MX2013004086A - Metodos para inhibir proliferacion celular en cancers accionados por egfr. - Google Patents

Metodos para inhibir proliferacion celular en cancers accionados por egfr.

Info

Publication number
MX2013004086A
MX2013004086A MX2013004086A MX2013004086A MX2013004086A MX 2013004086 A MX2013004086 A MX 2013004086A MX 2013004086 A MX2013004086 A MX 2013004086A MX 2013004086 A MX2013004086 A MX 2013004086A MX 2013004086 A MX2013004086 A MX 2013004086A
Authority
MX
Mexico
Prior art keywords
egfr
methods
cell proliferation
inhibiting cell
driven cancers
Prior art date
Application number
MX2013004086A
Other languages
English (en)
Inventor
Xiaotian Zhu
David C Dalgarno
Victor M Rivera
William C Shakepeare
Juan J Miret
Original Assignee
Ariad Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ariad Pharma Inc filed Critical Ariad Pharma Inc
Publication of MX2013004086A publication Critical patent/MX2013004086A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a un método para tratar pacientes quienes tienen un cáncer accionado por EGFR, el cual es, o se volverá, refractario a un inhibidor de tirosina cinasa, tal como erlotinib y gefitinib, al administrar un compuesto de la fórmula (I) al paciente. La invención también se refiere a cánceres accionados por EGFR que tienen una mutación de EGFR aquí identificada.
MX2013004086A 2010-10-14 2011-10-14 Metodos para inhibir proliferacion celular en cancers accionados por egfr. MX2013004086A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39329110P 2010-10-14 2010-10-14
PCT/US2011/056457 WO2012051587A1 (en) 2010-10-14 2011-10-14 Methods for inhibiting cell proliferation in egfr-driven cancers

Publications (1)

Publication Number Publication Date
MX2013004086A true MX2013004086A (es) 2013-07-05

Family

ID=45938740

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004086A MX2013004086A (es) 2010-10-14 2011-10-14 Metodos para inhibir proliferacion celular en cancers accionados por egfr.

Country Status (12)

Country Link
US (1) US20140024620A1 (es)
EP (1) EP2627179A4 (es)
JP (1) JP2013539795A (es)
KR (1) KR20130139999A (es)
CN (2) CN104814970A (es)
AU (1) AU2011315831B2 (es)
BR (1) BR112013008816A2 (es)
CA (1) CA2810900A1 (es)
EA (1) EA201390550A1 (es)
IL (1) IL225351A0 (es)
MX (1) MX2013004086A (es)
WO (1) WO2012051587A1 (es)

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CN112469713B (zh) * 2019-06-21 2023-09-01 江苏豪森药业集团有限公司 芳基磷氧化物类衍生物抑制剂、其制备方法和应用
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Also Published As

Publication number Publication date
CA2810900A1 (en) 2012-04-19
EP2627179A4 (en) 2014-04-02
JP2013539795A (ja) 2013-10-28
EP2627179A1 (en) 2013-08-21
EA201390550A1 (ru) 2013-08-30
AU2011315831B2 (en) 2015-01-22
US20140024620A1 (en) 2014-01-23
CN104814970A (zh) 2015-08-05
CN103153064B (zh) 2015-04-22
KR20130139999A (ko) 2013-12-23
WO2012051587A1 (en) 2012-04-19
BR112013008816A2 (pt) 2016-06-28
AU2011315831A1 (en) 2013-03-28
IL225351A0 (en) 2013-06-27
CN103153064A (zh) 2013-06-12

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