PL377795A1 - Pirymidyny będące inhibitorami Chk, Pdk i Akt, sposób ich wytwarzania oraz ich zastosowanie jako środków farmaceutycznych - Google Patents
Pirymidyny będące inhibitorami Chk, Pdk i Akt, sposób ich wytwarzania oraz ich zastosowanie jako środków farmaceutycznychInfo
- Publication number
- PL377795A1 PL377795A1 PL377795A PL37779503A PL377795A1 PL 377795 A1 PL377795 A1 PL 377795A1 PL 377795 A PL377795 A PL 377795A PL 37779503 A PL37779503 A PL 37779503A PL 377795 A1 PL377795 A1 PL 377795A1
- Authority
- PL
- Poland
- Prior art keywords
- pdk
- chk
- akt
- production
- pharmaceutical agents
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02026607 | 2002-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL377795A1 true PL377795A1 (pl) | 2006-02-20 |
Family
ID=32338009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL377795A PL377795A1 (pl) | 2002-11-28 | 2003-11-28 | Pirymidyny będące inhibitorami Chk, Pdk i Akt, sposób ich wytwarzania oraz ich zastosowanie jako środków farmaceutycznych |
Country Status (20)
Country | Link |
---|---|
US (1) | US7504410B2 (pl) |
EP (1) | EP1565446A1 (pl) |
JP (1) | JP2006508997A (pl) |
KR (1) | KR20050084027A (pl) |
CN (1) | CN1717396A (pl) |
AU (1) | AU2003288198A1 (pl) |
BR (1) | BR0316680A (pl) |
CA (1) | CA2502970A1 (pl) |
EA (1) | EA200500721A1 (pl) |
EC (1) | ECSP055899A (pl) |
HR (1) | HRP20050601A2 (pl) |
IL (1) | IL168102A0 (pl) |
IS (1) | IS7881A (pl) |
MX (1) | MXPA05005547A (pl) |
NO (1) | NO20053144D0 (pl) |
NZ (1) | NZ539823A (pl) |
PL (1) | PL377795A1 (pl) |
RS (1) | RS20050363A (pl) |
WO (1) | WO2004048343A1 (pl) |
ZA (1) | ZA200505184B (pl) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL367130A1 (pl) * | 2001-05-29 | 2005-02-21 | Schering Aktiengesellschaft | Pirymidynowe inhibitory CDK, sposób ich wytwarzania i ich zastosowanie jako leki |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
ES2445208T3 (es) | 2002-07-29 | 2014-02-28 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
US7157455B2 (en) | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
CA2523852A1 (en) * | 2003-04-28 | 2004-11-11 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
KR101201603B1 (ko) | 2003-07-30 | 2012-11-14 | 리겔 파마슈티칼스, 인크. | 자가면역 질환의 치료 또는 예방에 사용하기 위한2,4-피리미딘디아민 화합물 |
US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
CA2541460A1 (en) * | 2003-10-24 | 2005-05-06 | Schering Aktiengesellschaft | Indolinone derivatives and their use in treating disease-states such as cancer |
US7531548B2 (en) * | 2004-09-30 | 2009-05-12 | Tibotec Pharmaceuticals Ltd | HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines |
EP1814878B1 (en) | 2004-11-24 | 2012-01-04 | Rigel Pharmaceuticals, Inc. | Spiro-2, 4-pyrimidinediamine compounds and their uses |
US20060142572A1 (en) * | 2004-12-14 | 2006-06-29 | Gabriel Martinez-Botella | Inhibitors of ERK protein kinase and uses thereof |
US8716299B2 (en) * | 2004-12-20 | 2014-05-06 | University Of South Florida | XIAP-targeted prostate cancer therapy |
US7652041B2 (en) | 2005-01-14 | 2010-01-26 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity |
ATE451381T1 (de) | 2005-01-19 | 2009-12-15 | Rigel Pharmaceuticals Inc | Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
SI1869020T1 (sl) | 2005-03-29 | 2011-02-28 | Icos Corp | Derivati heteroaril uree, ki so uporabni za inhibicijo chk1 |
JP5118029B2 (ja) * | 2005-06-14 | 2013-01-16 | タイゲン バイオテクノロジー カンパニー,リミテッド | ピリミジン化合物 |
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ES2445208T3 (es) * | 2002-07-29 | 2014-02-28 | Rigel Pharmaceuticals, Inc. | Compuestos de 2,4-pirimidindiamina para uso en métodos para tratar o prevenir enfermedades autoinmunitarias |
CN100554245C (zh) * | 2002-08-09 | 2009-10-28 | 詹森药业有限公司 | 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法 |
-
2003
- 2003-11-28 MX MXPA05005547A patent/MXPA05005547A/es not_active Application Discontinuation
- 2003-11-28 CN CNA2003801045442A patent/CN1717396A/zh active Pending
- 2003-11-28 US US10/722,591 patent/US7504410B2/en not_active Expired - Fee Related
- 2003-11-28 KR KR1020057009682A patent/KR20050084027A/ko not_active Application Discontinuation
- 2003-11-28 RS YUP-2005/0363A patent/RS20050363A/sr unknown
- 2003-11-28 NZ NZ539823A patent/NZ539823A/en unknown
- 2003-11-28 EP EP03780086A patent/EP1565446A1/en not_active Withdrawn
- 2003-11-28 BR BR0316680-5A patent/BR0316680A/pt not_active IP Right Cessation
- 2003-11-28 EA EA200500721A patent/EA200500721A1/ru unknown
- 2003-11-28 WO PCT/EP2003/013443 patent/WO2004048343A1/en active Application Filing
- 2003-11-28 PL PL377795A patent/PL377795A1/pl not_active Application Discontinuation
- 2003-11-28 JP JP2004554522A patent/JP2006508997A/ja active Pending
- 2003-11-28 CA CA002502970A patent/CA2502970A1/en not_active Abandoned
- 2003-11-28 AU AU2003288198A patent/AU2003288198A1/en not_active Abandoned
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2005
- 2005-04-17 IL IL168102A patent/IL168102A0/en unknown
- 2005-06-02 IS IS7881A patent/IS7881A/is unknown
- 2005-06-27 NO NO20053144A patent/NO20053144D0/no not_active Application Discontinuation
- 2005-06-27 ZA ZA200505184A patent/ZA200505184B/en unknown
- 2005-06-28 EC EC2005005899A patent/ECSP055899A/es unknown
- 2005-06-28 HR HR20050601A patent/HRP20050601A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20053144L (no) | 2005-06-27 |
HRP20050601A2 (en) | 2005-10-31 |
CA2502970A1 (en) | 2004-06-10 |
EA200500721A1 (ru) | 2005-12-29 |
EP1565446A1 (en) | 2005-08-24 |
ECSP055899A (es) | 2005-11-22 |
JP2006508997A (ja) | 2006-03-16 |
NZ539823A (en) | 2008-04-30 |
US7504410B2 (en) | 2009-03-17 |
IS7881A (is) | 2005-06-02 |
IL168102A0 (en) | 2009-02-11 |
CN1717396A (zh) | 2006-01-04 |
AU2003288198A1 (en) | 2004-06-18 |
ZA200505184B (en) | 2006-09-27 |
NO20053144D0 (no) | 2005-06-27 |
BR0316680A (pt) | 2005-10-18 |
MXPA05005547A (es) | 2005-07-26 |
KR20050084027A (ko) | 2005-08-26 |
WO2004048343A1 (en) | 2004-06-10 |
RS20050363A (en) | 2007-11-15 |
US20040186118A1 (en) | 2004-09-23 |
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