CO7230336A2 - Inhibidores de indazol de la ruta de señalización de wnt y usos terapeúticos de los mismos - Google Patents
Inhibidores de indazol de la ruta de señalización de wnt y usos terapeúticos de los mismosInfo
- Publication number
- CO7230336A2 CO7230336A2 CO14219345A CO14219345A CO7230336A2 CO 7230336 A2 CO7230336 A2 CO 7230336A2 CO 14219345 A CO14219345 A CO 14219345A CO 14219345 A CO14219345 A CO 14219345A CO 7230336 A2 CO7230336 A2 CO 7230336A2
- Authority
- CO
- Colombia
- Prior art keywords
- wnt signaling
- signaling pathway
- wnt
- indazole
- therapeutic uses
- Prior art date
Links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Se divulgan compuestos de indazol para tratar diversas enfermedades y patologías. Más particularmente, la presente invención se refiere al uso de un compuesto de indazol o análogos del mismo en el tratamiento de trastornos caracterizados por la activación de la ruta de señalización de Wnt (por ejemplo,cáncer, proliferación celular anormal, angiogénesis, enfermedad de Alzheimer, enfermedad pulmonar y osteoartritis), la modulación de acontecimientos celulares mediados por la ruta de señalización de Wnt, así como enfermedades genéticas y afecciones/trastornos/enfermedades genéticas debidas a mutaciones o alteración de la regulación de la ruta de Wnt y/o uno o más de los componentes de señalización de Wnt. También se proporcionan métodos para tratar estados de enfermedad relacionados con Wnt. Una realización divulgada en el presente documento incluye un compuesto que tiene la estructura de Formula I:
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261620107P | 2012-04-04 | 2012-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7230336A2 true CO7230336A2 (es) | 2015-03-31 |
Family
ID=49292798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO14219345A CO7230336A2 (es) | 2012-04-04 | 2014-10-03 | Inhibidores de indazol de la ruta de señalización de wnt y usos terapeúticos de los mismos |
Country Status (32)
Country | Link |
---|---|
US (9) | US8673936B2 (es) |
EP (3) | EP3284744B1 (es) |
JP (3) | JP6167169B2 (es) |
KR (1) | KR102048107B1 (es) |
CN (2) | CN106892916A (es) |
AU (2) | AU2013243899B2 (es) |
BR (1) | BR112014023639B1 (es) |
CA (1) | CA2853703C (es) |
CL (1) | CL2014002511A1 (es) |
CO (1) | CO7230336A2 (es) |
CY (1) | CY1119485T1 (es) |
DK (1) | DK2760285T3 (es) |
ES (1) | ES2635386T3 (es) |
HR (1) | HRP20171322T1 (es) |
HU (1) | HUE033829T2 (es) |
IL (2) | IL234743A (es) |
LT (1) | LT2760285T (es) |
MA (1) | MA37450B1 (es) |
ME (1) | ME02832B (es) |
MX (1) | MX355435B (es) |
MY (1) | MY174896A (es) |
NZ (3) | NZ727358A (es) |
PE (1) | PE20142216A1 (es) |
PH (3) | PH12017500997A1 (es) |
PL (1) | PL2760285T3 (es) |
PT (1) | PT2760285T (es) |
RS (1) | RS56292B1 (es) |
RU (2) | RU2638932C2 (es) |
SG (2) | SG10201610539RA (es) |
SI (1) | SI2760285T1 (es) |
WO (1) | WO2013151708A1 (es) |
ZA (3) | ZA201406273B (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
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BR112012002854B1 (pt) | 2009-08-10 | 2020-02-18 | Samumed, Llc | Composto ou sal farmaceuticamente aceitável, composição farmacêutica e uso dos mesmos |
PL3001903T3 (pl) | 2009-12-21 | 2018-03-30 | Samumed, Llc | 1H-pirazolo[3,4-b]pirydyny i ich zastosowania terapeutyczne |
CN103929963A (zh) | 2011-09-14 | 2014-07-16 | 萨穆梅德有限公司 | 吲唑-3-羧酰胺及其作为WNT/β-CATENIN信号传导通路抑制剂的用途 |
PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
MA37577B1 (fr) | 2012-05-04 | 2018-05-31 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques |
JP6355648B2 (ja) | 2013-01-08 | 2018-07-11 | サミュメッド リミテッド ライアビリティ カンパニー | Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 |
GB201322333D0 (en) | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | WNT pathway modulators |
GB201322334D0 (en) * | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | Maleimide derivatives as modulators of WNT pathway |
JP6586104B2 (ja) * | 2014-03-20 | 2019-10-02 | サミュメッド リミテッド ライアビリティ カンパニー | 5−置換インダゾール−3−カルボキサミドならびにその調製および使用の方法 |
CN106458992B (zh) * | 2014-03-27 | 2019-03-15 | 默克专利股份公司 | 吡啶基哌啶 |
CA2952315A1 (en) | 2014-07-11 | 2016-01-14 | Genentech, Inc. | Notch pathway inhibition |
WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040185A1 (en) * | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
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WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
US11369623B2 (en) | 2015-06-16 | 2022-06-28 | Prism Pharma Co., Ltd. | Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor |
SG11201709593VA (en) | 2015-06-23 | 2017-12-28 | Eisai R&D Man Co Ltd | CRYSTAL OF (6S,9aS)-N-BENZYL-6-[(4-HYDROXYPHENYL)METHYL]- 4,7-DIOXO-8-({6-[3-(PIPERAZIN-1-YL)AZETIDIN-1-YL]PYRIDIN- 2-YL}METHYL)-2-(PROP-2-EN-1-YL)-OCTAHYDRO-1H-PYRAZINO[2,1-c][1,2,4]TRIAZINE-1-CARBOXAMIDE COMPOUND |
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US10285982B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
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WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
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