AR032072A1 - Derivados de quinuclidina novedosos y composiciones medicinales que los contienen - Google Patents
Derivados de quinuclidina novedosos y composiciones medicinales que los contienenInfo
- Publication number
- AR032072A1 AR032072A1 ARP010106065A ARP010106065A AR032072A1 AR 032072 A1 AR032072 A1 AR 032072A1 AR P010106065 A ARP010106065 A AR P010106065A AR P010106065 A ARP010106065 A AR P010106065A AR 032072 A1 AR032072 A1 AR 032072A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- straight
- hydrogen
- carbon atoms
- lower alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un compuesto de la formula (1), en donde R es un anillo fenilo, un grupo heteroaromático de 5 a 10 miembros que contiene un grupo benzo[1,3]dioxolilo, o bifenilo, R1, R2 y R3 cada uno independientemente representa un átomo de hidrogeno o halogeno, o un grupo hidroxi, un grupo fenilo, -OR7, -SR7, -NR7R8-, grupo alquilo inferior sustituido o sin sustituir, en donde R7 y R8 cada uno independientemente representa un átomo de hidrogeno, un grupo alquilo inferior recto o ramificado, o conjuntamente forman un anillo alicíclico o R1 y R2 conjuntamente forman un anillo aromático o alicíclico o un grupo heterocíclico; n es un entero de 0 a 4; A representa un grupo seleccionado entre -CH2-, CH=CR9-, CR9=CH-, CR9R10-, -CO-, -O-, -S-, -S(O)2 y -NR9-, en donde R9 y R10 cada uno independientemente representa un átomo de hidrogeno, un grupo alquilo recto o ramificado de alquilo inferior, o conjuntamente forman un anillo alicíclico; m es un entero de 0 a 8, siempre que cuando m = 0, A no es -CH2-; p es un entero de 1 a 2 y la sustitucion del anillo bicíclico de azonia puede ser en la posicion 2, 3 o 4 incluyendo todas las configuraciones posibles de los carbonos asimétricos; R4 representa un grupo de estructura (2) en donde R11 representa un átomo de hidrogeno o halogeno, un grupo hidroxi, un grupo alcoxi, un grupo nitro, un grupo ciano, -CO2R12, o NR12R13, en donde R12 y R13 son idénticos o diferentes y son seleccionados entre hidrogeno y grupos de alquilo inferior recto o ramificado, o un grupo alquilo inferior recto o ramificado, sustituido o no sustituido; R5 representa un grupo alquilo de 1 a 7 átomos de carbono, un grupo alquenilo que contiene 2 a 7 átomos de carbono; un grupo alquinilo que contiene 2 a 7 átomos de carbono, un grupo cicloalquilo de 3 a 7 átomos de carbonos, o un grupo de la formula (3), en donde q = 1 o 2 y R11 es tal como se define anteriormente; R6 representa un átomo de hidrogeno, un grupo hidroxi, un grupo metilo, o un grupo CH2OH. El carbono asimétrico en la posicion alfa con respecto al grupo éster, que es sustituido por R4, R5 y R6 puede tener configuracion R o S; X- representa un anion farmacéuticamente aceptable de un ácido mono o polivalente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200003130 | 2000-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032072A1 true AR032072A1 (es) | 2003-10-22 |
Family
ID=8496180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010106065A AR032072A1 (es) | 2000-12-28 | 2001-12-27 | Derivados de quinuclidina novedosos y composiciones medicinales que los contienen |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US7122558B2 (es) |
| EP (1) | EP1353919B1 (es) |
| JP (1) | JP4295985B2 (es) |
| KR (1) | KR100869721B1 (es) |
| CN (1) | CN1250545C (es) |
| AR (1) | AR032072A1 (es) |
| AT (1) | ATE334128T1 (es) |
| AU (1) | AU2002238471B2 (es) |
| BG (1) | BG66162B1 (es) |
| BR (1) | BR0116624A (es) |
| CA (1) | CA2433128C (es) |
| CY (1) | CY1105719T1 (es) |
| CZ (1) | CZ301209B6 (es) |
| DE (1) | DE60121813T2 (es) |
| DK (1) | DK1353919T3 (es) |
| EC (1) | ECSP034672A (es) |
| EE (1) | EE05404B1 (es) |
| ES (1) | ES2266291T3 (es) |
| HK (1) | HK1055739A1 (es) |
| HU (1) | HUP0303524A3 (es) |
| IL (2) | IL156558A0 (es) |
| MX (1) | MXPA03005862A (es) |
| MY (1) | MY136067A (es) |
| NO (1) | NO328772B1 (es) |
| NZ (1) | NZ526674A (es) |
| PE (1) | PE20020721A1 (es) |
| PL (1) | PL363807A1 (es) |
| PT (1) | PT1353919E (es) |
| RU (1) | RU2282629C2 (es) |
| SI (1) | SI1353919T1 (es) |
| SK (1) | SK287414B6 (es) |
| UA (1) | UA75626C2 (es) |
| WO (1) | WO2002053564A2 (es) |
| ZA (1) | ZA200305008B (es) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| IL156499A0 (en) | 2000-12-22 | 2004-01-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
| JP4295985B2 (ja) * | 2000-12-28 | 2009-07-15 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | 新規なキヌクリジン誘導体およびそれを含む医薬組成物 |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
| ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| BR0215801A (pt) * | 2002-07-08 | 2005-05-10 | Ranbaxy Lab Ltd | Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos |
| EP1545508A4 (en) * | 2002-08-09 | 2009-11-25 | Ranbaxy Lab Ltd | 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS |
| TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| CN100436414C (zh) * | 2003-04-11 | 2008-11-26 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的氮杂双环衍生物 |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| CN100445281C (zh) * | 2003-05-02 | 2008-12-24 | 诺瓦提斯公司 | 与毒蕈碱性m3受体结合的奎宁环衍生物 |
| AR044134A1 (es) | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
| ES2329133T3 (es) | 2003-05-28 | 2009-11-23 | Theravance, Inc. | Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos. |
| WO2005007645A1 (en) | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| ES2239546B1 (es) * | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
| TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| US7598267B2 (en) * | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| MXPA06013849A (es) * | 2004-05-31 | 2007-03-01 | Almirall Lab | Combinaciones que comprenden agentes antimuscarinicos e inhibidores de pde4. |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| EP1797040A1 (en) * | 2004-09-29 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| EP1817034A1 (en) * | 2004-10-25 | 2007-08-15 | Schering Corporation | M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| EP1957530A2 (en) | 2005-10-21 | 2008-08-20 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| DK2013211T3 (da) | 2006-04-21 | 2012-07-02 | Novartis Ag | Purinderivater til anvendelse som adenosin-A2A-receptoragonister |
| ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
| DE602007013441D1 (de) | 2006-09-29 | 2011-05-05 | Novartis Ag | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| DK2104535T3 (da) | 2007-01-10 | 2011-04-04 | Irm Llc | Forbindelser og sammensætninger som kanalaktiverende proteaseinhibitorer |
| EP2119716A4 (en) | 2007-02-09 | 2011-06-01 | Astellas Pharma Inc | AZA BRIDGE CYCLE COMPOUND |
| EP2121688A1 (en) * | 2007-02-15 | 2009-11-25 | Argenta Discovery Ltd | Heterocyclic derivatives as m3 muscarinic receptors |
| CA2685546A1 (en) | 2007-05-07 | 2008-11-13 | Novartis Ag | Organic compounds |
| MX2010002576A (es) | 2007-09-07 | 2010-04-01 | Theravance Inc | Compuestos que contienen guanidina, utiles como antagonistas de los receptores muscarinicos. |
| CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
| NZ585789A (en) | 2007-12-10 | 2012-03-30 | Novartis Ag | Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel |
| JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス， インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
| PL2231642T3 (pl) | 2008-01-11 | 2014-04-30 | Novartis Ag | Pirymidyny jako inhibitory kinazy |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| WO2009138707A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic m3 receptor antagonists |
| GB0808707D0 (en) * | 2008-05-13 | 2008-06-18 | Argenta Discovery Ltd | New compounds 275 |
| GB0808708D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
| MX2010013675A (es) | 2008-06-10 | 2011-02-15 | Novartis Ag | Derivados de pirazina como bloqueadores del canal de sodio epitelial. |
| US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
| GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| WO2010088335A1 (en) | 2009-01-29 | 2010-08-05 | Novartis Ag | Substituted benzimidazoles for the treatment of astrocytomas |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| EP2464649A1 (en) | 2009-08-12 | 2012-06-20 | Novartis AG | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
| NZ598220A (en) | 2009-08-17 | 2014-02-28 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| MX2012002179A (es) | 2009-08-20 | 2012-03-16 | Novartis Ag | Compuestos heterociclicos de oxima. |
| EP2490687A1 (en) | 2009-10-22 | 2012-08-29 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
| JP2014505088A (ja) | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物 |
| US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
| MA34969B1 (fr) | 2011-02-25 | 2014-03-01 | Irm Llc | Composes et compositions en tant qu inibiteurs de trk |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| BR112014006223A8 (pt) | 2011-09-15 | 2018-01-09 | Novartis Ag | 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação |
| EP2755652B1 (en) | 2011-09-16 | 2021-06-02 | Novartis AG | N-substituted heterocyclyl carboxamides |
| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| US9034879B2 (en) | 2011-09-16 | 2015-05-19 | Novartis Ag | Heterocyclic compounds for the treatment of CF |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
| JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン， エルエルシー | Ｍｔｏｒ阻害剤を使用する強化された治療レジメン |
| US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
| MX371119B (es) | 2012-04-03 | 2020-01-17 | Novartis Ag | Productos de combinacion con los inhibidores de cinasa de tirosina y su uso. |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン， エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
| CN105431432B (zh) * | 2013-07-13 | 2018-01-09 | 北京硕佰医药科技有限责任公司 | 奎宁类化合物、其光学异构体及其制备方法和医药用途 |
| TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途 |
| EA032075B1 (ru) | 2014-04-24 | 2019-04-30 | Новартис Аг | Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы |
| ES2761569T3 (es) | 2014-04-24 | 2020-05-20 | Novartis Ag | Derivados aminopiridínicos como inhibidores de fosfatidilinositol 3-cinasas |
| JP6404944B2 (ja) | 2014-04-24 | 2018-10-17 | ノバルティス アーゲー | ホスファチジルイノシトール３−キナーゼ阻害薬としてのピラジン誘導体 |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| JP6526789B2 (ja) | 2014-07-31 | 2019-06-05 | ノバルティス アーゲー | 組み合わせ療法 |
| AU2020290094B2 (en) | 2019-06-10 | 2024-01-18 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF, COPD, and bronchiectasis |
| AR119819A1 (es) | 2019-08-28 | 2022-01-12 | Novartis Ag | Derivados de 1,3-fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4465834A (en) | 1965-09-20 | 1984-08-14 | Fmc Corporation | Anticholinergic drugs |
| GB1219606A (en) | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| US4082756A (en) * | 1971-04-16 | 1978-04-04 | Colgate-Palmolive Company | Quaternary quinuclidinium carbamates and thiocarbamates |
| US4431627A (en) * | 1980-06-03 | 1984-02-14 | Research Corporation | Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same |
| EP0052645B1 (en) * | 1980-06-03 | 1987-05-13 | Research Corporation | Gamma-emitting receptor-binding quinuclidinyl benzilates methods of preparation thereof and imaging and assay methods utilizing same |
| FR2539135B1 (fr) | 1983-01-11 | 1986-02-28 | Essilor Int | Hydrogels de polyurethane et procede de fabrication |
| IL72788A (en) * | 1984-08-28 | 1989-07-31 | Israel State | Bis quaternary oxy-bis methylene(or trimethylene)bis-n-quinuclidines,pyridines and piperidines,their preparation and antidotes against organophosphorus and carbamate poisoning containing them |
| US4644003A (en) * | 1985-04-03 | 1987-02-17 | Research Corporation | 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors |
| US4675326A (en) * | 1985-05-08 | 1987-06-23 | Gabriel Amitai | Bisquaternary antidotes |
| US4843074A (en) | 1988-05-17 | 1989-06-27 | Marion Laboratories, Inc. | 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts |
| IT1230881B (it) * | 1989-06-20 | 1991-11-08 | Angeli Inst Spa | Derivati del r(-) 3-chinuclidinolo |
| DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| GB8923590D0 (en) | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
| ES2161211T3 (es) | 1990-09-06 | 2001-12-01 | Pfizer | Broncodilatadores antimuscarinicos. |
| DE4108393A1 (de) | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
| GB9119705D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic compounds |
| CA2182568A1 (en) | 1994-02-10 | 1995-08-17 | Makoto Takeuchi | Novel carbamate derivative and medicinal composition containing the same |
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| AU7145996A (en) * | 1995-10-13 | 1997-04-30 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
| PE92198A1 (es) | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| US7214687B2 (en) * | 1999-07-14 | 2007-05-08 | Almirall Ag | Quinuclidine derivatives and medicinal compositions containing the same |
| PL201530B1 (pl) | 2000-06-27 | 2009-04-30 | L V A T Lab Sa | Karbaminiany pochodne aryloalkiloamin i zastosowanie karbaminianów pochodnych aryloalkiloamin |
| IL156499A0 (en) * | 2000-12-22 | 2004-01-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
| JP4295985B2 (ja) * | 2000-12-28 | 2009-07-15 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | 新規なキヌクリジン誘導体およびそれを含む医薬組成物 |
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2001
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- 2001-12-20 WO PCT/EP2001/015168 patent/WO2002053564A2/en active IP Right Grant
- 2001-12-20 SK SK799-2003A patent/SK287414B6/sk not_active IP Right Cessation
- 2001-12-20 UA UA2003066042A patent/UA75626C2/uk unknown
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- 2001-12-20 SI SI200130596T patent/SI1353919T1/sl unknown
- 2001-12-20 US US10/250,447 patent/US7122558B2/en not_active Expired - Fee Related
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- 2001-12-20 CN CNB018222420A patent/CN1250545C/zh not_active Expired - Fee Related
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- 2001-12-20 EE EEP200300312A patent/EE05404B1/xx not_active IP Right Cessation
- 2001-12-20 PT PT01986924T patent/PT1353919E/pt unknown
- 2001-12-20 DK DK01986924T patent/DK1353919T3/da active
- 2001-12-20 EP EP01986924A patent/EP1353919B1/en not_active Expired - Lifetime
- 2001-12-20 RU RU2003123120/04A patent/RU2282629C2/ru not_active IP Right Cessation
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- 2001-12-20 BR BR0116624-7A patent/BR0116624A/pt not_active Application Discontinuation
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