BR112015030326A2 - Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos - Google Patents

Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Info

Publication number
BR112015030326A2
BR112015030326A2 BR112015030326A BR112015030326A BR112015030326A2 BR 112015030326 A2 BR112015030326 A2 BR 112015030326A2 BR 112015030326 A BR112015030326 A BR 112015030326A BR 112015030326 A BR112015030326 A BR 112015030326A BR 112015030326 A2 BR112015030326 A2 BR 112015030326A2
Authority
BR
Brazil
Prior art keywords
ultrapure
agonists
manufacturing
guanylate cyclase
lyophilization
Prior art date
Application number
BR112015030326A
Other languages
English (en)
Inventor
Shailubhai Kunwar
Comiskey Stephen
Feng Rong
Bai Juncai
Zhang Ruoping
Jia Jun
Zhou Junfeng
Zhao Qiao
Zhang Guoqing
Original Assignee
Synergy Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51062980&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015030326(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synergy Pharmaceuticals Inc filed Critical Synergy Pharmaceuticals Inc
Publication of BR112015030326A2 publication Critical patent/BR112015030326A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01002—Guanylate cyclase (4.6.1.2)

Abstract

AGONISTAS ULTRAPUROS DE GUANILATO CICLASE C, MÉTODO DE FABRICAR E USAR OS MESMOS. A invenção fornece processos de purificar um peptídeo incluindo uma sequência do agonista de GCC selecionada do grupo que consiste nas SEQ ID NOs: 1 a 251 aqui descritas. Os processos incluem uma etapa de troca de solvente antes de uma etapa de secagem por congelamento (liofilização).
BR112015030326A 2013-06-05 2014-06-05 Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos BR112015030326A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361831402P 2013-06-05 2013-06-05
PCT/US2014/041143 WO2014197720A2 (en) 2013-06-05 2014-06-05 Ultra-pure agonists of guanylate cyclase c, method of making and using same

Publications (1)

Publication Number Publication Date
BR112015030326A2 true BR112015030326A2 (pt) 2017-08-29

Family

ID=51062980

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015030326A BR112015030326A2 (pt) 2013-06-05 2014-06-05 Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Country Status (12)

Country Link
US (6) US10011637B2 (pt)
EP (1) EP3004138B1 (pt)
JP (1) JP6606491B2 (pt)
KR (1) KR102272746B1 (pt)
CN (2) CN113388007A (pt)
AU (3) AU2014274812B2 (pt)
BR (1) BR112015030326A2 (pt)
CA (1) CA2913737A1 (pt)
EA (1) EA201592263A1 (pt)
HK (1) HK1221959A1 (pt)
IL (1) IL242939B (pt)
WO (1) WO2014197720A2 (pt)

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MX2009013293A (es) * 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
AU2011302006A1 (en) * 2010-09-15 2013-03-07 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase C agonists and methods of use
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
JP2016534043A (ja) * 2013-10-09 2016-11-04 シナジー ファーマシューティカルズ インコーポレイテッド 炎症促進性サイトカインのダウンレギュレーションに有用なグアニル酸シクラーゼのアゴニスト
CN104628827B (zh) * 2015-03-10 2018-01-19 南京工业大学 一种普利卡那肽的制备方法
JP2019506383A (ja) 2016-01-11 2019-03-07 シナジー ファーマシューティカルズ インコーポレイテッド 潰瘍性大腸炎を治療するための製剤および方法
CN108864254B (zh) * 2017-05-10 2021-03-16 深圳翰宇药业股份有限公司 一种普利卡那肽的制备方法
CN107383170A (zh) * 2017-08-15 2017-11-24 苏州科技大学 一种普卡那肽的简易合成方法
CN107383171A (zh) * 2017-08-15 2017-11-24 苏州科技大学 一种通过二次环化固相合成普卡那肽的方法
CN110835365B (zh) * 2018-08-15 2021-09-17 深圳翰宇药业股份有限公司 一种普卡那肽的制备方法
EA202191604A1 (ru) * 2018-12-08 2021-10-27 Энжене Биосайенз Лимитед Усовершенствованный способ приготовления плеканатида
US20220235096A1 (en) * 2019-06-10 2022-07-28 Auro Peptides Ltd An improved process for the preparation of Plecanatide
US20230242581A1 (en) * 2020-06-17 2023-08-03 Anthem Biosciences Private Limited Synthesis of a guanylate cyclase agonist by fragments based approach
WO2022002369A1 (en) * 2020-06-30 2022-01-06 Ocvirk Soeren Pharmaceutical composition comprising a combination of a guanylate cyclase c (gucy2c) agonist and a short-chain fatty acid or prodrug thereof
CN112194708A (zh) * 2020-10-28 2021-01-08 杭州信海医药科技有限公司 一种普卡那肽的制备方法
CN113244791B (zh) * 2021-05-12 2022-06-17 佳木斯大学 一种共混大黄素的酚酞聚醚砜超滤膜的制备方法
CN114573662A (zh) * 2021-09-30 2022-06-03 深圳翰宇药业股份有限公司 一种普卡那肽铵盐的制备方法
CN117538461B (zh) * 2024-01-10 2024-03-26 地奥集团成都药业股份有限公司 一种盐酸贝那普利片有关物质的检测方法

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