DE69430747T2 - Verbindungen als pde iv und tnf inhibitoren - Google Patents
Verbindungen als pde iv und tnf inhibitorenInfo
- Publication number
- DE69430747T2 DE69430747T2 DE69430747T DE69430747T DE69430747T2 DE 69430747 T2 DE69430747 T2 DE 69430747T2 DE 69430747 T DE69430747 T DE 69430747T DE 69430747 T DE69430747 T DE 69430747T DE 69430747 T2 DE69430747 T2 DE 69430747T2
- Authority
- DE
- Germany
- Prior art keywords
- cyclic amp
- tnf
- amp phosphodiesterase
- inhibiting
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/70—Sulfur atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- C07C2603/64—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings having a tricyclo[2.2.1.0(2,6)]heptstructure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939315581A GB9315581D0 (en) | 1993-07-28 | 1993-07-28 | Novel compositions of matter |
GB939315632A GB9315632D0 (en) | 1993-07-28 | 1993-07-28 | New compositions of matter |
PCT/GB1994/001630 WO1995004045A1 (en) | 1993-07-28 | 1994-07-28 | Compounds as pde iv and tnf inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69430747D1 DE69430747D1 (de) | 2002-07-11 |
DE69430747T2 true DE69430747T2 (de) | 2003-03-06 |
Family
ID=26303291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430747T Expired - Lifetime DE69430747T2 (de) | 1993-07-28 | 1994-07-28 | Verbindungen als pde iv und tnf inhibitoren |
Country Status (13)
Country | Link |
---|---|
US (6) | US6472412B1 (de) |
EP (1) | EP0711282B1 (de) |
JP (3) | JP3775685B2 (de) |
AT (1) | ATE218549T1 (de) |
AU (1) | AU7267094A (de) |
CA (1) | CA2160928C (de) |
DE (1) | DE69430747T2 (de) |
DK (1) | DK0711282T3 (de) |
ES (1) | ES2176251T3 (de) |
IL (1) | IL110492A0 (de) |
PT (1) | PT711282E (de) |
WO (1) | WO1995004045A1 (de) |
ZA (1) | ZA945609B (de) |
Families Citing this family (43)
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EP0711282B1 (de) * | 1993-07-28 | 2002-06-05 | Aventis Pharma Limited | Verbindungen als pde iv und tnf inhibitoren |
GB9412571D0 (en) * | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
TW375612B (en) * | 1995-04-06 | 1999-12-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same |
GB9507297D0 (en) * | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
EP2223920A3 (de) | 1996-06-19 | 2011-09-28 | Aventis Pharma Limited | Substituierte Azabizyklische Verbindungen |
DE19628621A1 (de) * | 1996-07-16 | 1998-01-22 | Byk Gulden Lomberg Chem Fab | Neue 4-substituierte Benzofurane |
DE19628622A1 (de) * | 1996-07-16 | 1998-01-22 | Byk Gulden Lomberg Chem Fab | Neue 5-substituierte [2H] Chromene |
NZ334971A (en) * | 1996-10-02 | 2000-09-29 | Janssen Pharmaceutica Nv | 2-cyanoiminoimidazole derivatives for use as phosphodiesterase (PDE) IV inhibitors |
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JP4778612B2 (ja) * | 1998-04-01 | 2011-09-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Pdeiv阻害ピリジン誘導体 |
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US20040146561A1 (en) * | 2001-05-23 | 2004-07-29 | Naoki Sakurai | Compositions for promoting healing of bone fracture |
WO2002094320A1 (fr) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Compositions therapeutiques permettant de reparer la chondropathie |
PL222211B1 (pl) | 2001-06-26 | 2016-07-29 | Amgen Fremont Inc | Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza |
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BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
JP5198865B2 (ja) * | 2005-08-26 | 2013-05-15 | カルピス株式会社 | 筋肉痛抑制剤 |
FR2915100B1 (fr) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxalide pour le traitement des desordres moteurs lies a la maladie de parkinson |
FR2915098B1 (fr) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes de la moelle epiniere |
FR2915099B1 (fr) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CN101952274A (zh) * | 2007-11-20 | 2011-01-19 | 默沙东公司 | 非核苷逆转录酶抑制剂 |
SG190620A1 (en) | 2008-05-05 | 2013-06-28 | Sanofi Aventis | Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
AR077033A1 (es) * | 2009-06-11 | 2011-07-27 | Hoffmann La Roche | Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas |
AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
AU2013351145A1 (en) * | 2012-11-28 | 2015-06-11 | Sanofi | Process for preparing 4-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxido-4-pyridyl)-5-methoxypyridine-2-carboxamide |
WO2014083107A1 (en) * | 2012-11-28 | 2014-06-05 | Sanofi | METHOD OF PREPARATION OF CRYSTAL FORMS OF 4-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-1-OXIDOPYRIDYN-4-yl)-5-METHOXYPYRIDINE-2-CARBOXAMIDE AND CRISTAL FORMS THEREOF |
WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonisten der guanylatcyclase und deren verwendungen |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
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WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
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EP0711282B1 (de) * | 1993-07-28 | 2002-06-05 | Aventis Pharma Limited | Verbindungen als pde iv und tnf inhibitoren |
GB9401460D0 (en) | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
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-
1994
- 1994-07-28 EP EP94922940A patent/EP0711282B1/de not_active Expired - Lifetime
- 1994-07-28 DE DE69430747T patent/DE69430747T2/de not_active Expired - Lifetime
- 1994-07-28 ES ES94922940T patent/ES2176251T3/es not_active Expired - Lifetime
- 1994-07-28 CA CA002160928A patent/CA2160928C/en not_active Expired - Lifetime
- 1994-07-28 AT AT94922940T patent/ATE218549T1/de active
- 1994-07-28 JP JP50565795A patent/JP3775685B2/ja not_active Expired - Lifetime
- 1994-07-28 DK DK94922940T patent/DK0711282T3/da active
- 1994-07-28 PT PT94922940T patent/PT711282E/pt unknown
- 1994-07-28 WO PCT/GB1994/001630 patent/WO1995004045A1/en active IP Right Grant
- 1994-07-28 AU AU72670/94A patent/AU7267094A/en not_active Abandoned
- 1994-07-28 ZA ZA945609A patent/ZA945609B/xx unknown
- 1994-07-28 IL IL11049294A patent/IL110492A0/xx unknown
-
1996
- 1996-01-26 US US08/592,817 patent/US6472412B1/en not_active Expired - Lifetime
-
2002
- 2002-07-29 US US10/207,493 patent/US20030013713A1/en not_active Abandoned
-
2004
- 2004-03-03 US US10/792,579 patent/US7045660B2/en not_active Expired - Fee Related
-
2005
- 2005-01-06 JP JP2005001859A patent/JP4521283B2/ja not_active Expired - Lifetime
- 2005-11-30 US US11/290,322 patent/US20060084809A1/en not_active Abandoned
-
2007
- 2007-06-18 US US11/764,317 patent/US7652144B2/en not_active Expired - Fee Related
-
2010
- 2010-01-26 US US12/693,791 patent/US8129537B2/en not_active Expired - Fee Related
- 2010-03-08 JP JP2010050508A patent/JP2010195787A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20040171618A1 (en) | 2004-09-02 |
ZA945609B (en) | 1995-05-12 |
IL110492A0 (en) | 1994-10-21 |
EP0711282A1 (de) | 1996-05-15 |
US7652144B2 (en) | 2010-01-26 |
JP4521283B2 (ja) | 2010-08-11 |
DK0711282T3 (da) | 2002-09-16 |
CA2160928C (en) | 2005-07-05 |
WO1995004045A1 (en) | 1995-02-09 |
JPH09501155A (ja) | 1997-02-04 |
US20060084809A1 (en) | 2006-04-20 |
US20030013713A1 (en) | 2003-01-16 |
US20100240677A1 (en) | 2010-09-23 |
AU7267094A (en) | 1995-02-28 |
EP0711282B1 (de) | 2002-06-05 |
US7045660B2 (en) | 2006-05-16 |
JP3775685B2 (ja) | 2006-05-17 |
US6472412B1 (en) | 2002-10-29 |
JP2005225868A (ja) | 2005-08-25 |
US8129537B2 (en) | 2012-03-06 |
PT711282E (pt) | 2002-11-29 |
CA2160928A1 (en) | 1995-02-09 |
US20080132706A1 (en) | 2008-06-05 |
DE69430747D1 (de) | 2002-07-11 |
ES2176251T3 (es) | 2002-12-01 |
ATE218549T1 (de) | 2002-06-15 |
JP2010195787A (ja) | 2010-09-09 |
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