UA66810C2 - Похідні 4-амінотіазолу та композиції на їх основі як інгібітори циклінозалежних кіназ - Google Patents
Похідні 4-амінотіазолу та композиції на їх основі як інгібітори циклінозалежних кіназInfo
- Publication number
- UA66810C2 UA66810C2 UA2000042107A UA00042107A UA66810C2 UA 66810 C2 UA66810 C2 UA 66810C2 UA 2000042107 A UA2000042107 A UA 2000042107A UA 00042107 A UA00042107 A UA 00042107A UA 66810 C2 UA66810 C2 UA 66810C2
- Authority
- UA
- Ukraine
- Prior art keywords
- fused
- carbocyclic
- monocyclic
- heterocyclic
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Винахід стосується сполук формули І, , (I) де R1 - це заміщена або незаміщена група, вибрана із: С1-6алкілу, С1-6алкенілу; С1-6алкінілу; С1-6алкоксилу; С1-6алкоголю, карбоциклічного або гетероциклічного циклоалкілу, що може бути моноциклічним або конденсованим чи неконденсованим поліциклічним, карбоциклічного або гетероциклічного, моноциклічного або конденсованого чи неконденсованого поліциклічного арилу, карбонілу; ефіру; (С1-6алкілу)-карбонілу; (С1-6алкілу)-арилу; (С1-6алкілу)-циклоалкілу; (С1-6алкілу)-(С1-6алкоксилу); арил-(С1-6алкоксилу); тіоефіру; тіолу та сульфонілу; причому за умови заміщення R1, кожний замісник - це незалежно галоген, галоалкіл, С1-6алкіл, С1-6алкеніл; С1-6алкініл; гідроксил, С1-6алкоксил; аміногрупа; нітрогрупа; тіол; тіоефір, імін, ціаногрупа, амідогрупа, фосфонатогрупа, фосфін, карбоксил, тіокарбоніл, сульфоніл, сульфонамід, кетон, альдегід, естер, кисень; карбоциклічний або гетероциклічний циклоалкіл, що може бути моноциклічним або конденсованим чи неконденсованим поліциклічним, карбоциклічний або гетероциклічний, моноциклічний або конденсований чи неконденсований поліциклічний арил; та R2 - є карбоциклічною або гетероциклічною, моноциклічною або конденсованою чи неконденсованою поліциклічною кільцевою структурою, яка має замісник в позиції, суміжній пункту з'єднання, яка потім при необхідності може замістити кільцеву структуру, причому кожний замісник R2 - це незалежно галоген; галоалкіл; С1-6алкіл, С1-6алкеніл; С1-6алкініл; гідроксил, С1-6алкоксил; аміногрупа; нітрогрупа; тіол; тіоефір, імін, ціаногрупа, амідогрупа, фосфонатогрупа, фосфін, карбоксил, тіокарбоніл, сульфоніл, сульфонамід, кетон, альдегід або естер; кисень, карбоциклічний або гетероциклічний циклоалкіл, що може бути моноциклічним або конденсованим чи неконденсованим поліциклічним, карбоциклічний або гетероциклічний, моноциклічний або конденсований чи неконденсований поліциклічний арил; або фармацевтично прийнятної солі сполуки формули І; або пропрепарату або фармацевтично активного метаболіту сполуки формули І або її фармацевтично прийнятної солі, для інгібування циклінозалежних кіназ (ЦЗК), наприклад, ЦЗК1, ЦЗК2, ЦЗКЗ, ЦЗК4 та ЦЗК6. Крім того, винахід спрямований на терапевтичне або профілактичне застосування фармацевтичних композицій, які містять такі сполуки, та на створення способів боротьби із злоякісними утвореннями та іншими порушеннями шляхом призначення ефективної кількості таких сполук.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6363497P | 1997-10-27 | 1997-10-27 | |
US6366697P | 1997-10-28 | 1997-10-28 | |
PCT/US1998/022809 WO1999021845A2 (en) | 1997-10-27 | 1998-10-27 | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
UA66810C2 true UA66810C2 (uk) | 2004-06-15 |
Family
ID=26743609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2000042107A UA66810C2 (uk) | 1997-10-27 | 1998-10-27 | Похідні 4-амінотіазолу та композиції на їх основі як інгібітори циклінозалежних кіназ |
Country Status (34)
Country | Link |
---|---|
US (2) | US6569878B1 (uk) |
EP (1) | EP1056732B1 (uk) |
JP (1) | JP2004500304A (uk) |
KR (1) | KR20010082501A (uk) |
CN (1) | CN1158269C (uk) |
AP (1) | AP1445A (uk) |
AT (2) | ATE332896T1 (uk) |
AU (1) | AU738792B2 (uk) |
BG (1) | BG64195B1 (uk) |
BR (1) | BR9815200A (uk) |
CA (1) | CA2306082A1 (uk) |
DE (2) | DE69835241T2 (uk) |
EA (1) | EA003527B1 (uk) |
EE (1) | EE200000289A (uk) |
ES (2) | ES2267873T3 (uk) |
GE (1) | GEP20032896B (uk) |
HR (1) | HRP20000222A2 (uk) |
HU (1) | HUP0004512A3 (uk) |
ID (1) | ID24372A (uk) |
IL (1) | IL135574A0 (uk) |
IS (1) | IS5462A (uk) |
LT (1) | LT4855B (uk) |
LV (1) | LV12592B (uk) |
NO (1) | NO20001955L (uk) |
NZ (1) | NZ503788A (uk) |
OA (1) | OA11352A (uk) |
PL (1) | PL342447A1 (uk) |
RO (1) | RO119463B1 (uk) |
SI (1) | SI20324A (uk) |
SK (1) | SK5212000A3 (uk) |
TR (1) | TR200001081T2 (uk) |
UA (1) | UA66810C2 (uk) |
WO (1) | WO1999021845A2 (uk) |
YU (1) | YU22400A (uk) |
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