BRPI0613403A2 - tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina - Google Patents

tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina

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Publication number
BRPI0613403A2
BRPI0613403A2 BRPI0613403-3A BRPI0613403A BRPI0613403A2 BR PI0613403 A2 BRPI0613403 A2 BR PI0613403A2 BR PI0613403 A BRPI0613403 A BR PI0613403A BR PI0613403 A2 BRPI0613403 A2 BR PI0613403A2
Authority
BR
Brazil
Prior art keywords
serotonin
dopamine
norepinephrine
aryl
tetrahydrobenzodiazepines
Prior art date
Application number
BRPI0613403-3A
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English (en)
Inventor
Aruna Sambandam
Peter R Guzzo
Min Hu
Congxiang Zha
Kassoum Nacro
David D Manning
Matthew L Isherwood
Kristen N Fleming
Weng Cui
Richard E Olson
Bruce F Molino
Bristol-Myers Squibb Company
Shuang Liu
Original Assignee
Amr Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc filed Critical Amr Technology Inc
Publication of BRPI0613403A2 publication Critical patent/BRPI0613403A2/pt

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

TETRAHIDROBENZODIAZEPINAS ARIL- E HETE- ROARILA-SUBSTITUÍDAS E USO DAS MESMAS PARA BLOQUEAR A RECAPTAÇçO DE NOREPINEFRINA, DOPAMINA E SEROTONINA. A presente invenção refere-se aos compostos da presente invenção que são representados pelos seguintes derivados de tetrahidroben-zodiazepina e dihidrobenzodiazepina aril- e heteroarila-substítuídos tendo as fórmulas l(A-E) e a fórmula (II): onde o átomo de carbono designado * está na configuração R ou S e os substituintes X e R1-R9 são conforme definido aqui.
BRPI0613403-3A 2005-07-15 2006-07-17 tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina BRPI0613403A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70005705P 2005-07-15 2005-07-15
PCT/US2006/027574 WO2007011820A2 (en) 2005-07-15 2006-07-17 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Publications (1)

Publication Number Publication Date
BRPI0613403A2 true BRPI0613403A2 (pt) 2009-02-10

Family

ID=37669440

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0613403-3A BRPI0613403A2 (pt) 2005-07-15 2006-07-17 tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina

Country Status (17)

Country Link
US (4) US7956050B2 (pt)
EP (1) EP1904069B1 (pt)
JP (2) JP5258561B2 (pt)
KR (3) KR101594898B1 (pt)
CN (1) CN101495184A (pt)
AU (1) AU2006270071B2 (pt)
BR (1) BRPI0613403A2 (pt)
CA (1) CA2615403C (pt)
EA (1) EA019115B1 (pt)
GE (1) GEP20125566B (pt)
IL (3) IL188758A (pt)
MX (1) MX2008000717A (pt)
NZ (1) NZ565111A (pt)
PH (1) PH12014501033A1 (pt)
UA (1) UA95454C2 (pt)
WO (1) WO2007011820A2 (pt)
ZA (1) ZA200800440B (pt)

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ES2375929T3 (es) 2005-07-04 2012-03-07 High Point Pharmaceuticals, Llc Antagonistas del receptor histamina h3.
US7956050B2 (en) * 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2007137968A1 (en) 2006-05-29 2007-12-06 High Point Pharmaceuticals, Llc 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
KR20090009275A (ko) * 2006-05-31 2009-01-22 에프. 호프만-라 로슈 아게 모노아민 재흡수 억제제로서 벤즈아제핀 유도체
NZ580801A (en) * 2007-05-10 2012-09-28 Bristol Myers Squibb Co Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
BRPI0811200A8 (pt) 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidrobenzapinas arilóxi- e heteroarilóxi-substituídas e uso das mesmas para bloquear percepção de norepinefrina, dopamina, e serotonina
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
US8653100B2 (en) 2008-04-01 2014-02-18 Abbvie Inc. Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) * 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
DE102008035596A1 (de) * 2008-07-31 2010-02-04 Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts Derivate benzoannelierter Stickstoff-Heterocyclen
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US20070021408A1 (en) 2007-01-25
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