PE20030497A1 - Combinaciones de un inhibidor de pde 5 y otros agentes activos - Google Patents

Combinaciones de un inhibidor de pde 5 y otros agentes activos

Info

Publication number
PE20030497A1
PE20030497A1 PE2002000949A PE2002000949A PE20030497A1 PE 20030497 A1 PE20030497 A1 PE 20030497A1 PE 2002000949 A PE2002000949 A PE 2002000949A PE 2002000949 A PE2002000949 A PE 2002000949A PE 20030497 A1 PE20030497 A1 PE 20030497A1
Authority
PE
Peru
Prior art keywords
inhibitors
alcoxy
alkyl
hydroxy
server
Prior art date
Application number
PE2002000949A
Other languages
English (en)
Inventor
David Saul Cohen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20030497A1 publication Critical patent/PE20030497A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE UN INHIBIDOR DE PDE 5 DE FORMULA I DONDE R1 ES H, ALQUILO OPCIONALMENTE SUSTITUIDA POR HIDROXI, ALCOXI, ALQUILTIO; R2 ES H, ALQUILO, HIDROXIALQUILO, ALQUILCARBONILOXIALQUILO, ALCOXIALQUILO, ALQUILTIOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO OPCIONALMENTE SUSTITUIDA POR HIDROXI, ALCOXI ALQUILTIO; R4 ES H, ALQUILO; R5 ES QUINOLILO, ISOQUINOLILO, OXODIHIDROISOQUINOLILO OPCIONALMENTE FUSIONADO A UN GRUPO HETEROCICLO DE 5 MIEMBROS; R6 Y R7 SON H, ALQUILO OPCIONALMENTE SUSTITUIDO POR HIDROXI, ALCOXI; DE PREFERENCIA 3-ISOBUTIL-8-(6-METOXI-ISOQUINOLIN-4-ILMETIL)-1-3,7-DIHIDRO-PURIN-2,6-DIONA; UN AGENTE ACTIVO SELECCIONADO DE UN AGENTE ANTIDIABETICO TAL COMO INSULINA; INHIBIDORES DE HMGCOA REDUCTASA TAL COMO ATORVASTATINA, CERIVASTATINA, FLUVASTATINA, ROSUVASTATINA, ENTRE OTROS, UN AGENTE ANTIHIPERTENSIVO TAL COMO INHIBIDORES DE ACE, BLOQUEADORES ADRENERGICOS, DIURETICOS, ENTRE OTROS, INHIBIDOR DE LA REABSORCION DE SEROTONINA SSRI TAL COMO FLUVOXAMINA, FLUOXETINA, PAROXETINA, SERTRALINA, ENTRE OTROS. LA COMBINACION PUEDE SER UTIL PARA LA PREVENCION O TRATAMIENTO DE DISFUNCION SEXUAL, HIPERGLICEMIA, HIPERINSULINEMIA, HIPERLIPIDEMIA, DIABETES, HIPERTRIGLICERIDEMIA, OBESIDAD, RETINOPATIA DIABETICA, GLOMERULOESCLEROSIS
PE2002000949A 2001-09-27 2002-09-26 Combinaciones de un inhibidor de pde 5 y otros agentes activos PE20030497A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32548501P 2001-09-27 2001-09-27

Publications (1)

Publication Number Publication Date
PE20030497A1 true PE20030497A1 (es) 2003-07-04

Family

ID=23268071

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000949A PE20030497A1 (es) 2001-09-27 2002-09-26 Combinaciones de un inhibidor de pde 5 y otros agentes activos

Country Status (12)

Country Link
US (1) US20030114469A1 (es)
EP (1) EP1432423A2 (es)
JP (1) JP2005504113A (es)
CN (1) CN1694707A (es)
AR (1) AR036584A1 (es)
AU (1) AU2002338806A1 (es)
BR (1) BR0212852A (es)
CA (1) CA2458343A1 (es)
MY (1) MY134639A (es)
PE (1) PE20030497A1 (es)
TW (1) TW200412970A (es)
WO (1) WO2003028730A2 (es)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
US20030181461A1 (en) * 2002-01-25 2003-09-25 Lautt Wilfred Wayne Use of phosphodiesterase antagonists to treat insulin resistance
DE10335027A1 (de) * 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
CA2516250A1 (en) 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
MXPA05009242A (es) * 2003-03-17 2006-04-18 Pfizer Prod Inc Tratamiento de la diabetes tipo 1 con los inhibidores de la pde5.
JP2006522750A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
US7501405B2 (en) 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders
CA2525946C (en) * 2003-05-22 2013-01-29 Altana Pharma Ag Composition comprising a pde4 inhibitor and a pde5 inhibitor
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
US20050054731A1 (en) * 2003-09-08 2005-03-10 Franco Folli Multi-system therapy for diabetes, the metabolic syndrome and obesity
BRPI0416118A (pt) * 2003-10-31 2007-01-02 Pfizer Prod Inc inibição da fosfodiesterase 9 como tratamento para estados relacionados com a obesidade
TW200605893A (en) * 2004-02-12 2006-02-16 Novartis Ag Use of organic compounds
EP1737465A4 (en) * 2004-04-19 2007-10-03 Univ Loma Linda COMPOSITION AND METHOD FOR REDUCING RENAL ISCHEMIC DAMAGE
CN1980895A (zh) 2004-05-08 2007-06-13 神经能质公司 1－芳基－4－取代的异喹啉
PL1750862T3 (pl) 2004-06-04 2011-06-30 Teva Pharma Kompozycja farmaceutyczna zawierająca irbesartan
RS53141B (en) * 2004-11-05 2014-06-30 Boehringer Ingelheim International Gmbh TWO-LAYER TABLE CONTAINING TELMISARTAN AND AMLODIPINE
PT1894576E (pt) * 2005-06-08 2011-07-29 Kowa Co Novo agente redutor dos níveis de triglicéridos
US20070015839A1 (en) * 2005-07-14 2007-01-18 Franco Folli Daily Dosage Regimen for Treating Diabetes, Obesity, Metabolic Syndrome and Polycystic Ovary Syndrome
WO2007111027A1 (ja) * 2006-03-29 2007-10-04 Kowa Co., Ltd. トリグリセリド低下剤及び高インスリン血症改善剤
KR101061328B1 (ko) * 2006-04-21 2011-08-31 화이자 프로덕츠 인크. 피리딘[3,4-ｂ]피라지논
RS53084B (en) 2006-07-05 2014-06-30 Takeda Gmbh COMBINATION OF HMG-COA ROSUVASTATIN REDUCTASE INHIBITOR WITH PHOSPHODIESTERASE 4 INHIBITOR, WHICH IS ROFLUMILAST, ROFLUMILAST-N-OXIDE FOR THE TREATMENT OF INFLAMMATORY LUNG DISEASES
US8841300B2 (en) 2006-10-02 2014-09-23 Jerry M. Held Treatment for Parkinson's disease—combination high dose serotonergic synaptic reuptake inhibitor with phosphodiesterase inhibitor
CA2687679A1 (en) * 2007-05-18 2008-11-27 Vivus, Inc. Novel compositions comprising a phosphodiesterase-5 inhibitor and their use in methods of treatment
EP2266568A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
EP2266567A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
AU2012219316A1 (en) * 2011-02-18 2013-10-03 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
SI2854841T1 (sl) 2012-06-04 2017-06-30 Diamedica Inc. Glikozilacijske izooblike humanega tkivnega kalikreina-1
WO2014071044A1 (en) * 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
CN110446501A (zh) 2017-03-09 2019-11-12 代阿麦迪卡股份有限公司 组织激肽释放酶1的剂型
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

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EA200000526A1 (ru) * 1997-12-16 2000-12-25 Пфайзер Продактс Инк. Комбинация, эффективная для лечения импотенции
DE19844162A1 (de) * 1998-09-25 2000-03-30 Udo Dunzendorfer Medikamentenkombinationen zur Therapie der erektilen Dysfunktion
US6087362A (en) * 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
WO2002013798A2 (en) * 2000-08-11 2002-02-21 Pfizer Limited Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors
WO2002060422A2 (en) * 2001-02-02 2002-08-08 Pfizer Limited Treatment of diabetes mellitus using vardenafil

Also Published As

Publication number Publication date
EP1432423A2 (en) 2004-06-30
AR036584A1 (es) 2004-09-15
MY134639A (en) 2007-12-31
WO2003028730A3 (en) 2003-09-04
TW200412970A (en) 2004-08-01
CA2458343A1 (en) 2003-04-10
US20030114469A1 (en) 2003-06-19
BR0212852A (pt) 2004-10-13
JP2005504113A (ja) 2005-02-10
CN1694707A (zh) 2005-11-09
WO2003028730A2 (en) 2003-04-10
AU2002338806A1 (en) 2003-04-14

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