BR112015020772A2 - compostos de pirimidina e piridina e seu uso - Google Patents
compostos de pirimidina e piridina e seu usoInfo
- Publication number
- BR112015020772A2 BR112015020772A2 BR112015020772A BR112015020772A BR112015020772A2 BR 112015020772 A2 BR112015020772 A2 BR 112015020772A2 BR 112015020772 A BR112015020772 A BR 112015020772A BR 112015020772 A BR112015020772 A BR 112015020772A BR 112015020772 A2 BR112015020772 A2 BR 112015020772A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrimidine
- pyridine compounds
- yeg
- therapy
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
resumo patente de invenção: "compostos de pirimidina e piridina e seu uso". a presente invenção refere-se acompostos de pirimidina e piridina de fórmula (i) ou um sal farmaceuticamente aceitável dos mesmos, em que r1, r2, r3, r4, r5, x, y e g são como definidos na descrição para composições farmacêuticas contendo-os, um processo para prepará-los, e seu uso em terapia de uma doença responsável pela inibição de fgfr, por exemplo, câncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/072690 WO2014139145A1 (en) | 2013-03-15 | 2013-03-15 | Novel pyrimidine and pyridine compounds and usage thereof |
| CNPCT/CN2013/07269 | 2013-03-15 | ||
| PCT/CN2014/073444 WO2014139465A1 (en) | 2013-03-15 | 2014-03-14 | Novel pyrimidine and pyridine compounds and their usage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015020772A2 true BR112015020772A2 (pt) | 2017-07-18 |
| BR112015020772B1 BR112015020772B1 (pt) | 2022-06-07 |
Family
ID=51535826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015020772-3A BR112015020772B1 (pt) | 2013-03-15 | 2014-03-14 | Compostos de pirimidina e piridina e seu uso |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20160052926A1 (pt) |
| EP (1) | EP2970120B1 (pt) |
| JP (1) | JP6109969B2 (pt) |
| KR (1) | KR101697982B1 (pt) |
| CN (1) | CN105143185B (pt) |
| AR (1) | AR095430A1 (pt) |
| AU (1) | AU2014231437B2 (pt) |
| BR (1) | BR112015020772B1 (pt) |
| CA (1) | CA2900748C (pt) |
| CL (1) | CL2015002520A1 (pt) |
| CY (1) | CY1121804T1 (pt) |
| DK (1) | DK2970120T3 (pt) |
| EA (1) | EA028654B1 (pt) |
| ES (1) | ES2697697T3 (pt) |
| HK (1) | HK1212687A1 (pt) |
| HR (1) | HRP20181906T1 (pt) |
| IL (1) | IL240790B (pt) |
| LT (1) | LT2970120T (pt) |
| MX (1) | MX363397B (pt) |
| MY (1) | MY192641A (pt) |
| NZ (1) | NZ711460A (pt) |
| PE (1) | PE20151601A1 (pt) |
| PH (1) | PH12015502047A1 (pt) |
| PL (1) | PL2970120T3 (pt) |
| PT (1) | PT2970120T (pt) |
| RS (1) | RS58136B1 (pt) |
| SG (1) | SG11201506280SA (pt) |
| SI (1) | SI2970120T1 (pt) |
| TW (1) | TWI618698B (pt) |
| UA (1) | UA113470C2 (pt) |
| WO (2) | WO2014139145A1 (pt) |
| ZA (1) | ZA201505999B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9676765B2 (en) | 2012-11-07 | 2017-06-13 | Karus Therapeutics Limited | Histone deacetylase inhibitors and their use in therapy |
| US9278950B2 (en) | 2013-01-14 | 2016-03-08 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| PE20191245A1 (es) | 2013-01-15 | 2019-09-18 | Incyte Holdings Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim |
| LT2994465T (lt) | 2013-05-10 | 2018-10-10 | Karus Therapeutics Limited | Nauji histono deacetilazės inhibitoriai |
| SG11201601259YA (en) | 2013-08-23 | 2016-03-30 | Incyte Corp | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2018072707A1 (zh) * | 2016-10-18 | 2018-04-26 | 保诺科技（北京）有限公司 | 芳香族醚类衍生物、其制备方法及其在医药上的应用 |
| AU2017359819B2 (en) * | 2016-11-17 | 2020-05-28 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | FGFR4 inhibitor and preparation method and use thereof |
| CN108503593B (zh) * | 2017-02-28 | 2021-04-27 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
| CN108570032B (zh) * | 2017-03-09 | 2021-04-02 | 华东理工大学 | 新型罗丹明染料及其在抗致病菌中的应用 |
| CN107382836A (zh) * | 2017-08-04 | 2017-11-24 | 吴赣药业（苏州）有限公司 | 一种1‑(4‑氨基苯基)‑1h‑吡啶‑2‑酮的制备方法 |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| MX2022004274A (es) | 2019-10-14 | 2022-05-06 | Hutchison Medipharma Ltd | Las sales de un compuesto y sus formas cristalinas. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0406809A (pt) * | 2003-01-17 | 2005-12-27 | Warner Lambert Co | Heterociclos substituìdos de 2-aminopiridina como inibidores da proliferação celular |
| WO2005002673A1 (en) * | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| WO2006101977A2 (en) * | 2005-03-16 | 2006-09-28 | Targegen, Inc. | Pyrimidine compounds and methods of use |
| US20070149508A1 (en) * | 2005-11-02 | 2007-06-28 | Targegen, Inc. | Six membered heteroaromatic inhibitors targeting resistant kinase mutations |
| WO2008008234A1 (en) * | 2006-07-07 | 2008-01-17 | Targegen, Inc. | 2-amino-5-substituted pyrimidine inhibitors |
| JP5244118B2 (ja) | 2006-11-10 | 2013-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 新規キナーゼ阻害剤 |
| EP2022785A1 (en) * | 2007-06-20 | 2009-02-11 | Bayer Schering Pharma Aktiengesellschaft | Alkynylpyrimidines as Tie2 kinase inhibitors |
| JP2011524888A (ja) * | 2008-06-19 | 2011-09-08 | アストラゼネカ アクチボラグ | ピラゾール化合物４３６ |
| US8748458B2 (en) * | 2009-01-28 | 2014-06-10 | Karus Therapeutics Limited | Scriptaid isosteres and their use in therapy |
| ES2746288T3 (es) * | 2012-02-28 | 2020-03-05 | Astellas Pharma Inc | Compuesto heterocíclico aromático que contiene nitrógeno |
| PL2824181T3 (pl) | 2012-03-08 | 2019-02-28 | Astellas Pharma Inc. | Nowa fuzja fgfr3 |
-
2013
- 2013-03-15 WO PCT/CN2013/072690 patent/WO2014139145A1/en active Application Filing
- 2013-03-15 US US14/775,649 patent/US20160052926A1/en not_active Abandoned
-
2014
- 2014-03-12 TW TW103108613A patent/TWI618698B/zh active
- 2014-03-13 AR ARP140100975A patent/AR095430A1/es active IP Right Grant
- 2014-03-14 MY MYPI2015703158A patent/MY192641A/en unknown
- 2014-03-14 WO PCT/CN2014/073444 patent/WO2014139465A1/en active Application Filing
- 2014-03-14 BR BR112015020772-3A patent/BR112015020772B1/pt active IP Right Grant
- 2014-03-14 LT LTEP14764299.5T patent/LT2970120T/lt unknown
- 2014-03-14 PL PL14764299T patent/PL2970120T3/pl unknown
- 2014-03-14 KR KR1020157027380A patent/KR101697982B1/ko active IP Right Grant
- 2014-03-14 CN CN201480015314.7A patent/CN105143185B/zh active Active
- 2014-03-14 EP EP14764299.5A patent/EP2970120B1/en active Active
- 2014-03-14 EA EA201591301A patent/EA028654B1/ru unknown
- 2014-03-14 MX MX2015012363A patent/MX363397B/es unknown
- 2014-03-14 AU AU2014231437A patent/AU2014231437B2/en active Active
- 2014-03-14 CA CA2900748A patent/CA2900748C/en active Active
- 2014-03-14 PT PT14764299T patent/PT2970120T/pt unknown
- 2014-03-14 SI SI201430969T patent/SI2970120T1/sl unknown
- 2014-03-14 US US14/775,653 patent/US9701680B2/en active Active
- 2014-03-14 SG SG11201506280SA patent/SG11201506280SA/en unknown
- 2014-03-14 DK DK14764299.5T patent/DK2970120T3/en active
- 2014-03-14 ES ES14764299T patent/ES2697697T3/es active Active
- 2014-03-14 JP JP2015561928A patent/JP6109969B2/ja active Active
- 2014-03-14 UA UAA201509752A patent/UA113470C2/uk unknown
- 2014-03-14 RS RS20181394A patent/RS58136B1/sr unknown
- 2014-03-14 NZ NZ711460A patent/NZ711460A/en unknown
- 2014-03-14 PE PE2015001855A patent/PE20151601A1/es active IP Right Grant
-
2015
- 2015-08-19 ZA ZA2015/05999A patent/ZA201505999B/en unknown
- 2015-08-24 IL IL24079015A patent/IL240790B/en active IP Right Grant
- 2015-09-08 CL CL2015002520A patent/CL2015002520A1/es unknown
- 2015-09-10 PH PH12015502047A patent/PH12015502047A1/en unknown
-
2016
- 2016-01-19 HK HK16100550.4A patent/HK1212687A1/zh unknown
-
2018
- 2018-11-15 CY CY20181101211T patent/CY1121804T1/el unknown
- 2018-11-15 HR HRP20181906TT patent/HRP20181906T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/03/2014, OBSERVADAS AS CONDICOES LEGAIS |