CY1112941T1 - Δικυκλικοι αναστολεις της μεκ - Google Patents
Δικυκλικοι αναστολεις της μεκInfo
- Publication number
- CY1112941T1 CY1112941T1 CY20121100662T CY121100662T CY1112941T1 CY 1112941 T1 CY1112941 T1 CY 1112941T1 CY 20121100662 T CY20121100662 T CY 20121100662T CY 121100662 T CY121100662 T CY 121100662T CY 1112941 T1 CY1112941 T1 CY 1112941T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- micro
- bicycle suspensions
- mammals
- treatment
- Prior art date
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Αποκαλύπτονται ενώσεις του τύπου (Ι) και φαρμακευτικώς αποδεκτά άλατα και προφάρμακά τους, στον οποίο τα R1, R2, R8, R9 και R10, W, Χ και Ζ είναι όπως ορίζεται στην περιγραφή. Τέτοιες ενώσεις είναι αναστολείς της ΜΕΚ και χρησιμεύουν στη θεραπεία υπερπολλαπλασιαστικών νόσων, όπως καρκίνος και φλεγμονή, σε θηλαστικά, και φλεγμονωδών παθήσεων. Επίσης αποκαλύπτονται μέθοδοι χρήσης τέτοιων ενώσεων στη θεραπεία υπερπολλαπλασιαστικών νόσων σε θηλαστικά και φαρμακευτικές συνθέσεις οι οποίες περιέχουν τέτοιες ενώσεις.
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US52327003P | 2003-11-19 | 2003-11-19 | |
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CY (2) | CY1111155T1 (el) |
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