FR2831169B1 - Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2831169B1
FR2831169B1 FR0113576A FR0113576A FR2831169B1 FR 2831169 B1 FR2831169 B1 FR 2831169B1 FR 0113576 A FR0113576 A FR 0113576A FR 0113576 A FR0113576 A FR 0113576A FR 2831169 B1 FR2831169 B1 FR 2831169B1
Authority
FR
France
Prior art keywords
pharmaceutical compositions
preparation process
compositions containing
hydroxyalkyl derivatives
indolocarbazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0113576A
Other languages
English (en)
Other versions
FR2831169A1 (fr
Inventor
Michelle Prudhomme
Christelle Marminon
Pascale Moreau
John Hickman
Alain Pierre
Bruno Pfeiffer
Pierre Renard
Espiard Jean Guy Bizot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0113576A priority Critical patent/FR2831169B1/fr
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to NZ532365A priority patent/NZ532365A/en
Priority to US10/492,876 priority patent/US20040242508A1/en
Priority to BR0213403-9A priority patent/BR0213403A/pt
Priority to PCT/FR2002/003592 priority patent/WO2003035663A1/fr
Priority to CA002463923A priority patent/CA2463923A1/fr
Priority to ARP020103953A priority patent/AR036898A1/es
Priority to MXPA04003741A priority patent/MXPA04003741A/es
Priority to KR1020047005995A priority patent/KR100588222B1/ko
Priority to HU0401885A priority patent/HUP0401885A2/hu
Priority to CNB02820784XA priority patent/CN1253463C/zh
Priority to JP2003538176A priority patent/JP2005509641A/ja
Priority to EA200400533A priority patent/EA006201B1/ru
Priority to PL02368237A priority patent/PL368237A1/xx
Priority to EP02796813A priority patent/EP1438320A1/fr
Publication of FR2831169A1 publication Critical patent/FR2831169A1/fr
Publication of FR2831169B1 publication Critical patent/FR2831169B1/fr
Application granted granted Critical
Priority to ZA2004/02626A priority patent/ZA200402626B/en
Priority to NO20041761A priority patent/NO20041761L/no
Priority to HK05102890A priority patent/HK1072774A1/xx
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR0113576A 2001-10-22 2001-10-22 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2831169B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR0113576A FR2831169B1 (fr) 2001-10-22 2001-10-22 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200400533A EA006201B1 (ru) 2001-10-22 2002-10-21 Производные гидроксиалкилиндолкарбазола, способ их получения и фармацевтические композиции, которые их содержат
US10/492,876 US20040242508A1 (en) 2001-10-22 2002-10-21 Novel hydroxyalkyl indolocarbazole derivatives, preparation method and pharmaceutical compositions containing the same
PCT/FR2002/003592 WO2003035663A1 (fr) 2001-10-22 2002-10-21 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA002463923A CA2463923A1 (fr) 2001-10-22 2002-10-21 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ARP020103953A AR036898A1 (es) 2001-10-22 2002-10-21 Derivados de hidroxialquilo indolocarbazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
MXPA04003741A MXPA04003741A (es) 2001-10-22 2002-10-21 Derivados novedosos de hidroxialquil indolocarbazol, metodo de preparacion y composiciones farmaceuticas que los contienen.
KR1020047005995A KR100588222B1 (ko) 2001-10-22 2002-10-21 히드록시알킬 인돌로카르바졸 유도체, 제조방법 및 이들을함유하는 약제 조성물
PL02368237A PL368237A1 (en) 2001-10-22 2002-10-21 Novel hydroxyalkyl indolocarbazole derivatives, preparation method and pharmaceutical compositions containing same
CNB02820784XA CN1253463C (zh) 2001-10-22 2002-10-21 新的羟烷基吲哚并咔唑衍生物、制备方法和含有这些衍生物的药物组合物
NZ532365A NZ532365A (en) 2001-10-22 2002-10-21 New hydroxyalkylindolocarbazole compounds, a process for their preparation and pharmaceutical compositions containing them
BR0213403-9A BR0213403A (pt) 2001-10-22 2002-10-21 Derivados de hidroxialquila indolocarbazol, o respectivo processo de preparo, e as composições farmacêuticas que os contêm
HU0401885A HUP0401885A2 (hu) 2001-10-22 2002-10-21 Új hidroxialkil-indolokarbazol-származékok, eljárás ezek előállítására és ezeket tartalmazó gyógyszerkészítmények
EP02796813A EP1438320A1 (fr) 2001-10-22 2002-10-21 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2003538176A JP2005509641A (ja) 2001-10-22 2002-10-21 新規ヒドロキシアルキルインドロカルバゾール化合物、その調製方法、およびそれらを含む医薬組成物
ZA2004/02626A ZA200402626B (en) 2001-10-22 2004-04-02 New hydroxyalkylindolocarbazole compounds, a process for their preparation and pharmaceutical compositions containing them
NO20041761A NO20041761L (no) 2001-10-22 2004-04-29 Nye hydroksyalkylindolokarbazolforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
HK05102890A HK1072774A1 (en) 2001-10-22 2005-04-07 Novel hydroxyalkyl indolocarbazole derivatives, p reparation method and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0113576A FR2831169B1 (fr) 2001-10-22 2001-10-22 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2831169A1 FR2831169A1 (fr) 2003-04-25
FR2831169B1 true FR2831169B1 (fr) 2003-12-12

Family

ID=8868539

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0113576A Expired - Fee Related FR2831169B1 (fr) 2001-10-22 2001-10-22 Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US20040242508A1 (fr)
EP (1) EP1438320A1 (fr)
JP (1) JP2005509641A (fr)
KR (1) KR100588222B1 (fr)
CN (1) CN1253463C (fr)
AR (1) AR036898A1 (fr)
BR (1) BR0213403A (fr)
CA (1) CA2463923A1 (fr)
EA (1) EA006201B1 (fr)
FR (1) FR2831169B1 (fr)
HK (1) HK1072774A1 (fr)
HU (1) HUP0401885A2 (fr)
MX (1) MXPA04003741A (fr)
NO (1) NO20041761L (fr)
NZ (1) NZ532365A (fr)
PL (1) PL368237A1 (fr)
WO (1) WO2003035663A1 (fr)
ZA (1) ZA200402626B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
WO2008109591A1 (fr) * 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Analogues de phlorizine utilisés comme inhibiteurs du co-transporteur 2 du sodium-glucose
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
CN104031052B (zh) * 2014-05-20 2016-06-08 中国科学院南海海洋研究所 抗生素Indimicins A–E及其制备方法和在制备抗肿瘤药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4485400A (en) * 1999-04-26 2000-11-10 Advanced Life Sciences Inc. Synthetic indolocarbazole regioisomers and uses thereof
WO2004083228A1 (fr) * 1999-09-10 2004-09-30 Katsuhisa Kojiri Derives d'indolopyrrolocarbazole et agents antitumoraux
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
PL368237A1 (en) 2005-03-21
US20040242508A1 (en) 2004-12-02
NZ532365A (en) 2005-07-29
AR036898A1 (es) 2004-10-13
CN1253463C (zh) 2006-04-26
EA200400533A1 (ru) 2004-08-26
EP1438320A1 (fr) 2004-07-21
BR0213403A (pt) 2004-11-03
JP2005509641A (ja) 2005-04-14
WO2003035663A1 (fr) 2003-05-01
KR20040054735A (ko) 2004-06-25
CA2463923A1 (fr) 2003-05-01
MXPA04003741A (es) 2004-07-23
EA006201B1 (ru) 2005-10-27
HUP0401885A2 (hu) 2004-12-28
NO20041761L (no) 2004-04-29
FR2831169A1 (fr) 2003-04-25
CN1571793A (zh) 2005-01-26
HK1072774A1 (en) 2005-09-09
KR100588222B1 (ko) 2006-06-12
ZA200402626B (en) 2005-06-29

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20070629