MX2012000709A - Inhibidores de pirrolopiridina de cinasas. - Google Patents

Inhibidores de pirrolopiridina de cinasas.

Info

Publication number
MX2012000709A
MX2012000709A MX2012000709A MX2012000709A MX2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A
Authority
MX
Mexico
Prior art keywords
kinases
pyrrolopyridine
inhibitors
compounds
formula
Prior art date
Application number
MX2012000709A
Other languages
English (en)
Inventor
Yunsong Tong
Alan Florjancic
Thomas Penning
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2012000709A publication Critical patent/MX2012000709A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención se refiere a compuestos de fórmula (I) o sales farmacéuticas aceptables (ver fórmula (I)) en donde R1a, R1b, R1c, X, e Y se definen en la descripción. La presente invención se refiere también a composiciones que contiene los compuestos los cuales son útiles para inhibir las cinasas tal como Cdc7 y métodos para tratar enfermedades tal como el cáncer.
MX2012000709A 2009-07-15 2010-07-15 Inhibidores de pirrolopiridina de cinasas. MX2012000709A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22574209P 2009-07-15 2009-07-15
PCT/US2010/042067 WO2011008915A1 (en) 2009-07-15 2010-07-15 Pyrrolopyridine inhibitors of kinases

Publications (1)

Publication Number Publication Date
MX2012000709A true MX2012000709A (es) 2012-03-16

Family

ID=42813135

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000709A MX2012000709A (es) 2009-07-15 2010-07-15 Inhibidores de pirrolopiridina de cinasas.

Country Status (8)

Country Link
US (1) US8435980B2 (es)
EP (1) EP2454257B1 (es)
JP (1) JP2012533553A (es)
CN (1) CN102471339A (es)
CA (1) CA2767089A1 (es)
ES (1) ES2432029T3 (es)
MX (1) MX2012000709A (es)
WO (1) WO2011008915A1 (es)

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WO2014081906A2 (en) 2012-11-21 2014-05-30 Ptc Therapeutics, Inc. Substituted reverse pyrimidine bmi-1 inhibitors
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
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GB2515785A (en) * 2013-07-03 2015-01-07 Redx Pharma Ltd Compounds
EP3039015B1 (en) 2013-08-30 2019-10-30 PTC Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
JP6618901B2 (ja) 2013-11-13 2019-12-11 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
US10584115B2 (en) 2013-11-21 2020-03-10 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine BMI-1 inhibitors
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US10202373B2 (en) 2014-01-14 2019-02-12 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
WO2016058544A1 (en) * 2014-10-16 2016-04-21 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
AU2016242118B2 (en) 2015-04-02 2021-07-08 Proximagen, Llc Novel therapies for cancer
PL3090710T3 (pl) * 2015-05-07 2017-12-29 Mondi Ag Elastyczny element pieluchy
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CN108349893B (zh) 2015-09-16 2021-12-28 梅塔克林公司 类法尼醇x受体激动剂及其用途
CN110214138A (zh) * 2017-01-26 2019-09-06 韩美药品株式会社 嘧啶化合物及其药物用途
CN110637015B (zh) 2017-03-15 2024-04-02 奥加诺沃公司 法尼醇x受体激动剂及其用途
CN110637011A (zh) 2017-03-15 2019-12-31 梅塔科林公司 法尼醇x受体激动剂及其用途
GB201807147D0 (en) 2018-05-01 2018-06-13 Oncologica Uk Ltd Therapeutic combination
KR101954370B1 (ko) * 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
AU2019203034B1 (en) 2018-07-25 2019-09-26 Hanmi Pharm. Co., Ltd. Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
BR112021004919A2 (pt) 2018-09-18 2021-06-01 Metacrine, Inc. agonistas de receptor farnesoide x e usos dos mesmos
WO2020171649A1 (ko) * 2019-02-22 2020-08-27 한미약품 주식회사 Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
EP3991733A4 (en) * 2019-06-27 2023-07-05 Hanmi Pharm. Co., Ltd. PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE MYELOIC LEUKEMIA CONTAINING FLT3 INHIBITOR AND CHEMOTHERAPEUTICS
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BR112023004249A2 (pt) * 2020-09-15 2023-04-04 Mitsubishi Tanabe Pharma Corp Sal composto de triazina, forma cristalina do mesmo e método de produção do mesmo

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Also Published As

Publication number Publication date
CN102471339A (zh) 2012-05-23
US20110015173A1 (en) 2011-01-20
WO2011008915A1 (en) 2011-01-20
EP2454257B1 (en) 2013-08-21
JP2012533553A (ja) 2012-12-27
ES2432029T3 (es) 2013-11-29
CA2767089A1 (en) 2011-01-20
US8435980B2 (en) 2013-05-07
EP2454257A1 (en) 2012-05-23

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