AR046959A1 - Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio - Google Patents
Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorioInfo
- Publication number
- AR046959A1 AR046959A1 ARP040104755A ARP040104755A AR046959A1 AR 046959 A1 AR046959 A1 AR 046959A1 AR P040104755 A ARP040104755 A AR P040104755A AR P040104755 A ARP040104755 A AR P040104755A AR 046959 A1 AR046959 A1 AR 046959A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- substituted
- alkyl
- replication
- morfolinilo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Se refiere al morfolinilo que contiene benzimidazoles que tienen una actividad inhibitoria sobre la replicacion del virus sincitial respiratorio y que tienen la formula 1 una prodroga, un N-oxido, una sal de adicion, una amina cuaternaria, un complejo de metal o una forma estereoquímicamente isomérica de los mismos donde G es un enlace directo o C1-10 alcanediilo sustituido de manera opcional; R1 es Ar1 o un heterociclo monocíclico o bicíclico Q es R7, pirrolidinilo sustituido por R7, piperidinilo sustituido por R7 o homopiperidinilo sustituido por R7; uno de R2a y R3a es seleccionado a partir de halo, alquilo C1-6 opcionalmente mono- o polisustituido, alquenilo C2-6 opcionalmente mono- o polisustituido, nitro, hidroxi, Ar2, N(R4a R4b), N(R4a R4b)sulfonilo, N(R4aR4b)carbonilo, alquiloxi C1-6, Ar2oxi, Ar2oxi, Ar2alquiloxi C1-6, carboxilo, alquiloxicarbonilo C1-6, o -C(=Z)Ar2; y el otro de R2a y R3a es hidrogeno, en caso de que R2a sea diferente de hidrogeno, R2b es hidrogeno, alquilo C1-6 o halogeno y R3b es hidrogeno; en caso de que R3a sea diferente de hidrogeno, R3b es hidrogeno, alquilo C1-6 o halogeno y R2b es hidrogeno. Además se refiere a la preparacion de los mismos y a las composiciones que comprenden estos compuestos, al igual que al uso de los mismos como un medicamento.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104810 | 2003-12-18 | ||
| US56718204P | 2004-04-30 | 2004-04-30 | |
| EP04105312 | 2004-10-26 | ||
| PCT/EP2004/053620 WO2005058871A1 (en) | 2003-12-18 | 2004-12-20 | Morpholinyl containing benzimidazoles as inhibitors of respiratory syncytial virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046959A1 true AR046959A1 (es) | 2006-01-04 |
Family
ID=34704695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104755A AR046959A1 (es) | 2003-12-18 | 2004-12-17 | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US7449463B2 (es) |
| EP (1) | EP1697345B1 (es) |
| JP (1) | JP4951348B2 (es) |
| KR (1) | KR100967406B1 (es) |
| CN (2) | CN101412709B (es) |
| AP (1) | AP2150A (es) |
| AR (1) | AR046959A1 (es) |
| AT (1) | ATE388950T1 (es) |
| AU (1) | AU2004298460B2 (es) |
| BR (1) | BRPI0417268B8 (es) |
| CA (1) | CA2548668C (es) |
| CY (1) | CY1108142T1 (es) |
| DE (1) | DE602004012448T2 (es) |
| DK (1) | DK1697345T3 (es) |
| EA (1) | EA009876B1 (es) |
| EG (1) | EG25799A (es) |
| ES (1) | ES2303653T3 (es) |
| HK (1) | HK1130799A1 (es) |
| HR (1) | HRP20080245T3 (es) |
| IL (1) | IL175910A (es) |
| ME (1) | ME01042B (es) |
| MX (1) | MXPA06007112A (es) |
| MY (1) | MY143573A (es) |
| NO (1) | NO339314B1 (es) |
| NZ (1) | NZ547479A (es) |
| PL (1) | PL1697345T3 (es) |
| PT (1) | PT1697345E (es) |
| RS (1) | RS50584B (es) |
| SI (1) | SI1697345T1 (es) |
| TW (1) | TWI351401B (es) |
| UA (1) | UA84718C2 (es) |
| WO (1) | WO2005058871A1 (es) |
| ZA (1) | ZA200605894B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| AU2006260969B2 (en) * | 2005-06-20 | 2011-11-17 | Janssen Sciences Ireland Uc | 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| WO2006136562A1 (en) * | 2005-06-20 | 2006-12-28 | Tibotec Pharmaceuticals Ltd | Heterocyclylaminoalkyl substituted benzimidazoles |
| US20120148678A1 (en) | 2010-12-08 | 2012-06-14 | Advanced Technologies And Regenerative Medicine, Llc. | Sustained release of poorly water soluble active compounds |
| WO2013056070A2 (en) | 2011-10-14 | 2013-04-18 | Ambit Biosciences Corporation | Heterocyclic compounds and methods of use thereof |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| CN109562160B (zh) * | 2016-05-10 | 2022-07-29 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗rsv的双环稠合的吡唑衍生物 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| EA201992215A1 (ru) | 2017-03-20 | 2020-02-06 | Форма Терапьютикс, Инк. | Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| SG11202006141RA (en) | 2018-01-31 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
| WO2019206828A1 (en) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against rsv |
| EP3852791A4 (en) | 2018-09-19 | 2022-06-15 | Forma Therapeutics, Inc. | ACTIVATION OF PYRUVATE KINASE R |
| US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| GB201820751D0 (en) * | 2018-12-19 | 2019-01-30 | Bp Oil Int | Methods for preparing intermediates |
| PE20220937A1 (es) | 2019-07-22 | 2022-05-31 | Lupin Ltd | Compuestos macrociclicos como agonistas de sting y metodos y usos de los mismos |
| JP7329239B2 (ja) | 2019-09-20 | 2023-08-18 | 株式会社タマディック | フライトシミュレーター |
| WO2023018560A1 (en) * | 2021-08-13 | 2023-02-16 | Georgia State University Research Foundation, Inc. | Bicyclic fused pyrazole derivatives for the treatment of respiratory infections including rsv |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE258928T1 (de) * | 1999-06-28 | 2004-02-15 | Janssen Pharmaceutica Nv | Respiratorisches syncytialvirus replikation inhibitoren |
| CN1171887C (zh) * | 1999-06-28 | 2004-10-20 | 詹森药业有限公司 | 呼吸道合胞病毒复制抑制剂 |
| AP1552A (en) * | 1999-06-28 | 2006-01-17 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors. |
| CA2548657A1 (en) * | 2003-12-18 | 2005-06-30 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
-
2004
- 2004-12-17 AR ARP040104755A patent/AR046959A1/es active IP Right Grant
- 2004-12-20 UA UAA200606224A patent/UA84718C2/ru unknown
- 2004-12-20 AU AU2004298460A patent/AU2004298460B2/en not_active Ceased
- 2004-12-20 DE DE602004012448T patent/DE602004012448T2/de active Active
- 2004-12-20 ES ES04817576T patent/ES2303653T3/es active Active
- 2004-12-20 TW TW093139923A patent/TWI351401B/zh not_active IP Right Cessation
- 2004-12-20 CN CN200810166056.9A patent/CN101412709B/zh active Active
- 2004-12-20 JP JP2006544467A patent/JP4951348B2/ja active Active
- 2004-12-20 SI SI200430732T patent/SI1697345T1/sl unknown
- 2004-12-20 AT AT04817576T patent/ATE388950T1/de active
- 2004-12-20 PL PL04817576T patent/PL1697345T3/pl unknown
- 2004-12-20 AP AP2006003640A patent/AP2150A/xx active
- 2004-12-20 EP EP04817576A patent/EP1697345B1/en active Active
- 2004-12-20 BR BRPI0417268A patent/BRPI0417268B8/pt not_active IP Right Cessation
- 2004-12-20 DK DK04817576T patent/DK1697345T3/da active
- 2004-12-20 MY MYPI20045259A patent/MY143573A/en unknown
- 2004-12-20 PT PT04817576T patent/PT1697345E/pt unknown
- 2004-12-20 EA EA200601178A patent/EA009876B1/ru unknown
- 2004-12-20 RS RSP-2008/0266A patent/RS50584B/sr unknown
- 2004-12-20 KR KR1020067014047A patent/KR100967406B1/ko active IP Right Grant
- 2004-12-20 ME MEP-2008-207A patent/ME01042B/me unknown
- 2004-12-20 CN CNA2004800378255A patent/CN1894237A/zh active Pending
- 2004-12-20 NZ NZ547479A patent/NZ547479A/en not_active IP Right Cessation
- 2004-12-20 CA CA2548668A patent/CA2548668C/en active Active
- 2004-12-20 US US10/563,691 patent/US7449463B2/en active Active
- 2004-12-20 WO PCT/EP2004/053620 patent/WO2005058871A1/en active Application Filing
- 2004-12-20 MX MXPA06007112A patent/MXPA06007112A/es active IP Right Grant
-
2006
- 2006-05-25 IL IL175910A patent/IL175910A/en active IP Right Grant
- 2006-06-14 EG EGNA2006000561 patent/EG25799A/xx active
- 2006-07-17 ZA ZA2006/05894A patent/ZA200605894B/en unknown
- 2006-07-18 NO NO20063322A patent/NO339314B1/no not_active IP Right Cessation
-
2008
- 2008-06-03 HR HR20080245T patent/HRP20080245T3/xx unknown
- 2008-06-12 CY CY20081100633T patent/CY1108142T1/el unknown
- 2008-06-17 US US12/140,686 patent/US8883837B2/en active Active
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2009
- 2009-10-13 HK HK09109448.0A patent/HK1130799A1/xx not_active IP Right Cessation
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