ES2107118T3 - Procedimiento para la preparacion de diesteres cuaternarios. - Google Patents
Procedimiento para la preparacion de diesteres cuaternarios.Info
- Publication number
- ES2107118T3 ES2107118T3 ES94202451T ES94202451T ES2107118T3 ES 2107118 T3 ES2107118 T3 ES 2107118T3 ES 94202451 T ES94202451 T ES 94202451T ES 94202451 T ES94202451 T ES 94202451T ES 2107118 T3 ES2107118 T3 ES 2107118T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- atom
- group
- formula
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
Abstract
SE PRESENTA UN PROCESO PARA LA PREPARACION DE DIESTERES CUATERNARIOS DE LA FORMULA: (I) EN LA QUE X- REPRESENTA UN ATOMO DE HALOGENO, NOTABLEMENTE UN ATOMO DE CLORO O UN ATOMO DE BROMO; R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y TIENEN EL SIGNIFICADO DE UN GRUPO QUE TIENEN ENTRE 1 Y 3 ATOMOS DE CARBONO, UN GRUPO DE HIDROXIETILO, O PUEDEN ESTAR UNIDAS PARA FORMAR UN GRUPO DE ALQUILENO QUE TENGA ENTRE 4 Y 6 ATOMOS DE CARBONO QUE PUEDE ESTAR INTERRUMPIDO POR UN ATOMO DE N O UN ATOMO DE O, Y R3 Y R4 PUEDEN SER IGUALES O DIFERENTES Y TIENEN EL SIGNIFICADO DE UN GRUPO DE ALQUILO O UN GRUPO DE ALQUENILO QUE TIENE ENTRE 8 Y 22 ATOMOS DE CARBONO, O PUEDEN ESTAR UNIDAS ENTRE SI PARA FORMAR UN GRUPO DE ALK(EN)ILENO QUE TENGA ENTRE 8 Y 22 ATOMOS DE CARBONO, QUE SE CARACTERIZA EN QUE: A) UN AMINO SECUNDARIO DE LA FORMULA R{SUB, 1}-NH-R{SUB, 2} SE AÑADE GRADUALMENTE Y CONVIERTE CON UNO O MAS COMPUESTOS LIQUIDOS DE LA FORMULA II O III EN UNA PROPORCION MOLAR EN LA BANDA DE ENTRE 1,0:1,0 Y 1,0:1,2 DESPUES DE LO CUAL B) EL HIDROHALURO DE AMINO SOLIDO FORMADO SE SEPARA SIGUIENTE POR C) UN POSTRATAMIENTO, OPCIONALMENTE EN UN SOLVENTE, A ELEVADA TEMPERATURA HASTA QUE LA CONVERSION ESTE VIRTUALMENTE COMPLETA, DESPUES DE LO CUAL, SI SE DESEA, UN TRATAMIENTO ADICIONAL, TAL COMO LA RECRISTALIZACION A PARTIR DE UN SOLVENTE ORGANICO, SE LLEVA A CABO PARA CONSEGUIR UNA FORMA DE PRODUCTO ESPECIAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94202451A EP0699655B1 (en) | 1994-08-29 | 1994-08-29 | Process for the preparation of quaternary diesters |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107118T3 true ES2107118T3 (es) | 1997-11-16 |
Family
ID=8217141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94202451T Expired - Lifetime ES2107118T3 (es) | 1994-08-29 | 1994-08-29 | Procedimiento para la preparacion de diesteres cuaternarios. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5596125A (es) |
EP (1) | EP0699655B1 (es) |
JP (1) | JPH0867658A (es) |
AT (1) | ATE158568T1 (es) |
CA (1) | CA2157096A1 (es) |
DE (1) | DE69405864T2 (es) |
ES (1) | ES2107118T3 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001032625A1 (en) | 1999-11-03 | 2001-05-10 | Du Pont Pharmaceuticals Company | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
US7084152B2 (en) | 2000-07-11 | 2006-08-01 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
DK2805945T3 (da) | 2007-01-10 | 2019-07-15 | Msd Italia Srl | Amid-substituerede indazoler som poly(adp-ribose)polymerase- (parp) hæmmere |
EP2170076B1 (en) | 2007-06-27 | 2016-05-18 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
AR071997A1 (es) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
MX2011011907A (es) | 2009-05-12 | 2012-01-20 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma. |
AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
UA109417C2 (uk) | 2009-10-14 | 2015-08-25 | Мерк Шарп Енд Доме Корп. | ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ |
EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
KR102072631B1 (ko) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제 |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
CN103732592A (zh) | 2011-04-21 | 2014-04-16 | 默沙东公司 | ***-1受体抑制剂 |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
EP3358013B1 (en) | 2012-05-02 | 2020-06-24 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
CA2892361A1 (en) | 2012-11-28 | 2014-06-05 | Merck Sharp & Dohme Corp. | Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels |
WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
EP3833668A4 (en) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
US20210309688A1 (en) | 2018-08-07 | 2021-10-07 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926772A1 (de) * | 1979-07-03 | 1981-01-15 | Hoechst Ag | Quaternaere alkylamino-di-alkylcarbonsaeure-di-ester, verfahren zu deren herstellung und deren verwendung |
JPH08501074A (ja) * | 1992-06-10 | 1996-02-06 | ザ、プロクター、エンド、ギャンブル、カンパニー | 安定な生分解性布帛柔軟化化合物および組成物 |
-
1994
- 1994-08-29 EP EP94202451A patent/EP0699655B1/en not_active Expired - Lifetime
- 1994-08-29 DE DE69405864T patent/DE69405864T2/de not_active Expired - Fee Related
- 1994-08-29 ES ES94202451T patent/ES2107118T3/es not_active Expired - Lifetime
- 1994-08-29 AT AT94202451T patent/ATE158568T1/de not_active IP Right Cessation
-
1995
- 1995-08-25 US US08/519,558 patent/US5596125A/en not_active Expired - Fee Related
- 1995-08-25 JP JP7238935A patent/JPH0867658A/ja not_active Withdrawn
- 1995-08-28 CA CA002157096A patent/CA2157096A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0699655A1 (en) | 1996-03-06 |
EP0699655B1 (en) | 1997-09-24 |
CA2157096A1 (en) | 1996-03-01 |
JPH0867658A (ja) | 1996-03-12 |
DE69405864T2 (de) | 1998-03-26 |
DE69405864D1 (de) | 1997-10-30 |
ATE158568T1 (de) | 1997-10-15 |
US5596125A (en) | 1997-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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