MX2012000711A - Inhibidores de pirrolopirazina de cinasas. - Google Patents
Inhibidores de pirrolopirazina de cinasas.Info
- Publication number
- MX2012000711A MX2012000711A MX2012000711A MX2012000711A MX2012000711A MX 2012000711 A MX2012000711 A MX 2012000711A MX 2012000711 A MX2012000711 A MX 2012000711A MX 2012000711 A MX2012000711 A MX 2012000711A MX 2012000711 A MX2012000711 A MX 2012000711A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- kinases
- pyrrolopyrazine
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención se refiere a compuestos de fórmula (I) o sales farmacéuticas aceptables (ver fórmula (I)) en donde R1a, R1b, X, e Y se definen en la descripción. La presente invención se refiere también a composiciones que contiene los compuestos los cuales son útiles para inhibir las cinasas tal como Cdc7 y métodos para tratar enfermedades tal como el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22577009P | 2009-07-15 | 2009-07-15 | |
PCT/US2010/041935 WO2011008830A1 (en) | 2009-07-15 | 2010-07-14 | Pyrrolopyrazine inhibitors of kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012000711A true MX2012000711A (es) | 2012-03-16 |
Family
ID=42670335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012000711A MX2012000711A (es) | 2009-07-15 | 2010-07-14 | Inhibidores de pirrolopirazina de cinasas. |
Country Status (8)
Country | Link |
---|---|
US (1) | US8383624B2 (es) |
EP (1) | EP2454262B1 (es) |
JP (1) | JP2012533551A (es) |
CN (1) | CN102471345A (es) |
CA (1) | CA2767091A1 (es) |
ES (1) | ES2483594T3 (es) |
MX (1) | MX2012000711A (es) |
WO (1) | WO2011008830A1 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS56995B1 (sr) | 2008-12-19 | 2018-05-31 | Vertex Pharma | Derivati pirazina korisni kao inhibitori atr kinaze |
CN102869663A (zh) * | 2010-01-27 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 吡唑并吡嗪激酶抑制剂 |
EP2560971B1 (en) | 2010-04-19 | 2014-04-09 | Abbvie Inc. | Pyrrolopyridines as inhibitors of kinases |
WO2011143423A2 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
SG185524A1 (en) | 2010-05-12 | 2012-12-28 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
CN102947272A (zh) | 2010-05-12 | 2013-02-27 | 沃泰克斯药物股份有限公司 | 用作atr激酶抑制剂的2-氨基吡啶衍生物 |
US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
WO2011143419A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Pyrazines useful as inhibitors of atr kinase |
US8969356B2 (en) | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
MX2013000103A (es) | 2010-06-23 | 2013-06-13 | Vertex Pharma | Derivados de pirrolo-pirazina utiles como inhibidores de cinasa art. |
EP2601192B1 (en) * | 2010-08-04 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
DE102010049877A1 (de) * | 2010-11-01 | 2012-05-03 | Merck Patent Gmbh | 7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate |
EP2694498B1 (en) | 2011-04-05 | 2016-03-30 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of tra kinase |
WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
WO2012178124A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
WO2013049719A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
CN108464983A (zh) | 2011-09-30 | 2018-08-31 | 沃泰克斯药物股份有限公司 | 用atr抑制剂治疗胰腺癌和非小细胞肺癌 |
WO2013049722A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
PT2940017T (pt) | 2011-09-30 | 2019-10-31 | Vertex Pharma | Processos para a produção de compostos úteis como inibidores de atr quinase |
US8841337B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
EP2776419B1 (en) | 2011-11-09 | 2016-05-11 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
US8841450B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
WO2013071088A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US8846918B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
NZ700580A (en) | 2012-04-05 | 2016-07-29 | Vertex Pharma | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
WO2014062604A1 (en) | 2012-10-16 | 2014-04-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
WO2014060395A1 (en) * | 2012-10-16 | 2014-04-24 | F. Hoffmann-La Roche Ag | Serine/threonine kinase inhibitors |
WO2014081906A2 (en) | 2012-11-21 | 2014-05-30 | Ptc Therapeutics, Inc. | Substituted reverse pyrimidine bmi-1 inhibitors |
US9340546B2 (en) | 2012-12-07 | 2016-05-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
HUE046727T2 (hu) | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
AU2015271030B2 (en) | 2014-06-05 | 2019-05-16 | Vertex Pharmaceuticals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof |
PL3157566T3 (pl) | 2014-06-17 | 2019-10-31 | Vertex Pharma | Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
CN106432246B (zh) * | 2015-08-05 | 2020-07-07 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
JP7187308B2 (ja) | 2015-09-30 | 2022-12-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | Dna損傷剤とatr阻害剤との組み合わせを使用する、がんを処置するための方法 |
JP7071383B2 (ja) * | 2016-11-08 | 2022-05-18 | キャンサー・リサーチ・テクノロジー・リミテッド | cdc7阻害剤としてのピリミジノン誘導体 |
ES2686909B1 (es) | 2017-03-22 | 2019-08-16 | Consejo Superior Investigacion | Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas |
GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
ES2749743B2 (es) | 2018-09-21 | 2020-12-14 | Consejo Superior Investigacion | Derivados de purina inhibidores de cdc7 y su uso para el tratamiento de patologias neurologicas |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP9903330A2 (hu) | 1996-11-19 | 2000-03-28 | Amgen Inc. | Gyulladásgátló hatású, aril- és heteroaril csoporttal szubsztituált kondenzált pirrolszármazékok, valamint ezeket tartalmazó gyógyászati készítmények |
MXPA02006338A (es) * | 1999-12-24 | 2002-12-13 | Aventis Pharma Ltd | Azaindoles. |
WO2004078756A2 (en) | 2003-03-06 | 2004-09-16 | Eisai Co., Ltd. | Jnk inhibitors |
MXPA06011327A (es) * | 2004-03-30 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidores de jak y otras proteinas cinasas. |
WO2005123672A2 (en) * | 2004-06-14 | 2005-12-29 | Takeda San Diego, Inc. | Kinase inhibitors |
JP2008520738A (ja) * | 2004-11-22 | 2008-06-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なピロロピラジンおよびピラゾロピラジン |
DE102006012617A1 (de) | 2006-03-20 | 2007-09-27 | Merck Patent Gmbh | 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate |
MX2008013430A (es) * | 2006-04-19 | 2009-01-26 | Novartis Vaccines & Diagnostic | Compuestos de indazol y metodos para la inhibición de cdc7. |
KR20090129488A (ko) * | 2007-03-22 | 2009-12-16 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나아제의 억제제로서 유용한 n-헤테로사이클릭 화합물 |
ES2393430T3 (es) * | 2007-10-17 | 2012-12-21 | Novartis Ag | Derivados de imidazo[1,2-A]-piridina útiles como inhibidores de ALK |
CN102471339A (zh) * | 2009-07-15 | 2012-05-23 | 雅培制药有限公司 | 激酶的吡咯并吡啶抑制剂 |
-
2010
- 2010-07-14 CN CN2010800361565A patent/CN102471345A/zh active Pending
- 2010-07-14 EP EP10740056.6A patent/EP2454262B1/en not_active Not-in-force
- 2010-07-14 JP JP2012520741A patent/JP2012533551A/ja active Pending
- 2010-07-14 MX MX2012000711A patent/MX2012000711A/es active IP Right Grant
- 2010-07-14 WO PCT/US2010/041935 patent/WO2011008830A1/en active Application Filing
- 2010-07-14 CA CA2767091A patent/CA2767091A1/en not_active Abandoned
- 2010-07-14 ES ES10740056.6T patent/ES2483594T3/es active Active
- 2010-07-15 US US12/836,637 patent/US8383624B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2483594T3 (es) | 2014-08-06 |
EP2454262A1 (en) | 2012-05-23 |
US20110015172A1 (en) | 2011-01-20 |
US8383624B2 (en) | 2013-02-26 |
JP2012533551A (ja) | 2012-12-27 |
EP2454262B1 (en) | 2014-05-14 |
WO2011008830A1 (en) | 2011-01-20 |
CN102471345A (zh) | 2012-05-23 |
CA2767091A1 (en) | 2011-01-20 |
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Legal Events
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FG | Grant or registration | ||
GB | Transfer or rights |