NO20083247L - GABA-B reseptormodulatorer - Google Patents
GABA-B reseptormodulatorerInfo
- Publication number
- NO20083247L NO20083247L NO20083247A NO20083247A NO20083247L NO 20083247 L NO20083247 L NO 20083247L NO 20083247 A NO20083247 A NO 20083247A NO 20083247 A NO20083247 A NO 20083247A NO 20083247 L NO20083247 L NO 20083247L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- treatment
- gaba
- receptor modulators
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Foreliggende oppfinnelse angår nye imidazolderivater som har en positiv allosterisk GABAB reseptor (GBR) modulerende effekt, fremgangsmåter for fremstilling av nevnte forbindelser og deres anvendelse, eventuelt i kombinasjon med en GABAB agonist, for inhibering av forbigående lavere spiserørlukkemuskelrelaksasjoner, for behandling av gastrospiserørreflukssykdom, så vel som for behandling av funksjonelle gastrointestinale forstyrrelser og irritabel tarmsyndrom (IBS). Forbindelsene er representert med den generelle formelen (I) hvori R1, R2, R3 og R4 er som definert i beskrivelsen. For eksempel kan R1 være fenyl, R2 kan være dimetylaminopyrrolidin-1-yl, R3 kan være alkoksy og R4 kan være alkyl, arylalkyl, aryloksyalkyl, aryloksy eller heterocyklylalkyl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0502904 | 2005-12-23 | ||
PCT/SE2006/001464 WO2007073300A1 (en) | 2005-12-23 | 2006-12-21 | Gaba-b receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083247L true NO20083247L (no) | 2008-09-11 |
Family
ID=38188931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083247A NO20083247L (no) | 2005-12-23 | 2008-07-22 | GABA-B reseptormodulatorer |
Country Status (12)
Country | Link |
---|---|
US (1) | US7812026B2 (no) |
EP (1) | EP1968947A1 (no) |
JP (1) | JP2009521430A (no) |
KR (1) | KR20080087852A (no) |
CN (1) | CN101384558A (no) |
AU (1) | AU2006327317B2 (no) |
BR (1) | BRPI0620464A2 (no) |
CA (1) | CA2632021A1 (no) |
IL (1) | IL191766A0 (no) |
NO (1) | NO20083247L (no) |
WO (1) | WO2007073300A1 (no) |
ZA (1) | ZA200805242B (no) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
CA2632011A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Pyrazoles for the treatment of gerd and ibs |
BRPI0620345A2 (pt) * | 2005-12-23 | 2017-11-21 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, métodod para o tratamento de uma doença |
CN101341130A (zh) | 2005-12-23 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 用于治疗胃肠障碍的咪唑衍生物 |
WO2007073299A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazoles as gaba-b receptor modulators |
CN101384558A (zh) | 2005-12-23 | 2009-03-11 | 阿斯利康(瑞典)有限公司 | Gaba-b受体调节剂 |
MX2009002019A (es) | 2006-08-24 | 2009-03-09 | Novartis Ag | Derivados de 2-(pirazin-2-il)-tiazol y 2-(1h-pirazol-3-il)-tiazol asi como compuestos relacionados como inhibidores de la estearoil-coa-desaturasa (scd) para el tratamiento de trastornos metabolicos, cardiovasculares, y otros. |
AU2011265047B2 (en) | 2010-06-07 | 2014-10-23 | Novomedix, Llc | Furanyl compounds and the use thereof |
JP6619731B2 (ja) * | 2013-06-18 | 2019-12-11 | 4エスツェー アクチェンゲゼルシャフト | Dyrkキナーゼ阻害剤としての2,3−ジヒドロベンゾフラン−5−イル化合物 |
WO2015039333A1 (en) * | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
AU2019247533B2 (en) * | 2018-04-06 | 2023-09-28 | Altos Labs, Inc. | ATF6 inhibitors and uses thereof |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH449046A (de) | 1963-07-09 | 1967-12-31 | Ciba Geigy | Verfahren zur Herstellung neuer Aminosäuren |
US3876655A (en) | 1971-08-18 | 1975-04-08 | Beecham Group Ltd | Anti-inflammatory acyl imidazoles |
DE3014353A1 (de) * | 1980-04-15 | 1982-01-21 | Bayer Ag, 5090 Leverkusen | Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
US4659720A (en) | 1982-12-20 | 1987-04-21 | Merck & Co., Inc. | 5-amino or substituted amino imidazoles useful to treat coccidiosis |
GB8425872D0 (en) | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
GB8624879D0 (en) | 1986-10-17 | 1986-11-19 | May & Baker Ltd | Compositions of matter |
GB8820266D0 (en) | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
GB8911017D0 (en) | 1989-05-13 | 1989-06-28 | Ciba Geigy Ag | Substituted aminoalkylphosphinic acids |
FR2663934B1 (fr) | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
US5214063A (en) | 1990-06-27 | 1993-05-25 | Adir Et Compagnie | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors |
DE4213750A1 (de) | 1992-04-25 | 1993-10-28 | Basf Ag | Verfahren zur Herstellung von 3-(Hydroxyphenyl)-propionaldehyden und gegebenenfalls der Herstellung von 3-(hydroxyphenyl)-propanolen |
DK0674631T3 (da) * | 1992-12-17 | 2000-04-10 | Pfizer | Substituerede pyrazoler som CRF-antogonister |
EP0686157A1 (en) | 1993-02-26 | 1995-12-13 | Schering Corporation | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
FR2722192A1 (fr) | 1994-07-06 | 1996-01-12 | Adir | Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6448282B1 (en) | 1995-05-30 | 2002-09-10 | Gliatech, Inc. | 1H-4(5)-substituted imidazole derivatives |
AU1811397A (en) | 1996-02-29 | 1997-09-16 | Kissei Pharmaceutical Co. Ltd. | Imidazole derivatives and vascular wall thickening inhibitor |
SE9603408D0 (sv) | 1996-09-18 | 1996-09-18 | Astra Ab | Medical use |
BR9714181A (pt) * | 1996-12-24 | 2000-02-29 | Rhone Poulenc Agrochimie | Processo para controlar insetos por meio de aplicação de um ingrediente inseticidamente ativo, composições pesticida e afidicida, composto, e, processo para preparar o mesmo. |
US6211182B1 (en) | 1999-03-08 | 2001-04-03 | Schering Corporation | Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
SE9904508D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
SE9904507D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Ab | New compounds |
WO2001090141A2 (en) | 2000-05-25 | 2001-11-29 | Merck Frosst Canada & Co. | Gb1c isoform and nucleotides |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
KR100926247B1 (ko) * | 2001-02-24 | 2009-11-12 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 크산틴 유도체를 포함하는 약제학적 조성물 및 이의제조방법 |
WO2003024942A1 (fr) | 2001-09-14 | 2003-03-27 | Mitsubishi Pharma Corporation | Derive thiazolidine et son utilisation medicamenteuse |
GB0209481D0 (en) | 2002-04-24 | 2002-06-05 | Novartis Ag | Organic compounds |
CN107674077A (zh) * | 2002-08-21 | 2018-02-09 | 勃林格殷格翰制药两合公司 | 8‑[3‑氨基‑哌啶‑1‑基]‑黄嘌呤化合物,其制备方法及作为药物制剂的用途 |
WO2005066137A1 (en) * | 2003-12-19 | 2005-07-21 | Neurogen Corporation | 2,5-diaryl-1h-imidazole-4-carboxamides as neurokinin-3 receptor modulators for the treatment of central nervous system and peripheral diseases |
SE0401653D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
WO2007073299A1 (en) | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazoles as gaba-b receptor modulators |
CA2632011A1 (en) | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Pyrazoles for the treatment of gerd and ibs |
CN101341130A (zh) | 2005-12-23 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 用于治疗胃肠障碍的咪唑衍生物 |
CN101384558A (zh) | 2005-12-23 | 2009-03-11 | 阿斯利康(瑞典)有限公司 | Gaba-b受体调节剂 |
BRPI0620345A2 (pt) | 2005-12-23 | 2017-11-21 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, métodod para o tratamento de uma doença |
BRPI0810019A2 (pt) | 2007-04-18 | 2014-10-14 | Astrazeneca Ab | Composto, composição farmacêutica, e, uso de um composto |
US20080262064A1 (en) | 2007-04-18 | 2008-10-23 | Astrazeneca Ab | Novel Compounds For The Treatment Of GI Disorders 682 |
-
2006
- 2006-12-21 CN CNA2006800533230A patent/CN101384558A/zh active Pending
- 2006-12-21 EP EP06835879A patent/EP1968947A1/en not_active Withdrawn
- 2006-12-21 WO PCT/SE2006/001464 patent/WO2007073300A1/en active Application Filing
- 2006-12-21 KR KR1020087017998A patent/KR20080087852A/ko not_active Application Discontinuation
- 2006-12-21 JP JP2008547167A patent/JP2009521430A/ja active Pending
- 2006-12-21 AU AU2006327317A patent/AU2006327317B2/en not_active Expired - Fee Related
- 2006-12-21 CA CA002632021A patent/CA2632021A1/en not_active Abandoned
- 2006-12-21 US US12/158,141 patent/US7812026B2/en not_active Expired - Fee Related
- 2006-12-21 BR BRPI0620464-3A patent/BRPI0620464A2/pt not_active IP Right Cessation
-
2008
- 2008-05-27 IL IL191766A patent/IL191766A0/en unknown
- 2008-06-17 ZA ZA200805242A patent/ZA200805242B/xx unknown
- 2008-07-22 NO NO20083247A patent/NO20083247L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2632021A1 (en) | 2007-06-28 |
BRPI0620464A2 (pt) | 2011-11-16 |
US7812026B2 (en) | 2010-10-12 |
US20090149474A1 (en) | 2009-06-11 |
CN101384558A (zh) | 2009-03-11 |
AU2006327317A1 (en) | 2007-06-28 |
ZA200805242B (en) | 2009-11-25 |
JP2009521430A (ja) | 2009-06-04 |
KR20080087852A (ko) | 2008-10-01 |
WO2007073300A1 (en) | 2007-06-28 |
EP1968947A1 (en) | 2008-09-17 |
IL191766A0 (en) | 2008-12-29 |
AU2006327317B2 (en) | 2010-11-25 |
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