TW200504062A - Novel pyridopyrazines and the use thereof as kinase inhibitors - Google Patents
Novel pyridopyrazines and the use thereof as kinase inhibitorsInfo
- Publication number
- TW200504062A TW200504062A TW093114323A TW93114323A TW200504062A TW 200504062 A TW200504062 A TW 200504062A TW 093114323 A TW093114323 A TW 093114323A TW 93114323 A TW93114323 A TW 93114323A TW 200504062 A TW200504062 A TW 200504062A
- Authority
- TW
- Taiwan
- Prior art keywords
- kinase inhibitors
- novel
- pyridopyrazines
- novel pyridopyrazines
- medicaments
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10323345A DE10323345A1 (de) | 2003-05-23 | 2003-05-23 | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200504062A true TW200504062A (en) | 2005-02-01 |
Family
ID=33441206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093114323A TW200504062A (en) | 2003-05-23 | 2004-05-20 | Novel pyridopyrazines and the use thereof as kinase inhibitors |
Country Status (17)
Country | Link |
---|---|
US (3) | US7323468B2 (zh) |
EP (1) | EP1628976A1 (zh) |
JP (1) | JP2007500195A (zh) |
KR (1) | KR20060015283A (zh) |
CN (2) | CN1795195B (zh) |
AR (1) | AR045685A1 (zh) |
AU (1) | AU2004240746B2 (zh) |
BR (1) | BRPI0410632A (zh) |
CA (1) | CA2524948A1 (zh) |
DE (1) | DE10323345A1 (zh) |
MX (1) | MXPA05012592A (zh) |
NO (1) | NO20056030L (zh) |
RS (2) | RS51906B (zh) |
RU (1) | RU2005140378A (zh) |
TW (1) | TW200504062A (zh) |
WO (1) | WO2004104002A1 (zh) |
ZA (2) | ZA200508872B (zh) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10323345A1 (de) * | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
DE102004022383A1 (de) * | 2004-05-06 | 2005-12-01 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
MXPA05012645A (es) * | 2003-05-23 | 2006-02-08 | Zentaris Gmbh | Piridopirazinas novedosas y su uso como moduladores de cinasa. |
US20100132790A1 (en) * | 2005-05-09 | 2010-06-03 | Solaris Nanosciences, Inc. | Rechargeable Dye Sensitized Solar Cell |
CN101356173B (zh) * | 2005-11-11 | 2012-10-31 | 阿特纳赞塔里斯有限公司 | 新的吡啶并吡嗪和它们作为激酶调节剂的用途 |
EP1790342A1 (de) * | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
WO2007054556A1 (de) | 2005-11-11 | 2007-05-18 | Æterna Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
EP1785423A1 (de) * | 2005-11-11 | 2007-05-16 | Zentaris GmbH | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
EP1990342A1 (en) | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EP2508184A1 (en) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazine derivatives and their use |
WO2012167423A1 (en) * | 2011-06-08 | 2012-12-13 | Hutchison Medipharma Limited | Substituted pyridopyrazines as novel syk inhibitors |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
HUE053654T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR- és CMET-inhibitorok kombinációi a rák kezelésére |
JP6980385B2 (ja) | 2014-03-26 | 2021-12-15 | アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited | Fgfr阻害剤とigf1r阻害剤の組合せ |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
MX2018003564A (es) | 2015-09-23 | 2018-06-18 | Janssen Pharmaceutica Nv | 1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer. |
EP3353177B1 (en) | 2015-09-23 | 2020-06-03 | Janssen Pharmaceutica NV | Tricyclic heterocycles for the treatment of cancer |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5053394A (zh) | 1973-09-20 | 1975-05-12 | ||
GB9413975D0 (en) | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
TW274550B (zh) * | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
UA71555C2 (en) * | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
KR20040048411A (ko) * | 2001-09-14 | 2004-06-09 | 메틸진, 인크. | 히스톤 데아세틸라아제의 억제제 |
US20060142178A1 (en) | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
JP4394960B2 (ja) | 2002-04-08 | 2010-01-06 | メルク エンド カムパニー インコーポレーテッド | Akt活性阻害薬 |
WO2003086403A1 (en) | 2002-04-08 | 2003-10-23 | Merck & Co., Inc. | Inhibitors of akt activity |
WO2004005472A2 (en) | 2002-07-02 | 2004-01-15 | Southern Research Institute | Inhibitors of ftsz and uses thereof |
US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
KR20050056227A (ko) | 2002-10-03 | 2005-06-14 | 탈자진 인코포레이티드 | 혈관항상성 유지제 및 그의 사용 방법 |
US7199119B2 (en) * | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
DE10323345A1 (de) | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
CN1826341A (zh) | 2003-07-18 | 2006-08-30 | 巴斯福股份公司 | 芳基稠合的3-芳基吡啶化合物及其在防治病原性真菌中的用途 |
WO2005056825A1 (en) | 2003-12-05 | 2005-06-23 | Board Of Regents, The University Of Texas System | Screening for modulators of mekk2 and mekk3 |
JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
DE102004017932A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
CN101018783B (zh) | 2004-04-30 | 2012-11-21 | 遗传技术研究公司 | Hedgehog信号传导途径的喹喔啉抑制剂 |
GB0413955D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
GB0413953D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
TW200621251A (en) | 2004-10-12 | 2006-07-01 | Neurogen Corp | Substituted biaryl quinolin-4-ylamine analogues |
US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
JP2006137723A (ja) | 2004-11-15 | 2006-06-01 | Kyowa Hakko Kogyo Co Ltd | スルホンアミド誘導体 |
EP1824828A2 (en) | 2004-12-03 | 2007-08-29 | Peakdale Molecular Limited | Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products |
WO2006073938A2 (en) | 2004-12-30 | 2006-07-13 | East Carolina University | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds |
JP2008526997A (ja) | 2005-01-14 | 2008-07-24 | ニューロジェン・コーポレーション | ヘテロアリール置換キノリン−4−イルアミン類縁体 |
JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528598A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528613A (ja) | 2005-01-25 | 2008-07-31 | ニューロジェン・コーポレーション | 置換ピリダジニル−及びピリミジニル−キノリン−4−イルアミン類縁体 |
EP1846416A4 (en) | 2005-01-25 | 2009-07-01 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
JP2008528588A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
WO2006128172A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating b cell regulated autoimmune disorders |
WO2006128129A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating cancer |
-
2003
- 2003-05-23 DE DE10323345A patent/DE10323345A1/de not_active Withdrawn
-
2004
- 2004-05-19 JP JP2006529871A patent/JP2007500195A/ja not_active Withdrawn
- 2004-05-19 RS YU20050876A patent/RS51906B/sr unknown
- 2004-05-19 RS YUP-2005/0864A patent/RS20050864A/sr unknown
- 2004-05-19 EP EP04733782A patent/EP1628976A1/de not_active Withdrawn
- 2004-05-19 BR BRPI0410632-6A patent/BRPI0410632A/pt not_active IP Right Cessation
- 2004-05-19 CN CN2004800142149A patent/CN1795195B/zh not_active Expired - Fee Related
- 2004-05-19 CN CNA2004800142045A patent/CN1795194A/zh active Pending
- 2004-05-19 AU AU2004240746A patent/AU2004240746B2/en not_active Ceased
- 2004-05-19 CA CA002524948A patent/CA2524948A1/en not_active Abandoned
- 2004-05-19 KR KR1020057022237A patent/KR20060015283A/ko not_active Application Discontinuation
- 2004-05-19 MX MXPA05012592A patent/MXPA05012592A/es active IP Right Grant
- 2004-05-19 WO PCT/EP2004/005379 patent/WO2004104002A1/de not_active Application Discontinuation
- 2004-05-19 RU RU2005140378/04A patent/RU2005140378A/ru not_active Application Discontinuation
- 2004-05-20 TW TW093114323A patent/TW200504062A/zh unknown
- 2004-05-21 AR ARP040101771A patent/AR045685A1/es not_active Application Discontinuation
- 2004-05-21 US US10/851,966 patent/US7323468B2/en not_active Expired - Fee Related
-
2005
- 2005-02-11 ZA ZA200508872A patent/ZA200508872B/en unknown
- 2005-10-25 ZA ZA200508633A patent/ZA200508633B/en unknown
- 2005-12-19 NO NO20056030A patent/NO20056030L/no unknown
-
2007
- 2007-07-05 US US11/825,200 patent/US8193186B2/en not_active Expired - Fee Related
- 2007-11-12 US US11/985,031 patent/US20080113991A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2004240746B2 (en) | 2007-05-31 |
US20080113991A1 (en) | 2008-05-15 |
DE10323345A1 (de) | 2004-12-16 |
BRPI0410632A (pt) | 2006-06-13 |
WO2004104002A1 (de) | 2004-12-02 |
AU2004240746A1 (en) | 2004-12-02 |
US8193186B2 (en) | 2012-06-05 |
US20050032803A1 (en) | 2005-02-10 |
RU2005140378A (ru) | 2007-06-27 |
CA2524948A1 (en) | 2004-12-02 |
RS51906B (sr) | 2012-02-29 |
CN1795195B (zh) | 2010-04-21 |
NO20056030L (no) | 2006-02-15 |
ZA200508633B (en) | 2006-07-26 |
MXPA05012592A (es) | 2006-02-08 |
CN1795195A (zh) | 2006-06-28 |
ZA200508872B (en) | 2006-07-26 |
AR045685A1 (es) | 2005-11-09 |
RS20050864A (en) | 2008-04-04 |
CN1795194A (zh) | 2006-06-28 |
RS20050876A (en) | 2008-04-04 |
US20070275972A1 (en) | 2007-11-29 |
US7323468B2 (en) | 2008-01-29 |
EP1628976A1 (de) | 2006-03-01 |
JP2007500195A (ja) | 2007-01-11 |
KR20060015283A (ko) | 2006-02-16 |
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