PE20070069A1 - Piperazin-piperidinas como antagonistas y agonistas del receptor 5-ht1a - Google Patents

Piperazin-piperidinas como antagonistas y agonistas del receptor 5-ht1a

Info

Publication number
PE20070069A1
PE20070069A1 PE2006000646A PE2006000646A PE20070069A1 PE 20070069 A1 PE20070069 A1 PE 20070069A1 PE 2006000646 A PE2006000646 A PE 2006000646A PE 2006000646 A PE2006000646 A PE 2006000646A PE 20070069 A1 PE20070069 A1 PE 20070069A1
Authority
PE
Peru
Prior art keywords
piperazin
agonists
antagonists
quinolin
piperidin
Prior art date
Application number
PE2006000646A
Other languages
English (en)
Inventor
Magda Asselin
George Theodore Grosu
Wayne Everett Childers
Zhongqi Shen
Chae-Koo Chong
James Jacob Bicksler
Lisa Marie Havran
Annmarie Louise Sabb
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070069A1 publication Critical patent/PE20070069A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIPERAZIN-PIPERIDINA DE FORMULA (I'), DONDE R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 Y R16 SON H, ALQUILO C1-C6, CF3, NO2, ENTRE OTROS; Ra Y Rb SON H O CH3; n ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 6-METOXI-8-[4-(1-QUINOLIN-8-IL-PIPERIDIN-4-IL)-PIPERAZIN-1-IL]-QUINOLINA, 6-FLUORO-8-[4-(1-QUINOLIN-8-IL-PIPERIDIN-4-IL)-PIPERAZIN-1-IL]-QUINOLINA, 5-FLUORO-8-[4-(1-QUINOLIN-8-IL-PIPERIDIN-4-IL)--PIPERAZIN-1-IL]-QUINOLINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA FORMULACION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON AGENTES ENLAZANTES DEL RECEPTOR 5-HT1A, PARTICULARMENTE COMO ANTAGONISTAS Y AGONISTAS DE DICHO RECEPTOR Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL
PE2006000646A 2005-06-10 2006-06-09 Piperazin-piperidinas como antagonistas y agonistas del receptor 5-ht1a PE20070069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68946905P 2005-06-10 2005-06-10

Publications (1)

Publication Number Publication Date
PE20070069A1 true PE20070069A1 (es) 2007-03-15

Family

ID=37530084

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000646A PE20070069A1 (es) 2005-06-10 2006-06-09 Piperazin-piperidinas como antagonistas y agonistas del receptor 5-ht1a

Country Status (20)

Country Link
US (1) US7671056B2 (es)
EP (1) EP1888559A2 (es)
JP (1) JP2008543782A (es)
KR (1) KR20080021134A (es)
CN (1) CN101243073A (es)
AR (1) AR055059A1 (es)
AU (1) AU2006257874A1 (es)
BR (1) BRPI0613491A2 (es)
CA (1) CA2611711A1 (es)
CR (1) CR9560A (es)
EC (1) ECSP088094A (es)
GT (1) GT200600255A (es)
IL (1) IL187972A0 (es)
MX (1) MX2007015678A (es)
NO (1) NO20076344L (es)
PE (1) PE20070069A1 (es)
RU (1) RU2007146543A (es)
TW (1) TW200800959A (es)
WO (1) WO2006135839A2 (es)
ZA (1) ZA200710699B (es)

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TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
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AR065376A1 (es) * 2007-02-16 2009-06-03 Wyeth Corp Formulacion de pastillas de liberacion sostenida de antagonistas y agonistas de piperazina - piperidina del receptor 5 ht1a que tienen disolucion instestinal mejorada
WO2010033045A1 (en) * 2008-09-16 2010-03-25 Igor Anatolievich Pomytkin Compositions and methods for prevention or treatment of beta amyloid deposition
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
CN101797223B (zh) * 2009-02-06 2012-05-23 上海交通大学医学院 石杉碱甲眼用制剂及其应用
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
PL3061821T3 (pl) * 2009-07-22 2020-01-31 PureTech Health LLC Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego
BR112021005802B1 (pt) 2018-09-28 2022-02-15 Karuna Therapeutics, Inc Composição farmacêutica oral

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Also Published As

Publication number Publication date
GT200600255A (es) 2007-07-19
NO20076344L (no) 2008-02-27
AR055059A1 (es) 2007-08-01
JP2008543782A (ja) 2008-12-04
US7671056B2 (en) 2010-03-02
TW200800959A (en) 2008-01-01
CN101243073A (zh) 2008-08-13
CA2611711A1 (en) 2006-12-21
BRPI0613491A2 (pt) 2011-01-11
WO2006135839A2 (en) 2006-12-21
ECSP088094A (es) 2008-02-20
CR9560A (es) 2008-02-20
EP1888559A2 (en) 2008-02-20
WO2006135839A3 (en) 2007-11-22
RU2007146543A (ru) 2009-07-20
AU2006257874A1 (en) 2006-12-21
US20070027160A1 (en) 2007-02-01
KR20080021134A (ko) 2008-03-06
MX2007015678A (es) 2008-02-20
ZA200710699B (en) 2009-05-27
IL187972A0 (en) 2008-03-20

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