AR089143A1 - Triazolopiridinas sustituidas con actividad inhibidora de ttk - Google Patents
Triazolopiridinas sustituidas con actividad inhibidora de ttkInfo
- Publication number
- AR089143A1 AR089143A1 ARP120104640A ARP120104640A AR089143A1 AR 089143 A1 AR089143 A1 AR 089143A1 AR P120104640 A ARP120104640 A AR P120104640A AR P120104640 A ARP120104640 A AR P120104640A AR 089143 A1 AR089143 A1 AR 089143A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- compounds
- hydrogen atom
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Métodos para preparar dichos compuestos. Composiciones y combinaciones farmacéuticas que comprenden dichos compuestos. Uso de dichos compuestos para preparar una composición farmacéutica para el tratamiento o la profilaxis de una enfermedad. Compuestos intermediarios útiles para preparar dichos compuestos. Reivindicación 1: Un compuesto de la fórmula general (1) en donde: R¹ representa un resto de fórmula (2) donde * indica el punto de unión de dicho grupo con el resto de la molécula; R² representa un resto de fórmula (3) donde * indica el punto de unión de dicho grupo con el resto de la molécula; R³ representa un átomo de hidrógeno; R⁴ representa un átomo de hidrógeno; R⁵ representa un átomo de hidrógeno o un grupo alquilo C₁₋₃; R⁵ᵃ representa un grupo seleccionado entre: -alcoxi C₁₋₄-, halo-alcoxi C₁₋₄-, alquilo C₁₋₄; R⁵ᵇ representa un grupo seleccionado entre: -C(=O)N(H)R⁸, -C(=O)NR⁸R⁷, -N(R⁷)C(=O)OR⁸, R⁷-S(=O)₂-; R⁶ representa un grupo de fórmula (4); donde * indica el punto de unión de dicho grupo con el resto de la molécula; donde dicho grupo está opcionalmente sustituido, una o más veces, en forma idéntica o diferente, con un átomo de halógeno o un grupo metilo; R⁷ representa un grupo alquilo C₁₋₃ o un ciclopropilo; R⁸ representa un átomo de hidrógeno o un grupo alquilo C₁₋₆ o cicloalquilo C₃₋₆, donde dicho grupo alquilo C₁₋₆ o cicloalquilo C₃₋₆ está opcionalmente sustituido, una o más veces, con un átomo de halógeno; o R⁷ y R⁸ junto con el fragmento molecular al que se unen representan un anillo heterocíclico de entre 4 y 6 miembros, que está opcionalmente sustituido, una o más veces, en forma idéntica o diferente, con un átomo de halógeno, un grupo alquilo C₁₋₃, halo-alquilo C₁₋₃ o alcoxi C₁₋₃; R⁹ representa un grupo seleccionado entre: alquilo C₁₋₃, hidroxi-alquilo C₁₋₃, -N(H)R⁸, -N(R⁷)R⁸, N(H)(R⁸)-alquilo C₁₋₃, N(R⁷)(R⁸)-alquilo C₁₋₃; y Q representa CH o N; o un tautómero, un N-óxido, un hidrato, un solvato o una sal del mismo, o una mezcla de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11193011 | 2011-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089143A1 true AR089143A1 (es) | 2014-07-30 |
Family
ID=47427291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104640A Pending AR089143A1 (es) | 2011-12-12 | 2012-12-11 | Triazolopiridinas sustituidas con actividad inhibidora de ttk |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9663510B2 (es) |
| EP (1) | EP2791136B1 (es) |
| JP (1) | JP6181664B2 (es) |
| KR (1) | KR20140105552A (es) |
| CN (1) | CN104114552B (es) |
| AP (1) | AP4017A (es) |
| AR (1) | AR089143A1 (es) |
| AU (1) | AU2012350751B2 (es) |
| BR (1) | BR112014014184A2 (es) |
| CA (1) | CA2858683A1 (es) |
| CL (1) | CL2014001546A1 (es) |
| CO (1) | CO6980657A2 (es) |
| CR (1) | CR20140275A (es) |
| CU (1) | CU20140068A7 (es) |
| CY (1) | CY1116958T1 (es) |
| DK (1) | DK2791136T3 (es) |
| DO (1) | DOP2014000133A (es) |
| EC (1) | ECSP14004812A (es) |
| ES (1) | ES2550677T3 (es) |
| GT (1) | GT201400111A (es) |
| HK (1) | HK1203200A1 (es) |
| HR (1) | HRP20151103T1 (es) |
| HU (1) | HUE025937T2 (es) |
| IL (1) | IL232930A (es) |
| JO (1) | JO3111B1 (es) |
| MA (1) | MA35826B1 (es) |
| MX (1) | MX2014007057A (es) |
| PE (1) | PE20141597A1 (es) |
| PH (1) | PH12014501319A1 (es) |
| PL (1) | PL2791136T3 (es) |
| PT (1) | PT2791136E (es) |
| RS (1) | RS54288B1 (es) |
| RU (1) | RU2632464C1 (es) |
| SG (1) | SG11201402820SA (es) |
| SI (1) | SI2791136T1 (es) |
| TN (1) | TN2014000254A1 (es) |
| UA (1) | UA112096C2 (es) |
| UY (1) | UY34515A (es) |
| WO (1) | WO2013087579A1 (es) |
| ZA (1) | ZA201404031B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104603136B (zh) * | 2012-07-10 | 2017-06-27 | 拜耳医药股份有限公司 | 制备取代的***并吡啶的方法 |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
| PT3008062T (pt) * | 2013-06-11 | 2017-06-07 | Bayer Pharma AG | Derivados de profármaco de triazolopiridinas substituídas |
| MA38656A1 (fr) * | 2013-06-11 | 2018-05-31 | Bayer Pharma AG | Combinaisons pour le traitement du cancer comprenant un inhibiteur de la kinase mps-1 et un inhibiteur de la mitose |
| EP2860177A3 (en) | 2013-09-20 | 2015-06-10 | Bayer Intellectual Property GmbH | Synthesis of functionalized arenes |
| KR102330668B1 (ko) * | 2014-05-19 | 2021-11-24 | 유디씨 아일랜드 리미티드 | 고효율의 형광 유기 발광 소자 |
| MA41136A (fr) * | 2014-12-09 | 2017-10-17 | Bayer Pharma AG | Composés pour le traitement d'un cancer |
| EP3233127A1 (de) | 2014-12-15 | 2017-10-25 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit aglycosylierten anti-tweakrantikörpern |
| CN105985241A (zh) * | 2015-01-27 | 2016-10-05 | 邵阳学院 | α-取代苯乙酸酯类化合物α-糖苷酶抑制作用及其应用 |
| WO2016207094A1 (de) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-tweakr-antikörpern |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| TW201800408A (zh) | 2016-06-15 | 2018-01-01 | 拜耳製藥公司 | Mps-1抑制劑 |
| JP7022707B2 (ja) | 2016-06-15 | 2022-02-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｋｓｐ阻害剤および抗ｃｄ１２３抗体を含む特異的抗体－薬物－コンジュゲート（ａｄｃ） |
| EP3532474B1 (en) | 2016-10-27 | 2024-03-27 | Bayer AG | 4,5-annulated 1,2,4-triazolones |
| WO2018114578A1 (de) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Binder-wirkstoff-konjugate (adcs) mit enzymatisch spaltbaren gruppen |
| CA3047522A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | Specific antibody drug conjugates (adcs) having ksp inhibitors |
| CN106831555B (zh) * | 2017-01-22 | 2019-09-24 | 中国农业大学 | 吡啶酰胺类化合物及其制备方法与应用 |
| KR20200011060A (ko) | 2018-07-23 | 2020-02-03 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
| WO2020161257A1 (en) | 2019-02-07 | 2020-08-13 | Bayer Aktiengesellschaft | 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors |
| JP7266441B2 (ja) | 2019-02-15 | 2023-04-28 | 三星ディスプレイ株式會社 | 有機発光素子、及びそれを含んだ電子装置 |
| KR20210059153A (ko) | 2019-11-14 | 2021-05-25 | 삼성디스플레이 주식회사 | 유기 발광 소자 및 이를 포함한 장치 |
| WO2023167549A1 (en) * | 2022-03-04 | 2023-09-07 | Sillajen, Inc. | Pharmaceutical combinations for use in the treatment of neoplastic diseases |
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| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| WO2005030121A2 (en) | 2003-06-30 | 2005-04-07 | Hif Bio, Inc. | Compounds, compositions and methods |
| WO2007065010A2 (en) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
| CA2662074A1 (en) | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
| EA201000130A1 (ru) | 2007-07-18 | 2010-08-30 | Новартис Аг | Бициклические гетероарильные соединения и их применение в качестве ингибиторов киназы |
| KR20100057650A (ko) | 2007-08-23 | 2010-05-31 | 아스트라제네카 아베 | 증식성 질환의 치료를 위한 ｔｔｋ／ｍｐｓ１의 억제제로서 ２-아닐리노푸린-８-온 |
| CA2691448A1 (en) | 2007-08-31 | 2009-03-05 | Dominique Swinnen | Triazolopyridine compounds and their use as ask inhibitors |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| EA201000797A1 (ru) | 2007-11-27 | 2011-02-28 | Целльзом Лимитид | Аминотриазолы в качестве ингибиторов pi3k |
| WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| PE20120110A1 (es) | 2009-02-13 | 2012-02-20 | Fovea Pharmaceuticals | [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa |
| CA2760077A1 (en) | 2009-04-29 | 2010-11-04 | Marcus Koppitz | Substituted imidazoquinoxalines |
| WO2011026579A1 (en) | 2009-09-04 | 2011-03-10 | Bayer Schering Pharma Aktiengesellschaft | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
| EP2343294A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
| EP2343295A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| JP2011246389A (ja) * | 2010-05-26 | 2011-12-08 | Oncotherapy Science Ltd | Ｔｔｋ阻害作用を有する縮環ピラゾール誘導体 |
| UY33452A (es) * | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| AU2012244859B2 (en) * | 2011-04-21 | 2017-06-08 | Bayer Intellectual Property Gmbh | Triazolopyridines |
-
2012
- 2012-10-12 UA UAA201407687A patent/UA112096C2/uk unknown
- 2012-12-10 WO PCT/EP2012/074978 patent/WO2013087579A1/en active Application Filing
- 2012-12-10 PL PL12805516T patent/PL2791136T3/pl unknown
- 2012-12-10 HU HUE12805516A patent/HUE025937T2/en unknown
- 2012-12-10 MX MX2014007057A patent/MX2014007057A/es unknown
- 2012-12-10 US US14/362,836 patent/US9663510B2/en active Active
- 2012-12-10 SG SG11201402820SA patent/SG11201402820SA/en unknown
- 2012-12-10 CN CN201280069310.8A patent/CN104114552B/zh not_active Expired - Fee Related
- 2012-12-10 RS RS20150663A patent/RS54288B1/en unknown
- 2012-12-10 EP EP12805516.7A patent/EP2791136B1/en active Active
- 2012-12-10 BR BR112014014184A patent/BR112014014184A2/pt not_active Application Discontinuation
- 2012-12-10 ES ES12805516.7T patent/ES2550677T3/es active Active
- 2012-12-10 JP JP2014546446A patent/JP6181664B2/ja not_active Expired - Fee Related
- 2012-12-10 DK DK12805516.7T patent/DK2791136T3/en active
- 2012-12-10 AP AP2014007731A patent/AP4017A/en active
- 2012-12-10 KR KR1020147019041A patent/KR20140105552A/ko not_active Application Discontinuation
- 2012-12-10 PE PE2014000944A patent/PE20141597A1/es not_active Application Discontinuation
- 2012-12-10 PT PT128055167T patent/PT2791136E/pt unknown
- 2012-12-10 AU AU2012350751A patent/AU2012350751B2/en not_active Ceased
- 2012-12-10 CA CA2858683A patent/CA2858683A1/en not_active Abandoned
- 2012-12-10 RU RU2014128465A patent/RU2632464C1/ru not_active IP Right Cessation
- 2012-12-10 SI SI201230337T patent/SI2791136T1/sl unknown
- 2012-12-11 JO JOP/2012/0375A patent/JO3111B1/ar active
- 2012-12-11 AR ARP120104640A patent/AR089143A1/es active Pending
- 2012-12-12 UY UY0001034515A patent/UY34515A/es not_active Application Discontinuation
-
2014
- 2014-06-02 IL IL232930A patent/IL232930A/en not_active IP Right Cessation
- 2014-06-03 ZA ZA2014/04031A patent/ZA201404031B/en unknown
- 2014-06-10 PH PH12014501319A patent/PH12014501319A1/en unknown
- 2014-06-10 MA MA37115A patent/MA35826B1/fr unknown
- 2014-06-11 TN TNP2014000254A patent/TN2014000254A1/en unknown
- 2014-06-12 CU CU2014000068A patent/CU20140068A7/es unknown
- 2014-06-12 DO DO2014000133A patent/DOP2014000133A/es unknown
- 2014-06-12 CR CR20140275A patent/CR20140275A/es unknown
- 2014-06-12 EC ECIEPI20144812A patent/ECSP14004812A/es unknown
- 2014-06-12 CO CO14127883A patent/CO6980657A2/es unknown
- 2014-06-12 GT GT201400111A patent/GT201400111A/es unknown
- 2014-06-12 CL CL2014001546A patent/CL2014001546A1/es unknown
-
2015
- 2015-04-20 HK HK15103784.7A patent/HK1203200A1/xx not_active IP Right Cessation
- 2015-10-19 HR HRP20151103TT patent/HRP20151103T1/hr unknown
- 2015-10-23 CY CY20151100951T patent/CY1116958T1/el unknown
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