AR088000A1 - Derivados de pirazolquinolinona, su preparacion y su uso terapeutico - Google Patents

Derivados de pirazolquinolinona, su preparacion y su uso terapeutico

Info

Publication number
AR088000A1
AR088000A1 ARP120103515A ARP120103515A AR088000A1 AR 088000 A1 AR088000 A1 AR 088000A1 AR P120103515 A ARP120103515 A AR P120103515A AR P120103515 A ARP120103515 A AR P120103515A AR 088000 A1 AR088000 A1 AR 088000A1
Authority
AR
Argentina
Prior art keywords
nra
alkyl
aryl
nrarb
heterocycle
Prior art date
Application number
ARP120103515A
Other languages
English (en)
Inventor
Benazet Alexandre
Duclos Olivier
Guillo Nathalie
Lassalle Gilbert
Macary Karim
Vin Valerie
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of AR088000A1 publication Critical patent/AR088000A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/62—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino groups and at least two carboxyl groups bound to carbon atoms of the same six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

Abstract

La presente se refiere a compuestos que corresponden a la fórmula (1), como también a los procedimientos para prepararlos y su uso terapéutico y a medicamentos en base al compuesto. Reivindicación 1: Compuesto que corresponde a la fórmula (1) en la que: R¹ representa: -alquilo C₁₋₄; -haloalquilo C₁₋₄; R² representa: un grupo de fórmula (2); un grupo de fórmula (3); un grupo: -A-X; R³ representa: -H; halógeno; -alquilo C₁₋₆; un grupo ciano; -CO₂H; -CONH₂; A representa: un grupo arilo o heteroarilo; X está ausente o representa: halógeno, un grupo ciano, un grupo oxo, -(CH₂)ₙOH, -haloalquilo C₁₋₆, -alquilo C₁₋₆, -alcoxi C₁₋₆, -(CH₂)ₙ-arilo, -CHOH-arilo, heterociclo, heteroarilo, -alquil C₁₋₆-heterociclo, -alquil C₁₋₆-heteroarilo, -alquil C₁₋₆-COORᵃ, -alquil C₁₋₆-NRᵃRᵇ, -heteroaril-(CH₂)ₙ-NRᵃRᵇ, -(CH₂)ₙ-NRᵃ-C(O)-Rᵇ, -NRᵃRᵇ, -NRᵃ-(CH₂)ₙ-O-Rᵇ, -NRᵃ-heterociclo, -NRᵃ-arilo, -NRᵃ-C(O)-(CH₂)ₙ-NRᵃRᵇ, -NRᵃ-C(O)-arilo, -NRᵃC(O)-alquilo C₁₋₆, -NRᵃ-C(O)-alquil C₁₋₆-arilo, -NRᵃ-C(O)-(CH₂)ₙ-O-Rᵇ, -NRᵃ-SO₂-(CH₂)ₙ-arilo, -NRᵃ-SO₂-(CH₂)ₙ-NRᵃRᵇ, -NRᵃ-SO₂-Rᵇ, -NRᵃ-SO₂-aril-O-arilo, -NRᵃ-SO₂-aril-(CH₂)ₙ-NRᵇ-C(O)-Rᵇ, -COORᵃ, -CONRᵃRᵇ, -C(O)-NRᵃ-(CH₂)ₙ-O-Rᵇ, -C(O)-NRᵃ-aril-C(O)-NRᵃRᵇ, -C(O)-NRᵃ-(CH₂)ₙ-NRᵃRᵇ, -C(O)-NRᵃ-(CH₂)ₙ-heteroarilo, -O-(CH₂)ₙ-NRᵃRᵇ, -O-heterociclo, -CO-heterociclo, -CO-heteroarilo, -SO₂NRᵃRᵇ, -SO₂-heterociclo; Rᵃ y Rᵇ representan, independientemente: -H, -alquilo C₁₋₆; n representa 0, 1, 2 ó 3; en la forma de la base o de una sal de adición de ácidos, y también en la forma de hidrato.
ARP120103515A 2011-09-26 2012-09-25 Derivados de pirazolquinolinona, su preparacion y su uso terapeutico AR088000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11306217.8A EP2573073B1 (en) 2011-09-26 2011-09-26 Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof

Publications (1)

Publication Number Publication Date
AR088000A1 true AR088000A1 (es) 2014-04-30

Family

ID=46880738

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103515A AR088000A1 (es) 2011-09-26 2012-09-25 Derivados de pirazolquinolinona, su preparacion y su uso terapeutico

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EP (2) EP2573073B1 (es)
JP (1) JP6073328B2 (es)
KR (1) KR20140082743A (es)
CN (1) CN103958479B (es)
AR (1) AR088000A1 (es)
AU (1) AU2012314620B2 (es)
BR (1) BR112014007193A2 (es)
CA (1) CA2847921A1 (es)
CY (1) CY1115945T1 (es)
DK (1) DK2573073T3 (es)
ES (2) ES2527188T3 (es)
HK (1) HK1181763A1 (es)
HR (1) HRP20150024T1 (es)
IL (1) IL231386A (es)
MX (1) MX2014003675A (es)
PL (1) PL2573073T3 (es)
PT (1) PT2573073E (es)
RU (1) RU2621037C2 (es)
SG (1) SG11201400403SA (es)
SI (1) SI2573073T1 (es)
TW (1) TWI527815B (es)
UY (1) UY34350A (es)
WO (1) WO2013045400A1 (es)

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JP6042060B2 (ja) * 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
JP2016515541A (ja) 2013-03-25 2016-05-30 サノフイ Ｍｅｔａｐ２阻害剤（２型メチオニンアミノペプチターゼ）としてのピラゾロナフチリジノン誘導体
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JP5666755B1 (ja) * 2013-04-05 2015-02-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 ピラゾロキノリン誘導体の塩およびその結晶
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GB201516616D0 (en) * 2015-09-18 2015-11-04 Redx Pharma Plc Antibacterial compounds
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JP6469272B2 (ja) * 2017-03-01 2019-02-13 科研製薬株式会社 ビアリール誘導体又はその塩からなる医薬
CN108721621B (zh) * 2017-04-14 2022-03-01 中国科学院上海高等研究院 抑制肝纤维化的小分子化合物及应用
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TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
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CN110845478B (zh) * 2019-11-25 2022-07-08 南通大学 含1-取代吡啶基-3-三氟甲基吡唑单元的吡唑甲酰肟衍生物的制备和用途
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Publication number Publication date
TWI527815B (zh) 2016-04-01
EP2573073A1 (en) 2013-03-27
IL231386A0 (en) 2014-04-30
EP2573073B1 (en) 2014-10-22
KR20140082743A (ko) 2014-07-02
CA2847921A1 (en) 2013-04-04
AU2012314620A1 (en) 2014-03-27
IL231386A (en) 2016-04-21
PT2573073E (pt) 2015-02-05
AU2012314620B2 (en) 2017-06-29
SI2573073T1 (sl) 2015-02-27
ES2527188T3 (es) 2015-01-21
HK1181763A1 (en) 2013-11-15
CN103958479A (zh) 2014-07-30
RU2621037C2 (ru) 2017-05-31
TW201313719A (zh) 2013-04-01
UY34350A (es) 2013-04-30
EP2760841A1 (en) 2014-08-06
JP6073328B2 (ja) 2017-02-01
PL2573073T3 (pl) 2015-04-30
SG11201400403SA (en) 2014-08-28
CN103958479B (zh) 2017-06-13
ES2605152T3 (es) 2017-03-13
MX2014003675A (es) 2014-08-21
EP2760841B1 (en) 2016-08-24
BR112014007193A2 (pt) 2017-04-04
DK2573073T3 (en) 2015-01-19
JP2014526545A (ja) 2014-10-06
RU2014117035A (ru) 2015-11-10
WO2013045400A1 (en) 2013-04-04
CY1115945T1 (el) 2017-01-25
HRP20150024T1 (hr) 2015-02-13

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