PE20150774A1 - Aminoquinolinas como inhibidores de cinasa - Google Patents
Aminoquinolinas como inhibidores de cinasaInfo
- Publication number
- PE20150774A1 PE20150774A1 PE2015000276A PE2015000276A PE20150774A1 PE 20150774 A1 PE20150774 A1 PE 20150774A1 PE 2015000276 A PE2015000276 A PE 2015000276A PE 2015000276 A PE2015000276 A PE 2015000276A PE 20150774 A1 PE20150774 A1 PE 20150774A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase inhibitors
- aminoquinolines
- amino
- rip2
- priazol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La invencion se refiere a derivados de amino-quinolinas de formula I o su sal farmaceutica aceptable donde R1, R2, R3, R4 y R5 son como se definen en la memoria. Son compuestos preferidos: 1-((6-(terc-butilsulfonil)-4-((3,4-dimetil-1H-priazol-5-il)amino)quinolin-7-il)oxi)propan-2-ol, entre otros. Tambien se refiere a composiciones y metodos para elaborar los mismos. Dichos compuestos actuan como inhibidores de la RIP2 cinasa siendo utiles para el tratamiento de enfermedades autoinflamatorias reguladas por RIP2
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261700536P | 2012-09-13 | 2012-09-13 | |
US201361767378P | 2013-02-21 | 2013-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150774A1 true PE20150774A1 (es) | 2015-05-28 |
Family
ID=50278701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015000276A PE20150774A1 (es) | 2012-09-13 | 2013-09-13 | Aminoquinolinas como inhibidores de cinasa |
Country Status (21)
Country | Link |
---|---|
US (1) | US9216965B2 (es) |
EP (1) | EP2895167B1 (es) |
JP (1) | JP6258331B2 (es) |
KR (1) | KR20150053920A (es) |
CN (1) | CN104602692B (es) |
AR (1) | AR092530A1 (es) |
AU (1) | AU2013315387B2 (es) |
BR (1) | BR112015004967A2 (es) |
CA (1) | CA2883155A1 (es) |
CL (1) | CL2015000615A1 (es) |
CR (1) | CR20150133A (es) |
DO (1) | DOP2015000059A (es) |
EA (1) | EA027984B1 (es) |
ES (1) | ES2713172T3 (es) |
IL (1) | IL237158A0 (es) |
MX (1) | MX2015003275A (es) |
PE (1) | PE20150774A1 (es) |
PH (1) | PH12015500345A1 (es) |
SG (1) | SG11201500973WA (es) |
TW (1) | TW201425307A (es) |
WO (1) | WO2014043437A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
CA2829131C (en) | 2011-03-04 | 2018-11-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Amino-quinolines as kinase inhibitors |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
WO2014128622A1 (en) | 2013-02-21 | 2014-08-28 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
EP3359526A4 (en) | 2015-10-05 | 2019-04-03 | The Trustees of Columbia University in the City of New York | ACTIVATORS OF AUTOPHAGIC FLOW AND PHOSPHOLIPASE D AND CLAIRANCE OF PROTEIN AGGREGATES COMPRISING TAU AND TREATMENT OF PROTEINEOPATHIES |
CN107158385B (zh) * | 2016-03-14 | 2020-07-14 | 苏州大学 | Rip3抑制剂在制备抗血小板血栓药物中的用途 |
JP2019514878A (ja) | 2016-04-20 | 2019-06-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Ripk2阻害剤を含むコンジュゲート |
WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
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EP2552208A4 (en) | 2010-03-31 | 2014-07-09 | Glaxo Group Ltd | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS |
ES2552977T3 (es) | 2010-05-07 | 2015-12-03 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolinas como inhibidores de quinasa |
UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
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CA2829131C (en) * | 2011-03-04 | 2018-11-20 | Glaxosmithkline Intellectual Property (No.2) Limited | Amino-quinolines as kinase inhibitors |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
TWI592417B (zh) | 2012-09-13 | 2017-07-21 | 葛蘭素史克智慧財產發展有限公司 | 胺基喹唑啉激酶抑制劑之前藥 |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
WO2014128622A1 (en) | 2013-02-21 | 2014-08-28 | Glaxosmithkline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
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2013
- 2013-09-11 TW TW102132714A patent/TW201425307A/zh unknown
- 2013-09-11 AR ARP130103248A patent/AR092530A1/es unknown
- 2013-09-13 KR KR1020157006177A patent/KR20150053920A/ko not_active Application Discontinuation
- 2013-09-13 EP EP13836616.6A patent/EP2895167B1/en active Active
- 2013-09-13 ES ES13836616T patent/ES2713172T3/es active Active
- 2013-09-13 SG SG11201500973WA patent/SG11201500973WA/en unknown
- 2013-09-13 WO PCT/US2013/059600 patent/WO2014043437A1/en active Application Filing
- 2013-09-13 PE PE2015000276A patent/PE20150774A1/es not_active Application Discontinuation
- 2013-09-13 AU AU2013315387A patent/AU2013315387B2/en not_active Ceased
- 2013-09-13 JP JP2015532064A patent/JP6258331B2/ja not_active Expired - Fee Related
- 2013-09-13 CN CN201380045559.XA patent/CN104602692B/zh not_active Expired - Fee Related
- 2013-09-13 CA CA2883155A patent/CA2883155A1/en not_active Abandoned
- 2013-09-13 EA EA201590552A patent/EA027984B1/ru not_active IP Right Cessation
- 2013-09-13 MX MX2015003275A patent/MX2015003275A/es unknown
- 2013-09-13 BR BR112015004967A patent/BR112015004967A2/pt active Search and Examination
- 2013-09-13 US US14/396,559 patent/US9216965B2/en not_active Expired - Fee Related
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2015
- 2015-02-09 IL IL237158A patent/IL237158A0/en unknown
- 2015-02-17 PH PH12015500345A patent/PH12015500345A1/en unknown
- 2015-03-12 CL CL2015000615A patent/CL2015000615A1/es unknown
- 2015-03-13 CR CR20150133A patent/CR20150133A/es unknown
- 2015-03-13 DO DO2015000059A patent/DOP2015000059A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN104602692B (zh) | 2017-06-23 |
EA201590552A1 (ru) | 2015-06-30 |
EP2895167A4 (en) | 2016-03-16 |
CA2883155A1 (en) | 2014-03-20 |
EA027984B1 (ru) | 2017-09-29 |
AU2013315387A1 (en) | 2015-02-26 |
EP2895167B1 (en) | 2018-12-05 |
US20150094333A1 (en) | 2015-04-02 |
AU2013315387B2 (en) | 2016-09-08 |
CL2015000615A1 (es) | 2015-08-28 |
IL237158A0 (en) | 2015-04-30 |
JP6258331B2 (ja) | 2018-01-10 |
US9216965B2 (en) | 2015-12-22 |
PH12015500345A1 (en) | 2015-04-20 |
AR092530A1 (es) | 2015-04-22 |
CN104602692A (zh) | 2015-05-06 |
TW201425307A (zh) | 2014-07-01 |
ES2713172T3 (es) | 2019-05-20 |
MX2015003275A (es) | 2015-07-06 |
SG11201500973WA (en) | 2015-04-29 |
JP2015528508A (ja) | 2015-09-28 |
DOP2015000059A (es) | 2015-05-15 |
BR112015004967A2 (pt) | 2020-04-22 |
CR20150133A (es) | 2015-05-04 |
EP2895167A1 (en) | 2015-07-22 |
KR20150053920A (ko) | 2015-05-19 |
WO2014043437A1 (en) | 2014-03-20 |
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