PE20160670A1 - PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO - Google Patents
PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIOInfo
- Publication number
- PE20160670A1 PE20160670A1 PE2016000605A PE2016000605A PE20160670A1 PE 20160670 A1 PE20160670 A1 PE 20160670A1 PE 2016000605 A PE2016000605 A PE 2016000605A PE 2016000605 A PE2016000605 A PE 2016000605A PE 20160670 A1 PE20160670 A1 PE 20160670A1
- Authority
- PE
- Peru
- Prior art keywords
- pirrolo
- treat infections
- respiratory syncitial
- syncitial virus
- useful
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE TETRAHIDROFURANIL-PIRROLO[1,2-f][1,2,4]TRIAZINA-4-AMINA DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H O F; R3 ES OH O F; R4 ES CN, ALQUILO(C1-C4), ENTRE OTROS; R6 ES OH; R5 ES H, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2R,3S,4R,5S)-5-(4-AMINOPIRROLO[1,2-f][1,2,4]TRIAZIN-7-IL)-3,4-DIHIDROXI-2-(HIDROXIMETIL)TETRAHIDROFURAN-2-CARBONITRILO; (2R,3R,4R,5S)-5-(4-AMINOPIRROLO[1,2-f][1,2,4]TRIAZIN-7-IL)-2-ETINILO-4-FLUORO-2-(HIDROXIMETIL)TETRAHIDROFURAN-3-OL; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA TRATAR INFECCIONES POR EL VIRUS PNEUMOVIRINAE, QUE INCLUYE INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361902544P | 2013-11-11 | 2013-11-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20160670A1 true PE20160670A1 (es) | 2016-07-10 |
Family
ID=52003049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000605A PE20160670A1 (es) | 2013-11-11 | 2014-11-06 | PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO |
Country Status (36)
Country | Link |
---|---|
US (4) | US9388208B2 (es) |
EP (3) | EP3505173B1 (es) |
JP (7) | JP6234571B2 (es) |
KR (4) | KR102243724B1 (es) |
CN (3) | CN105899216B (es) |
AP (1) | AP2016009186A0 (es) |
AU (5) | AU2014346665A1 (es) |
BR (1) | BR112016010261B1 (es) |
CA (1) | CA2928674C (es) |
CL (1) | CL2016001120A1 (es) |
CR (1) | CR20160220A (es) |
CU (1) | CU20160065A7 (es) |
CY (1) | CY1121948T1 (es) |
DK (2) | DK3505173T3 (es) |
DO (1) | DOP2016000107A (es) |
EA (2) | EA039734B1 (es) |
ES (2) | ES2926155T3 (es) |
GT (1) | GT201600086A (es) |
HR (2) | HRP20220920T1 (es) |
HU (2) | HUE044960T2 (es) |
IL (1) | IL245324B (es) |
LT (2) | LT3068405T (es) |
MD (1) | MD4596C1 (es) |
MX (2) | MX2016006066A (es) |
MY (2) | MY182986A (es) |
NZ (1) | NZ719592A (es) |
PE (1) | PE20160670A1 (es) |
PH (1) | PH12016500867A1 (es) |
PL (2) | PL3505173T3 (es) |
PT (2) | PT3068405T (es) |
SG (1) | SG11201603427XA (es) |
SI (2) | SI3505173T1 (es) |
TR (1) | TR201910961T4 (es) |
UA (1) | UA119050C2 (es) |
WO (1) | WO2015069939A1 (es) |
ZA (1) | ZA201603123B (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102596979B (zh) | 2009-09-21 | 2014-12-10 | 吉里德科学公司 | 用于制备1’-取代碳核苷类似物的方法和中间体 |
SG186830A1 (en) | 2010-07-22 | 2013-02-28 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並[3,2-d]嘧啶、呋喃並[3,2-d]嘧啶及吡咯並[3,2-d]嘧啶化合物類 |
EA031726B1 (ru) | 2014-09-26 | 2019-02-28 | Рибосайенс Ллк | 4'-винилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк респираторно-синцитиального вируса |
TWI740546B (zh) | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
BR112017013858A2 (pt) | 2014-12-26 | 2018-02-27 | Univ Emory | n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos |
PL3785717T3 (pl) | 2015-09-16 | 2022-05-02 | Gilead Sciences, Inc. | Sposoby leczenia infekcji coronaviridae |
JP6768796B2 (ja) * | 2015-09-23 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 4’−置換ヌクレオシド逆転写酵素阻害剤及びその調製 |
JP6860585B2 (ja) | 2016-03-09 | 2021-04-14 | ヤンセン バイオファーマ インク. | 非環状抗ウイルス 優先出願の参照による組み込み |
CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
JP2020518578A (ja) | 2017-05-01 | 2020-06-25 | ギリアード サイエンシーズ, インコーポレイテッド | (S)−2−エチルブチル2−(((S)−(((2R,3S,4R,5R)−5−(4−アミノピロロ[2,1−f][1,2,4]トリアジン−7−イル)−5−シアノ−3,4−ジヒドロキシテトラヒドロフラン−2−イル)メトキシ)(フェノキシ)ホスホリル)アミノ)プロパノエートの結晶形態 |
TW201919648A (zh) | 2017-07-11 | 2019-06-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之含rna聚合酶抑制劑與環糊精的組合物 |
MA50172A (fr) | 2017-09-18 | 2021-04-07 | Janssen Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
CN109748921B (zh) * | 2017-11-03 | 2022-03-22 | 中国科学院上海药物研究所 | N-叔丁氧羰基保护的杂环类化合物、其制备方法及其用于制备c-核苷类似物的方法 |
WO2019113462A1 (en) | 2017-12-07 | 2019-06-13 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
CN108787177B (zh) * | 2018-08-07 | 2024-03-15 | 中南大学 | 淤浆法制备黄原酸盐的方法及*** |
US20220267362A1 (en) * | 2019-05-14 | 2022-08-25 | The Regents Of The University Of Michigan | Methods for Glycosylation |
US11660307B2 (en) | 2020-01-27 | 2023-05-30 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TW202315607A (zh) * | 2020-02-18 | 2023-04-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TW202322824A (zh) | 2020-02-18 | 2023-06-16 | 美商基利科學股份有限公司 | 抗病毒化合物 |
JP7429799B2 (ja) * | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
CN111187269A (zh) * | 2020-02-27 | 2020-05-22 | 江苏阿尔法药业有限公司 | 一种瑞德西韦中间体的合成方法 |
CN113336758B (zh) * | 2020-03-03 | 2022-08-19 | 北京桦冠医药科技有限公司 | 化合物7-碘吡咯并[2,1-f][1,2,4]三嗪-4-胺的一种新合成方法 |
CN111233870A (zh) * | 2020-03-11 | 2020-06-05 | 中国科学技术大学 | 用于快速制备瑞德西韦药物中间体的方法 |
TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
EP4132651A1 (en) | 2020-04-06 | 2023-02-15 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
CN112778310A (zh) | 2020-04-20 | 2021-05-11 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
CN113527303B (zh) * | 2020-04-21 | 2022-06-10 | 浙江工业大学 | 一种瑞德西韦母核中间体的制备工艺 |
CN111440176B (zh) * | 2020-04-28 | 2022-04-26 | 江苏大学 | 金属配合物促进的瑞德西韦中间体的合成方法 |
CA3179226A1 (en) | 2020-05-29 | 2021-12-02 | Tomas Cihlar | Remdesivir treatment methods |
CN111620903A (zh) * | 2020-06-17 | 2020-09-04 | 安徽贝克联合制药有限公司 | C-核苷类似物以及用于合成瑞德西韦合成的含腈c-核苷类化合物的制备方法及其应用 |
PE20230618A1 (es) | 2020-06-24 | 2023-04-14 | Gilead Sciences Inc | Analogos de nucleosido de 1'-ciano y usos de los mismos |
CN111732618A (zh) * | 2020-07-03 | 2020-10-02 | 镇江巨杰新材料技术研发中心(有限合伙) | 瑞德西韦关键片段的合成方法 |
CN111793101B (zh) * | 2020-07-17 | 2022-09-30 | 四川大学 | C-核苷化合物的合成方法 |
WO2022029704A1 (en) | 2020-08-06 | 2022-02-10 | Richter Gedeon Nyrt. | Remdesivir intermediates |
TW202233204A (zh) | 2020-08-27 | 2022-09-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
CN112500417B (zh) * | 2020-12-31 | 2022-01-21 | 山东诚汇双达药业有限公司 | 一种4-氨基吡咯并[2,1-f][1,2,4]三嗪的制备方法 |
CN117120444A (zh) | 2021-04-16 | 2023-11-24 | 吉利德科学公司 | 使用酰胺制备卡巴核苷的方法 |
AU2022328698A1 (en) | 2021-08-18 | 2024-02-01 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
KR20240050362A (ko) | 2021-08-20 | 2024-04-18 | 시오노기 앤드 컴파니, 리미티드 | 바이러스 증식 억제 작용을 갖는 뉴클레오사이드 유도체 및 그들의 프로드러그 |
US20230295172A1 (en) | 2022-03-02 | 2023-09-21 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
WO2023168194A1 (en) | 2022-03-03 | 2023-09-07 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
US20230382940A1 (en) | 2022-03-03 | 2023-11-30 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3361306A (en) | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
US3565070A (en) | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
FR2224175B1 (es) | 1973-04-04 | 1978-04-14 | Isf Spa | |
US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
IT1017153B (it) | 1974-07-15 | 1977-07-20 | Isf Spa | Apparecchio per inalazioni |
SE438261B (sv) | 1981-07-08 | 1985-04-15 | Draco Ab | Anvendning i dosinhalator av ett perforerat membran |
US4805811A (en) | 1985-03-29 | 1989-02-21 | Aktiebolaget Draco | Dosage device |
SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
US4955371A (en) | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
KR100246082B1 (ko) | 1991-07-02 | 2000-04-01 | 인헤일, 인코오포레이티드 | 에어로졸화된약제를전달하는방법및장치 |
US5261538A (en) | 1992-04-21 | 1993-11-16 | Glaxo Inc. | Aerosol testing method |
US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US5388572A (en) | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US5622163A (en) | 1994-11-29 | 1997-04-22 | Iep Group, Inc. | Counter for fluid dispensers |
US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
US6116234A (en) | 1999-02-01 | 2000-09-12 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler agitator |
KR100905221B1 (ko) * | 2000-10-18 | 2009-07-01 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한변형된 뉴클레오시드 |
GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
WO2003026589A2 (en) | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
AU2008206406A1 (en) | 2007-01-12 | 2008-07-24 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
EP2155758B1 (en) | 2007-05-10 | 2012-08-22 | Biocryst Pharmaceuticals, Inc. | Tetrahydrofuro[3,4-d]dioxolane compounds for use in the treatment of viral infections and cancer |
EP2019519B1 (en) | 2007-07-25 | 2011-07-06 | Nokia Siemens Networks Oy | Method for addressing ethernet streams with a structured GPON GEM Port ID |
SI2937350T1 (en) * | 2008-04-23 | 2018-05-31 | Gilead Sciences, Inc. | 1'-SUBSTITUTED CARBON-NUCLEOUS ANALOGS FOR ANTIVIRUSAL TREATMENT |
WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
CN102596979B (zh) | 2009-09-21 | 2014-12-10 | 吉里德科学公司 | 用于制备1’-取代碳核苷类似物的方法和中间体 |
LT2480552T (lt) | 2009-09-21 | 2017-02-10 | Gilead Sciences, Inc. | 2'-fluoru pakeisti karbanukleozidų analogai, skirti antivirusiniam gydymui |
US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
EA025311B1 (ru) * | 2010-07-19 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы получения диастереомерно чистых фосфорамидатных пролекарств |
SG186830A1 (en) | 2010-07-22 | 2013-02-28 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
KR101879887B1 (ko) * | 2010-09-20 | 2018-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 치료용 2'-플루오로 치환된 카바-누클레오시드 유사체 |
JP5891241B2 (ja) * | 2010-12-20 | 2016-03-22 | ギリアード サイエンシーズ, インコーポレイテッド | Hcvを処置するための組合せ |
EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
US20130143835A1 (en) * | 2011-12-05 | 2013-06-06 | Medivir Ab | HCV Polymerase Inhibitors |
CA3107640A1 (en) * | 2011-12-22 | 2013-06-27 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof and their use in ameliorating or treating a disease or condition associated with viral infections |
EA201791916A1 (ru) * | 2012-03-13 | 2018-07-31 | Джилид Сайэнс, Инк. | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
US10513534B2 (en) | 2012-10-08 | 2019-12-24 | Idenix Pharmaceuticals Llc | 2′-chloro nucleoside analogs for HCV infection |
TWI582077B (zh) | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物 |
UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
-
2014
- 2014-06-11 UA UAA201606308A patent/UA119050C2/uk unknown
- 2014-11-06 PT PT14806123T patent/PT3068405T/pt unknown
- 2014-11-06 EP EP18209267.6A patent/EP3505173B1/en active Active
- 2014-11-06 LT LTEP14806123.7T patent/LT3068405T/lt unknown
- 2014-11-06 MY MYPI2016701599A patent/MY182986A/en unknown
- 2014-11-06 HR HRP20220920TT patent/HRP20220920T1/hr unknown
- 2014-11-06 KR KR1020207013948A patent/KR102243724B1/ko active IP Right Grant
- 2014-11-06 WO PCT/US2014/064412 patent/WO2015069939A1/en active Application Filing
- 2014-11-06 HU HUE14806123A patent/HUE044960T2/hu unknown
- 2014-11-06 EA EA201792639A patent/EA039734B1/ru unknown
- 2014-11-06 KR KR1020217011476A patent/KR102355881B1/ko active IP Right Grant
- 2014-11-06 PL PL18209267.6T patent/PL3505173T3/pl unknown
- 2014-11-06 NZ NZ719592A patent/NZ719592A/en unknown
- 2014-11-06 EP EP22182880.9A patent/EP4122932A1/en active Pending
- 2014-11-06 PL PL14806123T patent/PL3068405T3/pl unknown
- 2014-11-06 SI SI201431978T patent/SI3505173T1/sl unknown
- 2014-11-06 KR KR1020167015220A patent/KR101864973B1/ko active IP Right Grant
- 2014-11-06 DK DK18209267.6T patent/DK3505173T3/da active
- 2014-11-06 EA EA201690978A patent/EA029712B1/ru unknown
- 2014-11-06 CN CN201480072871.2A patent/CN105899216B/zh active Active
- 2014-11-06 MX MX2016006066A patent/MX2016006066A/es active IP Right Grant
- 2014-11-06 PT PT182092676T patent/PT3505173T/pt unknown
- 2014-11-06 ES ES18209267T patent/ES2926155T3/es active Active
- 2014-11-06 HU HUE18209267A patent/HUE059683T2/hu unknown
- 2014-11-06 DK DK14806123.7T patent/DK3068405T3/da active
- 2014-11-06 CN CN202111444706.3A patent/CN114085243B/zh active Active
- 2014-11-06 EP EP14806123.7A patent/EP3068405B1/en active Active
- 2014-11-06 ES ES14806123T patent/ES2743619T3/es active Active
- 2014-11-06 CN CN201910045494.8A patent/CN110003215B/zh active Active
- 2014-11-06 MY MYPI2021000404A patent/MY197933A/en unknown
- 2014-11-06 SG SG11201603427XA patent/SG11201603427XA/en unknown
- 2014-11-06 US US14/534,715 patent/US9388208B2/en active Active
- 2014-11-06 SI SI201431284T patent/SI3068405T1/sl unknown
- 2014-11-06 JP JP2016528882A patent/JP6234571B2/ja active Active
- 2014-11-06 MD MDA20160063A patent/MD4596C1/ro not_active IP Right Cessation
- 2014-11-06 LT LTEP18209267.6T patent/LT3505173T/lt unknown
- 2014-11-06 CA CA2928674A patent/CA2928674C/en active Active
- 2014-11-06 PE PE2016000605A patent/PE20160670A1/es unknown
- 2014-11-06 BR BR112016010261-4A patent/BR112016010261B1/pt active IP Right Grant
- 2014-11-06 KR KR1020187014999A patent/KR102113705B1/ko active IP Right Grant
- 2014-11-06 TR TR2019/10961T patent/TR201910961T4/tr unknown
- 2014-11-06 AU AU2014346665A patent/AU2014346665A1/en not_active Abandoned
- 2014-11-06 AP AP2016009186A patent/AP2016009186A0/en unknown
-
2016
- 2016-04-27 IL IL245324A patent/IL245324B/en active IP Right Grant
- 2016-05-09 MX MX2020010628A patent/MX2020010628A/es unknown
- 2016-05-09 DO DO2016000107A patent/DOP2016000107A/es unknown
- 2016-05-10 PH PH12016500867A patent/PH12016500867A1/en unknown
- 2016-05-10 ZA ZA2016/03123A patent/ZA201603123B/en unknown
- 2016-05-11 GT GT201600086A patent/GT201600086A/es unknown
- 2016-05-11 CU CUP2016000065A patent/CU20160065A7/es unknown
- 2016-05-11 CL CL2016001120A patent/CL2016001120A1/es unknown
- 2016-05-11 CR CR20160220A patent/CR20160220A/es unknown
- 2016-06-14 US US15/182,529 patent/US9701682B2/en active Active
-
2017
- 2017-05-31 US US15/610,104 patent/US10059716B2/en active Active
- 2017-08-23 JP JP2017160336A patent/JP6393380B2/ja active Active
- 2017-09-18 AU AU2017232039A patent/AU2017232039C1/en active Active
-
2018
- 2018-01-05 JP JP2018000710A patent/JP2018070658A/ja not_active Withdrawn
- 2018-07-25 US US16/045,371 patent/US10377761B2/en active Active
-
2019
- 2019-06-21 AU AU2019204381A patent/AU2019204381B2/en active Active
- 2019-07-18 HR HRP20191303TT patent/HRP20191303T1/hr unknown
- 2019-07-30 CY CY20191100814T patent/CY1121948T1/el unknown
- 2019-12-09 JP JP2019222179A patent/JP7054394B2/ja active Active
-
2020
- 2020-11-20 JP JP2020193294A patent/JP7247155B2/ja active Active
-
2021
- 2021-03-11 AU AU2021201554A patent/AU2021201554B2/en active Active
-
2022
- 2022-04-07 JP JP2022063956A patent/JP2022088661A/ja not_active Withdrawn
-
2023
- 2023-04-26 AU AU2023202506A patent/AU2023202506A1/en active Pending
-
2024
- 2024-01-19 JP JP2024006714A patent/JP2024041986A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20160670A1 (es) | PIRROLO[1,2-f][1,2,4]TRIAZINAS UTILES PARA TRATAR INFECCIONES POR EL VIRUS SINCITIAL RESPIRATORIO | |
PH12017501016A1 (en) | Triazolopyrimidine compounds and uses thereof | |
PE20180024A1 (es) | Triazolopirazinonas como inhibidores de pde1 | |
PE20171155A1 (es) | Metodos y compuestos para tratar infecciones virales por paramyxoviridae | |
PH12015502443A1 (en) | 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection | |
GEP20207105B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors | |
CR20150491A (es) | 3-pirimidin-4-il oxazolidin -2- onas como inhibidores de idh mutante | |
EA201690598A1 (ru) | Аминогетероарил бензамиды в качестве ингибиторов киназы | |
EA201590748A1 (ru) | Противовирусные соединения против rsv | |
EA201492204A1 (ru) | Нуклеозиды на основе урацила и спирооксетана | |
EA201692506A3 (ru) | Ингибиторы репликации вирусов гриппа | |
GEP201706793B (en) | Substituted nucleosides, nucleotides and analogs thereof | |
EA200970510A1 (ru) | Гетеромоноциклическое соединение и его применение | |
UY35300A (es) | Formulación de combinación de dos compuestos antivirales | |
BR112015001502A2 (pt) | derivados de tipo azaindazol ou diazaindazol para tratamento de dor | |
EA201790599A1 (ru) | Соединения и композиции в качестве ингибиторов киназ | |
EA201891666A1 (ru) | Арилзамещенные пиримидины для применения при инфекции, вызванной вирусом гриппа | |
EA201491525A1 (ru) | Спиро[2.4]гептаны для лечения инфекций, вызванных flaviviridae | |
EA201590364A1 (ru) | Применение орвепитанта, его солей и кристаллических форм и композиций, его содержащих, для лечения зуда | |
BR112015029348A2 (pt) | inibidores da bace | |
PH12018500378A1 (en) | Novel annelated phenoxyacetamides | |
BR112015026967A8 (pt) | fenoxietil di-hidro-1h-isoquinolina, seus usos, e composição farmacêutica | |
BR112015020222A2 (pt) | compostos de azetidiniloxifenilpirrolidina | |
EA201600323A1 (ru) | Производные пиперазина и их применение в качестве лекарственного средства | |
BR112015000392A2 (pt) | novos indazóis para o tratamento e profilaxia da infecção por vírus sincicial respiratório |