MX2020008610A - Agente terapeutico para carcinoma hepatocelular. - Google Patents
Agente terapeutico para carcinoma hepatocelular.Info
- Publication number
- MX2020008610A MX2020008610A MX2020008610A MX2020008610A MX2020008610A MX 2020008610 A MX2020008610 A MX 2020008610A MX 2020008610 A MX2020008610 A MX 2020008610A MX 2020008610 A MX2020008610 A MX 2020008610A MX 2020008610 A MX2020008610 A MX 2020008610A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic agent
- hepatocellular carcinoma
- methoxyethoxy
- benzamide
- piperidin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe un agente terapéutico para carcinoma hepatocelular que comprende 5-((2-(4-(1-(2-hidroxietil)piperidin-4-il)benzamida) piridin-4-il)oxi)-6-(2-metoxietoxi)-N-metil-1H-indol-1-carboxamid a o una sal farmacológicamente aceptable de ésta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018061447 | 2018-03-28 | ||
PCT/JP2019/012971 WO2019189241A1 (ja) | 2018-03-28 | 2019-03-26 | 肝細胞癌治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020008610A true MX2020008610A (es) | 2020-09-21 |
Family
ID=68060624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020008610A MX2020008610A (es) | 2018-03-28 | 2019-03-26 | Agente terapeutico para carcinoma hepatocelular. |
Country Status (12)
Country | Link |
---|---|
US (1) | US11219619B2 (es) |
EP (1) | EP3777860A4 (es) |
JP (1) | JPWO2019189241A1 (es) |
KR (1) | KR20200135945A (es) |
CN (1) | CN111712245A (es) |
AU (1) | AU2019241625A1 (es) |
BR (1) | BR112020017922A2 (es) |
CA (1) | CA3091153A1 (es) |
IL (1) | IL276935A (es) |
MX (1) | MX2020008610A (es) |
SG (1) | SG11202007591RA (es) |
WO (1) | WO2019189241A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3180128A1 (en) | 2020-04-17 | 2021-10-21 | Eisai R&D Management Co., Ltd. | Breast cancer therapeutic agent |
JPWO2022025150A1 (es) | 2020-07-31 | 2022-02-03 | ||
CN116390757A (zh) | 2020-10-28 | 2023-07-04 | 卫材R&D管理有限公司 | 用于***的药物组合物 |
Family Cites Families (65)
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DE10006139A1 (de) | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
IL155447A0 (en) | 2000-10-20 | 2003-11-23 | Eisai Co Ltd | Nitrogenous aromatic ring compounds |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
NZ538617A (en) | 2002-08-30 | 2005-12-23 | Eisai Co Ltd | Azaarene derivatives |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
JP2006522756A (ja) | 2003-04-10 | 2006-10-05 | エフ.ホフマン−ラ ロシュ アーゲー | ピリミド化合物 |
US20050256154A1 (en) | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
FR2883286B1 (fr) | 2005-03-16 | 2008-10-03 | Sanofi Aventis Sa | NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, INHIBITEURS DE FGFs, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
MX2007014782A (es) | 2005-05-23 | 2008-02-19 | Novartis Ag | Formas cristalinas y otras formas de las sales de acido lactico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidazol-2 -il]-1h quinolin-2-ona. |
SMP200800041B (it) | 2005-12-21 | 2009-07-14 | Novartis Ag | Derivati di pirimidinil-aril-urea attivi come-fgf-inibitori |
TW200811134A (en) | 2006-07-12 | 2008-03-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
EP1891955A1 (en) | 2006-07-24 | 2008-02-27 | Sanofi-Aventis | Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
WO2008078091A1 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
CA2690355A1 (en) | 2007-06-25 | 2008-12-31 | Qinetiq Limited | Preconcentrator device incorporating a polymer of intrinsic microporosity |
WO2009019518A1 (en) | 2007-08-09 | 2009-02-12 | Astrazeneca Ab | Pyrimidine compounds having a fgfr inhibitory effect |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
WO2009056886A1 (en) | 2007-11-01 | 2009-05-07 | Astrazeneca Ab | Pyrimidine derivatives and their use as modulators of fgfr activity |
CL2008003675A1 (es) | 2007-12-13 | 2009-03-20 | Wyeth Corp | Compuestos derivados de 5-alquil o alquenil 3-cianopiridinas, procedimiento de preparacion, composicion farmaceutica, util para reducir la actividad incrementada de una enzima en un mamifero, en donde dicha enzima es una proteina quinasa, destinado al tratamiento de la inflamacion, asma, colitis, esclerosis multiple, soriasis, artritis reumatoide. |
AU2009248774B2 (en) | 2008-05-23 | 2012-05-31 | Novartis Ag | Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
CA2728063A1 (en) | 2008-06-19 | 2009-12-23 | Astrazeneca Ab | Pyrazole compounds 436 |
US8263610B2 (en) | 2008-12-30 | 2012-09-11 | Arqule, Inc. | Substituted imidazolyl-5,6-dihydrobenzo[N]isoquinoline compounds |
JP5739820B2 (ja) | 2008-12-30 | 2015-06-24 | アークル インコーポレイテッド | 置換5,6−ジヒドロ−6−フェニルベンゾ[f]イソキノリン−2−アミン化合物 |
AU2009335019A1 (en) | 2008-12-30 | 2011-08-18 | Arqule, Inc. | Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
US9002427B2 (en) | 2009-03-30 | 2015-04-07 | Lifewave Biomedical, Inc. | Apparatus and method for continuous noninvasive measurement of respiratory function and events |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
FR2947546B1 (fr) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
EP2270043A1 (en) | 2009-07-03 | 2011-01-05 | Sanofi-Aventis | Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor |
KR101529767B1 (ko) | 2009-08-07 | 2015-06-17 | 추가이 세이야쿠 가부시키가이샤 | 아미노피라졸 유도체 |
WO2011051425A1 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | N-oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea |
AR079257A1 (es) | 2009-12-07 | 2012-01-04 | Novartis Ag | Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
HUE041987T2 (hu) | 2011-07-19 | 2019-06-28 | Merck Sharp & Dohme | 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
FR2984325A1 (fr) | 2011-12-14 | 2013-06-21 | Sanofi Sa | Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique |
EP2657233B1 (en) | 2012-01-19 | 2014-08-27 | Taiho Pharmaceutical Co., Ltd. | 3,5-disubstituted alkynylbenzene compound and salt thereof |
IN2014DN05869A (es) | 2012-01-31 | 2015-05-22 | Novartis Ag | |
PT2821402T (pt) | 2012-02-28 | 2019-10-02 | Kotobuki Pharmaceutical Co Ltd | Composto aromático heterocíclico que contém nitrogénio |
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AR091424A1 (es) | 2012-06-13 | 2015-02-04 | Incyte Corp | Compuestos triciclicos sustituidos como inhibidores de receptores del factor de crecimiento del fibroplasto (fgfr) |
WO2014007369A1 (ja) | 2012-07-05 | 2014-01-09 | 独立行政法人国立がん研究センター | Fgfr2融合遺伝子 |
EP2872491B1 (en) | 2012-07-11 | 2021-05-05 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
WO2014044846A1 (en) | 2012-09-24 | 2014-03-27 | Evotec (Uk) Ltd. | 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia |
WO2014048878A1 (en) | 2012-09-26 | 2014-04-03 | Evotec (Uk) Ltd. | Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia |
JP6117222B2 (ja) | 2012-09-27 | 2017-04-19 | 中外製薬株式会社 | Fgfr3融合遺伝子およびそれを標的とする医薬 |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
WO2014145751A2 (en) | 2013-03-15 | 2014-09-18 | The Translational Genomics Research Institute | Targeted therapies for cancer |
TWI628176B (zh) | 2013-04-04 | 2018-07-01 | 奧利安公司 | 蛋白質激酶抑制劑 |
US9951047B2 (en) | 2014-08-18 | 2018-04-24 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
MX2017009892A (es) | 2015-03-25 | 2017-11-15 | Nat Cancer Ct | Agente terapeutico contra el colangiocarcinoma. |
CA3001969C (en) | 2015-12-17 | 2023-10-03 | Eisai R&D Management Co., Ltd. | Therapeutic agent for breast cancer |
-
2019
- 2019-03-26 MX MX2020008610A patent/MX2020008610A/es unknown
- 2019-03-26 AU AU2019241625A patent/AU2019241625A1/en not_active Withdrawn
- 2019-03-26 JP JP2020510951A patent/JPWO2019189241A1/ja not_active Ceased
- 2019-03-26 CA CA3091153A patent/CA3091153A1/en active Pending
- 2019-03-26 EP EP19777797.2A patent/EP3777860A4/en not_active Withdrawn
- 2019-03-26 KR KR1020207024300A patent/KR20200135945A/ko active Search and Examination
- 2019-03-26 WO PCT/JP2019/012971 patent/WO2019189241A1/ja unknown
- 2019-03-26 SG SG11202007591RA patent/SG11202007591RA/en unknown
- 2019-03-26 CN CN201980013339.6A patent/CN111712245A/zh active Pending
- 2019-03-26 US US16/970,683 patent/US11219619B2/en active Active
- 2019-03-26 BR BR112020017922-1A patent/BR112020017922A2/pt not_active IP Right Cessation
-
2020
- 2020-08-25 IL IL276935A patent/IL276935A/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2020127993A3 (es) | 2022-04-28 |
EP3777860A1 (en) | 2021-02-17 |
JPWO2019189241A1 (ja) | 2021-03-18 |
WO2019189241A1 (ja) | 2019-10-03 |
IL276935A (en) | 2020-10-29 |
SG11202007591RA (en) | 2020-09-29 |
RU2020127993A (ru) | 2022-04-28 |
KR20200135945A (ko) | 2020-12-04 |
CN111712245A (zh) | 2020-09-25 |
AU2019241625A1 (en) | 2020-09-03 |
CA3091153A1 (en) | 2019-10-03 |
EP3777860A4 (en) | 2021-12-15 |
US20200375970A1 (en) | 2020-12-03 |
BR112020017922A2 (pt) | 2020-12-22 |
US11219619B2 (en) | 2022-01-11 |
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