AR117189A1 - Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) - Google Patents

Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)

Info

Publication number
AR117189A1
AR117189A1 ARP190103182A ARP190103182A AR117189A1 AR 117189 A1 AR117189 A1 AR 117189A1 AR P190103182 A ARP190103182 A AR P190103182A AR P190103182 A ARP190103182 A AR P190103182A AR 117189 A1 AR117189 A1 AR 117189A1
Authority
AR
Argentina
Prior art keywords
carboxamidas
pirazin
pirazolo
dihidro
hbv
Prior art date
Application number
ARP190103182A
Other languages
English (en)
Inventor
Anita Wegert
Jasper Springer
Susanne Bonsmann
Andreas Urban
Alastair Donald
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of AR117189A1 publication Critical patent/AR117189A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Reivindicación 1: Compuesto de fórmula (1) en la que R¹, R², R³ y R⁴ se seleccionan, para cada posición, independientemente del grupo que comprende H, CF₂H, CF₃, CF₂CH₃, F, Cl, Br, CH₃, Et, i-Pr, c-Pr, D, CH₂OH, CH(CH₃)OH, CH₂F, CH(F)CH₃, I, C=C, C&
ARP190103182A 2018-11-02 2019-10-31 Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) AR117189A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18000878 2018-11-02

Publications (1)

Publication Number Publication Date
AR117189A1 true AR117189A1 (es) 2021-07-21

Family

ID=64426622

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103182A AR117189A1 (es) 2018-11-02 2019-10-31 Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)

Country Status (14)

Country Link
US (1) US20220081444A1 (es)
EP (1) EP3873910A1 (es)
JP (1) JP2022506337A (es)
KR (1) KR20210099563A (es)
CN (1) CN112996791A (es)
AR (1) AR117189A1 (es)
AU (1) AU2019370734A1 (es)
CA (1) CA3118381A1 (es)
EA (1) EA202191223A1 (es)
IL (1) IL282598A (es)
SG (1) SG11202104116VA (es)
TW (1) TW202031659A (es)
UY (1) UY38434A (es)
WO (1) WO2020089455A1 (es)

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WO2023009709A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Pyrazolo piperazines as jak2 inhibitors

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Also Published As

Publication number Publication date
CN112996791A (zh) 2021-06-18
WO2020089455A1 (en) 2020-05-07
SG11202104116VA (en) 2021-05-28
IL282598A (en) 2021-06-30
TW202031659A (zh) 2020-09-01
JP2022506337A (ja) 2022-01-17
EP3873910A1 (en) 2021-09-08
CA3118381A1 (en) 2020-05-07
UY38434A (es) 2020-05-29
US20220081444A1 (en) 2022-03-17
EA202191223A1 (ru) 2021-07-29
KR20210099563A (ko) 2021-08-12
AU2019370734A1 (en) 2021-05-27

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