CO5690593A2 - Nuevos derivados de pirimidin 2-amina - Google Patents

Nuevos derivados de pirimidin 2-amina

Info

Publication number
CO5690593A2
CO5690593A2 CO06032147A CO06032147A CO5690593A2 CO 5690593 A2 CO5690593 A2 CO 5690593A2 CO 06032147 A CO06032147 A CO 06032147A CO 06032147 A CO06032147 A CO 06032147A CO 5690593 A2 CO5690593 A2 CO 5690593A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
group
branched lower
substituted linear
linear
Prior art date
Application number
CO06032147A
Other languages
English (en)
Inventor
Juan Bernat Vidal
Trias Cristina Esteve
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of CO5690593A2 publication Critical patent/CO5690593A2/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

1.- Un compuesto de fórmula (I) en la que R1 representa un grupo arilo o heteroarilo monocíclico o policíclico opcionalmente sustituido con uno, dos o tres sustituyentes seleccionados del grupo constituido por átomos de halógeno, alquilo inferior lineal o ramificado opcionalmente sustituido, hidroxi, alcoxi inferior lineal o ramificado opcionalmente sustituido, -SH, alquiltio inferior lineal o ramificado opcionalmente sustituido, nitro, ciano, NR´R", -CO2R´, -C(O)-NR´R", -N(R"´)C(O)-R´, -N(R"´)C(O)NR´R", representando cada R´, R" y R´" independientemente un átomo de hidrógeno o un grupo alquilo inferior lineal o ramificado opcionalmente sustituido o R´ y R" junto con el átomo al que están unidos forman un grupo cíclico;R2 representa un grupo heteroarilo monocíclico que contiene N seleccionado del grupo de fórmulas (IIa) o (IIb):estando los grupos de fórmula (IIa) y (IIb) opcionalmente sustituidos con uno, dos o tres sustituyentes seleccionados del grupo formado por átomos de halógeno, alquilo inferior opcionalmente sustituido lineal o ramificado, hidroxi, alcoxi inferior opcionalmente sustituido lineal o ramificado, -SH, alquiltio inferior opcionalmente sustituido lineal o ramificado, nitro, ciano, -NR´R", -CO2R´, -C(O)-NR´R", -N(R"´)C(O)-R´, -N(R"´)-C{O)NR´R", en los que cada uno de R´, R"y R´" representa independientemente un átomo de hidrógeno o un grupo alquilo inferior opcionalmente sustituido lineal o ramificado, o R´ y R" junto con el átomo al que están unidos forman un grupo cíclico;R3 representa un grupo heteroarilo monocíclico o policíclico que está opcionalmente sustituido con uno, dos o tres sustítuyentes seleccionados del grupo de halógeno, alquilo inferior lineal o ramificado opcionalmente sustituido, hidroxi, oxo, alcoxi lineal o ramificado opcionalmente sustituido, -SH, alquiltio lineal o ramificado opcionalmente sustituido, nitro, ciano, -NR´R", -CO2R´, -C(O)-NR´R", -N(R"´)C(O)-R´, -N(R´´´)C(O)NR´R", representando cada R´, R" y R´" independientemente un átomo de hidrógeno o un grupo alquilo lineal o ramificado opcionalmente sustituido o R´ y R" junto con el átomo al que están unidos forman un grupo cíclico; o un N-óxido o una sal farmacéuticamente aceptable del mismo.
CO06032147A 2003-10-02 2006-03-31 Nuevos derivados de pirimidin 2-amina CO5690593A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200302275A ES2229928B1 (es) 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina.

Publications (1)

Publication Number Publication Date
CO5690593A2 true CO5690593A2 (es) 2006-10-31

Family

ID=34507890

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06032147A CO5690593A2 (es) 2003-10-02 2006-03-31 Nuevos derivados de pirimidin 2-amina

Country Status (24)

Country Link
US (1) US20070265273A1 (es)
EP (1) EP1668000A1 (es)
JP (1) JP2007507443A (es)
KR (1) KR20060097010A (es)
CN (1) CN1886402A (es)
AR (1) AR046170A1 (es)
AU (1) AU2004283800B8 (es)
BR (1) BRPI0415324A (es)
CA (1) CA2540765A1 (es)
CO (1) CO5690593A2 (es)
EC (1) ECSP066426A (es)
ES (1) ES2229928B1 (es)
IL (1) IL174771A0 (es)
MX (1) MXPA06003525A (es)
NO (1) NO20061952L (es)
NZ (1) NZ546266A (es)
PE (1) PE20050473A1 (es)
RU (1) RU2006114746A (es)
SG (1) SG149077A1 (es)
TW (1) TW200526645A (es)
UA (1) UA82563C2 (es)
UY (1) UY28529A1 (es)
WO (1) WO2005040155A1 (es)
ZA (1) ZA200602139B (es)

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KR20070063548A (ko) 2004-10-15 2007-06-19 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ｂ 아데노신 수용체 길항제를 사용하는, 기도 개형 및폐 염증의 예방 및 치료 방법
ES2270715B1 (es) * 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ES2274712B1 (es) * 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
DE102006046410A1 (de) * 2006-09-20 2008-03-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten
ES2303776B1 (es) * 2006-12-29 2009-08-07 Laboratorios Almirall S.A. Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
MX2009013262A (es) * 2007-06-08 2010-01-25 Bayer Cropscience Sa Derivados de heterociclil-pirimidinil-amino fungicidas.
ES2394126T3 (es) * 2007-07-26 2013-01-22 Novartis Ag Derivados de pirimidina útiles para el tratamiento de estados inflamatorios o alérgicos
EA017392B1 (ru) * 2007-08-22 2012-12-28 Айрм Ллк Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ
KR101218926B1 (ko) 2007-08-22 2013-01-04 아이알엠 엘엘씨 키나제 억제제로서의 5-(4-(할로알콕시)페닐)피리미딘-2-아민 화합물 및 조성물
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
AR079545A1 (es) 2009-12-21 2012-02-01 Bayer Cropscience Ag Tienilpiri(mi)dinilazol
JP2014500308A (ja) 2010-12-21 2014-01-09 ノバルティス アーゲー Ｖｐｓ３４阻害剤としてのビヘテロアリール化合物
CN111825698B (zh) 2019-07-30 2021-10-15 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂
CN112028891B (zh) 2019-07-30 2022-07-05 厦门宝太生物科技股份有限公司 腺苷受体拮抗剂
CN115477653B (zh) * 2022-10-11 2024-04-09 安徽省庆云医药股份有限公司 一种曲拉西利关键中间体及曲拉西利的制备方法

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Also Published As

Publication number Publication date
IL174771A0 (en) 2006-08-20
BRPI0415324A (pt) 2006-12-05
JP2007507443A (ja) 2007-03-29
KR20060097010A (ko) 2006-09-13
EP1668000A1 (en) 2006-06-14
ZA200602139B (en) 2007-06-27
UY28529A1 (es) 2005-04-29
NO20061952L (no) 2006-06-26
NZ546266A (en) 2008-10-31
ES2229928B1 (es) 2006-07-01
RU2006114746A (ru) 2007-11-20
SG149077A1 (en) 2009-01-29
CA2540765A1 (en) 2005-05-06
AU2004283800A1 (en) 2005-05-06
UA82563C2 (uk) 2008-04-25
TW200526645A (en) 2005-08-16
US20070265273A1 (en) 2007-11-15
WO2005040155A1 (en) 2005-05-06
AU2004283800B8 (en) 2009-06-18
MXPA06003525A (es) 2006-06-08
CN1886402A (zh) 2006-12-27
ES2229928A1 (es) 2005-04-16
AU2004283800B2 (en) 2009-05-07
ECSP066426A (es) 2006-10-17
PE20050473A1 (es) 2005-08-24
AR046170A1 (es) 2005-11-30
WO2005040155A8 (en) 2006-04-20

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