HK1201273A1 - -β- -脫氧- -氟- -硫代-β- -***呋喃糖基 胞嘧啶的鹽 - Google Patents

-β- -脫氧- -氟- -硫代-β- -***呋喃糖基 胞嘧啶的鹽

Info

Publication number
HK1201273A1
HK1201273A1 HK15101764.5A HK15101764A HK1201273A1 HK 1201273 A1 HK1201273 A1 HK 1201273A1 HK 15101764 A HK15101764 A HK 15101764A HK 1201273 A1 HK1201273 A1 HK 1201273A1
Authority
HK
Hong Kong
Prior art keywords
arabinofuranosyl
deoxy
cytosine
thio
fluoro
Prior art date
Application number
HK15101764.5A
Other languages
English (en)
Inventor
馬場康隆
村上達也
新谷純子
Original Assignee
富士膠片株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 富士膠片株式會社 filed Critical 富士膠片株式會社
Publication of HK1201273A1 publication Critical patent/HK1201273A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
HK15101764.5A 2012-03-28 2015-02-17 -β- -脫氧- -氟- -硫代-β- -***呋喃糖基 胞嘧啶的鹽 HK1201273A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012074525 2012-03-28
JP2013050846 2013-03-13
PCT/JP2013/058896 WO2013146833A1 (ja) 2012-03-28 2013-03-27 １－（２－デオキシ－２－フルオロ－４－チオ－β－Ｄ－アラビノフラノシル）シトシンの塩

Publications (1)

Publication Number Publication Date
HK1201273A1 true HK1201273A1 (zh) 2015-08-28

Family

ID=49260082

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101764.5A HK1201273A1 (zh) 2012-03-28 2015-02-17 -β- -脫氧- -氟- -硫代-β- -***呋喃糖基 胞嘧啶的鹽

Country Status (19)

Country Link
US (1) US9896471B2 (zh)
EP (1) EP2832740B1 (zh)
JP (1) JP5833225B2 (zh)
KR (2) KR101770246B1 (zh)
CN (1) CN104203969B (zh)
AU (1) AU2013241341B2 (zh)
BR (1) BR112014020416B1 (zh)
CA (2) CA2943998C (zh)
DK (1) DK2832740T3 (zh)
ES (1) ES2730679T3 (zh)
HK (1) HK1201273A1 (zh)
IL (1) IL234222A (zh)
MX (2) MX352423B (zh)
NZ (1) NZ701245A (zh)
PL (1) PL2832740T3 (zh)
RU (1) RU2600734C2 (zh)
SG (2) SG10201603288XA (zh)
TW (1) TWI637963B (zh)
WO (1) WO2013146833A1 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2883866T3 (pl) 2012-08-13 2019-07-31 Fujifilm Corporation Produkt pośredni do syntezy 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranosylo)cytozyny, produkt pośredni do syntezy tionukleozydu i sposoby otrzymywania tych produktów pośrednich
JP6175553B2 (ja) 2014-02-18 2017-08-09 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
JP6450356B2 (ja) 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
MX2019002430A (es) 2016-08-31 2019-07-04 Fujifilm Corp Agente antitumoral, mejorador del efecto antitumoral, y kit antitumoral.
CA3089728C (en) 2018-01-29 2023-01-10 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
WO2019176984A1 (ja) 2018-03-13 2019-09-19 富士フイルム株式会社 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
US20220033387A1 (en) 2018-09-25 2022-02-03 The Usa, As Represented By The Secretary, Department Of Health And Human Services 2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
KR102106096B1 (ko) 2019-08-19 2020-04-29 이명준 경추 지압 마사지기
WO2023008511A1 (ja) 2021-07-29 2023-02-02 富士フイルム株式会社 Ｂａｐ１およびｐｂｒｍ１の少なくとも１つの機能低下を有する腫瘍に対する医薬組成物および抗腫瘍剤
KR102454186B1 (ko) 2022-05-23 2022-10-14 이명준 경추 지압장치

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116282A (en) * 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
US3243425A (en) 1962-10-29 1966-03-29 Purdue Research Foundation Novel sulfur-containing compounds
JPS5148682A (ja) * 1974-10-15 1976-04-26 Asahi Chemical Ind Nukureochidojudotainoseiho
JPS53119810A (en) 1977-03-25 1978-10-19 Mitsubishi Chem Ind Ltd Preparation of aldehyde chloride
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4220774A (en) 1978-10-26 1980-09-02 Omnium Chimique Vincadifformine synthesis process
JPS5692239A (en) 1979-12-27 1981-07-25 Sagami Chem Res Center Preparation of 5-oxohexyl compound
US4803272A (en) 1987-02-24 1989-02-07 E. I. Du Pont De Nemours And Company S-modified adenosyl-1,8-diamino-3-thiooctane derivatives
IE74701B1 (en) 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
SE9003151D0 (sv) 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
CA2079413C (en) * 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
JP3138834B2 (ja) 1991-12-26 2001-02-26 生化学工業株式会社 フコピラノース類縁体の製造方法およびその合成中間化合物
GB9218810D0 (en) 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
GB9515279D0 (en) * 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
WO1996001834A1 (fr) 1994-07-12 1996-01-25 Yamasa Corporation 2'-desoxy-2'-(methylidene substitue ou non substitue)-4'-thionucleoside
JPH0853490A (ja) 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド
WO1997038001A1 (fr) 1996-04-09 1997-10-16 Yamasa Corporation 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES
WO1997037993A1 (fr) 1996-04-09 1997-10-16 Yamasa Corporation DERIVES DE 9-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)PURINE
JP4202327B2 (ja) 1996-04-09 2008-12-24 ヤマサ醤油株式会社 １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン
US7875733B2 (en) 2003-09-18 2011-01-25 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
HUP9601756A3 (en) 1996-06-25 1999-05-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical compositions containing them
JP4087471B2 (ja) 1997-03-31 2008-05-21 大日本印刷株式会社 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法
HUP9702348A3 (en) 1997-12-04 2000-12-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them
WO1999043690A1 (fr) 1998-02-25 1999-09-02 Rational Drug Design Laboratories Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant
ES2376862T3 (es) 1998-07-23 2012-03-20 Southern Research Institute Utilización de compuestos de tioarabinofuranosilo
AU2001240098A1 (en) 2000-03-08 2001-09-17 Southern Research Institute 4'-thio-l-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
KR100426030B1 (ko) 2000-07-22 2004-04-03 (주) 한켐 락톤계 당화합물에서의 키랄성 전환방법
TWI247609B (en) 2001-01-23 2006-01-21 Nihon Mediphysics Co Ltd Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease
BR0210594A (pt) 2001-06-22 2005-11-01 Pharmasset Ltd (beta)-d ou (beta)-l-3-halonucleosìdeo
JP2003172990A (ja) 2001-08-03 2003-06-20 Fuji Photo Film Co Ltd ハロゲン化銀乳剤及びハロゲン化銀写真感光材料
BR0310006A (pt) 2002-08-09 2005-02-15 Taisho Pharmaceutical Co Ltd Derivados de 5-tio-beta-d-glicopiranosìdeo de arila e agentes terapêuticos para diabetes contendo os mesmos
AU2003200960B2 (en) 2002-09-18 2005-01-06 Mackinnon, Sebastian Mr System for Ordering, Tracking and Payment of Goods and Services
CA2525099A1 (en) 2003-05-12 2004-11-25 Purdue Research Foundation Cytotoxic indeno and isoindoloisoquinolones
EP1630157A4 (en) 2003-05-28 2007-05-23 Japan Tobacco Inc ANTAGONIST OF CASR
JPWO2004106352A1 (ja) 2003-05-29 2006-07-20 大正製薬株式会社 アルドヘキソピラノース中間体の製造法
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
TW200637839A (en) 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
ATE516026T1 (de) 2005-02-21 2011-07-15 Shionogi & Co Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung
JP2006335737A (ja) 2005-06-03 2006-12-14 Ihara Nikkei Kagaku Kogyo Kk ベンゾ［ｃ］ヘテロ５員環化合物の製造方法
WO2007068113A1 (en) 2005-12-16 2007-06-21 Mcgill University 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof
CN100513395C (zh) 2006-04-17 2009-07-15 中国科学院化学研究所 一种制备多羟基环状硝酮的方法
JP5320284B2 (ja) 2006-05-03 2013-10-23 キメリクス，インコーポレーテッド 抗ウイルス性または抗増殖性のホスホネート、ヌクレオシドホスホネートおよびヌクレオシドホスフェートの代謝安定性アルコキシアルキルエステル
CN101200463B (zh) 2007-12-11 2011-06-22 复旦大学 全酰化-4-硫代-d-核糖及其制备方法
US8859589B2 (en) 2008-03-12 2014-10-14 Southern Research Institute Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents
CN101880287B (zh) 2009-05-05 2012-07-25 上海医药工业研究院 一类四氢噻吩核苷类似物的中间体化合物及其制备方法
CN102414216B (zh) * 2009-05-15 2015-01-21 德鲁塔负富莱制药股份有限公司 1-(2’-氰基-2’-脱氧-β-D-***呋喃糖基)胞嘧啶一盐酸盐的稳定型结晶
CN102656154B (zh) 2009-12-18 2014-04-09 天秤医药股份有限公司 用于制备取代的1-O-酰基-2-脱氧-2-氟-4-硫代-β-D-***呋喃糖的方法
GB201016855D0 (en) 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
DE102010042013A1 (de) 2010-10-06 2012-04-12 Robert Bosch Gmbh Verfahren zur Einstellung einer Temperatur eines Sensorelements
JP5776564B2 (ja) 2012-01-20 2015-09-09 日本精工株式会社 ワーク処理装置、及びワーク処理方法
US20140029864A1 (en) 2012-07-30 2014-01-30 Dror Reif Compression encoding and decoding method and apparatus
PL2883866T3 (pl) 2012-08-13 2019-07-31 Fujifilm Corporation Produkt pośredni do syntezy 1-(2-deoksy-2-fluoro-4-tio-beta-d-arabinofuranosylo)cytozyny, produkt pośredni do syntezy tionukleozydu i sposoby otrzymywania tych produktów pośrednich
JP6175553B2 (ja) 2014-02-18 2017-08-09 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
CN109553651B (zh) 2015-04-03 2021-08-06 四川科伦博泰生物医药股份有限公司 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用

Also Published As

Publication number Publication date
US20150011499A1 (en) 2015-01-08
CN104203969A (zh) 2014-12-10
MX352423B (es) 2017-11-24
WO2013146833A1 (ja) 2013-10-03
CA2865742C (en) 2017-04-18
AU2013241341A1 (en) 2014-09-11
PL2832740T3 (pl) 2019-09-30
SG10201603288XA (en) 2016-05-30
MX370733B (es) 2019-12-20
EP2832740B1 (en) 2019-04-24
CA2943998C (en) 2018-03-27
KR20170082650A (ko) 2017-07-14
IL234222A (en) 2017-11-30
JP5833225B2 (ja) 2015-12-16
JPWO2013146833A1 (ja) 2015-12-14
EP2832740A4 (en) 2015-11-11
CN104203969B (zh) 2016-08-31
EP2832740A1 (en) 2015-02-04
CA2943998A1 (en) 2013-10-03
TW201343665A (zh) 2013-11-01
CA2865742A1 (en) 2013-10-03
KR20140139108A (ko) 2014-12-04
AU2013241341B2 (en) 2016-09-08
TWI637963B (zh) 2018-10-11
MX2014011182A (es) 2014-11-13
SG11201406080VA (en) 2014-11-27
KR101770246B1 (ko) 2017-08-22
US9896471B2 (en) 2018-02-20
ES2730679T3 (es) 2019-11-12
RU2014143277A (ru) 2016-05-27
BR112014020416B1 (pt) 2022-03-29
RU2600734C2 (ru) 2016-10-27
NZ701245A (en) 2015-12-24
DK2832740T3 (da) 2019-07-15
BR112014020416A2 (pt) 2021-07-06

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