MX352423B - Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina. - Google Patents

Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina.

Info

Publication number
MX352423B
MX352423B MX2014011182A MX2014011182A MX352423B MX 352423 B MX352423 B MX 352423B MX 2014011182 A MX2014011182 A MX 2014011182A MX 2014011182 A MX2014011182 A MX 2014011182A MX 352423 B MX352423 B MX 352423B
Authority
MX
Mexico
Prior art keywords
arabinofuranosyl
deoxy
cytosine
thio
fluoro
Prior art date
Application number
MX2014011182A
Other languages
English (en)
Other versions
MX2014011182A (es
Inventor
Baba Yasutaka
Murakami Tatsuya
Shintani Junko
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of MX2014011182A publication Critical patent/MX2014011182A/es
Publication of MX352423B publication Critical patent/MX352423B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical

Abstract

El problema de la presente invención es proporcionar un agente anti-tumor superior. Una sal de 1-(2-desoxi-2-fluoro-4-tio-ß-D-ara binofuranosil)citosina es útil como el ingrediente activo de una medicina porque tiene por lo menos una de las características tales como las siguientes (1) excelente actividad antitumoral, (2) excelente cristalinidad, (3) una alta solubilidad en agua, (4) no es delicuescente, (5) tiene excelente fluidez, (6) tiene excelentes propiedades de formación de tabletas, (7) es producida bajo condiciones ambientales amigables y (8) es producida en masa.
MX2014011182A 2012-03-28 2013-03-27 Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina. MX352423B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012074525 2012-03-28
JP2013050846 2013-03-13
PCT/JP2013/058896 WO2013146833A1 (ja) 2012-03-28 2013-03-27 １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩

Publications (2)

Publication Number Publication Date
MX2014011182A MX2014011182A (es) 2014-11-13
MX352423B true MX352423B (es) 2017-11-24

Family

ID=49260082

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014011182A MX352423B (es) 2012-03-28 2013-03-27 Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina.
MX2017008865A MX370733B (es) 2012-03-28 2013-03-27 Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2017008865A MX370733B (es) 2012-03-28 2013-03-27 Sal de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil) citosina.

Country Status (19)

Country Link
US (1) US9896471B2 (es)
EP (1) EP2832740B1 (es)
JP (1) JP5833225B2 (es)
KR (2) KR20170082650A (es)
CN (1) CN104203969B (es)
AU (1) AU2013241341B2 (es)
BR (1) BR112014020416B1 (es)
CA (2) CA2943998C (es)
DK (1) DK2832740T3 (es)
ES (1) ES2730679T3 (es)
HK (1) HK1201273A1 (es)
IL (1) IL234222A (es)
MX (2) MX352423B (es)
NZ (1) NZ701245A (es)
PL (1) PL2832740T3 (es)
RU (1) RU2600734C2 (es)
SG (2) SG11201406080VA (es)
TW (1) TWI637963B (es)
WO (1) WO2013146833A1 (es)

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KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
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JP6450356B2 (ja) 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
WO2018043530A1 (ja) 2016-08-31 2018-03-08 富士フイルム株式会社 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
CA3089728C (en) 2018-01-29 2023-01-10 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
TW202002989A (zh) 2018-03-13 2020-01-16 日商富士軟片股份有限公司 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒
US20220033387A1 (en) 2018-09-25 2022-02-03 The Usa, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
KR102106096B1 (ko) 2019-08-19 2020-04-29 이명준 경추 지압 마사지기
CN117794548A (zh) 2021-07-29 2024-03-29 富士胶片株式会社 针对bap1及pbrm1中的至少一个的功能下降的肿瘤的药物组合物及抗肿瘤剂
KR102454186B1 (ko) 2022-05-23 2022-10-14 이명준 경추 지압장치

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Also Published As

Publication number Publication date
DK2832740T3 (da) 2019-07-15
PL2832740T3 (pl) 2019-09-30
ES2730679T3 (es) 2019-11-12
IL234222A (en) 2017-11-30
CN104203969A (zh) 2014-12-10
AU2013241341A1 (en) 2014-09-11
NZ701245A (en) 2015-12-24
US9896471B2 (en) 2018-02-20
JPWO2013146833A1 (ja) 2015-12-14
KR101770246B1 (ko) 2017-08-22
AU2013241341B2 (en) 2016-09-08
JP5833225B2 (ja) 2015-12-16
KR20140139108A (ko) 2014-12-04
WO2013146833A1 (ja) 2013-10-03
SG10201603288XA (en) 2016-05-30
TW201343665A (zh) 2013-11-01
BR112014020416A2 (pt) 2021-07-06
CA2865742A1 (en) 2013-10-03
CA2943998A1 (en) 2013-10-03
HK1201273A1 (zh) 2015-08-28
RU2600734C2 (ru) 2016-10-27
TWI637963B (zh) 2018-10-11
BR112014020416B1 (pt) 2022-03-29
CA2865742C (en) 2017-04-18
EP2832740A4 (en) 2015-11-11
EP2832740B1 (en) 2019-04-24
US20150011499A1 (en) 2015-01-08
CA2943998C (en) 2018-03-27
SG11201406080VA (en) 2014-11-27
RU2014143277A (ru) 2016-05-27
MX370733B (es) 2019-12-20
CN104203969B (zh) 2016-08-31
MX2014011182A (es) 2014-11-13
EP2832740A1 (en) 2015-02-04
KR20170082650A (ko) 2017-07-14

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