DK2300465T3 - Imidazopyridinderivater som hæmmere af receptortyrosinkinaser - Google Patents
Imidazopyridinderivater som hæmmere af receptortyrosinkinaser Download PDFInfo
- Publication number
- DK2300465T3 DK2300465T3 DK09761801.1T DK09761801T DK2300465T3 DK 2300465 T3 DK2300465 T3 DK 2300465T3 DK 09761801 T DK09761801 T DK 09761801T DK 2300465 T3 DK2300465 T3 DK 2300465T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptoryrosinkinases
- imidazopyridin
- derivatives
- understanding
- understanding receptoryrosinkinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6118408P | 2008-06-13 | 2008-06-13 | |
| GBGB0810902.7A GB0810902D0 (en) | 2008-06-13 | 2008-06-13 | New compounds |
| PCT/EP2009/057318 WO2009150240A1 (en) | 2008-06-13 | 2009-06-12 | Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2300465T3 true DK2300465T3 (da) | 2019-06-24 |
Family
ID=39672279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09761801.1T DK2300465T3 (da) | 2008-06-13 | 2009-06-12 | Imidazopyridinderivater som hæmmere af receptortyrosinkinaser |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8796244B2 (da) |
| EP (1) | EP2300465B1 (da) |
| JP (1) | JP5596023B2 (da) |
| KR (1) | KR101745730B1 (da) |
| CN (1) | CN102137859B (da) |
| AU (1) | AU2009256584B2 (da) |
| BR (1) | BRPI0915084B8 (da) |
| CA (1) | CA2727062A1 (da) |
| DK (1) | DK2300465T3 (da) |
| ES (1) | ES2735979T3 (da) |
| GB (1) | GB0810902D0 (da) |
| HR (1) | HRP20191027T1 (da) |
| HU (1) | HUE045300T2 (da) |
| IL (1) | IL209864A (da) |
| LT (1) | LT2300465T (da) |
| MX (1) | MX2010013743A (da) |
| NZ (1) | NZ589781A (da) |
| RU (1) | RU2518089C2 (da) |
| SI (1) | SI2300465T1 (da) |
| WO (1) | WO2009150240A1 (da) |
| ZA (1) | ZA201008961B (da) |
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| MX2009006706A (es) | 2006-12-22 | 2009-07-02 | Astex Therapeutics Ltd | Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos. |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US8729074B2 (en) | 2009-03-20 | 2014-05-20 | Amgen Inc. | Inhibitors of PI3 kinase |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| WO2011104731A1 (en) * | 2010-02-26 | 2011-09-01 | Decode Genetics Ehf | Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2727920B1 (en) | 2011-07-29 | 2016-11-02 | FUJIFILM Corporation | 1,5-naphthyridine derivative or salt thereof |
| UA111382C2 (uk) | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
| CN103214481B (zh) * | 2012-01-21 | 2016-08-03 | 中国科学院上海药物研究所 | 新型咪唑并[1,2-a]吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
| EP3822273B1 (en) | 2012-06-13 | 2024-04-10 | Incyte Holdings Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| CN102786543B (zh) * | 2012-07-24 | 2016-04-27 | 上海瑞博化学有限公司 | 咪唑并[1，2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法 |
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| SG10201708520YA (en) | 2013-04-19 | 2017-12-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| KR20210130843A (ko) | 2013-07-31 | 2021-11-01 | 노파르티스 아게 | 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도 |
| SG11201604821YA (en) | 2013-12-20 | 2016-07-28 | Signal Pharm Llc | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
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| BR112019004992A2 (pt) * | 2016-09-14 | 2019-06-04 | Univ Vanderbilt | inibição da sinalização de bmp, compostos, composições e usos destes |
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| CN114072402B (zh) | 2019-07-26 | 2023-12-26 | 盛世泰科生物医药技术(苏州)股份有限公司 | 作为fgfr和vegfr双重抑制剂的吡啶衍生物 |
| AU2020366006A1 (en) | 2019-10-14 | 2022-04-21 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN114502555A (zh) * | 2019-10-15 | 2022-05-13 | 常州千红生化制药股份有限公司 | 用于治疗增殖性疾病和疾患的4-(咪唑并[1,2-a]吡啶-3-基)-N-(吡啶-3-基)嘧啶-2-胺的衍生物 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN112851677A (zh) * | 2019-11-26 | 2021-05-28 | 中国科学院大连化学物理研究所 | 一种咪唑并吡啶或嘧啶衍生物的合成方法 |
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2008
- 2008-06-13 GB GBGB0810902.7A patent/GB0810902D0/en not_active Ceased
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2009
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- 2009-06-12 LT LTEP09761801.1T patent/LT2300465T/lt unknown
- 2009-06-12 BR BRPI0915084A patent/BRPI0915084B8/pt active IP Right Grant
- 2009-06-12 RU RU2011100786/04A patent/RU2518089C2/ru active
- 2009-06-12 CA CA2727062A patent/CA2727062A1/en not_active Abandoned
- 2009-06-12 SI SI200931974T patent/SI2300465T1/sl unknown
- 2009-06-12 JP JP2011512999A patent/JP5596023B2/ja active Active
- 2009-06-12 CN CN200980122215.8A patent/CN102137859B/zh active Active
- 2009-06-12 KR KR1020117000791A patent/KR101745730B1/ko active IP Right Grant
- 2009-06-12 DK DK09761801.1T patent/DK2300465T3/da active
- 2009-06-12 AU AU2009256584A patent/AU2009256584B2/en active Active
- 2009-06-12 ES ES09761801T patent/ES2735979T3/es active Active
- 2009-06-12 EP EP09761801.1A patent/EP2300465B1/en active Active
- 2009-06-12 NZ NZ589781A patent/NZ589781A/xx unknown
- 2009-06-12 MX MX2010013743A patent/MX2010013743A/es active IP Right Grant
- 2009-06-12 WO PCT/EP2009/057318 patent/WO2009150240A1/en active Application Filing
- 2009-06-12 HU HUE09761801A patent/HUE045300T2/hu unknown
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2010
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- 2010-12-13 ZA ZA2010/08961A patent/ZA201008961B/en unknown
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2019
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102137859B (zh) | 2015-07-01 |
| US8796244B2 (en) | 2014-08-05 |
| LT2300465T (lt) | 2019-06-25 |
| ES2735979T3 (es) | 2019-12-23 |
| IL209864A0 (en) | 2011-02-28 |
| HRP20191027T1 (hr) | 2019-11-29 |
| SI2300465T1 (sl) | 2019-08-30 |
| BRPI0915084A2 (pt) | 2015-10-27 |
| BRPI0915084B8 (pt) | 2021-05-25 |
| KR20110017000A (ko) | 2011-02-18 |
| JP5596023B2 (ja) | 2014-09-24 |
| MX2010013743A (es) | 2011-02-15 |
| RU2011100786A (ru) | 2012-07-20 |
| AU2009256584A1 (en) | 2009-12-17 |
| EP2300465B1 (en) | 2019-04-17 |
| US20120208791A1 (en) | 2012-08-16 |
| KR101745730B1 (ko) | 2017-06-12 |
| GB0810902D0 (en) | 2008-07-23 |
| EP2300465A1 (en) | 2011-03-30 |
| HUE045300T2 (hu) | 2019-12-30 |
| JP2011522866A (ja) | 2011-08-04 |
| ZA201008961B (en) | 2015-05-27 |
| IL209864A (en) | 2015-10-29 |
| BRPI0915084B1 (pt) | 2020-02-11 |
| AU2009256584B2 (en) | 2014-06-12 |
| CN102137859A (zh) | 2011-07-27 |
| CA2727062A1 (en) | 2009-12-17 |
| NZ589781A (en) | 2013-02-22 |
| WO2009150240A1 (en) | 2009-12-17 |
| RU2518089C2 (ru) | 2014-06-10 |
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