BR0215801A - Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos - Google Patents

Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos

Info

Publication number
BR0215801A
BR0215801A BR0215801-9A BR0215801A BR0215801A BR 0215801 A BR0215801 A BR 0215801A BR 0215801 A BR0215801 A BR 0215801A BR 0215801 A BR0215801 A BR 0215801A
Authority
BR
Brazil
Prior art keywords
muscarinic receptor
receptor antagonists
derivatives useful
present
useful
Prior art date
Application number
BR0215801-9A
Other languages
English (en)
Inventor
Anita Mehta
Arundutt Viswanatham Silamkoti
Jang Bahadur Gupta
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR0215801A publication Critical patent/BR0215801A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE 3,6-DISSUBSTITUìDO AZABICICLO [3.1.0] HEXANO úTEIS COMO ANTAGONISTAS DE RECEPTORES MUSCARìNICOS". A presente invenção refere-se a novos derivados 3,6 dissubstituído azabiciclo [3.1.0] hexanos. Os compostos da presente invenção são antagonistas de receptores muscarínicos que são úteis, inter alia, para o tratamento de várias doenças dos sistemas respiratório, urinário e gastrointestinal através de receptores muscarínicos. A invenção também refere-se a composições farmacêuticas contendo os compostos da presente invenção relacionados a métodos de tratamento das doenças mediadas através de receptores muscarínicos.
BR0215801-9A 2002-07-08 2002-07-08 Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos BR0215801A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/002663 WO2004004629A2 (en) 2002-07-08 2002-07-08 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
BR0215801A true BR0215801A (pt) 2005-05-10

Family

ID=30011691

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0215801-9A BR0215801A (pt) 2002-07-08 2002-07-08 Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos
BR0312572-6A BR0312572A (pt) 2002-07-08 2003-04-11 Derivados de azabiciclo como antagonistas de receptores muscarìnicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0312572-6A BR0312572A (pt) 2002-07-08 2003-04-11 Derivados de azabiciclo como antagonistas de receptores muscarìnicos

Country Status (20)

Country Link
US (2) US7399779B2 (pt)
EP (2) EP1546099B1 (pt)
JP (2) JP2006502985A (pt)
CN (2) CN1668585A (pt)
AT (2) ATE419236T1 (pt)
AU (2) AU2002345266B2 (pt)
BR (2) BR0215801A (pt)
CA (2) CA2492121A1 (pt)
CY (1) CY1105879T1 (pt)
DE (2) DE60230683D1 (pt)
DK (1) DK1551803T3 (pt)
EA (3) EA200500173A1 (pt)
ES (1) ES2274275T3 (pt)
HK (2) HK1079783A1 (pt)
MX (2) MXPA05000434A (pt)
NZ (2) NZ537584A (pt)
PT (1) PT1551803E (pt)
SI (1) SI1551803T1 (pt)
WO (2) WO2004004629A2 (pt)
ZA (1) ZA200500951B (pt)

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EA200500172A1 (ru) 2005-08-25
EP1551803A1 (en) 2005-07-13
HK1079783A1 (en) 2006-04-13
EA007932B1 (ru) 2007-02-27
EP1546099A2 (en) 2005-06-29
US7544708B2 (en) 2009-06-09
EP1546099B1 (en) 2008-12-31
PT1551803E (pt) 2007-01-31
EP1551803B8 (en) 2006-12-13
ATE419236T1 (de) 2009-01-15
EP1551803B1 (en) 2006-10-11
ES2274275T3 (es) 2007-05-16
BR0312572A (pt) 2005-05-10
MXPA05000434A (es) 2005-04-19
EA200500173A1 (ru) 2005-08-25
DE60309057T2 (de) 2007-04-12
WO2004004629A2 (en) 2004-01-15
JP2006502985A (ja) 2006-01-26
WO2004005252A1 (en) 2004-01-15
US20060111425A1 (en) 2006-05-25
NZ537585A (en) 2006-07-28
US20070004791A1 (en) 2007-01-04
AU2002345266A1 (en) 2004-01-23
DK1551803T3 (da) 2007-02-19
EA009942B1 (ru) 2008-04-28
AU2003226579B2 (en) 2009-01-22
CN1681784A (zh) 2005-10-12
EP1546099A4 (en) 2006-08-02
ATE342253T1 (de) 2006-11-15
DE60309057D1 (de) 2006-11-23
ZA200500951B (en) 2006-07-26
US7399779B2 (en) 2008-07-15
MXPA05000435A (es) 2005-04-19
CA2492121A1 (en) 2004-01-15
WO2004004629A3 (en) 2004-05-21
CN1668585A (zh) 2005-09-14
EA200501595A1 (ru) 2006-06-30
CN100519526C (zh) 2009-07-29
CY1105879T1 (el) 2011-02-02
JP2005535655A (ja) 2005-11-24
HK1082728A1 (en) 2006-06-16
DE60230683D1 (de) 2009-02-12
CA2491998A1 (en) 2004-01-15
NZ537584A (en) 2006-07-28
AU2003226579A1 (en) 2004-01-23
SI1551803T1 (sl) 2007-02-28
AU2002345266B2 (en) 2009-07-02

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