ZA200503841B - Combination administration of an indolinone with achemotherapeutic agent for cell proliferation dis orders - Google Patents

Combination administration of an indolinone with achemotherapeutic agent for cell proliferation dis orders Download PDF

Info

Publication number: ZA200503841B
Authority: ZA; South Africa
Prior art keywords: inhibitors; group; compound; cancer; chemotherapeutic agent
Prior art date: 2002-11-15

Application number

ZA200503841A

Other languages

English (en)

Inventor

Tinya Abrams

Nancy Pryer

Lesley Murray

Julie M Cherrington

Original Assignee

Sugen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-15

Filing date

2005-05-12

Publication date

2006-09-27

2005-05-12 Application filed by Sugen Inc filed Critical Sugen Inc

2006-09-27 Publication of ZA200503841B publication Critical patent/ZA200503841B/en

Links

JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title description 6
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125000000217 alkyl group Chemical group 0.000 claims description 86
239000000203 mixture Substances 0.000 claims description 78
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 62
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VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 6
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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

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Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200503841A 2002-11-15 2005-05-12 Combination administration of an indolinone with achemotherapeutic agent for cell proliferation dis orders ZA200503841B (en)

Applications Claiming Priority (1)

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US42638602P	2002-11-15	2002-11-15

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US (1)	US20040152759A1 (fr)
EP (1)	EP1562600A4 (fr)
JP (1)	JP2006508981A (fr)
KR (1)	KR20050086594A (fr)
CN (2)	CN100430060C (fr)
AR (1)	AR042042A1 (fr)
AU (1)	AU2003290943A1 (fr)
BR (1)	BR0315630A (fr)
CA (1)	CA2506308A1 (fr)
CO (1)	CO5700778A2 (fr)
GT (1)	GT200300245A (fr)
MX (1)	MXPA05005150A (fr)
NL (1)	NL1024779C2 (fr)
NO (1)	NO20052578L (fr)
PA (1)	PA8588601A1 (fr)
PE (1)	PE20040835A1 (fr)
PL (1)	PL376954A1 (fr)
RU (1)	RU2342140C2 (fr)
TW (1)	TW200418837A (fr)
UY (1)	UY28081A1 (fr)
WO (1)	WO2004045523A2 (fr)
ZA (1)	ZA200503841B (fr)

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DE60134679D1 (de) *	2000-10-20	2008-08-14	Eisai R&D Man Co Ltd	Stickstoff enthaltende aromatische Heterozyklen
US7994159B2 (en) *	2003-03-10	2011-08-09	Eisai R&D Management Co., Ltd.	c-Kit kinase inhibitor
JP4303726B2 (ja)	2003-11-11	2009-07-29	エーザイ・アール・アンド・ディー・マネジメント株式会社	ウレア誘導体およびその製造方法
CA2578336C (fr) *	2004-07-09	2013-09-24	Prolx Pharmaceuticals Corp.	Analogues de wortmannin et methodes d'utilisation de ceux-ci en combinaison avec des agents chimiotherapeutiques
US8969379B2 (en)	2004-09-17	2015-03-03	Eisai R&D Management Co., Ltd.	Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
US20090117197A1 (en) *	2005-03-21	2009-05-07	Vicus Therapeutics Llc	Compositions and methods for ameliorating cachexia
NZ561138A (en) *	2005-03-23	2009-06-26	Pfizer Prod Inc	Anti-CTLA4 antibody and indolinone combination therapy for treatment of cancer
US20080193448A1 (en) *	2005-05-12	2008-08-14	Pfizer Inc.	Combinations and Methods of Using an Indolinone Compound
JP5066446B2 (ja) *	2005-08-01	2012-11-07	エーザイ・アール・アンド・ディー・マネジメント株式会社	血管新生阻害物質の効果を予測する方法
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2003
- 2003-11-13 AR ARP030104194A patent/AR042042A1/es unknown
- 2003-11-14 TW TW092132030A patent/TW200418837A/zh unknown
- 2003-11-14 PA PA20038588601A patent/PA8588601A1/es unknown
- 2003-11-14 US US10/712,296 patent/US20040152759A1/en not_active Abandoned
- 2003-11-14 CN CNB200380103225XA patent/CN100430060C/zh not_active Expired - Fee Related
- 2003-11-14 WO PCT/US2003/036526 patent/WO2004045523A2/fr active Application Filing
- 2003-11-14 NL NL1024779A patent/NL1024779C2/nl not_active IP Right Cessation
- 2003-11-14 KR KR1020057008541A patent/KR20050086594A/ko not_active Application Discontinuation
- 2003-11-14 CA CA002506308A patent/CA2506308A1/fr not_active Abandoned
- 2003-11-14 MX MXPA05005150A patent/MXPA05005150A/es unknown
- 2003-11-14 GT GT200300245A patent/GT200300245A/es unknown
- 2003-11-14 PL PL376954A patent/PL376954A1/pl not_active Application Discontinuation
- 2003-11-14 PE PE2003001154A patent/PE20040835A1/es not_active Application Discontinuation
- 2003-11-14 RU RU2005118417/14A patent/RU2342140C2/ru not_active IP Right Cessation
- 2003-11-14 BR BR0315630-3A patent/BR0315630A/pt not_active IP Right Cessation
- 2003-11-14 AU AU2003290943A patent/AU2003290943A1/en not_active Abandoned
- 2003-11-14 CN CNA2008100814220A patent/CN101259131A/zh active Pending
- 2003-11-14 UY UY28081A patent/UY28081A1/es not_active Application Discontinuation
- 2003-11-14 EP EP03783527A patent/EP1562600A4/fr not_active Withdrawn
- 2003-11-14 JP JP2004553729A patent/JP2006508981A/ja not_active Withdrawn
2005
- 2005-05-11 CO CO05045078A patent/CO5700778A2/es not_active Application Discontinuation
- 2005-05-12 ZA ZA200503841A patent/ZA200503841B/en unknown
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Also Published As

Publication number	Publication date
NO20052578L (no)	2005-05-27
EP1562600A2 (fr)	2005-08-17
CO5700778A2 (es)	2006-11-30
RU2342140C2 (ru)	2008-12-27
GT200300245A (es)	2004-06-23
RU2005118417A (ru)	2006-01-20
MXPA05005150A (es)	2005-07-22
AU2003290943A1 (en)	2004-06-15
JP2006508981A (ja)	2006-03-16
TW200418837A (en)	2004-10-01
PA8588601A1 (es)	2004-05-21
NL1024779A1 (nl)	2004-05-18
CN1711089A (zh)	2005-12-21
WO2004045523A2 (fr)	2004-06-03
BR0315630A (pt)	2005-08-23
PL376954A1 (pl)	2006-01-09
AR042042A1 (es)	2005-06-08
CN100430060C (zh)	2008-11-05
PE20040835A1 (es)	2004-11-18
NL1024779C2 (nl)	2004-11-09
US20040152759A1 (en)	2004-08-05
KR20050086594A (ko)	2005-08-30
CA2506308A1 (fr)	2004-06-03
CN101259131A (zh)	2008-09-10
WO2004045523A3 (fr)	2004-09-30
UY28081A1 (es)	2004-06-30
EP1562600A4 (fr)	2008-06-25

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