SE9003151D0 - Nucleoside derivatives - Google Patents

Nucleoside derivatives

Info

Publication number
SE9003151D0
SE9003151D0 SE9003151A SE9003151A SE9003151D0 SE 9003151 D0 SE9003151 D0 SE 9003151D0 SE 9003151 A SE9003151 A SE 9003151A SE 9003151 A SE9003151 A SE 9003151A SE 9003151 D0 SE9003151 D0 SE 9003151D0
Authority
SE
Sweden
Prior art keywords
pct
date
ch2n3
ch2sh
ch2f
Prior art date
Application number
SE9003151A
Other languages
English (en)
Inventor
B O Classon
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Priority to SE9003151A priority Critical patent/SE9003151D0/sv
Publication of SE9003151D0 publication Critical patent/SE9003151D0/sv
Priority to IE337491A priority patent/IE913374A1/en
Priority to PCT/SE1991/000653 priority patent/WO1992006102A1/en
Priority to EP91917480A priority patent/EP0554274A1/en
Priority to US08/030,168 priority patent/US5473063A/en
Priority to KR1019930701006A priority patent/KR930702371A/ko
Priority to CA002093020A priority patent/CA2093020A1/en
Priority to AU86410/91A priority patent/AU8641091A/en
Priority to JP3516127A priority patent/JPH06501261A/ja
Priority to HU93964A priority patent/HUT63851A/hu
Priority to PT99130A priority patent/PT99130A/pt
Priority to NO931264A priority patent/NO931264D0/no
Priority to US08/516,551 priority patent/US5747473A/en
Priority to US09/041,135 priority patent/US5952500A/en
Priority to US09/334,756 priority patent/US6121431A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SE9003151A 1990-10-02 1990-10-02 Nucleoside derivatives SE9003151D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9003151A SE9003151D0 (sv) 1990-10-02 1990-10-02 Nucleoside derivatives
IE337491A IE913374A1 (en) 1990-10-02 1991-09-26 Nucleoside derivatives
HU93964A HUT63851A (en) 1990-10-02 1991-09-27 Process for producing nucleoside derivatives and pharmaceutical compositions comprising such compounds
CA002093020A CA2093020A1 (en) 1990-10-02 1991-09-27 Nucleoside derivatives
EP91917480A EP0554274A1 (en) 1990-10-02 1991-09-27 Nucleoside derivatives
US08/030,168 US5473063A (en) 1990-10-02 1991-09-27 Synthesis of furanosyl compounds useful as intermediates in preparation of nucleoside analogues
KR1019930701006A KR930702371A (ko) 1990-10-02 1991-09-27 뉴클레오시드 유도체
PCT/SE1991/000653 WO1992006102A1 (en) 1990-10-02 1991-09-27 Nucleoside derivatives
AU86410/91A AU8641091A (en) 1990-10-02 1991-09-27 Nucleoside derivatives
JP3516127A JPH06501261A (ja) 1990-10-02 1991-09-27 ヌクレオシド誘導体
PT99130A PT99130A (pt) 1990-10-02 1991-10-01 Processo de preparacao de derivados nucleosidos, dos seus intermediarios e de composicoes farmaceuticas
NO931264A NO931264D0 (no) 1990-10-02 1993-04-01 Nukleosid-derivater
US08/516,551 US5747473A (en) 1990-10-02 1995-08-18 L-nucleoside analogues and pharmaceutical compositions
US09/041,135 US5952500A (en) 1990-10-02 1998-03-12 Nucleoside derivatives
US09/334,756 US6121431A (en) 1990-10-02 1999-06-17 Nucleoside derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003151A SE9003151D0 (sv) 1990-10-02 1990-10-02 Nucleoside derivatives

Publications (1)

Publication Number Publication Date
SE9003151D0 true SE9003151D0 (sv) 1990-10-02

Family

ID=20380539

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9003151A SE9003151D0 (sv) 1990-10-02 1990-10-02 Nucleoside derivatives

Country Status (11)

Country Link
US (4) US5473063A (sv)
EP (1) EP0554274A1 (sv)
JP (1) JPH06501261A (sv)
KR (1) KR930702371A (sv)
AU (1) AU8641091A (sv)
CA (1) CA2093020A1 (sv)
HU (1) HUT63851A (sv)
IE (1) IE913374A1 (sv)
PT (1) PT99130A (sv)
SE (1) SE9003151D0 (sv)
WO (1) WO1992006102A1 (sv)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ234534A (en) * 1989-07-17 1994-12-22 Univ Birmingham Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor
US5728575A (en) 1990-02-01 1998-03-17 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5521163A (en) * 1990-07-13 1996-05-28 University Of Birmingham Antiviral pyrimidine nucleosides and methods for using same
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
EP0637965B1 (en) * 1991-11-26 2002-10-16 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
TW393513B (en) * 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
GB9218810D0 (en) * 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
WO1994021658A1 (en) * 1993-03-15 1994-09-29 Kalman Thomas I Antiviral imidazolinone nucleoside derivatives
US6200952B1 (en) * 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
AU697612B2 (en) * 1994-05-31 1998-10-15 Medivir Ab Post exposure prevention of HIV
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
DE69533856T2 (de) * 1994-10-24 2005-12-08 Genencor International, Inc., Palo Alto L-pyranosyl-nukleoside
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
CN1201463A (zh) * 1995-11-02 1998-12-09 株式会社钟根堂 新型核苷衍生物及其制备方法
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
ATE271063T1 (de) * 1996-10-16 2004-07-15 Icn Pharmaceuticals Purin-l-nukleoside, deren analoga und verwendungen
EP1072607A3 (en) * 1996-10-16 2001-09-12 ICN Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses therof
EP0970100B1 (en) 1997-02-13 2003-11-12 Glaxo Group Limited Benzimidazole derivatives
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
AU2003251524A1 (en) * 2002-06-17 2003-12-31 Isis Pharmaceuticals, Inc. Carbocyclic nucleoside analogs as RNA-antivirals
CA2594229A1 (en) * 2004-12-30 2006-07-06 Medivir Ab 2',3'-dideoxy-3'-c-hyroxymethylcytidine and prodrugs thereof for the treatment of drug escape mutant hiv
EP2268608A4 (en) 2008-04-01 2012-01-11 Biosearch Technologies Inc DARK NUCLEIC ACID STABILIZED FLUOROPHORE DEACTIVATOR PROBES
CN104203969B (zh) 2012-03-28 2016-08-31 富士胶片株式会社 1-(2-脱氧-2-氟-4-硫代-β-D-***呋喃糖基)胞嘧啶的盐
KR20170001722A (ko) 2012-08-13 2017-01-04 후지필름 가부시키가이샤 1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
WO2015125781A1 (ja) 2014-02-18 2015-08-27 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
EP4001283A1 (en) * 2015-05-12 2022-05-25 F. Hoffmann-La Roche AG Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection
SG11201901815WA (en) 2016-08-31 2019-04-29 Fujifilm Corp Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
CA3089728C (en) 2018-01-29 2023-01-10 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
CN114409655A (zh) * 2022-01-26 2022-04-29 郑州大学 3′,4′-不饱和核糖c-核苷类似物及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
FR2040177A1 (en) * 1969-01-31 1971-01-22 Robugen Gmbh 2-deoxyribosyl-uracil derivs
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
US4247544A (en) * 1979-07-02 1981-01-27 The Regents Of The University Of California C-5 Substituted uracil nucleosides
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides
JPS57146798A (en) * 1981-03-06 1982-09-10 Yamasa Shoyu Co Ltd Hexosyl nucleoside derivative
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
EP0286825A3 (en) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
SE8802173D0 (sv) * 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
FI95384C (sv) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Förfarande för framställning 3'-deoxi-3'-substituerade metylnukleosider och mellanprodukter som används i förfarandet
JPH03223264A (ja) * 1990-01-30 1991-10-02 Nippon Kayaku Co Ltd 新規なシクロペンタン誘導体及びその製造法
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
ATE273700T1 (de) * 1993-05-21 2004-09-15 Us Gov Health & Human Serv Neues verfahen zur hemmung der replication der virus - abhängigen reverse transciptase durch verwendung von dideoxydenucleotide-synthese inhibitoren
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
US5473063A (en) 1995-12-05
US5952500A (en) 1999-09-14
WO1992006102A1 (en) 1992-04-16
HUT63851A (en) 1993-10-28
EP0554274A1 (en) 1993-08-11
CA2093020A1 (en) 1992-04-03
IE913374A1 (en) 1992-04-08
PT99130A (pt) 1992-08-31
US6121431A (en) 2000-09-19
US5747473A (en) 1998-05-05
AU8641091A (en) 1992-04-28
KR930702371A (ko) 1993-09-08
JPH06501261A (ja) 1994-02-10
HU9300964D0 (en) 1993-06-28

Similar Documents

Publication Publication Date Title
SE9003151D0 (sv) Nucleoside derivatives
PA8483101A1 (es) Compuestos quimicos
FI930753A0 (fi) Nya fosfolipidderivat av nukleosider, deras framstaellning och deras anvaendning saosom antivirala laekemedel
NO920210L (no) Antivirale pyrimidinnukleosider
DK0671912T3 (da) Injicerbare præparater baseret på taxanderivater
NL300241I1 (nl) Hydroxymethyl(methyleencyclopentyl)uurines en -pyrimidines.
ATE254132T1 (de) Antivirale pyrimidin nucleoside derivate
ATE124412T1 (de) Antivirusderivate von (phosphonmethoxy)methoxy purin/pyrimidin.
ES2062558T3 (es) Compuestos contra el cancer.
DE69202286D1 (de) Verfahren zur Färbung keratinischer Fasern mit Isatin oder Isatinderivaten zusammen mit Aminopyrimidin oder Aminopyridin und Färbemittel.
PT97478A (pt) Processo de producao de derivados n-(3-fluoro-2-fosfonilmetoxipropilo) de bases puricas e pirimidicas heterociclicas e de composicoes farmaceuticas que os contem
SE8603099L (sv) Distamycinderivat och forfarande for deras framstellning
ES8401037A1 (es) "procedimiento para la preparacion de nuevos derivados de pirimidina o s-triacina".
DK428989D0 (da) Benzylaminderivater
HUP9700436A1 (hu) Triazingyűrűt tartalmazó anionos vegyületek antivirális hatással
DK58288D0 (da) Cyclopropancarboxylsyreestere, fremgangsmaade til deres fremstilling samt deres anvendelse til bekaempelse af parasitter
ES2105285T3 (es) Nuevos derivados de la adenosina, sus procedimientos de preparacion, composiciones farmaceuticas que los contienen.
ES2060970T3 (es) Nuevos derivados de benzonaftiridina-1,8, su preparacion y las composiciones que les contienen.
ES2072536T3 (es) Derivados de tiazolidina que presentan actividad anti-hipertensiva y su uso en terapeutica.
DE69127184D1 (de) Antiherpes-Zusammensetzungen
DE69110528D1 (de) Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien.
MX9303605A (es) Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
ES8501416A1 (es) 5'-alquil o alquenil-fosfatos de nucleosidos.
ATE26268T1 (de) 2-alkoxyaminosulfonylbenzolsulfonyl-harnstoffderivate.
SE8008189L (sv) Foreningar med antiallergisk och antiulceros verkan, nemligen 1-oxo-1h-tiazolo(3,2-a)pyrimidin-2-karboxamider och mellanprodukter for dessa