AR092270A1 - Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b - Google Patents

Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b

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Publication number
AR092270A1
AR092270A1 ARP130103057A ARP130103057A AR092270A1 AR 092270 A1 AR092270 A1 AR 092270A1 AR P130103057 A ARP130103057 A AR P130103057A AR P130103057 A ARP130103057 A AR P130103057A AR 092270 A1 AR092270 A1 AR 092270A1
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AR
Argentina
Prior art keywords
alkyl
independently selected
group
ring
cfh2
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Application number
ARP130103057A
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English (en)
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Janssen R&D Ireland
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49085019&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR092270(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Publication of AR092270A1 publication Critical patent/AR092270A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente también se relaciona con procesos para preparar dichos compuestos, composiciones farmacéuticas que los contienen y su uso, solos o en combinación con otros inhibidores del VHB, en una terapia contra el VHB. Reivindicación 1: Un compuesto de fórmula (1), o un estereoisómero o forma tautomérica del mismo, donde: B representa un anillo aromático monocíclico de 5 ó 6 miembros, que contiene opcionalmente uno o más heteroátomos seleccionados en forma independiente entre sí entre el grupo que consiste en O, S y N, donde dicho anillo aromático de 5 ó 6 miembros está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre sí entre el grupo que consiste en hidrógeno, halógeno, alquilo C₁₋₃, CN, CFH₂, CF₂H y CF₃; R¹ representa hidrógeno o C₁₋₃alquilo; R² representa alquilo C₁₋₆, alquenilo C₁₋₆, alquil C₁₋₆-R⁵, C(=O)-R⁵, CFH₂, CF₂H, CF₃, una unidad dihidroindenilo o tetrahidronaftalenilo opcionalmente sustituida con OH, o un anillo saturado de 3 - 7 miembros que contiene opcionalmente uno o más heteroátomos seleccionados en forma independiente entre sí entre el grupo que consiste en O, S y N, donde dicho anillo saturado de 3 - 7 miembros, alquil C₁₋₆-R⁵ o alquilo C₁₋₆ está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre sí entre el grupo que consiste en hidrógeno, halógeno, alquiloxi C₁₋₄, alquiloxi C₁₋₄carbonilo, oxo, C (=O)-alquilo C₁₋₃, alquilo C₁₋₄, OH, CN, CFH₂, CF₂H y CF₃; o R¹ y R² junto con el nitrógeno al cual están unidos forman un anillo bicíclico o en puente de 6 - 10 miembros o un anillo saturado de 5 - 7 miembros, donde dicha unidad bicíclica o en puente o anillo saturado contiene opcionalmente uno o más heteroátomos adicionales seleccionados en forma independiente entre sí entre el grupo que consiste en O, S y N, donde dicho anillo saturado de 5 - 7 miembros está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre sí entre el grupo que consiste en hidrógeno, halógeno, alquiloxi C₁₋₄, alquiloxi C₁₋₄carbonilo, oxo, C (=O)-alquilo C₁₋₃, alquilo C₁₋₄, OH, CN, CFH₂, CF₂H y CF₃; cada R⁴ se selecciona en forma independiente entre hidrógeno, halo, alquiloxi C₁₋₄, alquilo C₁₋₄, alquenilo C₁₋₄, OH, CN, CFH₂, CF₂H, CF₃, HCºC o un anillo saturado de 3 - 5 miembros que contiene opcionalmente uno o más heteroátomos seleccionados en forma independiente entre sí entre el grupo que consiste en O y N, donde dicho alquilo C₁₋₄ está opcionalmente sustituido con OH; R⁵ representa alquilo C₁₋₆, CFH₂, CF₂H, CF₃, fenilo, piridilo o un anillo saturado de 3 - 7 miembros que contiene opcionalmente uno o más heteroátomos seleccionados en forma independiente entre sí entre el grupo que consiste en O, S y N, donde dicho anillo saturado de 3 - 7 miembros está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre sí entre el grupo que consiste en hidrógeno, halógeno, alquiloxi C₁₋₄, alquiloxi C₁₋₄carbonilo, oxo, C(=O)-alquilo C₁₋₃, alquilo C₁₋₄, OH, CN, CFH₂, CF₂H y CF₃; o una sal farmacéuticamente aceptable o un solvato del mismo.
ARP130103057A 2012-08-28 2013-08-28 Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b AR092270A1 (es)

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