RS51906B - Novi piridopirazini i njihova upotreba kao modulatora kinaza - Google Patents

Novi piridopirazini i njihova upotreba kao modulatora kinaza

Info

Publication number
RS51906B
RS51906B YU20050876A YUP87605A RS51906B RS 51906 B RS51906 B RS 51906B YU 20050876 A YU20050876 A YU 20050876A YU P87605 A YUP87605 A YU P87605A RS 51906 B RS51906 B RS 51906B
Authority
RS
Serbia
Prior art keywords
alkyl
aryl
heteroaryl
cycloalkyl
heterocyclyl
Prior art date
Application number
YU20050876A
Other languages
English (en)
Inventor
Eckhard GĂśNTHER
Eckhard Claus
Irene Seipelt
Ulf-R. Rapp
Ludmilla Wixler
Original Assignee
Zentaris Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh. filed Critical Zentaris Gmbh.
Priority claimed from PCT/EP2004/005388 external-priority patent/WO2004104003A1/de
Publication of RS20050876A publication Critical patent/RS20050876A/sr
Publication of RS51906B publication Critical patent/RS51906B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
YU20050876A 2003-05-23 2004-05-19 Novi piridopirazini i njihova upotreba kao modulatora kinaza RS51906B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10323345A DE10323345A1 (de) 2003-05-23 2003-05-23 Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
PCT/EP2004/005388 WO2004104003A1 (de) 2003-05-23 2004-05-19 Neue pyridopyrazine und deren verwendung als modulatoren von kinasen

Publications (2)

Publication Number Publication Date
RS20050876A RS20050876A (en) 2008-04-04
RS51906B true RS51906B (sr) 2012-02-29

Family

ID=33441206

Family Applications (2)

Application Number Title Priority Date Filing Date
YU20050876A RS51906B (sr) 2003-05-23 2004-05-19 Novi piridopirazini i njihova upotreba kao modulatora kinaza
YUP-2005/0864A RS20050864A (en) 2003-05-23 2004-05-19 Novel pyridopyrazines and use thereof as kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
YUP-2005/0864A RS20050864A (en) 2003-05-23 2004-05-19 Novel pyridopyrazines and use thereof as kinase inhibitors

Country Status (17)

Country Link
US (3) US7323468B2 (sr)
EP (1) EP1628976A1 (sr)
JP (1) JP2007500195A (sr)
KR (1) KR20060015283A (sr)
CN (2) CN1795195B (sr)
AR (1) AR045685A1 (sr)
AU (1) AU2004240746B2 (sr)
BR (1) BRPI0410632A (sr)
CA (1) CA2524948A1 (sr)
DE (1) DE10323345A1 (sr)
MX (1) MXPA05012592A (sr)
NO (1) NO20056030L (sr)
RS (2) RS51906B (sr)
RU (1) RU2005140378A (sr)
TW (1) TW200504062A (sr)
WO (1) WO2004104002A1 (sr)
ZA (2) ZA200508872B (sr)

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AU2004240747B2 (en) * 2003-05-23 2008-01-03 Zentaris Gmbh Novel pyridopyrazines and use thereof as kinase modulators
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US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
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EP1790342A1 (de) * 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
EP1990342A1 (en) * 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
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EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
WO2012167423A1 (en) * 2011-06-08 2012-12-13 Hutchison Medipharma Limited Substituted pyridopyrazines as novel syk inhibitors
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
MA39784B1 (fr) 2014-03-26 2021-03-31 Astex Therapeutics Ltd Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer
RU2715893C2 (ru) 2014-03-26 2020-03-04 Астекс Терапьютикс Лтд Комбинации ингибитора fgfr и ингибитора igf1r
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
HRP20220012T1 (hr) 2015-09-23 2022-04-01 Janssen Pharmaceutica Nv Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka
MX2018003563A (es) 2015-09-23 2018-06-18 Janssen Pharmaceutica Nv Nuevos compuestos.

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Also Published As

Publication number Publication date
WO2004104002A1 (de) 2004-12-02
CA2524948A1 (en) 2004-12-02
US20050032803A1 (en) 2005-02-10
AR045685A1 (es) 2005-11-09
ZA200508633B (en) 2006-07-26
US7323468B2 (en) 2008-01-29
AU2004240746B2 (en) 2007-05-31
RU2005140378A (ru) 2007-06-27
JP2007500195A (ja) 2007-01-11
US8193186B2 (en) 2012-06-05
US20080113991A1 (en) 2008-05-15
AU2004240746A1 (en) 2004-12-02
RS20050864A (en) 2008-04-04
CN1795195B (zh) 2010-04-21
DE10323345A1 (de) 2004-12-16
EP1628976A1 (de) 2006-03-01
BRPI0410632A (pt) 2006-06-13
CN1795195A (zh) 2006-06-28
US20070275972A1 (en) 2007-11-29
ZA200508872B (en) 2006-07-26
NO20056030L (no) 2006-02-15
RS20050876A (en) 2008-04-04
MXPA05012592A (es) 2006-02-08
TW200504062A (en) 2005-02-01
CN1795194A (zh) 2006-06-28
KR20060015283A (ko) 2006-02-16

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