PL394604A1 - Pochodna winyloazacykloalkanowa, jej zastosowanie oraz kompozycja farmaceutyczna - Google Patents

Pochodna winyloazacykloalkanowa, jej zastosowanie oraz kompozycja farmaceutyczna

Info

Publication number
PL394604A1
PL394604A1 PL394604A PL39460404A PL394604A1 PL 394604 A1 PL394604 A1 PL 394604A1 PL 394604 A PL394604 A PL 394604A PL 39460404 A PL39460404 A PL 39460404A PL 394604 A1 PL394604 A1 PL 394604A1
Authority
PL
Poland
Prior art keywords
vinylazocycloalkanyl
derivative
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
PL394604A
Other languages
English (en)
Other versions
PL215059B1 (pl
Inventor
Jeffrey Daniel Schmitt
Gary Maurice Dull
Arielle Genevois-Borella
Marc Capet
Michel Cheve
Craig Harrison Miller
Original Assignee
Targacept Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc. filed Critical Targacept Inc.
Publication of PL394604A1 publication Critical patent/PL394604A1/pl
Publication of PL215059B1 publication Critical patent/PL215059B1/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
PL394604A 2003-03-05 2004-03-04 Pochodna winyloazacykloalkanowa, jej zastosowanie oraz kompozycja farmaceutyczna PL215059B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/379,868 US7098331B2 (en) 2003-03-05 2003-03-05 Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Publications (2)

Publication Number Publication Date
PL394604A1 true PL394604A1 (pl) 2011-07-18
PL215059B1 PL215059B1 (pl) 2013-10-31

Family

ID=32926772

Family Applications (5)

Application Number Title Priority Date Filing Date
PL378415A PL216979B1 (pl) 2003-03-05 2004-03-04 Pochodna arylowinyloazacykloalkanowa, jej zastosowanie i sposób wytwarzania
PL394604A PL215059B1 (pl) 2003-03-05 2004-03-04 Pochodna winyloazacykloalkanowa, jej zastosowanie oraz kompozycja farmaceutyczna
PL09075124T PL2085395T3 (pl) 2003-03-05 2004-03-04 Związki arylowinyloazacykloalkanowe oraz sposoby ich wytwarzania i zastosowania
PL04717398T PL1601670T3 (pl) 2003-03-05 2004-03-04 Związki arylowinyloazacykloalkanowe oraz sposoby ich wytwarzania i zastosowania
PL394600A PL394600A1 (pl) 2003-03-05 2004-03-04 Związek winyloazacykloalkanowy, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL378415A PL216979B1 (pl) 2003-03-05 2004-03-04 Pochodna arylowinyloazacykloalkanowa, jej zastosowanie i sposób wytwarzania

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL09075124T PL2085395T3 (pl) 2003-03-05 2004-03-04 Związki arylowinyloazacykloalkanowe oraz sposoby ich wytwarzania i zastosowania
PL04717398T PL1601670T3 (pl) 2003-03-05 2004-03-04 Związki arylowinyloazacykloalkanowe oraz sposoby ich wytwarzania i zastosowania
PL394600A PL394600A1 (pl) 2003-03-05 2004-03-04 Związek winyloazacykloalkanowy, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna

Country Status (32)

Country Link
US (8) US7098331B2 (pl)
EP (3) EP2085395B1 (pl)
JP (3) JP4663627B2 (pl)
KR (4) KR101185541B1 (pl)
CN (3) CN101255155A (pl)
AR (3) AR043469A1 (pl)
AT (3) ATE517893T1 (pl)
AU (3) AU2004217903B2 (pl)
BR (1) BRPI0409576A (pl)
CA (1) CA2516514C (pl)
CL (1) CL2004000452A1 (pl)
CY (2) CY1110391T1 (pl)
DE (2) DE602004031165D1 (pl)
DK (2) DK2085395T3 (pl)
EA (3) EA014714B1 (pl)
ES (3) ES2389106T3 (pl)
GT (1) GT200400033A (pl)
HK (3) HK1084949A1 (pl)
IL (3) IL170155A (pl)
JO (1) JO2488B1 (pl)
MX (1) MXPA05009386A (pl)
NO (3) NO331920B1 (pl)
NZ (1) NZ541795A (pl)
PA (1) PA8597201A1 (pl)
PE (1) PE20040930A1 (pl)
PL (5) PL216979B1 (pl)
PT (2) PT1601670E (pl)
SI (2) SI1601670T1 (pl)
TW (3) TW200927746A (pl)
UY (1) UY28218A1 (pl)
WO (1) WO2004078752A1 (pl)
ZA (1) ZA200506790B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
FR2896800B1 (fr) * 2006-01-30 2008-04-11 Servier Lab Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2008157365A2 (en) * 2007-06-15 2008-12-24 Targacept, Inc. Vinylazacycloalkanes for treating neuropathic pain
EP2296640A1 (en) * 2008-05-12 2011-03-23 Targacept Inc. Methods for preventing the development of retinopathy by the oral administration of nnr ligands
ES2820857T3 (es) * 2008-12-01 2021-04-22 Oyster Point Pharma Inc Síntesis y formas de sal novedosas de (R)-5-((E)-2-pirrolidin-3-ilvinil)pirimidina
TW201024283A (en) * 2008-12-01 2010-07-01 Targacept Inc Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
WO2010080757A2 (en) 2009-01-07 2010-07-15 Astrazeneca Ab Combinations with an alpha-4beta-2 nicotinic agonist
WO2010147938A2 (en) * 2009-06-17 2010-12-23 Targacept, Inc. Reversal of l-dopa-induced dyskinesia by neuronal nicotinic receptor ligands
KR20120120190A (ko) 2009-12-07 2012-11-01 타가셉트 인코포레이티드 신경원성 니코틴 아세틸콜린 수용체 리간드인 ３，６?디아자비시클로［３．１．１］헵탄
US20130237550A1 (en) * 2010-03-11 2013-09-12 Targacept, Inc. Arylvinylazacycloalkane compounds for constipation
US20110274628A1 (en) * 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
US20140081714A1 (en) * 2012-09-19 2014-03-20 Salesforce.Com, Inc. Systems and methods of rewarding users in an on-demand system
US20140278929A1 (en) * 2013-03-15 2014-09-18 Yahoo! Inc. System and method identifying opportunities for advertising entities based on user goal achievement
KR102512777B1 (ko) 2016-04-07 2023-03-23 오이스터 포인트 파마 인코포레이티드 안구 장애의 치료 방법
KR101848601B1 (ko) * 2016-07-27 2018-04-12 송기봉 일회용 위생 티슈
CN112638364A (zh) 2018-07-10 2021-04-09 奥伊斯特普安生物制药公司 用于治疗眼部病症的正向别构调节剂和烟碱型乙酰胆碱受体激动剂的组合
TW202019424A (zh) 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 治療眼部症狀之方法
TW202206078A (zh) 2020-04-28 2022-02-16 美商奧伊斯特普安生物製藥公司 局部投與菸鹼乙醯膽鹼受體促效劑用以抑制冠狀病毒感染

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989000158A1 (en) 1987-07-02 1989-01-12 Pfizer Inc. Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4922901A (en) 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
US5187166A (en) 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
IL107184A (en) 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
IT1274018B (it) 1994-02-23 1997-07-14 Riace Ets Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
GB2295387A (en) 1994-11-23 1996-05-29 Glaxo Inc Quinazoline antagonists of alpha 1c adrenergic receptors
US5604231A (en) 1995-01-06 1997-02-18 Smith; Carr J. Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5597919A (en) 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en) 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en) 1995-06-07 2006-10-05 Abbott Lab Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5616716A (en) 1996-01-06 1997-04-01 Dull; Gary M. (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US5663356A (en) 1996-04-23 1997-09-02 Ruecroft; Graham Method for preparation of aryl substituted alefinic secondary amino compounds
US5629325A (en) 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
US6437138B1 (en) 1996-06-06 2002-08-20 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
RU2205179C2 (ru) 1997-10-27 2003-05-27 НьюроСёрч А/С Производное гомопиперазина и фармацевтическая композиция
EP1185514A1 (en) 1999-06-07 2002-03-13 Targacept, Inc. Pharmaceutical compositions and methods for use
JP2003529547A (ja) 1999-09-14 2003-10-07 アボット・ラボラトリーズ 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物
WO2001032264A1 (en) 1999-11-01 2001-05-10 Targacept, Inc. Aryl olefinic azacyclic, and aryl acetylenic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors
US6624167B1 (en) * 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
WO2003008559A2 (en) 2001-07-19 2003-01-30 Medical College Of Georgia Research Institute Novel analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders
US7098331B2 (en) * 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof

Also Published As

Publication number Publication date
TWI377204B (en) 2012-11-21
ATE496046T1 (de) 2011-02-15
AU2008258187B2 (en) 2010-08-05
PE20040930A1 (es) 2005-02-18
NO20092231L (no) 2005-10-03
US20100267776A1 (en) 2010-10-21
PL216979B1 (pl) 2014-06-30
BRPI0409576A (pt) 2006-04-18
NZ541795A (en) 2008-03-28
NO331920B1 (no) 2012-04-30
AR070569A2 (es) 2010-04-21
CY1110391T1 (el) 2015-04-29
JO2488B1 (en) 2009-10-05
KR20090021227A (ko) 2009-02-27
AU2004217903B2 (en) 2010-03-04
US7098331B2 (en) 2006-08-29
US8063068B2 (en) 2011-11-22
CN101550132B (zh) 2012-03-28
NO20054120L (no) 2005-10-03
CN1756754A (zh) 2006-04-05
DE602004031165D1 (de) 2011-03-03
TWI339662B (en) 2011-04-01
EP1947100A1 (en) 2008-07-23
CY1111615T1 (el) 2015-10-07
ES2309507T3 (es) 2008-12-16
US20080293778A1 (en) 2008-11-27
JP5537084B2 (ja) 2014-07-02
SI2085395T1 (sl) 2011-05-31
KR20120014236A (ko) 2012-02-16
JP5537085B2 (ja) 2014-07-02
US20140107164A1 (en) 2014-04-17
KR101018083B1 (ko) 2011-03-02
ES2385941T3 (es) 2012-08-03
PL215059B1 (pl) 2013-10-31
MXPA05009386A (es) 2005-11-04
AU2004217903A1 (en) 2004-09-16
AU2008258188B2 (en) 2011-02-24
PL378415A1 (pl) 2006-04-03
CL2004000452A1 (es) 2005-05-20
IL170155A (en) 2013-08-29
US8633222B2 (en) 2014-01-21
IL197890A (en) 2013-11-28
US20040176348A1 (en) 2004-09-09
KR20090021228A (ko) 2009-02-27
DK2085395T3 (da) 2011-04-18
EP2085395A1 (en) 2009-08-05
KR101185541B1 (ko) 2012-09-24
EA014714B1 (ru) 2011-02-28
AR070570A2 (es) 2010-04-21
JP4663627B2 (ja) 2011-04-06
US8067443B2 (en) 2011-11-29
GT200400033A (es) 2005-05-29
NO20091888L (no) 2005-10-03
PT2085395E (pt) 2011-04-20
CN101550132A (zh) 2009-10-07
ES2389106T3 (es) 2012-10-23
CA2516514C (en) 2012-02-07
DK1601670T3 (da) 2008-08-25
EA019240B1 (ru) 2014-02-28
EA200900706A1 (ru) 2009-10-30
WO2004078752A1 (en) 2004-09-16
PA8597201A1 (es) 2004-09-28
EA010870B1 (ru) 2008-12-30
DE602004013553D1 (de) 2008-06-19
HK1130254A1 (en) 2009-12-24
KR100953150B1 (ko) 2010-04-19
PL394600A1 (pl) 2011-07-18
ATE394394T1 (de) 2008-05-15
PT1601670E (pt) 2008-07-11
US20110152293A1 (en) 2011-06-23
CN100526308C (zh) 2009-08-12
ZA200506790B (en) 2006-05-31
US7714001B2 (en) 2010-05-11
TW200927745A (en) 2009-07-01
ATE517893T1 (de) 2011-08-15
UY28218A1 (es) 2005-06-30
TW200927746A (en) 2009-07-01
CA2516514A1 (en) 2004-09-16
AU2008258188A1 (en) 2009-01-15
EA200501425A1 (ru) 2006-02-24
KR20060006006A (ko) 2006-01-18
HK1116800A1 (en) 2009-01-02
EP1601670A1 (en) 2005-12-07
CN101255155A (zh) 2008-09-03
PL1601670T3 (pl) 2008-10-31
JP2010001296A (ja) 2010-01-07
AR043469A1 (es) 2005-07-27
EP1947100B1 (en) 2011-07-27
AU2008258187A1 (en) 2009-01-15
EP1601670B1 (en) 2008-05-07
US20150164894A1 (en) 2015-06-18
EA200801764A1 (ru) 2008-12-30
US20060094732A1 (en) 2006-05-04
NO332293B1 (no) 2012-08-20
TW200505909A (en) 2005-02-16
JP2009292825A (ja) 2009-12-17
SI1601670T1 (sl) 2008-10-31
US20100010042A1 (en) 2010-01-14
HK1084949A1 (en) 2006-08-11
NO20054120D0 (no) 2005-09-05
JP2006519868A (ja) 2006-08-31
IL197889A (en) 2013-03-24
PL2085395T3 (pl) 2011-05-31
EP2085395B1 (en) 2011-01-19

Similar Documents

Publication Publication Date Title
IL176005A0 (en) 2,6-bisheteroaryl-4-aminopyrimidine derivatives and pharmaceutical compositions containing the same
IL173602A0 (en) Heteroarylaminosulfonylphenyl derivatives and pharmaceutical compositions containing the same
IL173627A0 (en) 2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives and pharmaceutical compositions containing the same
IL174479A (en) The derivatives of myastrin, pharmaceutical preparations containing them and their uses
IL173051A0 (en) N-glucoside derivatives and pharmaceutical compositions containing the same
IL225206A (en) A derivative of multinuclear carbamoylpyridone, its pharmaceutical composition and its use
IL171997A0 (en) Pyrrolodihydroisoquinoline derivatives and pharmaceutical compositions containing the same
IL175214A0 (en) 2-cyanopyrrolidinecarboxamide derivatives and pharmaceutical compositions containing the same
HK1167332A1 (en) Pharmaceutical composition, use thereof and method for making the same
IL170758A0 (en) 7-amino-isoindolyl compounds and their pharmaceutical uses
HK1084883A1 (en) 2-cyanopyrrolopyrimidines and pharmaceutical uses thereof
IL172159A0 (en) 2-oxo-pyridine derivatives and pharmaceutical compositions containing the same
EP1731524A4 (en) PHENOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVE, AND ITS MEDICINAL USE
IL177168A0 (en) N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same
IL221323A0 (en) 1-methyl-1h- pyridin-2-one- phenanthridine derivatives and pharmaceutical compositions containing the same
ZA200706254B (en) 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones and pharmaceutical preparations comprising the same
PL394604A1 (pl) Pochodna winyloazacykloalkanowa, jej zastosowanie oraz kompozycja farmaceutyczna
GB0300427D0 (en) Pharmaceutical composition
GB0307866D0 (en) Pharmaceutical composition
IL181730A0 (en) Benzodiazinone derivatives and pharmaceutical compositions containing the same
IL177498A0 (en) Difluoroethoxy -substituted hydroxy-6-phenylphenanthridine derivatives and pharmaceutical compositions containing the same
EP1699458A4 (en) PHARMACEUTICAL COMPOSITION
IL181216A0 (en) 3, 5-seco-4-norcholestane derivatives and pharmaceutical compositions containing the same
GB0317663D0 (en) Pharmaceutical composition
IL177497A0 (en) Isoamido-substituted hydroxy-6-phenylphenanthridine derivatives and pharmaceutical compositions containing the same