SG11201406080VA - SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE - Google Patents
SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINEInfo
- Publication number
- SG11201406080VA SG11201406080VA SG11201406080VA SG11201406080VA SG11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA
- Authority
- SG
- Singapore
- Prior art keywords
- arabinofuranosyl
- deoxy
- cytosine
- thio
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012074525 | 2012-03-28 | ||
| JP2013050846 | 2013-03-13 | ||
| PCT/JP2013/058896 WO2013146833A1 (en) | 2012-03-28 | 2013-03-27 | SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201406080VA true SG11201406080VA (en) | 2014-11-27 |
Family
ID=49260082
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201406080VA SG11201406080VA (en) | 2012-03-28 | 2013-03-27 | SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE |
| SG10201603288XA SG10201603288XA (en) | 2012-03-28 | 2013-03-27 | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201603288XA SG10201603288XA (en) | 2012-03-28 | 2013-03-27 | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9896471B2 (en) |
| EP (1) | EP2832740B1 (en) |
| JP (1) | JP5833225B2 (en) |
| KR (2) | KR101770246B1 (en) |
| CN (1) | CN104203969B (en) |
| AU (1) | AU2013241341B2 (en) |
| BR (1) | BR112014020416B1 (en) |
| CA (2) | CA2943998C (en) |
| DK (1) | DK2832740T3 (en) |
| ES (1) | ES2730679T3 (en) |
| HK (1) | HK1201273A1 (en) |
| IL (1) | IL234222A (en) |
| MX (2) | MX352423B (en) |
| NZ (1) | NZ701245A (en) |
| PL (1) | PL2832740T3 (en) |
| RU (1) | RU2600734C2 (en) |
| SG (2) | SG11201406080VA (en) |
| TW (1) | TWI637963B (en) |
| WO (1) | WO2013146833A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013303534B2 (en) | 2012-08-13 | 2016-06-30 | Fujifilm Corporation | Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same |
| CN106061959B (en) | 2014-02-18 | 2018-11-09 | 富士胶片株式会社 | The manufacturing method and thiophane matrix type sugar compounds of thiophane matrix type sugar compounds |
| JP6204223B2 (en) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | Method for producing thiopyranose compound, etc. |
| TWI678373B (en) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | Thionucleoside derivative or its salt and pharmaceutical composition |
| JP6450356B2 (en) | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | Liquid pharmaceutical formulation |
| CN109641009B (en) | 2016-08-31 | 2021-12-31 | 富士胶片株式会社 | Antitumor agent, antitumor effect enhancer, and antitumor kit |
| AU2018404329B2 (en) | 2018-01-29 | 2021-09-09 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
| CA3093794C (en) * | 2018-03-13 | 2023-03-14 | Fujifilm Corporation | Antitumor enhancer agent comprising 1-(2-deoxy-2-fluoro-4-thio-b-d-arabinofuranosyl)cytosine and an antitumor platinum complex |
| JP2022502378A (en) | 2018-09-25 | 2022-01-11 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 2'-Halogenation-4'-thio-2'-deoxy-5-azacitidine analog and its use |
| KR102106096B1 (en) | 2019-08-19 | 2020-04-29 | 이명준 | Acupressure Treatment Massager For Cervical |
| WO2023008511A1 (en) | 2021-07-29 | 2023-02-02 | 富士フイルム株式会社 | Pharmaceutical composition and anti-tumor agent for tumors that have at least either impaired bap1 or pbrm1 function |
| KR102454186B1 (en) | 2022-05-23 | 2022-10-14 | 이명준 | Acupressur device for cervical vertebral |
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| JPS5148682A (en) * | 1974-10-15 | 1976-04-26 | Asahi Chemical Ind | NUKUREOCHIDO JUDOTAINOSEIHO |
| JPS53119810A (en) | 1977-03-25 | 1978-10-19 | Mitsubishi Chem Ind Ltd | Preparation of aldehyde chloride |
| US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
| US4220774A (en) | 1978-10-26 | 1980-09-02 | Omnium Chimique | Vincadifformine synthesis process |
| JPS5692239A (en) | 1979-12-27 | 1981-07-25 | Sagami Chem Res Center | Preparation of 5-oxohexyl compound |
| US4803272A (en) | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
| IE74701B1 (en) | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
| SE9003151D0 (en) | 1990-10-02 | 1990-10-02 | Medivir Ab | NUCLEOSIDE DERIVATIVES |
| FI105556B (en) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Process for the preparation of drug-useful pyrimidine nucleoside derivatives with anti-tumor effect |
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| GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
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| EP0770621A4 (en) | 1994-07-12 | 1998-01-28 | Yamasa Corp | 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside |
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| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
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| AU2013303534B2 (en) * | 2012-08-13 | 2016-06-30 | Fujifilm Corporation | Synthetic intermediate of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine, synthetic intermediate of thionucleoside, and method for producing the same |
| CN106061959B (en) | 2014-02-18 | 2018-11-09 | 富士胶片株式会社 | The manufacturing method and thiophane matrix type sugar compounds of thiophane matrix type sugar compounds |
| JP6204223B2 (en) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | Method for producing thiopyranose compound, etc. |
| WO2016155593A1 (en) | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | Novel compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof |
-
2013
- 2013-03-27 TW TW102110915A patent/TWI637963B/en active
- 2013-03-27 DK DK13770090.2T patent/DK2832740T3/en active
- 2013-03-27 CA CA2943998A patent/CA2943998C/en active Active
- 2013-03-27 RU RU2014143277/04A patent/RU2600734C2/en active
- 2013-03-27 BR BR112014020416-0A patent/BR112014020416B1/en active IP Right Grant
- 2013-03-27 NZ NZ701245A patent/NZ701245A/en unknown
- 2013-03-27 MX MX2014011182A patent/MX352423B/en active IP Right Grant
- 2013-03-27 SG SG11201406080VA patent/SG11201406080VA/en unknown
- 2013-03-27 CA CA2865742A patent/CA2865742C/en active Active
- 2013-03-27 KR KR1020147030209A patent/KR101770246B1/en active IP Right Grant
- 2013-03-27 WO PCT/JP2013/058896 patent/WO2013146833A1/en active Application Filing
- 2013-03-27 CN CN201380016308.9A patent/CN104203969B/en active Active
- 2013-03-27 MX MX2017008865A patent/MX370733B/en unknown
- 2013-03-27 ES ES13770090T patent/ES2730679T3/en active Active
- 2013-03-27 EP EP13770090.2A patent/EP2832740B1/en active Active
- 2013-03-27 KR KR1020177018337A patent/KR20170082650A/en not_active Application Discontinuation
- 2013-03-27 JP JP2014507938A patent/JP5833225B2/en active Active
- 2013-03-27 SG SG10201603288XA patent/SG10201603288XA/en unknown
- 2013-03-27 PL PL13770090T patent/PL2832740T3/en unknown
- 2013-03-27 AU AU2013241341A patent/AU2013241341B2/en active Active
-
2014
- 2014-08-21 IL IL234222A patent/IL234222A/en active IP Right Grant
- 2014-09-26 US US14/498,334 patent/US9896471B2/en active Active
-
2015
- 2015-02-17 HK HK15101764.5A patent/HK1201273A1/en unknown
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