869A1 (de) | 1992-06-17 |
EP0489869B1 (de) | 1998-11-11 |
WO1991003200A1 (en) | 1991-03-21 |
DE69032761T2 (de) | 1999-04-22 |
EP0489869A4 (en) | 1993-03-17 |
CA2065290A1 (en) | 1991-03-01 |
JPH05503072A (ja) | 1993-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |