PE20001483A1 - Acidos oxamicos y derivados como ligandos de receptores tiroideos - Google Patents

Acidos oxamicos y derivados como ligandos de receptores tiroideos

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Publication number
PE20001483A1
PE20001483A1 PE2000000166A PE0001662000A PE20001483A1 PE 20001483 A1 PE20001483 A1 PE 20001483A1 PE 2000000166 A PE2000000166 A PE 2000000166A PE 0001662000 A PE0001662000 A PE 0001662000A PE 20001483 A1 PE20001483 A1 PE 20001483A1
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PE
Peru
Prior art keywords
alkyl
oxamic
heterocycle
phenyl
together form
Prior art date
Application number
PE2000000166A
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English (en)
Inventor
Robert Lee Dow
Yuan-Ching Phoebe Chiang
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Pfizer Prod Inc
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Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001483A1 publication Critical patent/PE20001483A1/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract

SE REFIERE A ACIDOS OXAMICOS DE FORMULA I DONDE R1, R2, R3 SON H, HALOGENO, ALQUILO C1-C6, TRIFLUOROMETILO, CN, OCF3, O-ALQUILO C1-C6; R4 ES H, ALQUILO C1-C12, ENTRE OTROS; CUANDO R5 NO ES F; R4 ES SO2NR9R10, CONR9R10, ENTRE OTROS; O R3 Y R4 FORMAN JUNTOS UN CARBOCICLO A: -(CH2)b-, HETEROCICLO A: Q-(CH2)c; (CH2)j-Q-(CH2)k; Q ES O, S, NR17; R5 ES F, OH, ALCOXI C1-C4, OCOR9; R4 Y R5 JUNTOS FORMAN UN HETEROCICLO B: R9C=CR10NH, N=CR9-NH, R9C=CH-O, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO C1-C4, TRIFLUOROMETILO; R7 ES H, ALQUILO C1-C6; R8 ES OR9, NR19R20; R9 Y R10 SON H, ALQUILO C1-C12, ALQUENILO C2-C12, CICLOALQUILO C3-C10, ARILO, HET, ENTRE OTROS O R9 Y R10 JUNTOS FORMAN UN HETEROCICLO C, ENTRE OTROS, R11 ES ALQUILO C1-C12; R17 ES H, ALQUILO C1-C6, COR9; W ES O, SOd, CH2, NR9; b ES 3-7; c, j Y k SON 2-6. SON COMPUESTOS PREFERIDOS ACIDO N-[3-CLORO-4-(3-CICLOPROPILSULFAMOIL-4-HIDROXI-FENOXI)-5-METIL-FENIL]OXAMICO, ACIDO-N-[4-(3-CICLOPROPILSULFAMOIL-4-HIDROXI-FENOXI)-3,5-DIMETIL-FENIL]OXAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS A UN AGENTE ANOREXIGENICO O UN INHIBIDOR DE LIPASA. EL COMPUESTO I ES UN LIGANDO DEL RECEPTOR TIROIDEO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA OBESIDAD, HIPERLIPIDEMIA, GLAUCOMA, ARRITMIA CARDIACA, TRASTORNOS DE LA PIEL, ENFERMEDAD DE TIROIDES, HIPOTIROIDISMO
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