EA201691795A1 - Способ улучшения растворимости белка и пептида за счет использования связывания с фрагментом fc иммуноглобулина - Google Patents
Способ улучшения растворимости белка и пептида за счет использования связывания с фрагментом fc иммуноглобулинаInfo
- Publication number
- EA201691795A1 EA201691795A1 EA201691795A EA201691795A EA201691795A1 EA 201691795 A1 EA201691795 A1 EA 201691795A1 EA 201691795 A EA201691795 A EA 201691795A EA 201691795 A EA201691795 A EA 201691795A EA 201691795 A1 EA201691795 A1 EA 201691795A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- immunoglobulin
- fragment
- solubility
- peptide
- improving
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Изобретение относится к способу улучшения растворимости физиологически активного белка или пептида по сравнению с растворимостью физиологически активного белка или пептида, не конъюгированного с фрагментом Fc иммуноглобулина, включающий стадию связывания физиологически активного белка или пептида с фрагментом Fc иммуноглобулина; и к композиции для улучшения растворимости физиологически активного белка или пептида, содержащей фрагмент Fc иммуноглобулина и демонстрирующей улучшенную растворимость по сравнению с композицией, не содержащей фрагмент Fc иммуноглобулина.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140038032 | 2014-03-31 | ||
PCT/KR2015/003195 WO2015152618A1 (ko) | 2014-03-31 | 2015-03-31 | 면역글로불린 fc 단편 결합을 이용한 단백질 및 펩타이드의 용해도를 개선시키는 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201691795A1 true EA201691795A1 (ru) | 2017-03-31 |
Family
ID=54240858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691795A EA201691795A1 (ru) | 2014-03-31 | 2015-03-31 | Способ улучшения растворимости белка и пептида за счет использования связывания с фрагментом fc иммуноглобулина |
Country Status (21)
Country | Link |
---|---|
US (2) | US20170128589A1 (ru) |
EP (2) | EP3889185A3 (ru) |
JP (3) | JP2017511335A (ru) |
KR (2) | KR102385120B1 (ru) |
CN (2) | CN106488933A (ru) |
AU (1) | AU2015242657B2 (ru) |
CA (1) | CA2944138C (ru) |
DK (1) | DK3127923T3 (ru) |
EA (1) | EA201691795A1 (ru) |
ES (1) | ES2897935T3 (ru) |
HU (1) | HU231358B1 (ru) |
IL (1) | IL248111B (ru) |
MX (1) | MX2016012788A (ru) |
MY (1) | MY192248A (ru) |
NO (1) | NO20161667A1 (ru) |
PH (1) | PH12016501937A1 (ru) |
PL (1) | PL3127923T3 (ru) |
SG (2) | SG11201608120TA (ru) |
UA (1) | UA124182C2 (ru) |
WO (1) | WO2015152618A1 (ru) |
ZA (1) | ZA201607344B (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU231358B1 (hu) * | 2014-03-31 | 2023-03-28 | Hanmi Pharm. Co., Ltd | Eljárás fehérjék és peptidek oldhatóságának javítására immunoglobulin Fc fragmentum kapcsolás alkalmazása révén |
EP3384935A4 (en) * | 2015-12-02 | 2019-08-21 | Hanmi Pharm. Co., Ltd. | PROTEIN COMPLEX UTILIZING A FATTY ACID DERIVATIVE, AND PROCESS FOR PREPARING THE SAME |
CN110545849A (zh) * | 2017-02-03 | 2019-12-06 | 韩美药品株式会社 | 具有增加的持续性的生理活性物质的缀合物及其应用 |
CN106892978A (zh) * | 2017-04-18 | 2017-06-27 | 天津世传生物科技有限公司 | 复合物、蛋白质及二者的制备方法 |
KR20200016874A (ko) | 2017-06-20 | 2020-02-17 | 마드리갈 파마슈티칼스 인코포레이티드 | 표적화 치료제를 포함하는 병용 요법 |
KR102053009B1 (ko) | 2018-09-19 | 2019-12-09 | 주식회사 바이오앱 | 돼지 열병 백신용 조성물 및 이의 제조 방법 |
KR102288367B1 (ko) | 2018-11-15 | 2021-08-11 | 주식회사 바이오앱 | 식물체에서 바이러스-유사 입자를 발현하는 재조합 벡터 및 이를 이용한 써코바이러스-유사 입자를 포함하는 백신 조성물의 제조방법 |
KR102250576B1 (ko) | 2018-11-15 | 2021-05-12 | 주식회사 바이오앱 | 식물 발현 시스템에서 캡시드 단백질의 발현을 증가시키는 재조합 벡터 및 이를 이용한 바이러스-유사 입자의 제조방법 |
WO2020101187A1 (ko) | 2018-11-15 | 2020-05-22 | 주식회사 바이오앱 | 식물체에서 바이러스-유사 입자를 발현하는 재조합 벡터 및 이를 이용한 써코바이러스-유사 입자를 포함하는 백신 조성물의 제조방법 |
US20200262887A1 (en) | 2018-11-30 | 2020-08-20 | Opko Ireland Global Holdings, Ltd. | Oxyntomodulin peptide analog formulations |
EP4025237A1 (en) * | 2019-09-06 | 2022-07-13 | Novartis AG | Therapeutic fusion proteins |
KR102450007B1 (ko) * | 2020-10-16 | 2022-10-04 | 주식회사 아이엠바이오로직스 | IgM 영역을 이용한 융합단백질 플랫폼 |
KR20220122815A (ko) | 2021-02-25 | 2022-09-05 | 주식회사 바이오앱 | 식물 발현 시스템을 이용한 알팔파 모자이크 바이러스 유사 입자 제조 방법 및 이의 활용 |
KR20240027904A (ko) | 2022-08-22 | 2024-03-05 | (주) 에빅스젠 | 용해도 개선용 펩티드 및 이를 포함하는 용해도 개선 조성물 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
EP0904107B1 (en) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
EA005584B1 (ru) * | 2000-12-07 | 2005-04-28 | Эли Лилли Энд Компани | Слитые белки glp-1 |
SI1641823T1 (sl) * | 2003-06-12 | 2011-12-30 | Lilly Co Eli | Fuzijski proteini analogni glp-1 |
US8263084B2 (en) * | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
ES2378167T3 (es) * | 2003-11-13 | 2012-04-09 | Hanmi Holdings Co., Ltd | Complejo de proteína que utiliza fragmento de inmunoglobulina y el método para su preparación |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
EP2168982A1 (en) * | 2004-12-22 | 2010-03-31 | Eli Lilly & Company | GLP-1 analog fusion protein formulations |
TWI376234B (en) * | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
KR100755315B1 (ko) | 2005-04-11 | 2007-09-05 | 엘지전자 주식회사 | 멀티에어컨 시스템 및 그 동작 방법 |
GB2427360A (en) * | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
CN101273134B (zh) * | 2005-07-27 | 2012-01-04 | 王庆华 | 用于预防和治疗ⅰ型和ⅱ型糖尿病的组合物和方法 |
KR100824505B1 (ko) | 2005-08-16 | 2008-04-22 | 한미약품 주식회사 | 개시 메티오닌 잔기가 제거된 면역글로불린 Fc 영역의대량 생산방법 |
JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
EP2162472B1 (en) * | 2007-05-30 | 2013-02-27 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
JP2009019027A (ja) | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体 |
JPWO2009020094A1 (ja) * | 2007-08-09 | 2010-11-04 | 第一三共株式会社 | 疎水性分子で修飾した抗体 |
AU2009210570B2 (en) * | 2008-01-30 | 2014-11-20 | Indiana University Research And Technology Corporation | Ester-based insulin prodrugs |
ES2523043T3 (es) * | 2008-07-23 | 2014-11-20 | Hanmi Science Co., Ltd. | Un complejo polipeptídico que comprende un polímero no peptidílico que tiene tres extremos funcionales |
AU2009335712B2 (en) * | 2008-12-19 | 2015-09-17 | Indiana University Research And Technology Corporation | Insulin analogs |
JP5909755B2 (ja) * | 2009-07-27 | 2016-04-27 | リポクセン テクノロジーズ リミテッド | 非血液凝固タンパク質の糖ポリシアル酸化 |
WO2011064758A2 (en) * | 2009-11-30 | 2011-06-03 | Pfizer Limited | Fusion protein |
WO2011090306A2 (en) * | 2010-01-19 | 2011-07-28 | Hanmi Holdings Co., Ltd | Liquid formulations for long-acting erythropoietin conjugate |
HUE034398T2 (en) * | 2010-01-19 | 2018-02-28 | Hanmi Science Co Ltd | Liquid preparations for sustained G-CSF conjugate |
AR081755A1 (es) * | 2010-04-02 | 2012-10-17 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo |
AR081066A1 (es) * | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
US9981017B2 (en) * | 2010-04-02 | 2018-05-29 | Hanmi Science Co., Ltd. | Insulin conjugate using an immunoglobulin fragment |
AR080993A1 (es) * | 2010-04-02 | 2012-05-30 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina |
KR101337797B1 (ko) * | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
KR101382593B1 (ko) * | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
KR101303388B1 (ko) * | 2010-10-26 | 2013-09-03 | 한미사이언스 주식회사 | 지속형 인터페론 알파 결합체의 액상 제제 |
KR101830344B1 (ko) * | 2010-10-26 | 2018-02-22 | 한미사이언스 주식회사 | 피브로넥틴 단편 및 면역글로불린 단편의 융합 단백질 및 이의 용도 |
JPWO2012137479A1 (ja) * | 2011-04-04 | 2014-07-28 | 国立大学法人 東京医科歯科大学 | Hiv立体構造認識抗体誘導ペプチド |
UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
SG10201604564XA (en) | 2011-06-10 | 2016-07-28 | Hanmi Science Co Ltd | Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same |
UA114709C2 (uk) * | 2011-06-17 | 2017-07-25 | Ханмі Сайенс Ко., Лтд. | Кон'югат, що містить похідну оксинтомодуліну, fc-ділянку імуноглобуліну та непептидильний полімер, та його застосування |
US9789202B2 (en) * | 2011-09-05 | 2017-10-17 | Hanmi Science Co., Ltd. | Method for treating cancer using an interferon alpha conjugate |
JP6108630B2 (ja) * | 2011-10-06 | 2017-04-05 | ハンミ サイエンス カンパニー リミテッドHanmi Science Co.,Ltd. | 血液凝固因子VII及びVIIa誘導体、それらを含む結合体及び複合体、並びにそれらの使用 |
KR20130049671A (ko) * | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
KR101895047B1 (ko) * | 2011-12-30 | 2018-09-06 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체 |
KR102041412B1 (ko) * | 2011-12-30 | 2019-11-11 | 한미사이언스 주식회사 | 면역글로불린 Fc 단편 유도체 |
AR090281A1 (es) * | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
US10064951B2 (en) * | 2012-03-30 | 2018-09-04 | Hanmi Science Co., Ltd. | Liquid formulation of highly concentrated long-acting human growth hormone conjugate |
CN103509118B (zh) * | 2012-06-15 | 2016-03-23 | 郭怀祖 | 胰岛素-Fc融合蛋白 |
JP6429773B2 (ja) * | 2012-07-19 | 2018-11-28 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素構築物 |
KR101968344B1 (ko) * | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
AR092862A1 (es) * | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
AR091902A1 (es) * | 2012-07-25 | 2015-03-11 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de un conjugado de insulina de accion prolongada |
US10441665B2 (en) * | 2012-07-25 | 2019-10-15 | Hanmi Pharm. Co., Ltd. | Liquid formulation of long acting insulinotropic peptide conjugate |
AR094821A1 (es) * | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
NZ739063A (en) * | 2012-11-06 | 2019-11-29 | Hanmi Pharm Ind Co Ltd | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
AR096890A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn |
AR096891A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
AU2014329003A1 (en) * | 2013-09-27 | 2016-05-12 | Hanmi Pharm. Co., Ltd. | A formulation of long-acting human growth hormone conjugate |
HU231358B1 (hu) | 2014-03-31 | 2023-03-28 | Hanmi Pharm. Co., Ltd | Eljárás fehérjék és peptidek oldhatóságának javítására immunoglobulin Fc fragmentum kapcsolás alkalmazása révén |
TWI684458B (zh) * | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
KR20150140177A (ko) * | 2014-06-05 | 2015-12-15 | 한미약품 주식회사 | 단백질 및 펩타이드의 면역원성을 감소시키는 방법 |
CR20180380A (es) * | 2015-12-31 | 2018-12-07 | Hanmi Pharm Ind Co Ltd | Agosnista triple de receptores de glucagón/glp-1/gip |
EP3479841A4 (en) * | 2016-06-29 | 2020-03-04 | Hanmi Pharm. Co., Ltd. | GLUCAGON DERIVATIVE, CONJUGATE THEREOF, COMPOSITION COMPRISING SAME, AND THERAPEUTIC USE THEREOF |
-
2015
- 2015-03-31 HU HUP1600621A patent/HU231358B1/hu unknown
- 2015-03-31 MX MX2016012788A patent/MX2016012788A/es unknown
- 2015-03-31 ES ES15772562T patent/ES2897935T3/es active Active
- 2015-03-31 KR KR1020150045621A patent/KR102385120B1/ko active IP Right Grant
- 2015-03-31 CN CN201580028749.XA patent/CN106488933A/zh active Pending
- 2015-03-31 EP EP21169291.8A patent/EP3889185A3/en active Pending
- 2015-03-31 SG SG11201608120TA patent/SG11201608120TA/en unknown
- 2015-03-31 CA CA2944138A patent/CA2944138C/en active Active
- 2015-03-31 JP JP2016560523A patent/JP2017511335A/ja active Pending
- 2015-03-31 WO PCT/KR2015/003195 patent/WO2015152618A1/ko active Application Filing
- 2015-03-31 PL PL15772562T patent/PL3127923T3/pl unknown
- 2015-03-31 UA UAA201610351A patent/UA124182C2/uk unknown
- 2015-03-31 US US15/129,897 patent/US20170128589A1/en not_active Abandoned
- 2015-03-31 EA EA201691795A patent/EA201691795A1/ru unknown
- 2015-03-31 EP EP15772562.3A patent/EP3127923B1/en active Active
- 2015-03-31 AU AU2015242657A patent/AU2015242657B2/en active Active
- 2015-03-31 SG SG10202107752PA patent/SG10202107752PA/en unknown
- 2015-03-31 MY MYPI2016703516A patent/MY192248A/en unknown
- 2015-03-31 DK DK15772562.3T patent/DK3127923T3/da active
- 2015-03-31 CN CN202310720671.4A patent/CN117065044A/zh active Pending
-
2016
- 2016-09-28 IL IL248111A patent/IL248111B/en unknown
- 2016-09-29 PH PH12016501937A patent/PH12016501937A1/en unknown
- 2016-10-19 NO NO20161667A patent/NO20161667A1/en unknown
- 2016-10-25 ZA ZA2016/07344A patent/ZA201607344B/en unknown
-
2019
- 2019-11-25 JP JP2019212180A patent/JP7333249B2/ja active Active
-
2021
- 2021-07-26 JP JP2021121272A patent/JP7322105B2/ja active Active
-
2022
- 2022-03-22 KR KR1020220035314A patent/KR20220042326A/ko not_active Application Discontinuation
- 2022-06-13 US US17/839,053 patent/US20230220034A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201691795A1 (ru) | Способ улучшения растворимости белка и пептида за счет использования связывания с фрагментом fc иммуноглобулина | |
EA201791029A1 (ru) | Антитела против интерлейкина-33 и их применение | |
EA201792589A1 (ru) | Антитела против cd123 и конъюгаты указанных антител | |
EA201890493A1 (ru) | РЕПРЕССОРЫ Htt И ИХ ПРИМЕНЕНИЕ | |
EA201890285A1 (ru) | Антитела против pd-1, активируемые антитела против pd-1 и способы их применения | |
EA201990293A1 (ru) | Мультиспецифичные антитела против cd40 и cd137 | |
EA202092435A2 (ru) | Моноклональные антитела против bcma | |
EA201890712A1 (ru) | Антитела к про-/латентному миостатину и их применения | |
EA201890131A1 (ru) | Иммуномодуляция и лечение солидных опухолей антителами, которые специфически связывают cd38 | |
EA201692539A1 (ru) | Антитела и антигенсвязывающие фрагменты, которые специфично связываются с белком тау, ассоциированным с микротрубочками | |
EA201790545A1 (ru) | Антитела и иммуноконъюгаты против her2 | |
EA201790173A1 (ru) | Антитела, связывающие axl | |
EA201591750A1 (ru) | Антитела против b7-h4 и иммуноконъюгаты | |
EA201890305A1 (ru) | Гуманизированные или химерные cd3-антитела | |
EA201891709A1 (ru) | Антигенсвязывающие белки, связывающие pd-l1 | |
EA201591661A1 (ru) | Пептиды и композиции для лечения повреждений суставов | |
PH12016501366A1 (en) | Novel anti-baff antibodies | |
EA202091315A2 (ru) | Антитела человека, связывающиеся с g-белком rsv | |
EA201792220A1 (ru) | Опосредуемая антителом нейтрализация вируса чикунгунья | |
MX2023006415A (es) | Anticuerpos, usos y metodos. | |
EA202090084A1 (ru) | Новый терапевтический ферментный слитый белок и его применение | |
EA201892368A1 (ru) | ИНГИБИТОРЫ ErbB И ИХ ПРИМЕНЕНИЕ | |
EA201792262A1 (ru) | Пироглутамат вортиоксетина | |
EA201790336A1 (ru) | Антитела к ангиопоэтинподобному белку 4 и способы применения | |
TW201613977A (en) | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |