MX2009011089A - Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. - Google Patents

Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12.

Info

Publication number
MX2009011089A
MX2009011089A MX2009011089A MX2009011089A MX2009011089A MX 2009011089 A MX2009011089 A MX 2009011089A MX 2009011089 A MX2009011089 A MX 2009011089A MX 2009011089 A MX2009011089 A MX 2009011089A MX 2009011089 A MX2009011089 A MX 2009011089A
Authority
MX
Mexico
Prior art keywords
compounds
formula
adp receptor
platelet adp
antagonists
Prior art date
Application number
MX2009011089A
Other languages
English (en)
Inventor
Marc Nazare
Melitta Just
Gerhard Hessler
Joerg Czech
Gernot Zech
Tilo Weiss
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38462433&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009011089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2009011089A publication Critical patent/MX2009011089A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

La presente invención se refiere a compuestos de fórmula I, (ver fórmula (I)) en la que R1, R2, R3, R4, R5, R6; Z; A; B; E; X; Q; J; V; G y M tienen los significados indicados en las reivindicaciones. Los compuestos de fórmula I son valiosos compuestos farmacológicamente activos. Exhiben un fuerte efecto anti-agregante sobre plaquetas y, así, un efecto anti-trombótico y son adecuados, p. ej., para la terapia y profilaxis de trastornos cardiovasculares tales como enfermedades tromboembólicas o restenosis. Son antagonistas reversibles del receptor de ADP de plaquetas P2Y12 y, en general, pueden emplearse en condiciones en las que está presente una activación indeseada del receptor de ADP de plaquetas P2Y12 o para la curación o prevención de las que se pretende una inhibición del receptor de ADP de plaquetas P2Y12. La invención se refiere además a procedimientos para preparar compuestos de fórmula I, a su uso, en particular como ingredientes activos en productos farmacéuticos, y a preparaciones farmacéuticas que los contienen.
MX2009011089A 2007-04-23 2008-04-09 Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. MX2009011089A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07008209 2007-04-23
PCT/EP2008/002790 WO2008128647A1 (en) 2007-04-23 2008-04-09 Quinoline-carboxamide derivatives as p2y12 antagonists

Publications (1)

Publication Number Publication Date
MX2009011089A true MX2009011089A (es) 2009-10-30

Family

ID=38462433

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011089A MX2009011089A (es) 2007-04-23 2008-04-09 Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12.

Country Status (19)

Country Link
US (1) US8669266B2 (es)
EP (1) EP2148871A1 (es)
JP (1) JP5309131B2 (es)
KR (1) KR20100015886A (es)
CN (1) CN101663293B (es)
AR (1) AR066225A1 (es)
AU (1) AU2008241091B2 (es)
BR (1) BRPI0810462A2 (es)
CA (1) CA2684644A1 (es)
CL (1) CL2008001157A1 (es)
HK (1) HK1141803A1 (es)
IL (1) IL201620A (es)
MX (1) MX2009011089A (es)
MY (1) MY153427A (es)
PA (1) PA8777901A1 (es)
PE (1) PE20090241A1 (es)
TW (1) TW200848042A (es)
UY (1) UY31039A1 (es)
WO (1) WO2008128647A1 (es)

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US8288371B2 (en) 2007-10-05 2012-10-16 Pharmacopeia, Llc Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation
NZ586445A (en) 2007-11-29 2012-06-29 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
AR071653A1 (es) 2008-04-11 2010-07-07 Actelion Pharmaceuticals Ltd Derivados 2-fenil-4-ciclopropil-pirimidina
CN102264403B (zh) * 2009-01-28 2015-06-03 泰尔茂株式会社 湿润时表面具有润滑性的医疗用具
US8288385B2 (en) * 2009-04-08 2012-10-16 Actelion Pharmaceuticals Ltd. 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines
SG175297A1 (en) 2009-04-22 2011-12-29 Actelion Pharmaceuticals Ltd Thiazole derivatives and their use as p2y12 receptor antagonists
JP5597202B2 (ja) 2009-08-28 2014-10-01 第一三共株式会社 ３−（ビアリールオキシ）プロピオン酸誘導体
AR079451A1 (es) * 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CA2829131C (en) 2011-03-04 2018-11-20 Glaxosmithkline Intellectual Property (No.2) Limited Amino-quinolines as kinase inhibitors
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
EP2750676B1 (en) 2011-08-30 2018-01-10 University of Utah Research Foundation Methods and compositions for treating nephrogenic diabetes insipidus
CN102584852B (zh) * 2011-12-30 2014-08-13 厦门大学 真菌代谢产物桥南霉素及其制备方法和应用
TWI592417B (zh) 2012-09-13 2017-07-21 葛蘭素史克智慧財產發展有限公司 胺基喹唑啉激酶抑制劑之前藥
TW201425307A (zh) 2012-09-13 2014-07-01 Glaxosmithkline Llc 作為激酶抑制劑之胺基－喹啉類
EP2725025A1 (fr) * 2012-10-26 2014-04-30 Sanofi Dérives de 1H-indole-3-carboxamide et leurs utilisation comme antagonistes du P2Y12
WO2014128622A1 (en) 2013-02-21 2014-08-28 Glaxosmithkline Intellectual Property Development Limited Quinazolines as kinase inhibitors
CN104109158A (zh) * 2013-04-16 2014-10-22 上海医药工业研究院 一种纯化利伐沙班的方法
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
DE102015217396B4 (de) 2014-09-11 2018-07-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. System, insbesondere System zur Eingabesteuerung für eine Arbeitshilfe
CN106496249B (zh) * 2015-09-07 2019-12-13 江苏恒瑞医药股份有限公司 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用
WO2018013770A1 (en) * 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Bicyclic heteroaryl substituted compounds
SI3515924T1 (sl) 2016-09-22 2022-04-29 Idorsia Pharmaceuticals Ltd. Kristalinične oblike
TWI765002B (zh) 2017-03-15 2022-05-21 瑞士商愛杜西亞製藥有限公司 受體拮抗劑之皮下投藥
CN107648607A (zh) * 2017-09-11 2018-02-02 南昌大学 嘌呤2y12受体拮抗剂在制备糖尿病神经病理损伤疾病药物中的应用
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

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Also Published As

Publication number Publication date
JP2010524984A (ja) 2010-07-22
IL201620A (en) 2013-11-28
CA2684644A1 (en) 2008-10-30
AU2008241091B2 (en) 2013-05-09
PA8777901A1 (es) 2008-11-19
CN101663293A (zh) 2010-03-03
PE20090241A1 (es) 2009-04-03
KR20100015886A (ko) 2010-02-12
TW200848042A (en) 2008-12-16
CN101663293B (zh) 2013-07-31
WO2008128647A1 (en) 2008-10-30
US8669266B2 (en) 2014-03-11
US20100135999A1 (en) 2010-06-03
EP2148871A1 (en) 2010-02-03
HK1141803A1 (en) 2010-11-19
AU2008241091A1 (en) 2008-10-30
CL2008001157A1 (es) 2008-11-03
MY153427A (en) 2015-02-13
UY31039A1 (es) 2008-11-28
AR066225A1 (es) 2009-08-05
IL201620A0 (en) 2010-05-31
JP5309131B2 (ja) 2013-10-09
BRPI0810462A2 (pt) 2014-10-14

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