BR0210874A - Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso - Google Patents

Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso

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Publication number
BR0210874A
BR0210874A BRPI0210874-7A BR0210874A BR0210874A BR 0210874 A BR0210874 A BR 0210874A BR 0210874 A BR0210874 A BR 0210874A BR 0210874 A BR0210874 A BR 0210874A
Authority
BR
Brazil
Prior art keywords
cell proliferation
methods
pharmaceutical compositions
thiazole
benzamide derivatives
Prior art date
Application number
BRPI0210874-7A
Other languages
English (en)
Inventor
Shao Song Chu
Larry Andrew Alegria
Ted Michael Bleckman
Wesley K M Chong
Rohit K Duvadie
Lin Li
Siegfried H Reich
William H Romines
Michael B Wallace
Yi Yang
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of BR0210874A publication Critical patent/BR0210874A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07—ORGANIC CHEMISTRY
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Rheumatology (AREA)
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Abstract

"DERIVADOS DE TIAZOL-BENZAMIDA E COMPOSIçõES FARMACêUTICAS PARA A INIBIçãO DA PROLIFERAçãO CELULAR E MéTODOS PARA O SEU USO". A presente invenção refere-se a compostos de aminotiazol com benzamida mono-/dissubstituída que são representados pela Fórmula (I), seus sais farmaceuticamente aceitáveis, pró-drogas farmaceuticamente aceitáveis, metabólitos farmaceuticamente ativos e sais farmaceuticamente aceitáveis dos referidos metabólitos. Estes agentes modulam e/ou inibem a proliferação celular e a atividade de proteína-quinases e são úteis como agentes farmacêuticos para o tratamento de malignidades e outras distúrbios.
BRPI0210874-7A 2001-07-06 2002-07-05 Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso BR0210874A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30367901P 2001-07-06 2001-07-06
US30527401P 2001-07-13 2001-07-13
PCT/US2002/021280 WO2003004467A2 (en) 2001-07-06 2002-07-05 Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Publications (1)

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BR0210874A true BR0210874A (pt) 2006-10-24

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BRPI0210874-7A BR0210874A (pt) 2001-07-06 2002-07-05 Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso

Country Status (13)

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US (1) US6720346B2 (pt)
EP (1) EP1438046A4 (pt)
JP (1) JP2005521631A (pt)
AU (1) AU2002354801A1 (pt)
BR (1) BR0210874A (pt)
CA (1) CA2452609A1 (pt)
HN (1) HN2002000156A (pt)
MX (1) MXPA04000069A (pt)
PA (1) PA8550101A1 (pt)
PE (1) PE20030269A1 (pt)
SV (1) SV2003001148A (pt)
UY (1) UY27370A1 (pt)
WO (1) WO2003004467A2 (pt)

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