UA75880C2 - Indazole compounds as antiproliferative agents, a pharmaceutical composition (variants) and a method for treatment of diseases and disorders (variants) associated wiyh unwanted angiogenesis and/or cellular proliferation - Google Patents

Indazole compounds as antiproliferative agents, a pharmaceutical composition (variants) and a method for treatment of diseases and disorders (variants) associated wiyh unwanted angiogenesis and/or cellular proliferation Download PDF

Info

Publication number: UA75880C2
Authority: UA; Ukraine
Prior art keywords: ring atoms; compound; nitrogen heteroatoms; substituted; carbocycle
Prior art date: 2000-01-18

Application number

UA2002086633A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Agouron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2001-01-18

Publication date

2006-06-15

2001-01-18 Application filed by Agouron Pharma filed Critical Agouron Pharma

2006-06-15 Publication of UA75880C2 publication Critical patent/UA75880C2/uk

Links

238000000034 method Methods 0.000 title claims abstract description 181
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239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 23
230000033115 angiogenesis Effects 0.000 title claims abstract description 18
125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title abstract description 3
230000001028 anti-proliverative effect Effects 0.000 title description 6
208000037765 diseases and disorders Diseases 0.000 title 1
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 73
150000003839 salts Chemical class 0.000 claims description 68
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 31
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229940124597 therapeutic agent Drugs 0.000 description 1
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
- B22D41/00—Casting melt-holding vessels, e.g. ladles, tundishes, cups or the like
- B22D41/50—Pouring-nozzles
- B22D41/56—Means for supporting, manipulating or changing a pouring-nozzle
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

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Chemical & Material Sciences (AREA)
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Engineering & Computer Science (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Mechanical Engineering (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

UA2002086633A 2000-01-18 2001-01-18 Indazole compounds as antiproliferative agents, a pharmaceutical composition (variants) and a method for treatment of diseases and disorders (variants) associated wiyh unwanted angiogenesis and/or cellular proliferation UA75880C2 (en)

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US17648400P	2000-01-18	2000-01-18
PCT/US2001/001477 WO2001053268A2 (en)	2000-01-18	2001-01-18	Indazole compounds, pharmaceutical compositions, and their use for mediating or inhibiting cell proliferation

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US (4)	US6555539B2 (et)
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JP (1)	JP2003520273A (et)
KR (1)	KR20020073505A (et)
CN (1)	CN1394205A (et)
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AR (1)	AR032438A1 (et)
AU (1)	AU785013B2 (et)
BG (1)	BG107011A (et)
BR (1)	BR0107783A (et)
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CO (1)	CO5280070A1 (et)
CR (1)	CR6630A (et)
DO (1)	DOP2001000120A (et)
DZ (1)	DZ3301A1 (et)
EA (1)	EA200200768A1 (et)
EE (1)	EE200200398A (et)
GE (1)	GEP20043363B (et)
GT (1)	GT200100009A (et)
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HR (1)	HRP20020675A2 (et)
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IS (1)	IS6474A (et)
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Publication number	Publication date
AP2002002564A0 (en)	2002-06-30
BR0107783A (pt)	2002-11-19
US20050239855A1 (en)	2005-10-27
YU54202A (sh)	2006-01-16
WO2001053268B1 (en)	2002-01-24
CA2388885A1 (en)	2001-07-26
EP1250326A2 (en)	2002-10-23
US20020161022A1 (en)	2002-10-31
GEP20043363B (en)	2004-05-10
WO2001053268A2 (en)	2001-07-26
HUP0203965A3 (en)	2003-07-28
AU2953901A (en)	2001-07-31
US6919461B2 (en)	2005-07-19
US7232912B2 (en)	2007-06-19
PA8509901A1 (es)	2002-08-26
HRP20020675A2 (en)	2004-12-31
IL150730A0 (en)	2003-02-12
GT200100009A (es)	2002-03-14
EA200200768A1 (ru)	2003-02-27
CO5280070A1 (es)	2003-05-30
US6555539B2 (en)	2003-04-29
DZ3301A1 (fr)	2001-07-26
JP2003520273A (ja)	2003-07-02
AR032438A1 (es)	2003-11-12
NO20022117L (no)	2002-09-16
CR6630A (es)	2004-01-29
KR20020073505A (ko)	2002-09-26
HUP0203965A2 (en)	2003-05-28
HN2001000007A (es)	2001-06-13
MY136604A (en)	2008-10-31
MXPA02007058A (es)	2003-01-28
MA27589A1 (fr)	2005-11-01
SV2002000293A (es)	2002-12-02
US20030139463A1 (en)	2003-07-24
PE20011334A1 (es)	2002-01-14
US20060111322A1 (en)	2006-05-25
CN1394205A (zh)	2003-01-29
WO2001053268A3 (en)	2001-12-27
NZ518531A (en)	2004-09-24
EE200200398A (et)	2003-10-15
IS6474A (is)	2002-07-16
PL357590A1 (en)	2004-07-26
OA12160A (en)	2006-05-08
SK10052002A3 (sk)	2003-03-04
ZA200203040B (en)	2003-08-11
AU785013B2 (en)	2006-08-24
AP1609A (en)	2006-05-08
BG107011A (bg)	2003-04-30
DOP2001000120A (es)	2002-04-15
NO20022117D0 (no)	2002-05-03

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